SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZZ8_A_GCSA208_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 GLU A  49
ARG A 335
ASP A 305
ALA A 303
 None
 1.00A 4zz8A-1cj2A:
undetectable		 4zz8A-1cj2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dsf ANTICANCER ANTIBODY
B1

(Mus musculus) 		PF07686
(V-set) 		4 ARG H  94
TYR H 100
ASP H  31
TYR H  99
 None
 0.95A 4zz8A-1dsfH:
2.9		 4zz8A-1dsfH:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		4 GLU A  22
ARG A 117
GLU A 127
ALA A  78
 None
 0.96A 4zz8A-1f1uA:
0.0		 4zz8A-1f1uA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLU A  22
ARG A 117
GLU A 127
ALA A  78
 None
 0.98A 4zz8A-1f1xA:
0.0		 4zz8A-1f1xA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 GLU A 205
GLU A 329
ALA A 328
TYR A 225
 None
 1.14A 4zz8A-1guqA:
0.0		 4zz8A-1guqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 GLU A 390
ARG A 284
ALA A 191
TYR A 393
 None
 0.83A 4zz8A-1hc7A:
0.0		 4zz8A-1hc7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		4 GLU A 519
ARG A  13
ASP A  14
ALA A  12
 None
 1.12A 4zz8A-1iokA:
0.0		 4zz8A-1iokA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 GLU A  96
ARG A 232
TYR A  94
ALA A 326
 None
 0.91A 4zz8A-1krmA:
0.0		 4zz8A-1krmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus) 		PF00625
(Guanylate_kin) 		4 ARG A  44
TYR A  81
GLU A  47
ASP A  52
 5GP  A1202 (-3.1A)
5GP  A1202 (-3.8A)
None
None
 1.13A 4zz8A-1lvgA:
0.0		 4zz8A-1lvgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 GLU C  66
ARG C 171
GLU C 137
ALA C 169
 None
 1.19A 4zz8A-1n61C:
undetectable		 4zz8A-1n61C:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 379
ARG A 414
GLU A 393
ALA A 475
 None
 0.90A 4zz8A-1typA:
undetectable		 4zz8A-1typA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 379
ARG A 414
TYR A 478
GLU A 393
 None
 0.97A 4zz8A-1typA:
undetectable		 4zz8A-1typA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 4 GLU A 178
ARG A 229
GLU A 226
TYR A 193
 None
 1.07A 4zz8A-1u5uA:
undetectable		 4zz8A-1u5uA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		4 GLU A  99
ARG A 235
TYR A  97
ALA A 329
 None
 0.97A 4zz8A-1uioA:
undetectable		 4zz8A-1uioA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 GLU A 511
TYR A 507
ALA A 194
TYR A 494
 SO3  A 540 ( 4.7A)
None
SO3  A 540 (-3.4A)
None
 0.89A 4zz8A-1yt8A:
undetectable		 4zz8A-1yt8A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6g GUANYLATE KINASE

(Plasmodium
falciparum) 		PF00625
(Guanylate_kin) 		4 ARG A  44
TYR A  81
GLU A  47
ASP A  52
 None
 1.08A 4zz8A-1z6gA:
undetectable		 4zz8A-1z6gA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 GLU A 389
ARG A 429
TYR A 402
GLU A 425
 None
 1.09A 4zz8A-2csdA:
undetectable		 4zz8A-2csdA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		4 GLU A 345
GLU A 357
ALA A 349
TYR A 344
 None
 1.19A 4zz8A-2du7A:
undetectable		 4zz8A-2du7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 GLU A  38
ARG A  24
GLU A  25
ALA A  29
 None
 1.07A 4zz8A-2gfnA:
undetectable		 4zz8A-2gfnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 GLU A 271
TYR A 298
ASP A 313
ALA A 310
 None
 1.08A 4zz8A-2gouA:
undetectable		 4zz8A-2gouA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A 450
TYR A  98
ASP A 556
ALA A 526
 None
 0.90A 4zz8A-2hdiA:
undetectable		 4zz8A-2hdiA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3e G-RICH

(Carassius
auratus) 		PF05881
(CNPase) 		4 ARG A 151
TYR A  84
ASP A 131
ALA A 130
 None
 1.14A 4zz8A-2i3eA:
undetectable		 4zz8A-2i3eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipa PROTEIN ARSC

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 GLU B  21
ASP B  65
ALA B  37
TYR B  35
 None
 1.20A 4zz8A-2ipaB:
undetectable		 4zz8A-2ipaB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 GLU A 147
ARG A 113
ASP A 112
ALA A 116
 None
 1.02A 4zz8A-2oodA:
undetectable		 4zz8A-2oodA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbj PROSTAGLANDIN E
SYNTHASE 2

(Macaca
fascicularis) 		PF13417
(GST_N_3) 		4 ARG A 252
TYR A 308
ASP A 348
ALA A 349
 None
 1.07A 4zz8A-2pbjA:
undetectable		 4zz8A-2pbjA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		4 TYR A  25
ASP A 134
ALA A 135
TYR A  20
 None
None
SAH  A 301 ( 3.7A)
None
 0.85A 4zz8A-2pxxA:
undetectable		 4zz8A-2pxxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLU A 297
ASP A 217
ALA A 235
TYR A 236
 None
 1.18A 4zz8A-2qk4A:
undetectable		 4zz8A-2qk4A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5s UNCHARACTERIZED
PROTEIN VP0806

(Vibrio
parahaemolyticus) 		PF14559
(TPR_19)
PF14561
(TPR_20) 		4 GLU A 206
TYR A 226
GLU A 198
ALA A 197
 None
None
None
EDO  A   3 ( 4.5A)
 1.13A 4zz8A-2r5sA:
undetectable		 4zz8A-2r5sA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		4 GLU A  51
ARG A  50
ASP A  60
ALA A  59
 None
None
MG  A 266 ( 4.0A)
None
 0.87A 4zz8A-2rdsA:
undetectable		 4zz8A-2rdsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 GLU A 203
ASP A 259
ALA A 260
TYR A 263
 A2G  A1428 (-2.7A)
None
A2G  A1428 (-3.4A)
None
 1.20A 4zz8A-2w7yA:
undetectable		 4zz8A-2w7yA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 321
ASP A 313
ALA A 276
TYR A 312
 None
 1.19A 4zz8A-2xt6A:
undetectable		 4zz8A-2xt6A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay2 LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		4 GLU A 110
ASP A 111
ALA A 109
TYR A 162
 None
 1.14A 4zz8A-3ay2A:
undetectable		 4zz8A-3ay2A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		4 GLU A 127
ARG A  99
ASP A 100
ALA A  97
 SO4  A 344 ( 3.1A)
SO4  A 344 ( 4.3A)
None
None
 1.21A 4zz8A-3cerA:
undetectable		 4zz8A-3cerA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 336
ARG A 280
GLU A 233
ASP A 234
 None
 1.03A 4zz8A-3dfhA:
undetectable		 4zz8A-3dfhA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLU A 178
ARG A 229
GLU A 226
TYR A 193
 None
 1.01A 4zz8A-3dy5A:
undetectable		 4zz8A-3dy5A:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 GLU A  36
GLU A 274
ALA A 269
TYR A  25
 EDO  A 316 ( 4.7A)
EDO  A 312 (-4.6A)
None
None
 0.90A 4zz8A-3e02A:
undetectable		 4zz8A-3e02A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLU A  22
ARG A 117
GLU A 127
ALA A  78
 None
 0.98A 4zz8A-3eckA:
undetectable		 4zz8A-3eckA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grd UNCHARACTERIZED
NTF2-SUPERFAMILY
PROTEIN

(Bacillus cereus) 		PF12680
(SnoaL_2) 		4 TYR A  67
ASP A 123
ALA A 102
TYR A  89
 None
None
None
ACT  A 134 (-4.2A)
 1.19A 4zz8A-3grdA:
undetectable		 4zz8A-3grdA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP7

(Saccharomyces
cerevisiae) 		PF12328
(Rpp20) 		4 GLU B  91
TYR B 139
GLU B 135
TYR B  62
 None
 1.13A 4zz8A-3iabB:
undetectable		 4zz8A-3iabB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF06544
(DUF1115)
PF08572
(PRP3) 		4 GLU K 167
ARG B 135
TYR K 159
GLU B 139
 None
 1.16A 4zz8A-3jcmK:
undetectable		 4zz8A-3jcmK:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		4 GLU A 126
TYR A 125
GLU A  78
ASP A  40
 None
 1.17A 4zz8A-3kh1A:
undetectable		 4zz8A-3kh1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld3 INORGANIC
PYROPHOSPHATASE

(Anaplasma
phagocytophilum) 		PF00719
(Pyrophosphatase) 		4 GLU A 146
GLU A  99
ASP A  98
TYR A 142
 None
PO4  A 200 ( 4.9A)
None
PO4  A 200 (-4.6A)
 1.13A 4zz8A-3ld3A:
undetectable		 4zz8A-3ld3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		4 GLU A  36
GLU A 277
ALA A 272
TYR A  25
 None
 0.89A 4zz8A-3lotA:
undetectable		 4zz8A-3lotA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 GLU A  45
TYR A  48
ASP A 140
ALA A 141
 None
 1.13A 4zz8A-3lxdA:
undetectable		 4zz8A-3lxdA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4h PUTATIVE TAUTOMERASE

(Corynebacterium
glutamicum) 		PF14552
(Tautomerase_2) 		4 GLU A  30
ARG A  84
GLU A  88
ALA A  23
 None
 1.21A 4zz8A-3n4hA:
undetectable		 4zz8A-3n4hA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		4 GLU A 271
ARG A 147
TYR A 305
GLU A 349
 None
 1.08A 4zz8A-3qc2A:
undetectable		 4zz8A-3qc2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		4 ARG A 331
TYR A  95
GLU A 334
ASP A  40
 None
 1.12A 4zz8A-3qm3A:
undetectable		 4zz8A-3qm3A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 336
ARG A 280
GLU A 233
ASP A 234
 None
MG  A 402 (-4.7A)
MG  A 402 (-2.8A)
None
 1.13A 4zz8A-3s47A:
undetectable		 4zz8A-3s47A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se3 INTERFERON
ALPHA/BETA RECEPTOR
2

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 GLU C  77
TYR C  79
GLU C  50
TYR C  43
 None
 1.22A 4zz8A-3se3C:
undetectable		 4zz8A-3se3C:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tih HIV-1 CLADE C
ZM109F.PB4 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 GLU A  62
TYR A  61
ASP A  57
ALA A  58
 None
 1.04A 4zz8A-3tihA:
undetectable		 4zz8A-3tihA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		4 GLU A 577
ASP A 485
ALA A 484
TYR A 563
 None
 1.20A 4zz8A-3ty9A:
undetectable		 4zz8A-3ty9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 ARG A 758
TYR A 796
GLU A 761
ASP A 766
 None
 0.96A 4zz8A-3uatA:
undetectable		 4zz8A-3uatA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLU A 402
ARG A 295
TYR A 303
ALA A 298
 None
 1.10A 4zz8A-3vb9A:
1.3		 4zz8A-3vb9A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 4 GLU A 710
TYR A 736
GLU A 748
TYR A 762
 None
 1.11A 4zz8A-3vu1A:
0.4		 4zz8A-3vu1A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1

(Homo sapiens) 		PF00625
(Guanylate_kin) 		4 ARG A 773
TYR A 811
GLU A 776
ASP A 781
 None
 1.08A 4zz8A-3w9yA:
undetectable		 4zz8A-3w9yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 TYR A 575
ASP A 596
ALA A 597
TYR A 605
 None
 1.20A 4zz8A-3zuqA:
undetectable		 4zz8A-3zuqA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 GLU A  92
TYR A  93
ASP A 294
ALA A 238
 None
 1.13A 4zz8A-4a01A:
undetectable		 4zz8A-4a01A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		4 GLU C  72
TYR C  71
ASP C  83
ALA C  79
 None
 1.21A 4zz8A-4a7lC:
undetectable		 4zz8A-4a7lC:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 GLU A 234
TYR A 237
GLU A  11
TYR A 257
 None
 1.18A 4zz8A-4aq4A:
undetectable		 4zz8A-4aq4A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 GLU A 386
ARG A 464
TYR A 621
GLU A 460
 None
 1.16A 4zz8A-4ar9A:
undetectable		 4zz8A-4ar9A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLU A 878
TYR A1035
ASP A 968
TYR A1028
 None
 0.97A 4zz8A-4bedA:
undetectable		 4zz8A-4bedA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 334
ARG A 278
GLU A 231
ASP A 232
 None
None
MG  A 401 (-2.7A)
None
 1.16A 4zz8A-4hnlA:
undetectable		 4zz8A-4hnlA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 GLU A 794
TYR A 648
ASP A 423
TYR A 644
 None
 1.19A 4zz8A-4il1A:
undetectable		 4zz8A-4il1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 GLU A 681
TYR A 702
ASP A 595
ALA A 594
 None
 1.00A 4zz8A-4krfA:
undetectable		 4zz8A-4krfA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldy AUXIN RESPONSE
FACTOR 1

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		4 GLU A 299
ARG A 267
ASP A 206
ALA A 207
 None
 0.95A 4zz8A-4ldyA:
undetectable		 4zz8A-4ldyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 TYR A 247
ASP A 266
ALA A 265
TYR A 237
 None
 1.16A 4zz8A-4lglA:
undetectable		 4zz8A-4lglA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		4 ARG A 103
ASP A  21
ALA A  22
TYR A  76
 None
 0.81A 4zz8A-4mynA:
undetectable		 4zz8A-4mynA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 4 ARG A 281
TYR A 335
GLU A 260
TYR A 334
 None
 1.16A 4zz8A-4nzmA:
undetectable		 4zz8A-4nzmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzy PROBABLE THYMIDYLATE
KINASE

(Sulfurisphaera
tokodaii) 		PF02223
(Thymidylate_kin) 		4 GLU A  10
ASP A 102
ALA A 100
TYR A  99
 None
 1.11A 4zz8A-4nzyA:
undetectable		 4zz8A-4nzyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 GLU C 466
TYR C 449
ASP C 483
ALA C 487
 None
 1.21A 4zz8A-4u1dC:
undetectable		 4zz8A-4u1dC:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfj ARGININOSUCCINATE
SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00764
(Arginosuc_synth) 		4 GLU A 260
TYR A  87
ASP A 177
ALA A 184
 ARG  A 503 (-3.1A)
None
ANP  A 501 (-4.6A)
ARG  A 503 ( 3.9A)
 0.97A 4zz8A-4xfjA:
undetectable		 4zz8A-4xfjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		4 GLU A 307
ARG A 258
ASP A 256
ALA A 116
 None
None
MPD  A 402 (-3.5A)
MPD  A 402 ( 4.6A)
 1.13A 4zz8A-4y0eA:
undetectable		 4zz8A-4y0eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		4 GLU A 101
TYR A 103
ASP A 154
ALA A 155
 None
 0.82A 4zz8A-4ybrA:
undetectable		 4zz8A-4ybrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 539
ASP A 518
ALA A 519
TYR A 540
 None
 1.21A 4zz8A-5a0zA:
undetectable		 4zz8A-5a0zA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aju PHOSPHORIBOHYDROLASE
LONELY GUY

(Claviceps
purpurea) 		PF03641
(Lysine_decarbox) 		4 GLU A  55
GLU A 217
ASP A 215
ALA A 216
 None
 1.15A 4zz8A-5ajuA:
undetectable		 4zz8A-5ajuA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 GLU A 775
ARG A 126
TYR A  37
TYR A  41
 None
 1.20A 4zz8A-5c9iA:
undetectable		 4zz8A-5c9iA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwf DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 GLU A 165
ARG A 150
ASP A 153
ALA A 154
 None
 1.18A 4zz8A-5cwfA:
undetectable		 4zz8A-5cwfA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dze ENDO-GLUCANASE

(Vitis vinifera) 		PF00722
(Glyco_hydro_16) 		4 GLU A  82
TYR A 167
ASP A  88
ALA A  89
 GLC  A 301 (-2.1A)
None
None
GLC  A 301 ( 3.8A)
 1.03A 4zz8A-5dzeA:
4.6		 4zz8A-5dzeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		4 GLU A1150
ARG A1200
TYR A1139
TYR A1137
 None
 1.19A 4zz8A-5fguA:
undetectable		 4zz8A-5fguA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A  74
TYR A  73
ASP A 126
ALA A  27
 None
 1.11A 4zz8A-5hqlA:
undetectable		 4zz8A-5hqlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 GLU A  75
TYR A  61
GLU A  54
TYR A  57
 None
 1.21A 4zz8A-5ixpA:
undetectable		 4zz8A-5ixpA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLU A  89
TYR A  86
ALA A  29
TYR A  32
 None
 1.10A 4zz8A-5j5jA:
undetectable		 4zz8A-5j5jA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		4 GLU A 470
ARG A 538
GLU A 541
ALA A 525
 None
 1.09A 4zz8A-5kkbA:
undetectable		 4zz8A-5kkbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l83 AUTOPHAGY-RELATED
PROTEIN

(Solanum
tuberosum) 		PF02991
(Atg8) 		4 GLU A  97
TYR A  96
ASP A  28
ALA A  54
 EDO  A 205 (-3.6A)
None
None
EDO  A 205 ( 4.2A)
 1.19A 4zz8A-5l83A:
undetectable		 4zz8A-5l83A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		4 GLU A 582
ARG A 588
TYR A 575
TYR A 558
 None
 1.15A 4zz8A-5m9nA:
undetectable		 4zz8A-5m9nA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLU A 770
ARG A 776
TYR A 763
TYR A 746
 None
 1.13A 4zz8A-5m9oA:
undetectable		 4zz8A-5m9oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 2

(Mus musculus) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		4 ARG B 204
ASP B 183
ALA B 184
TYR B 197
 None
 1.18A 4zz8A-5mx5B:
undetectable		 4zz8A-5mx5B:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 4 GLU A 521
ARG A 320
GLU A 340
ALA A 318
 None
 1.04A 4zz8A-5o3wA:
undetectable		 4zz8A-5o3wA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 4 GLU A 376
ARG A 454
TYR A 611
GLU A 450
 None
 1.06A 4zz8A-5o7eA:
undetectable		 4zz8A-5o7eA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLU A 541
TYR A 537
GLU A 468
ALA A 467
 None
 1.08A 4zz8A-5tusA:
undetectable		 4zz8A-5tusA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ARG D1123
TYR D1077
GLU D1120
ASP D1117
 None
 1.20A 4zz8A-5uheD:
undetectable		 4zz8A-5uheD:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 GLU A 684
TYR A 705
ASP A 598
ALA A 597
 None
 1.12A 4zz8A-5vm9A:
undetectable		 4zz8A-5vm9A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		4 GLU A 131
ASP A 184
ALA A 185
TYR A 103
 None
 1.14A 4zz8A-5x0eA:
undetectable		 4zz8A-5x0eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 4 GLU A  32
TYR A  84
ASP A  92
ALA A  91
 None
 0.95A 4zz8A-5ygrA:
undetectable		 4zz8A-5ygrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 4 GLU A 245
ARG A 116
ASP A 238
ALA A 237
 None
 0.71A 4zz8A-5ysmA:
undetectable		 4zz8A-5ysmA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 4 GLU A 192
ASP A 230
ALA A 233
TYR A 232
 None
 1.19A 4zz8A-6bc5A:
undetectable		 4zz8A-6bc5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 4 GLU A  49
ARG A 335
ASP A 305
ALA A 303
 CL  A 402 ( 4.6A)
CL  A 402 (-3.5A)
None
None
 0.91A 4zz8A-6dllA:
undetectable		 4zz8A-6dllA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 4 GLU A  20
ARG A  54
ASP A  58
ALA A  55
 None
 1.20A 4zz8A-6f5zA:
undetectable		 4zz8A-6f5zA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 GLU h  65
ARG h  73
TYR p  63
ALA h  50
TYR p  61
 None
 1.44A 4zz8A-6g2jh:
undetectable		 4zz8A-6g2jh:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A  73
TYR A  72
ASP A 125
ALA A  27
 None
 1.15A 4zz8A-9rubA:
undetectable		 4zz8A-9rubA:
15.17