SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZUD_A_OLMA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 PHE A 490
SER A 477
LEU A 480
ARG A 554
ILE A 334
 1PE  A 962 ( 4.4A)
None
None
None
None
 1.47A 4zudA-3m62A:
2.7		 4zudA-3m62A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A  71
SER A  70
LEU A  69
ARG A  53
ILE A 148
 None
 1.04A 4zudA-3rzeA:
23.4		 4zudA-3rzeA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b1l LEVANASE

(Bacillus
subtilis) 		PF06439
(DUF1080) 		5 PHE A 654
VAL A 653
SER A 652
ILE A 613
TYR A 589
 None
 1.31A 4zudA-4b1lA:
0.0		 4zudA-4b1lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b1m LEVANASE

(Bacillus
subtilis) 		PF06439
(DUF1080) 		5 PHE A 654
VAL A 653
SER A 652
ILE A 613
TYR A 589
 None
 1.29A 4zudA-4b1mA:
0.0		 4zudA-4b1mA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 PHE A 695
TRP A 708
SER A 698
LEU A 705
ILE A 645
 None
 1.50A 4zudA-4w8yA:
2.0		 4zudA-4w8yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 5 TYR A  44
PHE A 149
VAL A  77
LEU A  78
ILE A  84
 None
 1.26A 4zudA-5m22A:
0.0		 4zudA-5m22A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 PHE A 186
VAL A 199
SER A 198
LEU A 195
ARG A 206
 None
 1.38A 4zudA-5mifA:
0.0		 4zudA-5mifA:
22.27