SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZZB_E_ACTE403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		3 ARG A  53
TYR A  25
GLU A  27
 None
 0.59A 4zzbE-1azwA:
undetectable		 4zzbE-1azwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuw MONELLIN

(Dioscoreophyllum
cumminsii) 		PF09200
(Monellin) 		3 ARG A  82
TYR A  56
GLU A  75
 None
 0.69A 4zzbE-1fuwA:
undetectable		 4zzbE-1fuwA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 ARG A  54
TYR A  48
GLU A  58
 None
 0.70A 4zzbE-1jaeA:
undetectable		 4zzbE-1jaeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		3 ARG A  60
TYR A 212
GLU A 201
 PO4  A 301 (-3.8A)
None
None
 0.47A 4zzbE-1k27A:
undetectable		 4zzbE-1k27A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khu SMAD1

(Homo sapiens) 		PF03166
(MH2) 		3 ARG A 319
TYR A 276
GLU A 278
 None
 0.58A 4zzbE-1khuA:
undetectable		 4zzbE-1khuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ARG A 393
TYR A 436
GLU A 404
 None
 0.67A 4zzbE-1mewA:
undetectable		 4zzbE-1mewA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 ARG A 246
TYR A 158
GLU A 160
 NA  A1007 (-4.1A)
None
None
 0.67A 4zzbE-1o4zA:
undetectable		 4zzbE-1o4zA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ARG B 133
TYR B 194
GLU B 189
 None
 0.66A 4zzbE-1olxB:
undetectable		 4zzbE-1olxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		3 ARG A 139
TYR A 148
GLU A 142
 None
 0.53A 4zzbE-1qycA:
undetectable		 4zzbE-1qycA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Homo sapiens) 		PF03166
(MH2) 		3 ARG B 372
TYR B 328
GLU B 330
 None
 0.67A 4zzbE-1u7vB:
undetectable		 4zzbE-1u7vB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ARG B 116
TYR B 177
GLU B 172
 None
 0.60A 4zzbE-1umbB:
undetectable		 4zzbE-1umbB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN ALPHA
CONVULXIN BETA

(Crotalus
durissus;
Crotalus
durissus) 		PF00059
(Lectin_C)
PF00059
(Lectin_C) 		3 ARG A 114
TYR C 289
GLU C 291
 None
 0.71A 4zzbE-1umrA:
undetectable		 4zzbE-1umrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urx BETA-AGARASE A

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 ARG A 204
TYR A 121
GLU A 123
 None
 0.64A 4zzbE-1urxA:
undetectable		 4zzbE-1urxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfurisphaera
tokodaii) 		PF01048
(PNP_UDP_1) 		3 ARG A  59
TYR A 207
GLU A 196
 None
 0.48A 4zzbE-1v4nA:
undetectable		 4zzbE-1v4nA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 ARG A 339
TYR A 367
GLU A 371
 None
 0.67A 4zzbE-1vdkA:
2.5		 4zzbE-1vdkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ARG B 115
TYR B 176
GLU B 171
 None
 0.67A 4zzbE-1w85B:
undetectable		 4zzbE-1w85B:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		3 ARG A  17
TYR A 122
GLU A 133
 None
 0.71A 4zzbE-1wdvA:
undetectable		 4zzbE-1wdvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Aeropyrum
pernix) 		PF01048
(PNP_UDP_1) 		3 ARG A  62
TYR A 211
GLU A 200
 PO4  A 400 (-3.8A)
None
None
 0.50A 4zzbE-1wtaA:
undetectable		 4zzbE-1wtaA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		3 ARG A  56
TYR A  28
GLU A  30
 None
 0.69A 4zzbE-1x2bA:
undetectable		 4zzbE-1x2bA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535

(Pseudomonas
aeruginosa) 		PF08682
(DUF1780) 		3 ARG A  36
TYR A  45
GLU A  39
 None
 0.71A 4zzbE-1y0kA:
undetectable		 4zzbE-1y0kA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 ARG A  84
TYR A 142
GLU A  79
 None
 0.68A 4zzbE-2ecrA:
undetectable		 4zzbE-2ecrA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erx GTP-BINDING PROTEIN
DI-RAS2

(Homo sapiens) 		PF00071
(Ras) 		3 ARG A 171
TYR A   8
GLU A 169
 None
 0.68A 4zzbE-2erxA:
undetectable		 4zzbE-2erxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6b FAMILY 11 XYLANASE

(Bacillus) 		PF00457
(Glyco_hydro_11) 		3 ARG A  49
TYR A 177
GLU A 178
 None
 0.71A 4zzbE-2f6bA:
undetectable		 4zzbE-2f6bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		3 ARG A 149
TYR A 158
GLU A 152
 None
 0.65A 4zzbE-2gasA:
undetectable		 4zzbE-2gasA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf0 GTP-BINDING PROTEIN
DI-RAS1

(Homo sapiens) 		PF00071
(Ras) 		3 ARG A 170
TYR A   8
GLU A 168
 None
 0.65A 4zzbE-2gf0A:
undetectable		 4zzbE-2gf0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		3 ARG A  93
TYR A 125
GLU A 215
 None
 0.60A 4zzbE-2hruA:
undetectable		 4zzbE-2hruA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 ARG A 371
TYR A 238
GLU A 345
 None
 0.58A 4zzbE-2jf4A:
undetectable		 4zzbE-2jf4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 ARG A 435
TYR A 396
GLU A 432
 None
 0.29A 4zzbE-2ptsA:
2.8		 4zzbE-2ptsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3h RAS HOMOLOG GENE
FAMILY, MEMBER U

(Homo sapiens) 		PF00071
(Ras) 		3 ARG A 166
TYR A 200
GLU A 202
 None
 0.54A 4zzbE-2q3hA:
undetectable		 4zzbE-2q3hA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		3 ARG A 137
TYR A 146
GLU A 140
 None
 0.59A 4zzbE-2qw8A:
undetectable		 4zzbE-2qw8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ARG A 190
TYR A 400
GLU A 440
 None
 0.41A 4zzbE-2vmfA:
4.0		 4zzbE-2vmfA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		3 ARG A 554
TYR A 309
GLU A 601
 None
 0.58A 4zzbE-2w8dA:
undetectable		 4zzbE-2w8dA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdv MYC-INDUCED NUCLEAR
ANTIGEN

(Homo sapiens) 		PF08007
(Cupin_4) 		3 ARG A 216
TYR A 180
GLU A 212
 None
 0.67A 4zzbE-2xdvA:
undetectable		 4zzbE-2xdvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 ARG A 911
TYR A1048
GLU A 882
 None
 0.69A 4zzbE-2xt6A:
undetectable		 4zzbE-2xt6A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymj PROTEIN QUAKING-A

(Xenopus laevis) 		PF16544
(STAR_dimer) 		3 ARG A  75
TYR A  41
GLU A  72
 None
 0.66A 4zzbE-2ymjA:
undetectable		 4zzbE-2ymjA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzj 167AA LONG
HYPOTHETICAL DUTPASE

(Sulfurisphaera
tokodaii) 		PF00692
(dUTPase) 		3 ARG A  63
TYR A  79
GLU A  48
 None
 0.69A 4zzbE-2yzjA:
undetectable		 4zzbE-2yzjA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		3 ARG A 338
TYR A 375
GLU A 364
 None
 0.48A 4zzbE-3allA:
undetectable		 4zzbE-3allA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		3 ARG B  46
TYR B  22
GLU B  18
 None
 0.67A 4zzbE-3aqcB:
undetectable		 4zzbE-3aqcB:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		3 ARG A  97
TYR A  51
GLU A  94
 None
 0.66A 4zzbE-3aw9A:
undetectable		 4zzbE-3aw9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		3 ARG A 136
TYR A 145
GLU A 139
 None
 0.65A 4zzbE-3c1oA:
undetectable		 4zzbE-3c1oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 ARG A 479
TYR A 520
GLU A 476
 None
 0.65A 4zzbE-3cp2A:
undetectable		 4zzbE-3cp2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dit PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		PF03166
(MH2) 		3 ARG A 309
TYR A 266
GLU A 268
 None
 0.61A 4zzbE-3ditA:
undetectable		 4zzbE-3ditA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 ARG A 479
TYR A 520
GLU A 476
 None
 0.64A 4zzbE-3g05A:
undetectable		 4zzbE-3g05A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkf ALDOLASE LSRF

(Escherichia
coli) 		no annotation 3 ARG O 107
TYR O 143
GLU O 121
 None
 0.69A 4zzbE-3gkfO:
undetectable		 4zzbE-3gkfO:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		no annotation 3 ARG D 309
TYR D 266
GLU D 268
 None
 0.57A 4zzbE-3gmjD:
undetectable		 4zzbE-3gmjD:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3igq GLR4197 PROTEIN

(Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		3 ARG A  85
TYR A 102
GLU A 104
 ACY  A 701 ( 3.2A)
ACY  A 701 ( 4.8A)
ACY  A 701 ( 4.8A)
 0.22A 4zzbE-3igqA:
24.3		 4zzbE-3igqA:
68.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		3 ARG A 180
TYR A 166
GLU A 177
 None
 0.35A 4zzbE-3laoA:
undetectable		 4zzbE-3laoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyd UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF10738
(Lpp-LpqN) 		3 ARG A  84
TYR A  79
GLU A  81
 None
 0.48A 4zzbE-3lydA:
undetectable		 4zzbE-3lydA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B) 		3 ARG A 208
TYR A 116
GLU A  57
 None
 0.65A 4zzbE-3mmlA:
undetectable		 4zzbE-3mmlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		3 ARG A 420
TYR A 333
GLU A 275
 None
 0.68A 4zzbE-3oepA:
undetectable		 4zzbE-3oepA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		3 ARG A  66
TYR A 215
GLU A 204
 None
 0.44A 4zzbE-3ozbA:
undetectable		 4zzbE-3ozbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p02 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		3 ARG A  76
TYR A 157
GLU A 151
 None
 0.56A 4zzbE-3p02A:
undetectable		 4zzbE-3p02A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00903
(Glyoxalase) 		3 ARG A 117
TYR A  11
GLU A  68
 None
 0.68A 4zzbE-3rheA:
undetectable		 4zzbE-3rheA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		3 ARG A 350
TYR A 209
GLU A 207
 None
 0.52A 4zzbE-3s6bA:
undetectable		 4zzbE-3s6bA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		3 ARG A 202
TYR A 163
GLU A 199
 None
 0.68A 4zzbE-3t33A:
2.6		 4zzbE-3t33A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		3 ARG A  58
TYR A 206
GLU A 195
 SO4  A 902 (-4.0A)
None
None
 0.49A 4zzbE-3t94A:
undetectable		 4zzbE-3t94A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trj PHOSPHOHEPTOSE
ISOMERASE

(Francisella
tularensis) 		PF13580
(SIS_2) 		3 ARG A 164
TYR A 156
GLU A 162
 None
 0.65A 4zzbE-3trjA:
undetectable		 4zzbE-3trjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		3 ARG A 445
TYR A 390
GLU A 365
 None
 0.63A 4zzbE-3u7gA:
undetectable		 4zzbE-3u7gA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		3 ARG A  37
TYR A  47
GLU A  40
 None
 0.68A 4zzbE-3uhjA:
undetectable		 4zzbE-3uhjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A1292
TYR A1182
GLU A1124
 None
 0.68A 4zzbE-3va7A:
undetectable		 4zzbE-3va7A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		3 ARG A 793
TYR A 773
GLU A 767
 None
 0.60A 4zzbE-3vkwA:
undetectable		 4zzbE-3vkwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 ARG A 911
TYR A1048
GLU A 882
 None
 0.65A 4zzbE-3zhrA:
undetectable		 4zzbE-3zhrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC

(Escherichia
coli) 		PF01551
(Peptidase_M23) 		3 ARG A 405
TYR A 401
GLU A 403
 IOD  A1420 ( 4.6A)
None
None
 0.70A 4zzbE-4bh5A:
undetectable		 4zzbE-4bh5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		3 ARG A 458
TYR A 495
GLU A 460
 DMX  A2690 (-3.1A)
DMX  A2690 ( 4.4A)
None
 0.71A 4zzbE-4c4aA:
undetectable		 4zzbE-4c4aA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 ARG A 192
TYR A 427
GLU A 467
 None
 0.44A 4zzbE-4cvuA:
undetectable		 4zzbE-4cvuA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Pyrococcus
horikoshii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		3 ARG A 144
TYR A 223
GLU A 147
 None
 0.69A 4zzbE-4firA:
undetectable		 4zzbE-4firA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 ARG A 461
TYR A 442
GLU A 451
 None
 0.67A 4zzbE-4fvlA:
undetectable		 4zzbE-4fvlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		3 ARG A  64
TYR A 214
GLU A 203
 None
 0.45A 4zzbE-4glfA:
undetectable		 4zzbE-4glfA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhe QUINOLINATE SYNTHASE
A

(Pyrococcus
furiosus) 		PF02445
(NadA) 		3 ARG A  13
TYR A 272
GLU A  10
 None
 0.68A 4zzbE-4hheA:
undetectable		 4zzbE-4hheA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF07245
(Phlebovirus_G2) 		3 ARG A 848
TYR A 913
GLU A 907
 None
 0.71A 4zzbE-4hjcA:
2.8		 4zzbE-4hjcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv6 N-TERMINAL
ACETYLTRANSFERASE
COMPLEX SUBUNIT
[ARD1]

(Thermoplasma
volcanium) 		no annotation 3 ARG C  76
TYR C 140
GLU C 114
 None
 0.65A 4zzbE-4pv6C:
undetectable		 4zzbE-4pv6C:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 3 ARG A 193
TYR A 339
GLU A 268
 None
 0.69A 4zzbE-4rh0A:
undetectable		 4zzbE-4rh0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		3 ARG A 155
TYR A 140
GLU A 146
 None
 0.65A 4zzbE-4txgA:
undetectable		 4zzbE-4txgA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 ARG A1585
TYR A1581
GLU A1583
 None
 0.66A 4zzbE-4u48A:
3.3		 4zzbE-4u48A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		3 ARG A  63
TYR A  14
GLU A  28
 None
 0.67A 4zzbE-4x00A:
undetectable		 4zzbE-4x00A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 ARG A  85
TYR A 102
GLU A 104
 CL  A 502 (-4.3A)
None
None
 0.11A 4zzbE-4x5tA:
35.0		 4zzbE-4x5tA:
70.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		3 ARG A 421
TYR A 228
GLU A 281
 None
 0.42A 4zzbE-4x8dA:
2.1		 4zzbE-4x8dA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		3 ARG A 354
TYR A  49
GLU A  38
 None
 0.62A 4zzbE-5b48A:
undetectable		 4zzbE-5b48A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 ARG A 282
TYR A 143
GLU A 279
 None
 0.66A 4zzbE-5dp2A:
undetectable		 4zzbE-5dp2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee4 HPUA

(Kingella
denitrificans) 		PF16960
(HpuA) 		3 ARG A 305
TYR A 194
GLU A 178
 None
 0.68A 4zzbE-5ee4A:
undetectable		 4zzbE-5ee4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 ARG A  54
TYR A 222
GLU A 211
 None
 0.52A 4zzbE-5f7oA:
undetectable		 4zzbE-5f7oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 2

(Homo sapiens) 		PF04153
(NOT2_3_5) 		3 ARG B 481
TYR B 518
GLU B 495
 None
 0.52A 4zzbE-5fu7B:
undetectable		 4zzbE-5fu7B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 3 ARG A 607
TYR A 444
GLU A 456
 None
 0.60A 4zzbE-5hdtA:
2.8		 4zzbE-5hdtA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A1292
TYR A1182
GLU A1124
 None
 0.68A 4zzbE-5i8iA:
undetectable		 4zzbE-5i8iA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		3 ARG A  77
TYR A  61
GLU A  75
 None
 0.62A 4zzbE-5ixpA:
undetectable		 4zzbE-5ixpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 ARG A 482
TYR A 573
GLU A 485
 None
 0.58A 4zzbE-5k5mA:
undetectable		 4zzbE-5k5mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		3 ARG A  16
TYR A 136
GLU A 103
 None
 0.60A 4zzbE-5kh0A:
undetectable		 4zzbE-5kh0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 ARG A 344
TYR A 449
GLU A 313
 None
 0.66A 4zzbE-5l46A:
undetectable		 4zzbE-5l46A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 ARG A 273
TYR A 221
GLU A 250
 None
 0.69A 4zzbE-5m42A:
undetectable		 4zzbE-5m42A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 3 ARG A 107
TYR A  78
GLU A 104
 ILE  A 201 (-4.0A)
None
ILE  A 201 (-2.8A)
 0.71A 4zzbE-5n0lA:
undetectable		 4zzbE-5n0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		3 ARG A 303
TYR A 155
GLU A 326
 CL  A 508 (-3.2A)
None
None
 0.70A 4zzbE-5ncwA:
undetectable		 4zzbE-5ncwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN
ACYL CARRIER
PROTEIN,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF00467
(KOW)
PF17136
(ribosomal_L24)
PF01016
(Ribosomal_L27) 		3 ARG v  36
TYR w  90
GLU w 117
 None
 0.62A 4zzbE-5oomv:
undetectable		 4zzbE-5oomv:
14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 3 ARG A  84
TYR A 101
GLU A 103
 CL  A 504 (-4.7A)
None
None
 0.23A 4zzbE-5osbA:
32.8		 4zzbE-5osbA:
70.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01493
(GXGXG) 		3 ARG B 264
TYR C 135
GLU C 161
 None
 0.70A 4zzbE-5t5iB:
undetectable		 4zzbE-5t5iB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		3 ARG A 883
TYR A 856
GLU A 794
 None
 0.59A 4zzbE-5uj6A:
3.1		 4zzbE-5uj6A:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 3 ARG C  85
TYR C 102
GLU C 104
 None
 0.46A 4zzbE-5v6nC:
33.9		 4zzbE-5v6nC:
99.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 3 ARG A 624
TYR A 617
GLU A 514
 None
 0.64A 4zzbE-5xflA:
5.6		 4zzbE-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 3 ARG A 206
TYR A 415
GLU A 455
 None
 0.45A 4zzbE-6byiA:
3.3		 4zzbE-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 3 ARG A  30
TYR A 101
GLU A  29
 None
 0.48A 4zzbE-6ei3A:
2.1		 4zzbE-6ei3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 3 ARG A 176
TYR A 168
GLU A 172
 None
 0.67A 4zzbE-6gkvA:
undetectable		 4zzbE-6gkvA:
undetectable