SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZP0_A_DXCA500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		5 ASN A 334
ASP A 255
LEU A 336
LEU A 219
GLY A 339
 None
 1.16A 4zp0A-1ipkA:
undetectable		 4zp0A-1ipkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 MET A 187
LEU A 184
LEU A 150
GLY A 195
GLN A 169
 None
None
None
G  D 915 ( 4.2A)
G  D 915 ( 3.9A)
 1.38A 4zp0A-1j2bA:
undetectable		 4zp0A-1j2bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 MET A 301
LEU A 298
PRO A 259
LEU A 263
GLY A 282
 None
None
None
None
FAD  A3005 ( 4.6A)
 1.30A 4zp0A-1jroA:
0.0		 4zp0A-1jroA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 5 TYR A 221
LEU A  60
PRO A 217
LEU A 226
GLY A 152
 None
 1.32A 4zp0A-1onsA:
0.0		 4zp0A-1onsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7r PREDICTED
AMIDOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF01174
(SNO) 		5 MET A  74
LEU A  43
PRO A  63
LEU A  96
GLY A  46
 None
 1.34A 4zp0A-1q7rA:
undetectable		 4zp0A-1q7rA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ASN A 170
LEU A 167
PRO A  94
GLY A  10
GLN A  80
 None
 1.35A 4zp0A-2dpnA:
0.0		 4zp0A-2dpnA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 TYR A 807
LEU A 183
PRO A 341
LEU A 261
GLN A 191
 None
 1.49A 4zp0A-2dw4A:
1.1		 4zp0A-2dw4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 TYR A 228
ASN A 227
PRO A 231
GLY A 345
GLN A 343
 None
 1.44A 4zp0A-2y8nA:
0.0		 4zp0A-2y8nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn7 OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 TYR A 392
LEU A 288
LEU A 384
GLY A 282
MET A 285
 None
 1.47A 4zp0A-2yn7A:
2.2		 4zp0A-2yn7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpu MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 ASN A 690
LEU A 717
LEU A 706
GLY A 665
GLN A 666
 None
 1.32A 4zp0A-3bpuA:
undetectable		 4zp0A-3bpuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 MET P 341
LEU P 318
LEU P 320
GLY P 159
MET P 179
 None
 1.35A 4zp0A-3c5wP:
0.0		 4zp0A-3c5wP:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 ASP A 392
LEU A 201
LEU A 370
GLY A 195
MET A 198
 None
 1.45A 4zp0A-3mcaA:
undetectable		 4zp0A-3mcaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 TYR A1000
LEU A 926
LEU A1014
GLY A 920
MET A 923
 None
 1.19A 4zp0A-3mpxA:
3.9		 4zp0A-3mpxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ASP A 223
LEU A 194
LEU A 228
GLY A 186
GLN A 248
 None
 1.21A 4zp0A-3u95A:
undetectable		 4zp0A-3u95A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TYR A1322
LEU A1448
PRO A1264
LEU A1270
GLY A1313
 None
 1.40A 4zp0A-3va7A:
undetectable		 4zp0A-3va7A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 ASN A1253
MET A1243
LEU A1251
LEU A1108
GLY A1363
 None
 1.20A 4zp0A-4aygA:
undetectable		 4zp0A-4aygA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		5 ASP A 240
MET A 404
LEU A 405
LEU A 235
GLY A 190
 None
 1.47A 4zp0A-4c1tA:
undetectable		 4zp0A-4c1tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 MET A 582
LEU A 585
LEU A 530
GLN A 592
MET A 588
 None
 1.50A 4zp0A-4c90A:
1.4		 4zp0A-4c90A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 5 TYR A 224
MET A  65
LEU A  63
LEU A 229
GLY A 156
 None
 1.44A 4zp0A-4i4nA:
undetectable		 4zp0A-4i4nA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		5 TYR A  19
MET A 154
LEU A 146
LEU A  90
GLY A  58
 None
 1.06A 4zp0A-4jerA:
undetectable		 4zp0A-4jerA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		5 MET A 179
LEU A 176
LEU A 127
GLY A 212
GLN A 168
 None
 1.39A 4zp0A-4oqfA:
undetectable		 4zp0A-4oqfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 LEU A  36
PRO A 100
LEU A  93
GLY A  39
GLN A  44
 None
GSH  A 302 ( 4.7A)
None
None
None
 1.43A 4zp0A-4puaA:
0.4		 4zp0A-4puaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		5 TYR A  45
LEU A  36
PRO A   7
LEU A  15
GLY A  70
 None
 1.40A 4zp0A-4q7aA:
undetectable		 4zp0A-4q7aA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 MET A 367
LEU A 363
GLY A 356
GLN A 359
MET A 360
 None
 1.50A 4zp0A-4qfuA:
undetectable		 4zp0A-4qfuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 TYR A 405
MET A 367
GLY A 356
GLN A 359
MET A 360
 None
 1.44A 4zp0A-4qfuA:
undetectable		 4zp0A-4qfuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		5 MET A 673
LEU A 669
PRO A 487
LEU A 660
GLN A 496
 None
 1.35A 4zp0A-4xb0A:
undetectable		 4zp0A-4xb0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 MET A  17
LEU A  29
LEU A  94
GLY A 104
GLN A 103
 None
 1.26A 4zp0A-4ywoA:
undetectable		 4zp0A-4ywoA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		8 TYR A  30
ASN A  33
ASP A  34
LEU A  62
PRO A 154
GLY A 354
GLN A 357
MET A 358
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
None
CLM  A 500 ( 4.4A)
None
None
None
 0.61A 4zp0A-4zowA:
68.7		 4zp0A-4zowA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		9 TYR A  30
ASN A  33
ASP A  34
MET A  58
LEU A  62
PRO A 154
LEU A 236
GLY A 354
GLN A 357
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
CLM  A 500 (-4.7A)
None
CLM  A 500 ( 4.4A)
CLM  A 500 (-4.9A)
None
None
 0.30A 4zp0A-4zowA:
68.7		 4zp0A-4zowA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g23 TYPE-IV LIKE PILIN
TTHA1219

(Thermus
thermophilus) 		no annotation 5 ASP A  81
LEU A 205
PRO A  76
LEU A 209
GLY A 153
 None
 1.14A 4zp0A-5g23A:
undetectable		 4zp0A-5g23A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TYR A1322
LEU A1448
PRO A1264
LEU A1270
GLY A1313
 None
 1.39A 4zp0A-5i8iA:
undetectable		 4zp0A-5i8iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izt OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 TYR A 392
LEU A 288
LEU A 384
GLY A 282
MET A 285
 None
 1.48A 4zp0A-5iztA:
2.4		 4zp0A-5iztA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 MET A 366
LEU A 362
GLY A 355
GLN A 358
MET A 359
 None
 1.47A 4zp0A-5msyA:
undetectable		 4zp0A-5msyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 TYR A 404
MET A 366
GLY A 355
GLN A 358
MET A 359
 None
 1.39A 4zp0A-5msyA:
undetectable		 4zp0A-5msyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 TYR A 523
ASN A 521
ASP A 508
LEU A 534
GLN A 590
 9FQ  A 911 (-4.0A)
None
None
None
None
 1.25A 4zp0A-5o0sA:
1.1		 4zp0A-5o0sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 5 MET A 374
LEU A  20
LEU A 381
GLY A  26
MET A  19
 None
 1.36A 4zp0A-5ukgA:
undetectable		 4zp0A-5ukgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu8 COFILIN-2

(Gallus gallus) 		no annotation 5 TYR H  68
ASP H  66
LEU H 166
PRO H  67
GLY H 154
 None
 1.12A 4zp0A-5yu8H:
undetectable		 4zp0A-5yu8H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu8 COFILIN-2

(Gallus gallus) 		no annotation 5 TYR H  68
ASP H  66
LEU H 166
PRO H  67
GLY H 155
 None
 1.23A 4zp0A-5yu8H:
undetectable		 4zp0A-5yu8H:
undetectable