SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZVC_A_BEZA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		5 ILE A  67
LEU A  66
ILE A  77
LEU A  79
LEU A  27
 None
 0.97A 4zvcA-1c9kA:
0.0
4zvcB-1c9kA:
0.0		 4zvcA-1c9kA:
19.78
4zvcB-1c9kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		5 ILE A  77
LEU A  79
LEU A  27
ILE A  67
LEU A  66
 None
 0.97A 4zvcA-1c9kA:
0.0
4zvcB-1c9kA:
0.0		 4zvcA-1c9kA:
19.78
4zvcB-1c9kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 ILE A 146
LEU A 150
ILE A 320
LEU A 215
 None
 0.79A 4zvcA-1dc1A:
1.8
4zvcB-1dc1A:
1.7		 4zvcA-1dc1A:
17.41
4zvcB-1dc1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 ILE A 320
LEU A 215
ILE A 146
LEU A 150
 None
 0.79A 4zvcA-1dc1A:
1.8
4zvcB-1dc1A:
1.7		 4zvcA-1dc1A:
17.41
4zvcB-1dc1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ILE A  92
LEU A  90
ILE A 131
LEU A  70
 None
 0.82A 4zvcA-1fcpA:
undetectable
4zvcB-1fcpA:
undetectable		 4zvcA-1fcpA:
10.96
4zvcB-1fcpA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pio BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		4 ILE A 123
LEU A 119
LEU A  81
ILE A 138
 None
 0.80A 4zvcA-1pioA:
0.0
4zvcB-1pioA:
0.0		 4zvcA-1pioA:
17.44
4zvcB-1pioA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pio BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		4 ILE A 138
ILE A 123
LEU A 119
LEU A  81
 None
 0.80A 4zvcA-1pioA:
0.0
4zvcB-1pioA:
0.0		 4zvcA-1pioA:
17.44
4zvcB-1pioA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis) 		PF00440
(TetR_N) 		4 ILE A  17
ILE A  58
LEU A  54
LEU A 104
 None
 0.79A 4zvcA-2f07A:
2.8
4zvcB-2f07A:
3.0		 4zvcA-2f07A:
21.08
4zvcB-2f07A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis) 		PF00440
(TetR_N) 		4 ILE A  58
LEU A  54
LEU A 104
ILE A  17
 None
 0.79A 4zvcA-2f07A:
2.8
4zvcB-2f07A:
3.0		 4zvcA-2f07A:
21.08
4zvcB-2f07A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 152
LEU A 192
ILE A 170
LEU A 242
 None
 0.82A 4zvcA-2fymA:
0.3
4zvcB-2fymA:
0.5		 4zvcA-2fymA:
15.31
4zvcB-2fymA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 170
LEU A 242
ILE A 152
LEU A 192
 None
 0.82A 4zvcA-2fymA:
0.3
4zvcB-2fymA:
0.5		 4zvcA-2fymA:
15.31
4zvcB-2fymA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 ILE A 178
LEU A 176
LEU A  91
ARG A 226
 None
 0.73A 4zvcA-2hufA:
undetectable
4zvcB-2hufA:
0.0		 4zvcA-2hufA:
16.03
4zvcB-2hufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 LEU A  91
ARG A 226
ILE A 178
LEU A 176
 None
 0.74A 4zvcA-2hufA:
undetectable
4zvcB-2hufA:
0.0		 4zvcA-2hufA:
16.03
4zvcB-2hufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 ILE A 428
LEU A 409
ILE A 438
ARG A 443
 None
 0.77A 4zvcA-2i3oA:
0.0
4zvcB-2i3oA:
0.1		 4zvcA-2i3oA:
14.60
4zvcB-2i3oA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 ILE A 438
ARG A 443
ILE A 428
LEU A 409
 None
 0.78A 4zvcA-2i3oA:
0.0
4zvcB-2i3oA:
0.1		 4zvcA-2i3oA:
14.60
4zvcB-2i3oA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l81 ENHANCER OF
FILAMENTATION 1

(Homo sapiens) 		PF08824
(Serine_rich) 		4 ILE A 162
LEU A 158
LEU A  26
LEU A 102
 None
 0.76A 4zvcA-2l81A:
7.4
4zvcB-2l81A:
7.3		 4zvcA-2l81A:
20.12
4zvcB-2l81A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l81 ENHANCER OF
FILAMENTATION 1

(Homo sapiens) 		PF08824
(Serine_rich) 		4 LEU A 102
ILE A 162
LEU A 158
LEU A  26
 None
 0.78A 4zvcA-2l81A:
7.4
4zvcB-2l81A:
7.3		 4zvcA-2l81A:
20.12
4zvcB-2l81A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnj PROTEIN INTERACTING
WITH HSP90 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B  50
ARG B  40
LEU B  48
ILE B  83
 None
 0.82A 4zvcA-2mnjB:
undetectable
4zvcB-2mnjB:
undetectable		 4zvcA-2mnjB:
21.24
4zvcB-2mnjB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnj PROTEIN INTERACTING
WITH HSP90 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B  83
ILE B  50
ARG B  40
LEU B  48
 None
 0.79A 4zvcA-2mnjB:
undetectable
4zvcB-2mnjB:
undetectable		 4zvcA-2mnjB:
21.24
4zvcB-2mnjB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2moq IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B

(Staphylococcus
aureus) 		PF05031
(NEAT) 		4 ILE A 223
LEU A 211
LEU A 129
LEU A 125
 None
 0.79A 4zvcA-2moqA:
undetectable
4zvcB-2moqA:
undetectable		 4zvcA-2moqA:
18.75
4zvcB-2moqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2moq IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B

(Staphylococcus
aureus) 		PF05031
(NEAT) 		4 LEU A 129
LEU A 125
ILE A 223
LEU A 211
 None
 0.77A 4zvcA-2moqA:
undetectable
4zvcB-2moqA:
undetectable		 4zvcA-2moqA:
18.75
4zvcB-2moqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 ILE A 510
ILE A 614
ARG A 586
LEU A 588
 None
 0.70A 4zvcA-2o1xA:
undetectable
4zvcB-2o1xA:
undetectable		 4zvcA-2o1xA:
11.36
4zvcB-2o1xA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 ILE A 614
ARG A 586
LEU A 588
ILE A 510
 None
 0.69A 4zvcA-2o1xA:
undetectable
4zvcB-2o1xA:
undetectable		 4zvcA-2o1xA:
11.36
4zvcB-2o1xA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		4 LEU A 250
ILE A 244
ARG A 354
LEU A 355
 None
 0.83A 4zvcA-2o4jA:
1.1
4zvcB-2o4jA:
2.4		 4zvcA-2o4jA:
20.82
4zvcB-2o4jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ook HYPOTHETICAL PROTEIN

(Shewanella
frigidimarina) 		PF11964
(SpoIIAA-like) 		4 ILE A  10
LEU A  41
LEU A  76
LEU A  55
 None
 0.80A 4zvcA-2ookA:
undetectable
4zvcB-2ookA:
undetectable		 4zvcA-2ookA:
19.01
4zvcB-2ookA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ook HYPOTHETICAL PROTEIN

(Shewanella
frigidimarina) 		PF11964
(SpoIIAA-like) 		4 LEU A  76
LEU A  55
ILE A  10
LEU A  41
 None
 0.80A 4zvcA-2ookA:
undetectable
4zvcB-2ookA:
undetectable		 4zvcA-2ookA:
19.01
4zvcB-2ookA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 ILE G 279
LEU G 291
ILE G 309
LEU G 167
 None
 0.73A 4zvcA-2ooxG:
undetectable
4zvcB-2ooxG:
undetectable		 4zvcA-2ooxG:
17.24
4zvcB-2ooxG:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 ILE G 309
LEU G 167
ILE G 279
LEU G 291
 None
 0.73A 4zvcA-2ooxG:
undetectable
4zvcB-2ooxG:
undetectable		 4zvcA-2ooxG:
17.24
4zvcB-2ooxG:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 ILE A 339
LEU A 343
LEU A 441
ILE A 358
 None
 0.63A 4zvcA-3c49A:
3.5
4zvcB-3c49A:
3.3		 4zvcA-3c49A:
15.28
4zvcB-3c49A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 ILE A 358
ILE A 339
LEU A 343
LEU A 441
 None
 0.61A 4zvcA-3c49A:
3.5
4zvcB-3c49A:
3.3		 4zvcA-3c49A:
15.28
4zvcB-3c49A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 ILE A 358
LEU A 355
LEU A 343
LEU A 441
 None
 0.80A 4zvcA-3c49A:
3.5
4zvcB-3c49A:
3.3		 4zvcA-3c49A:
15.28
4zvcB-3c49A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 LEU A 343
LEU A 441
ILE A 358
LEU A 355
 None
 0.80A 4zvcA-3c49A:
3.5
4zvcB-3c49A:
3.3		 4zvcA-3c49A:
15.28
4zvcB-3c49A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 ILE A  71
LEU A  59
ILE A  43
LEU A  46
 None
 0.79A 4zvcA-3opbA:
undetectable
4zvcB-3opbA:
undetectable		 4zvcA-3opbA:
10.96
4zvcB-3opbA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		PF02205
(WH2)
no annotation
PF07815
(Abi_HHR) 		4 ILE D  37
LEU D  41
ILE E  25
LEU F  58
 None
 0.75A 4zvcA-3p8cD:
undetectable
4zvcB-3p8cD:
undetectable		 4zvcA-3p8cD:
17.08
4zvcB-3p8cD:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		PF02205
(WH2)
no annotation
PF07815
(Abi_HHR) 		4 ILE E  25
LEU F  58
ILE D  37
LEU D  41
 None
 0.74A 4zvcA-3p8cE:
undetectable
4zvcB-3p8cE:
undetectable		 4zvcA-3p8cE:
21.74
4zvcB-3p8cE:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666) 		PF04909
(Amidohydro_2) 		4 ILE A   5
LEU A   7
LEU A 324
LEU A 283
 None
 0.81A 4zvcA-3s4tA:
undetectable
4zvcB-3s4tA:
undetectable		 4zvcA-3s4tA:
15.52
4zvcB-3s4tA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666) 		PF04909
(Amidohydro_2) 		4 LEU A 283
ILE A   5
LEU A   7
LEU A 324
 None
 0.79A 4zvcA-3s4tA:
undetectable
4zvcB-3s4tA:
undetectable		 4zvcA-3s4tA:
15.52
4zvcB-3s4tA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A  87
LEU A  84
ILE A  92
LEU A  77
 None
 0.81A 4zvcA-3t1pA:
undetectable
4zvcB-3t1pA:
undetectable		 4zvcA-3t1pA:
17.31
4zvcB-3t1pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A  92
LEU A  77
ILE A  87
LEU A  84
 None
 0.81A 4zvcA-3t1pA:
undetectable
4zvcB-3t1pA:
undetectable		 4zvcA-3t1pA:
17.31
4zvcB-3t1pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF08646
(Rep_fac-A_C) 		5 ILE C 611
LEU C 610
LEU C 585
LEU C 587
LEU C 646
 None
 1.48A 4zvcA-3u50C:
undetectable
4zvcB-3u50C:
undetectable		 4zvcA-3u50C:
21.05
4zvcB-3u50C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF08646
(Rep_fac-A_C) 		5 LEU C 587
LEU C 646
ILE C 611
LEU C 610
LEU C 585
 None
 1.48A 4zvcA-3u50C:
undetectable
4zvcB-3u50C:
undetectable		 4zvcA-3u50C:
21.05
4zvcB-3u50C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ILE A 541
LEU A 557
ILE A 586
LEU A 582
 None
 0.74A 4zvcA-3ut2A:
1.6
4zvcB-3ut2A:
1.6		 4zvcA-3ut2A:
9.57
4zvcB-3ut2A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ILE A 586
LEU A 582
ILE A 541
LEU A 557
 None
 0.74A 4zvcA-3ut2A:
1.6
4zvcB-3ut2A:
1.6		 4zvcA-3ut2A:
9.57
4zvcB-3ut2A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 ILE A  10
LEU A   8
ILE A  20
LEU A  82
 None
 0.66A 4zvcA-3votA:
undetectable
4zvcB-3votA:
undetectable		 4zvcA-3votA:
13.85
4zvcB-3votA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 ILE A  20
LEU A  82
ILE A  10
LEU A   8
 None
 0.66A 4zvcA-3votA:
undetectable
4zvcB-3votA:
undetectable		 4zvcA-3votA:
13.85
4zvcB-3votA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 ILE A 214
LEU A 113
ILE A 229
ARG A 224
 None
 0.66A 4zvcA-3vx6A:
undetectable
4zvcB-3vx6A:
undetectable		 4zvcA-3vx6A:
19.23
4zvcB-3vx6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 ILE A 229
ARG A 224
ILE A 214
LEU A 113
 None
 0.66A 4zvcA-3vx6A:
undetectable
4zvcB-3vx6A:
undetectable		 4zvcA-3vx6A:
19.23
4zvcB-3vx6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 254
ILE A 248
ARG A 358
LEU A 359
 None
 0.81A 4zvcA-3wgpA:
2.1
4zvcB-3wgpA:
undetectable		 4zvcA-3wgpA:
20.99
4zvcB-3wgpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 ARG A 131
LEU A 127
ILE A  80
LEU A 146
 None
 0.74A 4zvcA-3wq8A:
undetectable
4zvcB-3wq8A:
undetectable		 4zvcA-3wq8A:
13.18
4zvcB-3wq8A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 ILE A  80
LEU A 146
ARG A 131
LEU A 127
 None
 0.75A 4zvcA-3wq8A:
undetectable
4zvcB-3wq8A:
undetectable		 4zvcA-3wq8A:
13.18
4zvcB-3wq8A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)

(Geobacillus
stearothermophilus) 		PF01281
(Ribosomal_L9_N)
PF03948
(Ribosomal_L9_C) 		4 ILE K  98
LEU K 102
ILE K 115
LEU K 110
 None
 0.79A 4zvcA-487dK:
undetectable
4zvcB-487dK:
undetectable		 4zvcA-487dK:
19.89
4zvcB-487dK:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)

(Geobacillus
stearothermophilus) 		PF01281
(Ribosomal_L9_N)
PF03948
(Ribosomal_L9_C) 		4 ILE K 115
LEU K 110
ILE K  98
LEU K 102
 None
 0.79A 4zvcA-487dK:
undetectable
4zvcB-487dK:
undetectable		 4zvcA-487dK:
19.89
4zvcB-487dK:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 4 ILE H 185
LEU H 262
LEU H 170
LEU H 180
 None
 0.77A 4zvcA-4he8H:
undetectable
4zvcB-4he8H:
undetectable		 4zvcA-4he8H:
17.13
4zvcB-4he8H:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 4 LEU H 170
LEU H 180
ILE H 185
LEU H 262
 None
 0.78A 4zvcA-4he8H:
undetectable
4zvcB-4he8H:
undetectable		 4zvcA-4he8H:
17.13
4zvcB-4he8H:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ILE X 465
LEU X 516
ILE X 479
ARG X 524
 None
 0.79A 4zvcA-4hscX:
undetectable
4zvcB-4hscX:
undetectable		 4zvcA-4hscX:
12.92
4zvcB-4hscX:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ILE X 479
ARG X 524
ILE X 465
LEU X 516
 None
 0.81A 4zvcA-4hscX:
undetectable
4zvcB-4hscX:
undetectable		 4zvcA-4hscX:
12.92
4zvcB-4hscX:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		4 ILE A  15
ILE A  60
LEU A  56
LEU A  47
 None
 0.64A 4zvcA-4lq0A:
2.3
4zvcB-4lq0A:
2.3		 4zvcA-4lq0A:
16.23
4zvcB-4lq0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		4 ILE A  60
LEU A  56
LEU A  47
ILE A  15
 None
 0.65A 4zvcA-4lq0A:
2.3
4zvcB-4lq0A:
2.3		 4zvcA-4lq0A:
16.23
4zvcB-4lq0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 211
LEU A  27
ILE A 227
LEU A 242
 None
 0.83A 4zvcA-4lutA:
undetectable
4zvcB-4lutA:
undetectable		 4zvcA-4lutA:
17.20
4zvcB-4lutA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 227
LEU A 242
ILE A 211
LEU A  27
 None
 0.83A 4zvcA-4lutA:
undetectable
4zvcB-4lutA:
undetectable		 4zvcA-4lutA:
17.20
4zvcB-4lutA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6b SERINE
ACETYLTRANSFERASE
APOENZYME

(Glycine max) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ILE A  24
LEU A  52
ILE A  46
LEU A 114
 None
 0.81A 4zvcA-4n6bA:
undetectable
4zvcB-4n6bA:
undetectable		 4zvcA-4n6bA:
21.59
4zvcB-4n6bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6b SERINE
ACETYLTRANSFERASE
APOENZYME

(Glycine max) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ILE A  46
LEU A 114
ILE A  24
LEU A  52
 None
 0.81A 4zvcA-4n6bA:
undetectable
4zvcB-4n6bA:
undetectable		 4zvcA-4n6bA:
21.59
4zvcB-4n6bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ILE A  86
LEU A  85
ILE A 115
LEU A 117
 None
 0.78A 4zvcA-4rs3A:
undetectable
4zvcB-4rs3A:
undetectable		 4zvcA-4rs3A:
14.83
4zvcB-4rs3A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ILE A 115
LEU A 117
ILE A  86
LEU A  85
 None
 0.78A 4zvcA-4rs3A:
undetectable
4zvcB-4rs3A:
undetectable		 4zvcA-4rs3A:
14.83
4zvcB-4rs3A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 ILE A1680
LEU A1852
ILE A1775
LEU A1687
 None
 0.72A 4zvcA-4uclA:
undetectable
4zvcB-4uclA:
undetectable		 4zvcA-4uclA:
14.42
4zvcB-4uclA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 ILE A1775
LEU A1687
ILE A1680
LEU A1852
 None
 0.72A 4zvcA-4uclA:
undetectable
4zvcB-4uclA:
undetectable		 4zvcA-4uclA:
14.42
4zvcB-4uclA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		4 ILE A 156
LEU A 152
LEU A 301
ILE A 279
 None
 0.68A 4zvcA-4woyA:
undetectable
4zvcB-4woyA:
undetectable		 4zvcA-4woyA:
15.24
4zvcB-4woyA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		4 ILE A 279
ILE A 156
LEU A 152
LEU A 301
 None
 0.67A 4zvcA-4woyA:
undetectable
4zvcB-4woyA:
undetectable		 4zvcA-4woyA:
15.24
4zvcB-4woyA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsi MAGUK P55 SUBFAMILY
MEMBER 5

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 ILE A 485
LEU A 577
ILE A 594
LEU A 585
 None
 0.71A 4zvcA-4wsiA:
undetectable
4zvcB-4wsiA:
undetectable		 4zvcA-4wsiA:
17.31
4zvcB-4wsiA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 ILE A  41
LEU A  37
ILE A 351
LEU A 347
 None
CLR  A 604 (-4.4A)
CLR  A 604 (-4.3A)
None
 0.81A 4zvcA-4xnuA:
2.1
4zvcB-4xnuA:
2.1		 4zvcA-4xnuA:
12.17
4zvcB-4xnuA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 ILE A 351
LEU A 347
ILE A  41
LEU A  37
 CLR  A 604 (-4.3A)
None
None
CLR  A 604 (-4.4A)
 0.80A 4zvcA-4xnuA:
2.1
4zvcB-4xnuA:
2.1		 4zvcA-4xnuA:
12.17
4zvcB-4xnuA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yy5 DTOR_3X33L

(synthetic
construct) 		no annotation 4 ILE A  13
LEU A   9
ILE A  46
LEU A  75
 None
 0.80A 4zvcA-4yy5A:
undetectable
4zvcB-4yy5A:
undetectable		 4zvcA-4yy5A:
24.06
4zvcB-4yy5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yy5 DTOR_3X33L

(synthetic
construct) 		no annotation 4 ILE A  46
LEU A  42
ILE A  79
LEU A   9
 None
 0.80A 4zvcA-4yy5A:
undetectable
4zvcB-4yy5A:
undetectable		 4zvcA-4yy5A:
24.06
4zvcB-4yy5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yy5 DTOR_3X33L

(synthetic
construct) 		no annotation 4 ILE A  46
LEU A  75
ILE A  13
LEU A   9
 None
 0.80A 4zvcA-4yy5A:
undetectable
4zvcB-4yy5A:
undetectable		 4zvcA-4yy5A:
24.06
4zvcB-4yy5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yy5 DTOR_3X33L

(synthetic
construct) 		no annotation 4 ILE A  79
LEU A   9
ILE A  46
LEU A  42
 None
 0.79A 4zvcA-4yy5A:
undetectable
4zvcB-4yy5A:
undetectable		 4zvcA-4yy5A:
24.06
4zvcB-4yy5A:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zvc DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		no annotation 4 ILE A 197
LEU A 201
ARG A 265
LEU A 269
 BEZ  A 301 (-4.9A)
BEZ  A 301 (-3.9A)
BEZ  A 301 (-3.6A)
BEZ  A 301 ( 4.9A)
 0.00A 4zvcA-4zvcA:
25.0
4zvcB-4zvcA:
23.9		 4zvcA-4zvcA:
100.00
4zvcB-4zvcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zvc DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		no annotation 4 ILE A 197
LEU A 201
ARG A 265
LEU A 269
 BEZ  A 301 (-4.9A)
BEZ  A 301 (-3.9A)
BEZ  A 301 (-3.6A)
BEZ  A 301 ( 4.9A)
 0.05A 4zvcA-4zvcA:
25.0
4zvcB-4zvcA:
23.9		 4zvcA-4zvcA:
100.00
4zvcB-4zvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		4 ILE A  55
LEU A  91
ILE A  85
LEU A  13
 None
 0.82A 4zvcA-5d86A:
undetectable
4zvcB-5d86A:
undetectable		 4zvcA-5d86A:
17.03
4zvcB-5d86A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		4 ILE A  85
LEU A  13
ILE A  55
LEU A  91
 None
 0.81A 4zvcA-5d86A:
undetectable
4zvcB-5d86A:
undetectable		 4zvcA-5d86A:
17.03
4zvcB-5d86A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		4 ILE A 135
LEU A 352
ILE A 334
LEU A 312
 FAD  A 503 (-4.4A)
None
None
None
 0.74A 4zvcA-5dqrA:
undetectable
4zvcB-5dqrA:
undetectable		 4zvcA-5dqrA:
15.51
4zvcB-5dqrA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		4 ILE A 334
LEU A 312
ILE A 135
LEU A 352
 None
None
FAD  A 503 (-4.4A)
None
 0.74A 4zvcA-5dqrA:
undetectable
4zvcB-5dqrA:
undetectable		 4zvcA-5dqrA:
15.51
4zvcB-5dqrA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii) 		PF02171
(Piwi) 		4 ILE A 584
LEU A 581
ILE A 549
LEU A 545
 None
 0.83A 4zvcA-5g5tA:
undetectable
4zvcB-5g5tA:
undetectable		 4zvcA-5g5tA:
10.25
4zvcB-5g5tA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		4 ILE A  92
LEU A  89
ILE A  97
LEU A  82
 None
 0.75A 4zvcA-5hgcA:
undetectable
4zvcB-5hgcA:
undetectable		 4zvcA-5hgcA:
14.40
4zvcB-5hgcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		4 ILE A  97
LEU A  82
ILE A  92
LEU A  89
 None
 0.76A 4zvcA-5hgcA:
undetectable
4zvcB-5hgcA:
undetectable		 4zvcA-5hgcA:
14.40
4zvcB-5hgcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 ILE A 429
LEU A 432
LEU A 410
ILE A 452
LEU A 444
 ILE  A 429 ( 0.7A)
LEU  A 432 ( 0.6A)
LEU  A 410 ( 0.6A)
ILE  A 452 ( 0.7A)
LEU  A 444 ( 0.6A)
 1.49A 4zvcA-5hiuA:
undetectable
4zvcB-5hiuA:
2.1		 4zvcA-5hiuA:
13.09
4zvcB-5hiuA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 ILE A 452
LEU A 444
ILE A 429
LEU A 432
LEU A 410
 ILE  A 452 ( 0.7A)
LEU  A 444 ( 0.6A)
ILE  A 429 ( 0.7A)
LEU  A 432 ( 0.6A)
LEU  A 410 ( 0.6A)
 1.49A 4zvcA-5hiuA:
undetectable
4zvcB-5hiuA:
2.1		 4zvcA-5hiuA:
13.09
4zvcB-5hiuA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		4 ILE A  40
LEU A  36
LEU A 124
ILE A  77
 None
 0.76A 4zvcA-5iw9A:
undetectable
4zvcB-5iw9A:
undetectable		 4zvcA-5iw9A:
22.70
4zvcB-5iw9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		4 ILE A  77
ILE A  40
LEU A  36
LEU A 124
 None
 0.76A 4zvcA-5iw9A:
undetectable
4zvcB-5iw9A:
undetectable		 4zvcA-5iw9A:
22.70
4zvcB-5iw9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 ILE A 505
LEU A 521
ILE A 551
LEU A 547
 None
 0.69A 4zvcA-5kqiA:
undetectable
4zvcB-5kqiA:
1.7		 4zvcA-5kqiA:
10.31
4zvcB-5kqiA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 ILE A 551
LEU A 547
ILE A 505
LEU A 521
 None
 0.68A 4zvcA-5kqiA:
undetectable
4zvcB-5kqiA:
1.7		 4zvcA-5kqiA:
10.31
4zvcB-5kqiA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 ILE A  96
LEU A 193
ILE A 206
LEU A 207
 None
 0.77A 4zvcA-5vj7A:
undetectable
4zvcB-5vj7A:
undetectable		 4zvcA-5vj7A:
14.38
4zvcB-5vj7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 ILE A 206
LEU A 207
ILE A  96
LEU A 193
 None
 0.77A 4zvcA-5vj7A:
undetectable
4zvcB-5vj7A:
undetectable		 4zvcA-5vj7A:
14.38
4zvcB-5vj7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 ILE A 505
LEU A 521
ILE A 550
LEU A 546
 None
 0.78A 4zvcA-5whsA:
undetectable
4zvcB-5whsA:
undetectable		 4zvcA-5whsA:
undetectable
4zvcB-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 ILE A 550
LEU A 546
ILE A 505
LEU A 521
 None
 0.78A 4zvcA-5whsA:
undetectable
4zvcB-5whsA:
undetectable		 4zvcA-5whsA:
undetectable
4zvcB-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 4 ILE A 373
LEU A 375
ILE A 397
LEU A 395
 None
 0.82A 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable		 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 4 ILE A 397
LEU A 395
ILE A 373
LEU A 375
 None
 0.81A 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable		 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 ILE B  18
LEU B  71
ILE B  21
LEU B 726
 None
 0.78A 4zvcA-5yewB:
4.5
4zvcB-5yewB:
4.4		 4zvcA-5yewB:
undetectable
4zvcB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 ILE B  21
LEU B 726
ILE B  18
LEU B  71
 None
 0.78A 4zvcA-5yewB:
4.5
4zvcB-5yewB:
4.4		 4zvcA-5yewB:
undetectable
4zvcB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus) 		no annotation 4 ILE A 314
LEU A 306
ILE A 374
LEU A 370
 None
 0.81A 4zvcA-6ao3A:
2.1
4zvcB-6ao3A:
2.1		 4zvcA-6ao3A:
undetectable
4zvcB-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus) 		no annotation 4 ILE A 374
LEU A 370
ILE A 314
LEU A 306
 None
 0.80A 4zvcA-6ao3A:
2.1
4zvcB-6ao3A:
2.1		 4zvcA-6ao3A:
undetectable
4zvcB-6ao3A:
undetectable