SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZPH_A_PRLA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLN A 144
LEU A 141
SER A 138
GLU A 139
 None
 1.09A 4zphA-1b4pA:
0.0
4zphB-1b4pA:
0.0		 4zphA-1b4pA:
20.64
4zphB-1b4pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b69 PROTEIN (INTEGRASE)

(Enterococcus
faecalis) 		PF02920
(Integrase_DNA) 		4 VAL A  39
LEU A  60
SER A  59
GLU A  62
 None
 1.08A 4zphA-1b69A:
undetectable
4zphB-1b69A:
0.0		 4zphA-1b69A:
10.35
4zphB-1b69A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		4 VAL E 101
LEU E 103
SER E 104
GLU E 107
 None
 1.07A 4zphA-1cziE:
0.0
4zphB-1cziE:
0.0		 4zphA-1cziE:
21.52
4zphB-1cziE:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 VAL A 278
GLN A 114
LEU A 292
GLU A 282
 None
 1.05A 4zphA-1d4eA:
0.0
4zphB-1d4eA:
0.0		 4zphA-1d4eA:
21.40
4zphB-1d4eA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzp STAPHYLOCOCCAL
ACCESSORY REGULATOR
A

(Staphylococcus
aureus) 		no annotation 4 VAL D 111
LEU D 107
SER D 106
GLU D 105
 None
 1.09A 4zphA-1fzpD:
undetectable
4zphB-1fzpD:
undetectable		 4zphA-1fzpD:
16.18
4zphB-1fzpD:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 VAL A 352
LEU A 324
SER A 323
GLU A 326
 None
 0.99A 4zphA-1g59A:
0.0
4zphB-1g59A:
0.0		 4zphA-1g59A:
20.53
4zphB-1g59A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 VAL A  49
LEU A 391
SER A 388
GLU A 395
 None
 1.06A 4zphA-1li7A:
0.0
4zphB-1li7A:
undetectable		 4zphA-1li7A:
17.86
4zphB-1li7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 GLN A 631
TRP A 737
LEU A 670
SER A 669
 None
 0.90A 4zphA-1no7A:
0.0
4zphB-1no7A:
0.0		 4zphA-1no7A:
18.89
4zphB-1no7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  17
GLN A   2
LEU A 300
SER A 299
 None
 1.10A 4zphA-1o8cA:
0.0
4zphB-1o8cA:
0.0		 4zphA-1o8cA:
21.65
4zphB-1o8cA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 ARG A 184
VAL A 183
LEU A 338
SER A 339
 None
 0.97A 4zphA-1q50A:
0.0
4zphB-1q50A:
0.0		 4zphA-1q50A:
23.22
4zphB-1q50A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 VAL A  99
LEU A 139
SER A 141
GLU A 143
 None
 0.99A 4zphA-1qlmA:
0.0
4zphB-1qlmA:
undetectable		 4zphA-1qlmA:
20.78
4zphB-1qlmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		4 VAL A  70
GLN A  53
SER A  46
GLU A  25
 None
 1.02A 4zphA-1s2tA:
undetectable
4zphB-1s2tA:
undetectable		 4zphA-1s2tA:
21.64
4zphB-1s2tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		4 VAL A 134
GLN A  28
SER A 127
GLU A 128
 None
 1.00A 4zphA-1t8bA:
undetectable
4zphB-1t8bA:
undetectable		 4zphA-1t8bA:
19.22
4zphB-1t8bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN

(Leishmania
major) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 VAL A  46
LEU A  62
SER A  61
GLU A 153
 None
SO4  A 203 (-4.6A)
SO4  A 203 (-2.4A)
None
 0.80A 4zphA-1y1xA:
undetectable
4zphB-1y1xA:
undetectable		 4zphA-1y1xA:
19.95
4zphB-1y1xA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 ARG A 294
VAL A 314
GLN A 293
GLU A 296
 None
 0.93A 4zphA-1yi7A:
undetectable
4zphB-1yi7A:
undetectable		 4zphA-1yi7A:
20.89
4zphB-1yi7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		4 ARG A 130
VAL A 133
TRP A 198
SER A 153
 WO4  A 501 (-2.7A)
None
None
None
 1.10A 4zphA-2akcA:
undetectable
4zphB-2akcA:
undetectable		 4zphA-2akcA:
20.56
4zphB-2akcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ARG A 242
VAL A 222
LEU A 245
GLU A 243
 None
 1.10A 4zphA-2be4A:
undetectable
4zphB-2be4A:
undetectable		 4zphA-2be4A:
20.31
4zphB-2be4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 VAL A 776
LEU A 722
SER A 721
GLU A 724
 None
 0.93A 4zphA-2cbzA:
undetectable
4zphB-2cbzA:
undetectable		 4zphA-2cbzA:
20.97
4zphB-2cbzA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpf RNA BINDING MOTIF
PROTEIN 19

(Mus musculus) 		PF00076
(RRM_1) 		4 VAL A 400
LEU A 402
SER A 403
GLU A 373
 None
 1.04A 4zphA-2cpfA:
undetectable
4zphB-2cpfA:
undetectable		 4zphA-2cpfA:
14.52
4zphB-2cpfA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4p BIPHENYL DIOXYGENASE
FERREDOXIN SUBUNIT

(Pseudomonas sp.) 		PF00355
(Rieske) 		4 VAL A  61
LEU A  50
SER A  49
GLU A  52
 None
 1.09A 4zphA-2e4pA:
undetectable
4zphB-2e4pA:
undetectable		 4zphA-2e4pA:
14.84
4zphB-2e4pA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 VAL A 100
LEU A 198
SER A 199
GLU A 196
 None
 1.06A 4zphA-2ej5A:
undetectable
4zphB-2ej5A:
undetectable		 4zphA-2ej5A:
19.54
4zphB-2ej5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4i HYPOTHETICAL PROTEIN
TM0957

(Thermotoga
maritima) 		PF10054
(DUF2291) 		4 VAL A  99
GLN A 214
LEU A 185
SER A 184
 None
 1.02A 4zphA-2f4iA:
undetectable
4zphB-2f4iA:
undetectable		 4zphA-2f4iA:
18.73
4zphB-2f4iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		4 ARG A 142
VAL A 121
LEU A 111
SER A 112
 None
 0.87A 4zphA-2g5cA:
undetectable
4zphB-2g5cA:
undetectable		 4zphA-2g5cA:
21.70
4zphB-2g5cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if7 SLAM FAMILY MEMBER 6

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 159
TRP A 144
LEU A 151
SER A 152
 None
 0.81A 4zphA-2if7A:
undetectable
4zphB-2if7A:
undetectable		 4zphA-2if7A:
21.07
4zphB-2if7A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt6 OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF13953
(PapC_C) 		4 VAL A  67
LEU A  53
SER A  54
GLU A  28
 None
 1.01A 4zphA-2kt6A:
undetectable
4zphB-2kt6A:
undetectable		 4zphA-2kt6A:
13.47
4zphB-2kt6A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pro ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF02983
(Pro_Al_protease) 		4 VAL A 121
GLN A  92
LEU A  88
SER A  87
 None
 0.87A 4zphA-2proA:
undetectable
4zphB-2proA:
undetectable		 4zphA-2proA:
18.80
4zphB-2proA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whn PILUS ASSEMBLY
PROTEIN PILC

(Thermus
thermophilus) 		PF00482
(T2SSF) 		4 VAL A 135
LEU A 121
SER A 122
GLU A 119
 None
 1.06A 4zphA-2whnA:
undetectable
4zphB-2whnA:
undetectable		 4zphA-2whnA:
14.77
4zphB-2whnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A  51
LEU A  53
SER A  54
GLU A  62
 None
AKG  A1223 (-4.2A)
None
None
 1.10A 4zphA-2xkoA:
undetectable
4zphB-2xkoA:
undetectable		 4zphA-2xkoA:
20.51
4zphB-2xkoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		4 VAL A  51
LEU A  41
SER A  40
GLU A  43
 None
 1.08A 4zphA-2ylnA:
undetectable
4zphB-2ylnA:
undetectable		 4zphA-2ylnA:
20.51
4zphB-2ylnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 ARG A 288
VAL A 291
LEU A 262
SER A 263
 None
 0.93A 4zphA-2zuxA:
undetectable
4zphB-2zuxA:
undetectable		 4zphA-2zuxA:
20.78
4zphB-2zuxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ARG A 492
GLN A 563
LEU A 333
GLU A 332
 None
 1.07A 4zphA-2zwaA:
undetectable
4zphB-2zwaA:
0.0		 4zphA-2zwaA:
20.63
4zphB-2zwaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		4 VAL A 236
LEU A 162
SER A 161
GLU A 145
 None
 1.04A 4zphA-3a1nA:
undetectable
4zphB-3a1nA:
undetectable		 4zphA-3a1nA:
20.69
4zphB-3a1nA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 VAL A 260
GLN A 246
LEU A 265
GLU A 267
 None
B12  B 601 (-2.9A)
None
None
 0.84A 4zphA-3anyA:
undetectable
4zphB-3anyA:
undetectable		 4zphA-3anyA:
21.89
4zphB-3anyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 VAL A 218
GLN A 256
LEU A 264
SER A 263
 None
 0.86A 4zphA-3cprA:
undetectable
4zphB-3cprA:
undetectable		 4zphA-3cprA:
20.75
4zphB-3cprA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID

(Escherichia
coli) 		PF01510
(Amidase_2) 		4 VAL A 198
GLN A 248
LEU A 203
GLU A 205
 None
 0.82A 4zphA-3d2zA:
undetectable
4zphB-3d2zA:
undetectable		 4zphA-3d2zA:
18.88
4zphB-3d2zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 VAL A  78
LEU A  11
SER A 346
GLU A 345
 None
FAD  A 444 (-4.2A)
FAD  A 444 (-3.3A)
None
 0.99A 4zphA-3g5sA:
undetectable
4zphB-3g5sA:
undetectable		 4zphA-3g5sA:
22.57
4zphB-3g5sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 4 ARG D 142
VAL D 121
LEU D 111
SER D 112
 None
 0.85A 4zphA-3gggD:
undetectable
4zphB-3gggD:
undetectable		 4zphA-3gggD:
22.89
4zphB-3gggD:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 158
LEU A 198
SER A 197
GLU A 200
 GOL  A 414 ( 4.7A)
None
None
None
 1.03A 4zphA-3k5pA:
undetectable
4zphB-3k5pA:
undetectable		 4zphA-3k5pA:
22.30
4zphB-3k5pA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcm THIOREDOXIN FAMILY
PROTEIN

(Geobacter
metallireducens) 		PF00578
(AhpC-TSA) 		4 TRP A 153
LEU A  77
SER A  73
GLU A  70
 None
 1.02A 4zphA-3kcmA:
undetectable
4zphB-3kcmA:
undetectable		 4zphA-3kcmA:
19.27
4zphB-3kcmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A  52
LEU A  54
SER A  55
GLU A  63
 None
AKG  A 224 (-4.3A)
None
None
 1.02A 4zphA-3la2A:
undetectable
4zphB-3la2A:
undetectable		 4zphA-3la2A:
22.25
4zphB-3la2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C

(Homo sapiens) 		PF02828
(L27)
PF09058
(L27_1) 		4 VAL A   3
GLN A  53
LEU A 115
SER A 114
 None
 1.09A 4zphA-3lraA:
undetectable
4zphB-3lraA:
undetectable		 4zphA-3lraA:
20.15
4zphB-3lraA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		4 ARG A 250
VAL A 217
LEU A 205
SER A 206
 None
 0.86A 4zphA-3pplA:
undetectable
4zphB-3pplA:
undetectable		 4zphA-3pplA:
21.13
4zphB-3pplA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		4 VAL A 191
LEU A 202
SER A 201
GLU A 204
 None
 0.86A 4zphA-3q1yA:
undetectable
4zphB-3q1yA:
undetectable		 4zphA-3q1yA:
22.28
4zphB-3q1yA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 VAL A 649
LEU A 239
SER A 235
GLU A 301
 None
 0.97A 4zphA-4a01A:
undetectable
4zphB-4a01A:
0.0		 4zphA-4a01A:
18.09
4zphB-4a01A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 VAL A 593
GLN A 598
LEU A 469
SER A 472
 None
 0.92A 4zphA-4a0hA:
undetectable
4zphB-4a0hA:
undetectable		 4zphA-4a0hA:
18.68
4zphB-4a0hA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 VAL A2030
GLN A2006
LEU A2032
SER A2033
 None
 1.10A 4zphA-4asiA:
undetectable
4zphB-4asiA:
undetectable		 4zphA-4asiA:
19.20
4zphB-4asiA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN

(Thermotoga
maritima) 		PF06964
(Alpha-L-AF_C) 		4 VAL A 420
LEU A 392
SER A 368
GLU A 369
 None
 1.10A 4zphA-4atwA:
undetectable
4zphB-4atwA:
undetectable		 4zphA-4atwA:
23.32
4zphB-4atwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 VAL A 776
LEU A 722
SER A 721
GLU A 724
 None
 0.96A 4zphA-4c3zA:
undetectable
4zphB-4c3zA:
undetectable		 4zphA-4c3zA:
22.39
4zphB-4c3zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		4 ARG A 258
VAL A 261
LEU A 232
SER A 233
 None
 0.96A 4zphA-4cagA:
undetectable
4zphB-4cagA:
undetectable		 4zphA-4cagA:
20.20
4zphB-4cagA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckk DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		4 VAL A 268
GLN A 325
LEU A 273
GLU A 275
 None
 0.81A 4zphA-4ckkA:
undetectable
4zphB-4ckkA:
undetectable		 4zphA-4ckkA:
23.33
4zphB-4ckkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 321
TRP A 285
LEU A 313
SER A 314
 None
 1.08A 4zphA-4d4gA:
undetectable
4zphB-4d4gA:
undetectable		 4zphA-4d4gA:
20.70
4zphB-4d4gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 VAL A 352
LEU A 429
SER A 428
GLU A 427
 None
 0.96A 4zphA-4e51A:
undetectable
4zphB-4e51A:
undetectable		 4zphA-4e51A:
20.77
4zphB-4e51A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 ARG A 211
VAL A 203
LEU A 184
SER A 185
 SO4  A 401 (-3.1A)
None
None
SO4  A 401 (-3.6A)
 1.08A 4zphA-4gq1A:
undetectable
4zphB-4gq1A:
undetectable		 4zphA-4gq1A:
23.01
4zphB-4gq1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		4 ARG A 336
VAL A 374
GLN A 330
LEU A 359
 None
 1.02A 4zphA-4hbsA:
undetectable
4zphB-4hbsA:
undetectable		 4zphA-4hbsA:
22.72
4zphB-4hbsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlz FAB C179 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL G 183
TRP G 154
LEU G 159
SER G 160
 None
 0.83A 4zphA-4hlzG:
undetectable
4zphB-4hlzG:
undetectable		 4zphA-4hlzG:
19.38
4zphB-4hlzG:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1q BRIDGING INTEGRATOR
2

(Homo sapiens) 		PF03114
(BAR) 		4 VAL A 103
GLN A  86
LEU A  99
GLU A  97
 None
 0.73A 4zphA-4i1qA:
undetectable
4zphB-4i1qA:
0.0		 4zphA-4i1qA:
18.25
4zphB-4i1qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 VAL A 711
TRP A 491
LEU A 487
SER A 488
 None
 1.10A 4zphA-4kkdA:
undetectable
4zphB-4kkdA:
undetectable		 4zphA-4kkdA:
23.03
4zphB-4kkdA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		4 VAL A 393
LEU A 516
SER A 517
GLU A 521
 None
 0.88A 4zphA-4mbrA:
undetectable
4zphB-4mbrA:
undetectable		 4zphA-4mbrA:
19.33
4zphB-4mbrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 ARG A 150
VAL A 147
LEU A 203
SER A 195
 None
 1.06A 4zphA-4o8uA:
0.0
4zphB-4o8uA:
undetectable		 4zphA-4o8uA:
22.13
4zphB-4o8uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of8 IRREGULAR CHIASM
C-ROUGHEST PROTEIN

(Drosophila
melanogaster) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 VAL A  45
GLN A  37
LEU A  47
SER A  91
 None
 1.05A 4zphA-4of8A:
undetectable
4zphB-4of8A:
undetectable		 4zphA-4of8A:
18.91
4zphB-4of8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofi KIN OF IRRE, ISOFORM
A

(Drosophila
melanogaster) 		PF07686
(V-set) 		4 VAL A  99
GLN A  91
LEU A 101
SER A 145
 None
 0.98A 4zphA-4ofiA:
undetectable
4zphB-4ofiA:
undetectable		 4zphA-4ofiA:
15.22
4zphB-4ofiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 VAL A 165
LEU A 158
SER A 157
GLU A 238
 None
 1.05A 4zphA-4p1lA:
undetectable
4zphB-4p1lA:
undetectable		 4zphA-4p1lA:
21.86
4zphB-4p1lA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ARG A 284
LEU A 238
SER A 239
GLU A 197
 None
 1.07A 4zphA-4q73A:
undetectable
4zphB-4q73A:
undetectable		 4zphA-4q73A:
17.56
4zphB-4q73A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo5 HYPOTHETICAL
MULTIHEME PROTEIN

(Ignicoccus
hospitalis) 		PF13435
(Cytochrome_C554)
PF13447
(Multi-haem_cyto) 		4 VAL A 321
TRP A 301
LEU A 319
SER A 318
 None
None
HEC  A 605 (-4.8A)
HEC  A 605 (-2.7A)
 1.02A 4zphA-4qo5A:
0.9
4zphB-4qo5A:
undetectable		 4zphA-4qo5A:
20.31
4zphB-4qo5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 VAL A4100
LEU A4107
SER A4108
GLU A4110
 None
 0.99A 4zphA-4rh7A:
undetectable
4zphB-4rh7A:
undetectable		 4zphA-4rh7A:
7.30
4zphB-4rh7A:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 4 ARG A 320
VAL A 317
LEU A 278
SER A 279
 None
 1.06A 4zphA-4rxxA:
undetectable
4zphB-4rxxA:
undetectable		 4zphA-4rxxA:
22.05
4zphB-4rxxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Clostridium
perfringens) 		PF00936
(BMC) 		4 VAL A 128
LEU A 135
SER A 136
GLU A 143
 None
 0.89A 4zphA-4tlhA:
undetectable
4zphB-4tlhA:
undetectable		 4zphA-4tlhA:
20.41
4zphB-4tlhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ARG A  48
VAL A  47
SER A  83
GLU A  80
 PO4  A 804 (-3.2A)
None
PO4  A 804 (-4.3A)
None
 0.93A 4zphA-4u1rA:
undetectable
4zphB-4u1rA:
0.0		 4zphA-4u1rA:
19.50
4zphB-4u1rA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 ARG A 443
VAL A 445
LEU A 378
SER A 379
 None
 1.09A 4zphA-4wikA:
undetectable
4zphB-4wikA:
undetectable		 4zphA-4wikA:
20.16
4zphB-4wikA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8w LOQUACIOUS, ISOFORM
B

(Drosophila
melanogaster) 		PF16482
(Staufen_C) 		4 VAL A 427
LEU A 429
SER A 430
GLU A 408
 None
 0.97A 4zphA-4x8wA:
undetectable
4zphB-4x8wA:
undetectable		 4zphA-4x8wA:
10.53
4zphB-4x8wA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 565
GLN A 526
LEU A 543
SER A 582
 None
 1.07A 4zphA-4xeuA:
undetectable
4zphB-4xeuA:
undetectable		 4zphA-4xeuA:
19.64
4zphB-4xeuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 VAL A1017
LEU A1015
SER A1013
GLU A1012
 None
 1.10A 4zphA-4xgtA:
undetectable
4zphB-4xgtA:
undetectable		 4zphA-4xgtA:
18.03
4zphB-4xgtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yot 3-5 EXONUCLEASE
PHOEXO I

(Pyrococcus
horikoshii) 		PF13680
(DUF4152) 		4 ARG A 142
VAL A 139
LEU A 195
SER A 187
 None
 1.09A 4zphA-4yotA:
undetectable
4zphB-4yotA:
undetectable		 4zphA-4yotA:
21.57
4zphB-4yotA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqd ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		5 GLN B 306
TRP B 318
LEU B 344
SER B 345
GLU B 348
 None
 0.58A 4zphA-4zqdB:
11.1
4zphB-4zqdB:
28.7		 4zphA-4zqdB:
28.54
4zphB-4zqdB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 VAL A1021
GLN A1115
LEU A1105
GLU A1110
 None
 1.09A 4zphA-5a42A:
undetectable
4zphB-5a42A:
undetectable		 4zphA-5a42A:
13.78
4zphB-5a42A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 VAL A  73
LEU A  79
SER A  78
GLU A 212
 None
 1.01A 4zphA-5b04A:
undetectable
4zphB-5b04A:
undetectable		 4zphA-5b04A:
21.86
4zphB-5b04A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 4 VAL A 200
GLN A 190
LEU A 198
SER A 195
 None
 1.05A 4zphA-5bykA:
undetectable
4zphB-5bykA:
undetectable		 4zphA-5bykA:
19.44
4zphB-5bykA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cff STAUFEN

(Drosophila
melanogaster) 		PF16482
(Staufen_C) 		4 VAL E 983
LEU E 985
SER E 986
GLU E 965
 None
 0.77A 4zphA-5cffE:
undetectable
4zphB-5cffE:
undetectable		 4zphA-5cffE:
13.45
4zphB-5cffE:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 VAL A 309
LEU A 292
SER A 289
GLU A 188
 None
 1.07A 4zphA-5cjuA:
undetectable
4zphB-5cjuA:
undetectable		 4zphA-5cjuA:
16.43
4zphB-5cjuA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4y PROTEIN SHROOM2

(Homo sapiens) 		PF08687
(ASD2) 		4 VAL A1461
GLN A1588
LEU A1457
GLU A1455
 None
 1.06A 4zphA-5f4yA:
undetectable
4zphB-5f4yA:
undetectable		 4zphA-5f4yA:
19.25
4zphB-5f4yA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		4 GLN A 127
LEU A  98
SER A  99
GLU A 101
 None
 1.04A 4zphA-5ff5A:
undetectable
4zphB-5ff5A:
undetectable		 4zphA-5ff5A:
21.79
4zphB-5ff5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 VAL g 143
LEU g 412
SER g 413
GLU g 503
 None
 1.01A 4zphA-5gw4g:
undetectable
4zphB-5gw4g:
undetectable		 4zphA-5gw4g:
22.04
4zphB-5gw4g:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 VAL A 420
TRP A 453
LEU A 427
SER A 426
 None
 0.98A 4zphA-5gweA:
undetectable
4zphB-5gweA:
undetectable		 4zphA-5gweA:
24.02
4zphB-5gweA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 VAL A 290
LEU A  85
SER A  86
GLU A  88
 None
 1.08A 4zphA-5hyhA:
undetectable
4zphB-5hyhA:
undetectable		 4zphA-5hyhA:
20.29
4zphB-5hyhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifn PARASPECKLE
COMPONENT 1

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 ARG A 228
VAL A 230
LEU A 163
SER A 164
 None
 0.96A 4zphA-5ifnA:
undetectable
4zphB-5ifnA:
undetectable		 4zphA-5ifnA:
18.94
4zphB-5ifnA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 VAL A 266
TRP A 165
LEU A 230
GLU A 169
 None
 0.92A 4zphA-5jvkA:
undetectable
4zphB-5jvkA:
undetectable		 4zphA-5jvkA:
21.02
4zphB-5jvkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 VAL A 444
GLN A 437
LEU A 433
SER A 432
 None
 0.81A 4zphA-5lrbA:
undetectable
4zphB-5lrbA:
undetectable		 4zphA-5lrbA:
18.50
4zphB-5lrbA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvy ADHESIN PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A  52
GLN A 103
LEU A  38
SER A  14
 None
 0.98A 4zphA-5lvyA:
undetectable
4zphB-5lvyA:
undetectable		 4zphA-5lvyA:
16.67
4zphB-5lvyA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpg HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ARG A  82
VAL A  84
LEU A  21
SER A  22
 U  B   1 ( 3.0A)
None
None
None
 0.94A 4zphA-5mpgA:
undetectable
4zphB-5mpgA:
undetectable		 4zphA-5mpgA:
15.49
4zphB-5mpgA:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus;
Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		6 ARG A 266
VAL A 305
TRP B 380
LEU B 406
SER B 407
GLU B 410
 None
 0.64A 4zphA-5sy5A:
10.7
4zphB-5sy5A:
11.0		 4zphA-5sy5A:
100.00
4zphB-5sy5A:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 TRP B 412
LEU B 438
SER B 439
GLU B 442
 None
 0.38A 4zphA-5sy7B:
12.3
4zphB-5sy7B:
14.0		 4zphA-5sy7B:
26.23
4zphB-5sy7B:
35.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 4 VAL A 196
GLN A 186
LEU A 194
SER A 191
 None
 1.06A 4zphA-5tizA:
undetectable
4zphB-5tizA:
undetectable		 4zphA-5tizA:
17.48
4zphB-5tizA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 VAL A 393
TRP A 426
LEU A 400
SER A 399
 None
 1.00A 4zphA-5xjnA:
undetectable
4zphB-5xjnA:
undetectable		 4zphA-5xjnA:
23.46
4zphB-5xjnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9h SAFD,PUTATIVE OUTER
MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN

(Salmonella
enterica) 		no annotation 4 VAL A 167
GLN A 294
LEU A 303
SER A 306
 None
 1.08A 4zphA-5y9hA:
undetectable
4zphB-5y9hA:
undetectable		 4zphA-5y9hA:
24.06
4zphB-5y9hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 ARG A 111
VAL A 108
LEU A  87
SER A  86
GLU A  89
 MLI  A 301 (-3.3A)
None
None
MLI  A 301 (-3.0A)
None
 1.49A 4zphA-6apgA:
undetectable
4zphB-6apgA:
undetectable		 4zphA-6apgA:
undetectable
4zphB-6apgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 4 VAL A 261
GLN A 236
LEU A 232
SER A 231
 None
 0.86A 4zphA-6ar3A:
undetectable
4zphB-6ar3A:
undetectable		 4zphA-6ar3A:
21.71
4zphB-6ar3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 ARG A  77
VAL A  78
LEU A 155
GLU A  73
 None
 1.02A 4zphA-6at7A:
undetectable
4zphB-6at7A:
undetectable		 4zphA-6at7A:
undetectable
4zphB-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 VAL A 576
LEU A 566
SER A 565
GLU A 568
 None
 0.91A 4zphA-6au1A:
undetectable
4zphB-6au1A:
undetectable		 4zphA-6au1A:
undetectable
4zphB-6au1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL3
GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 VAL N 281
GLN M 405
LEU N 278
GLU N 367
 None
 1.04A 4zphA-6cetN:
undetectable
4zphB-6cetN:
undetectable		 4zphA-6cetN:
undetectable
4zphB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7mdh PROTEIN (MALATE
DEHYDROGENASE)

(Sorghum bicolor) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ARG A 351
VAL A 234
LEU A 348
GLU A 350
 None
 1.02A 4zphA-7mdhA:
undetectable
4zphB-7mdhA:
undetectable		 4zphA-7mdhA:
22.69
4zphB-7mdhA:
20.76