SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZOW_A_CLMA500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		5 LEU A  42
LEU A 275
LEU A 276
ILE A 279
LEU A 190
 None
 0.94A 4zowA-1c3xA:
0.0		 4zowA-1c3xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		6 TYR A 159
LEU A 135
LEU A 125
LEU A  75
LEU A  73
ILE A 142
 None
 1.26A 4zowA-1cjbA:
0.1		 4zowA-1cjbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 MET A 312
LEU A 316
LEU A  12
LEU A  86
LEU A  70
 None
 0.98A 4zowA-1dk5A:
0.2		 4zowA-1dk5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		5 LEU A  41
LEU A 113
LEU A  63
ILE A 111
LEU A 144
 None
 1.04A 4zowA-1eceA:
undetectable		 4zowA-1eceA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		6 LEU A 130
LEU A 165
LEU A 103
LEU A 209
ILE A 199
LEU A  53
 None
 1.43A 4zowA-1exfA:
undetectable		 4zowA-1exfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 225
LEU A 163
LEU A 160
ILE A 218
LEU A 379
 None
 1.04A 4zowA-1jswA:
2.4		 4zowA-1jswA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE
S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum;
Solanum
tuberosum) 		PF01536
(SAM_decarbox)
PF01536
(SAM_decarbox) 		5 LEU A  75
LEU A 108
LEU B  40
LEU B  45
LEU A 106
 None
 1.04A 4zowA-1mhmA:
undetectable		 4zowA-1mhmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		6 LEU A  74
LEU A  71
LEU A 140
LEU A 153
LEU A 190
LEU A 149
 None
EDO  A 715 ( 4.9A)
None
None
None
None
 1.44A 4zowA-1n97A:
0.0		 4zowA-1n97A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 MET A 127
LEU A 123
LEU A 120
LEU A  29
LEU A  89
 None
 1.01A 4zowA-1oy1A:
0.1		 4zowA-1oy1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 149
LEU A  88
LEU A 107
LEU A 129
LEU A  86
 None
 1.05A 4zowA-1oznA:
undetectable		 4zowA-1oznA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU B 259
LEU B 186
LEU B 212
LEU B 213
LEU B 171
 None
 0.96A 4zowA-1pjmB:
0.0		 4zowA-1pjmB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 LEU A 234
LEU A 227
LEU A 231
ILE A 230
LEU A 323
 None
 0.96A 4zowA-1pq4A:
0.0		 4zowA-1pq4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 LEU A 504
LEU A 425
LEU A 470
ILE A 437
LEU A 539
 None
 1.03A 4zowA-1su7A:
undetectable		 4zowA-1su7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442

(Thermotoga
maritima) 		PF01740
(STAS) 		5 LEU A   6
LEU A   4
LEU A  81
LEU A  49
LEU A  92
 None
 1.04A 4zowA-1t6rA:
undetectable		 4zowA-1t6rA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 184
LEU D 129
LEU D 167
LEU D 163
LEU D 144
 None
 1.01A 4zowA-1u0nD:
undetectable		 4zowA-1u0nD:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug8 POLY(A)-SPECIFIC
RIBONUCLEASE

(Mus musculus) 		PF01424
(R3H) 		5 TYR A  53
LEU A  32
LEU A  24
LEU A  34
ILE A  71
 None
 1.01A 4zowA-1ug8A:
undetectable		 4zowA-1ug8A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 LEU A 724
LEU A 658
LEU A 684
ILE A 985
LEU A 409
 None
 1.04A 4zowA-1urjA:
undetectable		 4zowA-1urjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 297
LEU A  86
LEU A  85
ILE A  82
LEU A 242
 None
 1.04A 4zowA-1vp4A:
undetectable		 4zowA-1vp4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqb HYPOTHETICAL UPF0066
PROTEIN HI0510

(Haemophilus
influenzae) 		PF01980
(UPF0066) 		5 ASP A 134
LEU A  57
LEU A  38
ILE A   9
LEU A 119
 None
 1.01A 4zowA-1xqbA:
undetectable		 4zowA-1xqbA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		5 MET A  62
LEU A  63
LEU A 209
LEU A 146
LEU A 176
 None
 0.98A 4zowA-1yw6A:
undetectable		 4zowA-1yw6A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		5 LEU A  10
LEU A 208
LEU A 161
LEU A 165
ILE A 164
 None
 1.01A 4zowA-2a35A:
undetectable		 4zowA-2a35A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		6 MET A 218
LEU A 215
LEU A 248
LEU A 167
LEU A 181
ILE A 185
 None
None
None
LYS  A 420 (-4.7A)
None
None
 1.00A 4zowA-2a5hA:
undetectable		 4zowA-2a5hA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 169
LEU A 141
LEU A 142
ILE A 145
LEU A 192
 None
GOL  A 379 (-4.2A)
None
None
GOL  A 379 ( 4.0A)
 0.99A 4zowA-2awaA:
undetectable		 4zowA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		6 LEU A 336
LEU A 360
LEU A 290
LEU A 314
LEU A 342
LEU A 288
 None
 1.20A 4zowA-2bexA:
undetectable		 4zowA-2bexA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 LEU A 185
LEU A 115
LEU A 139
LEU A 167
LEU A 113
 None
 1.03A 4zowA-2bnhA:
undetectable		 4zowA-2bnhA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 LEU A 332
LEU A 286
LEU A 310
LEU A 338
LEU A 284
 None
 1.04A 4zowA-2bnhA:
undetectable		 4zowA-2bnhA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		5 LEU A 116
LEU A 105
LEU A  57
ILE A  60
LEU A  47
 None
 1.03A 4zowA-2cbnA:
undetectable		 4zowA-2cbnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		5 LEU A 167
LEU A 158
LEU A 157
ILE A 154
LEU A 128
 None
 1.04A 4zowA-2d2eA:
undetectable		 4zowA-2d2eA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 MET A 299
LEU A 287
LEU A 556
ILE A 559
LEU A 462
 None
 0.86A 4zowA-2fafA:
undetectable		 4zowA-2fafA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		5 LEU A 201
LEU A 278
LEU A 238
LEU A  66
LEU A 275
 None
 1.00A 4zowA-2greA:
undetectable		 4zowA-2greA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 ASN A  38
LEU A  88
LEU A 323
ILE A 322
LEU A  92
 None
 0.87A 4zowA-2h8oA:
1.7		 4zowA-2h8oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jva PEPTIDYL-TRNA
HYDROLASE DOMAIN
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00472
(RF-1) 		5 LEU A  56
LEU A  10
LEU A   2
ILE A  15
LEU A  48
 None
 1.05A 4zowA-2jvaA:
undetectable		 4zowA-2jvaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 173
LEU A 106
LEU A 125
LEU A 149
LEU A 104
 None
 0.96A 4zowA-2o6rA:
undetectable		 4zowA-2o6rA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 LEU A 124
LEU A 165
LEU A 169
ILE A 168
LEU A 103
 None
 0.99A 4zowA-2okjA:
undetectable		 4zowA-2okjA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LEU A 346
LEU A 363
LEU A 382
ILE A 385
LEU A 344
 None
 1.01A 4zowA-2omvA:
undetectable		 4zowA-2omvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 LEU A 372
LEU A 390
LEU A 568
LEU A 570
LEU A 541
 None
 0.86A 4zowA-2pggA:
undetectable		 4zowA-2pggA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 LEU A 318
LEU A   8
LEU A 307
ILE A 249
LEU A  18
 None
 0.98A 4zowA-2ppvA:
undetectable		 4zowA-2ppvA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		6 LEU B 441
LEU B 379
LEU B 398
LEU B 419
ILE B 422
LEU B 377
 None
 1.23A 4zowA-2v9tB:
undetectable		 4zowA-2v9tB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		5 LEU A 399
LEU A 347
LEU A 407
LEU A 366
LEU A   3
 None
 0.99A 4zowA-2vc2A:
undetectable		 4zowA-2vc2A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x06 L-SULFOLACTATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF02615
(Ldh_2) 		5 TYR A  52
LEU A  85
LEU A 328
ILE A 331
LEU A 324
 None
 1.03A 4zowA-2x06A:
undetectable		 4zowA-2x06A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		6 LEU A   8
LEU A 169
LEU A 123
LEU A  15
LEU A  12
ILE A  64
 None
 1.13A 4zowA-2x77A:
undetectable		 4zowA-2x77A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		6 LEU A  40
LEU A 123
LEU A  15
LEU A  12
ILE A  64
LEU A 180
 None
 1.35A 4zowA-2x77A:
undetectable		 4zowA-2x77A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 405
LEU A 402
LEU A 358
ILE A 359
LEU A 304
 None
 1.04A 4zowA-2y6eA:
undetectable		 4zowA-2y6eA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE

(Thermus
thermophilus) 		PF01081
(Aldolase) 		5 LEU A  55
LEU A  46
LEU A 155
LEU A  64
LEU A  10
 None
 1.04A 4zowA-2yw4A:
undetectable		 4zowA-2yw4A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 570
LEU A 503
LEU A 522
LEU A 546
LEU A 501
 None
 1.03A 4zowA-2z63A:
undetectable		 4zowA-2z63A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 TYR A 551
LEU A 503
LEU A 522
LEU A 546
LEU A 501
 None
 0.95A 4zowA-2z66A:
undetectable		 4zowA-2z66A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 LEU A 288
LEU A 369
LEU A 372
ILE A 368
LEU A 284
 None
 1.03A 4zowA-2zbzA:
undetectable		 4zowA-2zbzA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		6 LEU A 109
LEU A 209
LEU A 157
LEU A  90
LEU A  86
ILE A 149
 None
 1.48A 4zowA-2zcxA:
2.3		 4zowA-2zcxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		6 LEU A 209
LEU A 157
LEU A  90
LEU A  86
ILE A 149
LEU A 156
 None
 1.50A 4zowA-2zcxA:
2.3		 4zowA-2zcxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		5 MET A  70
LEU A 184
LEU A 140
ILE A 100
LEU A 147
 None
 1.03A 4zowA-2ziiA:
undetectable		 4zowA-2ziiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zrr MUNDTICIN KS
IMMUNITY PROTEIN

(Enterococcus
mundtii) 		PF08951
(EntA_Immun) 		5 LEU A  77
LEU A  45
LEU A  88
LEU A  85
ILE A  66
 None
 0.93A 4zowA-2zrrA:
undetectable		 4zowA-2zrrA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		5 ASN A  80
LEU A  73
LEU A 119
ILE A 118
LEU A  49
 None
 0.93A 4zowA-3auxA:
undetectable		 4zowA-3auxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		5 LEU A  66
LEU A  63
LEU A  88
ILE A 119
LEU A 111
 None
 1.06A 4zowA-3bbhA:
undetectable		 4zowA-3bbhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		5 LEU A 255
LEU A 336
LEU A 301
LEU A 303
ILE A 328
 None
 1.06A 4zowA-3beoA:
undetectable		 4zowA-3beoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 LEU A 434
LEU A 443
LEU A  20
LEU A 400
LEU A  16
 None
 1.06A 4zowA-3c5wA:
undetectable		 4zowA-3c5wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 LEU A 331
LEU A 327
LEU A  32
LEU A  25
LEU A  30
 None
 1.05A 4zowA-3d6kA:
undetectable		 4zowA-3d6kA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 314
LEU A 260
LEU A 274
LEU A 294
LEU A 257
 None
 1.01A 4zowA-3g06A:
undetectable		 4zowA-3g06A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 374
LEU A 320
LEU A 334
LEU A 354
LEU A 317
 None
 1.05A 4zowA-3g06A:
undetectable		 4zowA-3g06A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 465
LEU A 457
LEU A 407
LEU A 444
LEU A 424
 None
 1.03A 4zowA-3g06A:
undetectable		 4zowA-3g06A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		6 MET A 183
LEU A 223
LEU A  82
LEU A  98
LEU A  72
LEU A 105
 None
 1.38A 4zowA-3g8aA:
undetectable		 4zowA-3g8aA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 LEU A 237
LEU A 376
LEU A 303
LEU A 305
ILE A 331
 None
 1.04A 4zowA-3gehA:
3.3		 4zowA-3gehA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grc SENSOR PROTEIN,
KINASE

(Polaromonas sp.
JS666) 		PF00072
(Response_reg) 		5 LEU A 601
LEU A 613
LEU A 609
ILE A 610
LEU A 622
 None
 1.05A 4zowA-3grcA:
undetectable		 4zowA-3grcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  15
LEU A  97
LEU A  90
ILE A  66
LEU A  73
 None
 1.00A 4zowA-3hi8A:
undetectable		 4zowA-3hi8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqf RESTRICTION
ENDONUCLEASE

(Escherichia
coli) 		PF09217
(EcoRII-N) 		5 TYR A  21
LEU A  25
LEU A 108
ILE A 136
LEU A  66
 None
 0.99A 4zowA-3hqfA:
undetectable		 4zowA-3hqfA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		5 LEU A 715
LEU A 727
LEU A 787
LEU A 816
LEU A 832
 None
 1.01A 4zowA-3j0aA:
undetectable		 4zowA-3j0aA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		6 ASN A1567
MET A1586
LEU A1593
LEU A1597
ILE A1584
LEU A1767
 None
 1.47A 4zowA-3jb9A:
undetectable		 4zowA-3jb9A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrv PROTEIN K7

(Vaccinia virus) 		PF06227
(Poxvirus) 		5 TYR A  33
LEU A 140
LEU A 148
LEU A 144
ILE A  20
 None
 1.03A 4zowA-3jrvA:
undetectable		 4zowA-3jrvA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		5 LEU A 504
LEU A 579
LEU A 531
LEU A 532
ILE A 535
 None
 0.96A 4zowA-3k7dA:
undetectable		 4zowA-3k7dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 5 MET A 322
LEU A 326
LEU A 310
LEU A 307
LEU A 257
 None
 0.97A 4zowA-3ly9A:
undetectable		 4zowA-3ly9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 117
LEU A  63
LEU A  82
LEU A 104
LEU A  61
 None
 1.01A 4zowA-3o53A:
undetectable		 4zowA-3o53A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		5 LEU A 117
LEU A  63
LEU A  82
LEU A 104
LEU A  61
 None
 1.00A 4zowA-3ojaA:
undetectable		 4zowA-3ojaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis) 		PF10988
(DUF2807) 		5 LEU A 189
LEU A 176
LEU A 130
LEU A 150
LEU A 113
 None
 0.94A 4zowA-3petA:
undetectable		 4zowA-3petA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		5 LEU A 108
LEU A 117
LEU A 146
ILE A 151
LEU A 133
 None
 1.03A 4zowA-3qa8A:
undetectable		 4zowA-3qa8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 345
LEU A 172
LEU A 208
ILE A 214
LEU A 164
 None
 1.05A 4zowA-3qfvA:
undetectable		 4zowA-3qfvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 148
LEU A  84
LEU A 103
LEU A 127
LEU A  82
 None
 1.02A 4zowA-3rg1A:
undetectable		 4zowA-3rg1A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		6 LEU A 316
LEU A 312
LEU A 302
LEU A 290
LEU A 287
LEU A 299
 None
 1.21A 4zowA-3rg2A:
undetectable		 4zowA-3rg2A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 TYR A 445
LEU A 413
LEU A 410
LEU A 340
LEU A 361
 None
None
FAD  A 601 ( 4.1A)
None
None
 0.90A 4zowA-3t58A:
undetectable		 4zowA-3t58A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 123
LEU A 139
LEU A 284
ILE A 286
LEU A 169
 None
 0.93A 4zowA-3tqhA:
undetectable		 4zowA-3tqhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		6 ASP E  31
LEU E  10
LEU E  85
LEU E  63
LEU E  35
LEU E  87
 None
 1.37A 4zowA-3tsrE:
undetectable		 4zowA-3tsrE:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 390
LEU A 323
LEU A 342
LEU A 366
LEU A 321
 None
 1.05A 4zowA-3v44A:
undetectable		 4zowA-3v44A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 394
LEU A 342
LEU A 402
LEU A 361
LEU A   3
 None
 0.96A 4zowA-3vi3A:
undetectable		 4zowA-3vi3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		6 ASN A 280
LEU A 230
LEU A 217
LEU A  45
LEU A 211
LEU A 289
 None
 1.46A 4zowA-3w6oA:
3.7		 4zowA-3w6oA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 MET A 234
LEU A 238
LEU A 241
LEU A 188
ILE A 157
 None
None
None
None
NDP  A 300 (-4.4A)
 1.05A 4zowA-3wxbA:
undetectable		 4zowA-3wxbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz2 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 LEU A 140
LEU A 113
LEU A 174
ILE A 111
LEU A  37
 None
 1.04A 4zowA-3wz2A:
undetectable		 4zowA-3wz2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		5 TYR A 131
LEU A 101
LEU A 152
LEU A  78
LEU A 166
 None
 1.01A 4zowA-3zhbA:
1.1		 4zowA-3zhbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 324
LEU A 262
LEU A 281
LEU A 305
LEU A 260
 None
 1.03A 4zowA-3zyoA:
undetectable		 4zowA-3zyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		5 TYR A 336
LEU A 340
LEU A 352
LEU A 348
LEU A 301
 None
 0.94A 4zowA-4ag6A:
undetectable		 4zowA-4ag6A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 LEU A 398
LEU A 339
LEU A 354
LEU A 402
LEU A 400
LEU A 199
 None
 1.35A 4zowA-4b56A:
undetectable		 4zowA-4b56A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU R 440
LEU R 373
LEU R 392
LEU R 416
LEU R 371
 None
 1.03A 4zowA-4bv4R:
undetectable		 4zowA-4bv4R:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 LEU A 293
LEU A  55
LEU A 130
LEU A  82
LEU A 172
 None
 1.00A 4zowA-4ccdA:
undetectable		 4zowA-4ccdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		6 ASN A 594
ASP A 590
LEU A 564
LEU A 575
LEU A 629
LEU A 625
 None
 1.43A 4zowA-4cekA:
1.2		 4zowA-4cekA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 399
LEU A 390
LEU A  38
LEU A 363
ILE A 379
 None
 0.97A 4zowA-4cvqA:
undetectable		 4zowA-4cvqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 108
LEU A 117
LEU A 146
ILE A 151
LEU A 133
 None
 0.75A 4zowA-4e3cA:
undetectable		 4zowA-4e3cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 6

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C  79
LEU C  61
LEU C  96
LEU C  93
ILE C  98
 None
 1.06A 4zowA-4ejsC:
1.0		 4zowA-4ejsC:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ett RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF02026
(RyR) 		6 TYR A2935
MET A2816
LEU A2813
LEU A2751
LEU A2926
LEU A2862
 None
None
None
GOL  A3002 (-4.5A)
None
None
 1.25A 4zowA-4ettA:
undetectable		 4zowA-4ettA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 277
LEU A 269
LEU A 219
LEU A 285
LEU A 281
ILE A 246
 None
 1.36A 4zowA-4eutA:
undetectable		 4zowA-4eutA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 277
LEU A 269
LEU A 219
LEU A 285
LEU A 281
ILE A 246
 None
 1.35A 4zowA-4euuA:
undetectable		 4zowA-4euuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 LEU A 320
LEU A 256
LEU A 274
LEU A 307
LEU A 254
 None
 1.06A 4zowA-4fcgA:
undetectable		 4zowA-4fcgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpc HEME OXYGENASE

(Corynebacterium
diphtheriae) 		PF01126
(Heme_oxygenase) 		5 LEU A 113
LEU A  12
LEU A  72
LEU A  73
LEU A 180
 None
 1.06A 4zowA-4gpcA:
1.3		 4zowA-4gpcA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		5 LEU A 296
LEU A 324
LEU A 334
LEU A 248
LEU A 249
 None
 1.00A 4zowA-4h0pA:
undetectable		 4zowA-4h0pA:
21.31