SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZZB_C_ACTC404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 ILE A 447
ILE A 462
ARG A 465
TYR A 452
 None
 1.23A 4zzbC-1csjA:
0.3		 4zzbC-1csjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbt FRUCTOSE-2,6-BISPHOS
PHATASE

(Rattus
norvegicus) 		PF00300
(His_Phos_1) 		4 ILE A 128
ILE A   3
ARG A   1
TYR A 152
 None
 1.34A 4zzbC-1fbtA:
undetectable		 4zzbC-1fbtA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		4 ILE A 363
ILE A 181
ARG A 187
TYR A 371
 None
 1.36A 4zzbC-1hjoA:
0.0		 4zzbC-1hjoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 ILE A 250
ILE A 164
ARG A 127
TYR A 248
 None
 1.23A 4zzbC-2c1cA:
1.1		 4zzbC-2c1cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		4 ILE A 151
ILE A 125
ARG A 123
TYR A 103
 None
 1.15A 4zzbC-2f4nA:
undetectable		 4zzbC-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ILE A1153
ILE A1167
ARG A1160
TYR A1102
 None
 1.48A 4zzbC-2vxrA:
0.0		 4zzbC-2vxrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Thermotoga
maritima) 		PF04029
(2-ph_phosp) 		4 ILE A 110
ILE A 130
ARG A  15
TYR A 123
 None
 1.45A 4zzbC-2yyvA:
undetectable		 4zzbC-2yyvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		4 ILE A 282
ILE A 349
ARG A 305
TYR A 284
 None
 1.47A 4zzbC-3hdoA:
0.0		 4zzbC-3hdoA:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3igq GLR4197 PROTEIN

(Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 ILE A  73
ILE A  76
ARG A  85
TYR A 102
 NA  A 801 ( 4.4A)
ACY  A 701 (-4.5A)
ACY  A 701 ( 3.2A)
ACY  A 701 ( 4.8A)
 0.40A 4zzbC-3igqA:
24.5		 4zzbC-3igqA:
68.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 220
ILE A 177
ARG A 207
TYR A 230
 None
 1.37A 4zzbC-4emwA:
0.3		 4zzbC-4emwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 122
ILE A 118
ARG A  10
TYR A 106
 None
 1.09A 4zzbC-4jr7A:
1.5		 4zzbC-4jr7A:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ILE A  73
ILE A  76
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.12A 4zzbC-4x5tA:
35.2		 4zzbC-4x5tA:
70.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 ILE A 134
ILE A 115
ARG A  86
TYR A 194
 None
None
EDO  A 302 (-4.3A)
None
 1.47A 4zzbC-5ko5A:
undetectable		 4zzbC-5ko5A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 4 ILE A  72
ILE A  75
ARG A  84
TYR A 101
 None
None
CL  A 504 (-4.7A)
None
 0.24A 4zzbC-5osbA:
32.9		 4zzbC-5osbA:
70.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 4 ILE C  73
ILE C  76
ARG C  85
TYR C 102
 None
 0.55A 4zzbC-5v6nC:
34.0		 4zzbC-5v6nC:
99.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 4 ILE A  51
ILE A  36
ARG A  62
TYR A 115
 None
 1.11A 4zzbC-5x1tA:
1.3		 4zzbC-5x1tA:
undetectable