SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZO1_X_T3X500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ILE A  44
ALA A 147
ALA A  52
LEU A 140
ASN A 145
 None
 1.19A 4zo1X-1d6sA:
0.0		 4zo1X-1d6sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ILE A 324
ALA A 336
ALA A 380
LEU A 333
PHE A 309
 None
 1.33A 4zo1X-1f7uA:
0.9		 4zo1X-1f7uA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF08934
(Rb_C) 		5 ILE B 724
ALA B 727
ARG B 668
ALA B 734
PHE B 721
 None
 1.44A 4zo1X-1guxB:
3.0		 4zo1X-1guxB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 225
ALA A 226
ARG A 230
ALA A 162
ASN A 492
 None
None
None
FAD  A 800 (-3.5A)
None
 1.44A 4zo1X-1knrA:
0.0		 4zo1X-1knrA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 ILE A 294
ALA A 318
ARG A 356
LEU A 323
ASN A 322
 None
 1.45A 4zo1X-1kt1A:
0.0		 4zo1X-1kt1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leo NUCLEOSIDE
DIPHOSPHATE KINASE

(Dictyostelium
discoideum) 		PF00334
(NDK) 		5 ILE A  28
ARG A 109
ALA A  91
ARG A  92
LEU A  13
 None
 1.47A 4zo1X-1leoA:
0.0		 4zo1X-1leoA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
HIS A 381
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.75A 4zo1X-1navA:
37.4		 4zo1X-1navA:
81.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 222
ALA A 263
ARG A 266
LEU A 276
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 ( 3.8A)
None
IH5  A 600 (-4.0A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.13A 4zo1X-1navA:
37.4		 4zo1X-1navA:
81.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5q FK506-BINDING
PROTEIN 4

(Homo sapiens) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF07719
(TPR_2) 		5 ILE A 192
ALA A 168
ALA A 162
ASN A 165
PHE A 190
 None
 1.44A 4zo1X-1p5qA:
0.0		 4zo1X-1p5qA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ALA A 317
ARG A 320
LEU A 330
ASN A 331
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 (-4.2A)
G24  A 462 ( 3.9A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.59A 4zo1X-1q4xA:
37.5		 4zo1X-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 204
ALA A 128
ARG A 151
LEU A 172
PHE A 232
 None
 1.30A 4zo1X-1qp8A:
undetectable		 4zo1X-1qp8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		5 ILE A 215
ALA A 214
ARG A 198
ALA A  90
LEU A 237
 None
 1.22A 4zo1X-1ry6A:
undetectable		 4zo1X-1ry6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		5 ILE A 211
ALA A 212
ALA A 229
LEU A  44
PHE A 265
 None
 1.44A 4zo1X-1s5pA:
undetectable		 4zo1X-1s5pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4)
PF11430
(EGL-1) 		5 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.15A 4zo1X-1ty4A:
undetectable		 4zo1X-1ty4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		5 ILE A 111
ALA A 131
ARG A 133
LEU A 135
PHE A  60
 None
 1.26A 4zo1X-1vl5A:
undetectable		 4zo1X-1vl5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens) 		PF01661
(Macro) 		5 ALA A 268
ALA A 308
LEU A 205
HIS A 273
PHE A 239
 None
 1.29A 4zo1X-1zr5A:
undetectable		 4zo1X-1zr5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		5 ALA A 100
ALA A  97
LEU A  84
ASN A  81
HIS A  10
 None
None
None
None
ZN  A1501 ( 3.3A)
 1.28A 4zo1X-2dvuA:
undetectable		 4zo1X-2dvuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 ILE B 335
ALA B 336
ALA B 342
ARG B 344
ASN B 337
 None
 1.40A 4zo1X-2fpgB:
undetectable		 4zo1X-2fpgB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ILE A 154
ALA A 157
ALA A 206
LEU A 202
MET A 263
 None
 1.01A 4zo1X-2ivpA:
undetectable		 4zo1X-2ivpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 ILE A 173
ALA A  85
LEU A  29
ASN A  65
PHE A 163
 FAD  A 401 (-4.1A)
FAD  A 401 ( 4.2A)
None
FAD  A 401 (-3.9A)
None
 1.49A 4zo1X-2mbrA:
undetectable		 4zo1X-2mbrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 ILE A 346
ALA A 344
MET A  17
ALA A  19
ASN A  28
 None
 1.48A 4zo1X-2o0rA:
undetectable		 4zo1X-2o0rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923

(Corynebacterium
glutamicum) 		PF09754
(PAC2) 		5 ILE A  29
ALA A  31
ALA A  41
LEU A 217
PHE A 104
 None
 1.49A 4zo1X-2p90A:
undetectable		 4zo1X-2p90A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		5 ILE A 357
ALA A 336
MET A 107
ALA A 110
LEU A 328
 None
 1.01A 4zo1X-2pefA:
undetectable		 4zo1X-2pefA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 488
ALA A 485
MET A 329
ALA A 331
ARG A 335
 None
 1.47A 4zo1X-2vwkA:
undetectable		 4zo1X-2vwkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfc PEROXIREDOXIN 5

(Arenicola
marina) 		PF08534
(Redoxin) 		5 ALA A  69
MET A 123
MET A 108
ALA A 110
PHE A  64
 None
 1.39A 4zo1X-2wfcA:
undetectable		 4zo1X-2wfcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 ILE A 402
ALA A 406
LEU A 357
ASN A 358
PHE A 346
 None
 1.29A 4zo1X-2wzsA:
undetectable		 4zo1X-2wzsA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 ILE A 118
ALA A 120
ALA A 403
LEU A 131
PHE A 198
 None
 1.39A 4zo1X-3aupA:
undetectable		 4zo1X-3aupA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ILE A 296
ALA A 391
MET A 279
ALA A 311
PHE A 263
 None
 1.37A 4zo1X-3ek1A:
undetectable		 4zo1X-3ek1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		5 ALA A1269
ARG A1273
ALA A1317
LEU A1314
PHE A 261
 None
 1.26A 4zo1X-3eujA:
undetectable		 4zo1X-3eujA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13462
(Thioredoxin_4) 		5 ILE A 113
ALA A 114
ARG A 118
ALA A 107
PHE A 128
 None
 1.45A 4zo1X-3gn3A:
undetectable		 4zo1X-3gn3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		5 ILE A 102
ALA A 161
ALA A 187
ARG A 185
LEU A 163
 None
 1.42A 4zo1X-3h2bA:
undetectable		 4zo1X-3h2bA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 ILE A 297
ALA A 300
ARG A 638
MET A 270
ALA A 268
 None
 1.22A 4zo1X-3i6sA:
undetectable		 4zo1X-3i6sA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		5 ILE A 254
ALA A 250
MET A 209
ASN A 247
PHE A 259
 None
 1.35A 4zo1X-3iwgA:
undetectable		 4zo1X-3iwgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0b PREDICTED
N6-ADENINE-SPECIFIC
DNA METHYLASE

(Listeria
monocytogenes) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ILE A  45
ALA A  48
ALA A 239
ASN A  49
PHE A   4
 None
 1.48A 4zo1X-3k0bA:
undetectable		 4zo1X-3k0bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 ILE A 258
ALA A 237
ALA A 244
LEU A 148
PHE A 225
 None
 0.92A 4zo1X-3k0sA:
undetectable		 4zo1X-3k0sA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 397
ALA A 396
ALA A 428
ASN A 122
PHE A 387
 None
 1.48A 4zo1X-3l84A:
undetectable		 4zo1X-3l84A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ILE A  12
ALA A  11
ALA A  56
ARG A  55
LEU A  79
 None
None
MG  A 300 (-4.3A)
None
None
 1.44A 4zo1X-3ppiA:
undetectable		 4zo1X-3ppiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ILE A  61
ALA A  88
ALA A  80
ARG A  79
PHE A  44
 None
 1.47A 4zo1X-3pwzA:
undetectable		 4zo1X-3pwzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 ILE A 107
ALA A 106
ARG A 109
ARG A 146
LEU A 141
 None
 1.45A 4zo1X-3qanA:
undetectable		 4zo1X-3qanA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		5 ILE A 149
ARG A 155
ALA A 261
ASN A 268
MET A 107
 None
 1.09A 4zo1X-3u1tA:
undetectable		 4zo1X-3u1tA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC)
no annotation 		5 ILE B 239
ALA B 235
MET B 192
HIS A  65
PHE B 243
 None
 1.46A 4zo1X-3wxxB:
undetectable		 4zo1X-3wxxB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		5 ILE A 443
ALA A 442
ALA A 275
ARG A 438
PHE A 616
 None
 1.47A 4zo1X-3x3yA:
undetectable		 4zo1X-3x3yA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		5 ILE A 216
ALA A 215
ARG A 199
ALA A  86
LEU A 242
 None
 1.27A 4zo1X-3zfcA:
undetectable		 4zo1X-3zfcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A 535
ALA A 574
LEU A 523
HIS A 560
PHE A   7
 None
 1.27A 4zo1X-4bb9A:
undetectable		 4zo1X-4bb9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A 535
ARG A 533
ALA A 574
LEU A 523
PHE A   7
 None
 1.36A 4zo1X-4bb9A:
undetectable		 4zo1X-4bb9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4br6 SUPEROXIDE DISMUTASE

(Chaetomium
thermophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A 159
ARG A 111
ALA A 175
ASN A 115
PHE A  77
 None
 1.49A 4zo1X-4br6A:
undetectable		 4zo1X-4br6A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		5 ILE A 133
ALA A 137
ALA A 290
LEU A 291
HIS A 110
 None
 1.49A 4zo1X-4ci0A:
undetectable		 4zo1X-4ci0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 ALA A 399
ALA A 421
ARG A 424
ASN A 400
HIS A 435
 None
 1.25A 4zo1X-4dalA:
undetectable		 4zo1X-4dalA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		5 ALA A 282
ALA A 237
ARG A 287
LEU A 290
ASN A 286
 None
 1.21A 4zo1X-4ed9A:
undetectable		 4zo1X-4ed9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 197
ALA A 195
ALA A 291
LEU A 203
PHE A 250
 None
 1.28A 4zo1X-4egjA:
undetectable		 4zo1X-4egjA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		5 ILE A 724
ALA A 727
ARG A 668
ALA A 734
PHE A 721
 None
 1.49A 4zo1X-4eljA:
undetectable		 4zo1X-4eljA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 453
ALA A 450
LEU A 466
MET A 363
PHE A 432
 None
 1.17A 4zo1X-4eudA:
undetectable		 4zo1X-4eudA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 ALA A  74
ALA A 310
ARG A  79
LEU A  78
PHE A 132
 None
None
None
None
PG4  A 504 ( 3.8A)
 1.19A 4zo1X-4f0sA:
undetectable		 4zo1X-4f0sA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		5 ILE A 532
ARG A 648
ALA A 580
LEU A 530
PHE A 448
 None
CBI  A 802 (-3.7A)
None
None
None
 1.26A 4zo1X-4fusA:
undetectable		 4zo1X-4fusA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 ALA A 680
MET A 689
ALA A 685
LEU A 600
MET A 557
 None
 1.48A 4zo1X-4fwgA:
undetectable		 4zo1X-4fwgA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoj REGF PROTEIN

(Neisseria
gonorrhoeae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A 150
ALA A 153
ARG A  15
MET A  97
ASN A  64
 None
None
None
ACT  A 303 (-4.7A)
None
 1.08A 4zo1X-4hojA:
undetectable		 4zo1X-4hojA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		5 ILE A  73
ARG A 388
ALA A 160
LEU A  77
PHE A  70
 None
 1.45A 4zo1X-4humA:
2.1		 4zo1X-4humA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 ILE A 216
MET A 228
ALA A 186
LEU A 187
HIS A 229
 None
 1.45A 4zo1X-4i2wA:
undetectable		 4zo1X-4i2wA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		5 ILE A 638
ARG A 572
ALA A 587
ASN A 582
PHE A 650
 None
 1.37A 4zo1X-4j5tA:
undetectable		 4zo1X-4j5tA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		5 ILE A 331
ARG A 193
ALA A 180
LEU A 210
PHE A 354
 None
 1.33A 4zo1X-4j8fA:
undetectable		 4zo1X-4j8fA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 5 ILE A 659
ARG A 341
ALA A  55
LEU A 129
ASN A 130
 None
 1.00A 4zo1X-4jzaA:
undetectable		 4zo1X-4jzaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02917
(Pertussis_S1) 		5 ILE G  78
ALA G  77
ARG G  80
LEU G 151
PHE G 208
 None
 1.19A 4zo1X-4k6lG:
undetectable		 4zo1X-4k6lG:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		5 ILE A 192
ALA A 168
ALA A 162
ASN A 165
PHE A 190
 None
 1.48A 4zo1X-4lawA:
undetectable		 4zo1X-4lawA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01520
(Amidase_3) 		5 ILE A  97
ALA A 168
ARG A  27
LEU A 165
PHE A   6
 None
None
None
None
PT  A 308 (-4.5A)
 1.40A 4zo1X-4lq6A:
undetectable		 4zo1X-4lq6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 ILE A 116
ALA A 106
ARG A 105
LEU A  59
PHE A 130
 None
 1.49A 4zo1X-4lrsA:
undetectable		 4zo1X-4lrsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 ILE A 116
MET A 138
ALA A 106
ARG A 105
LEU A  59
 None
PEG  A 406 ( 4.9A)
None
None
None
 1.48A 4zo1X-4lrsA:
undetectable		 4zo1X-4lrsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Burkholderia
ambifaria) 		PF03480
(DctP) 		5 ILE A 256
ALA A 260
MET A  48
LEU A  55
PHE A 240
 None
 1.46A 4zo1X-4n17A:
undetectable		 4zo1X-4n17A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ILE A 106
ALA A 107
ARG A 111
ARG A 350
PHE A  89
 None
 1.30A 4zo1X-4oo2A:
undetectable		 4zo1X-4oo2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		5 ILE A 224
ALA A 192
ALA A 236
LEU A 233
PHE A 216
 None
None
None
None
SO4  A 401 (-4.9A)
 1.46A 4zo1X-4pm4A:
undetectable		 4zo1X-4pm4A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 ILE A 465
ALA A 424
ALA A 454
ASN A 406
PHE A 508
 None
 1.50A 4zo1X-4rbnA:
undetectable		 4zo1X-4rbnA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 ILE A 133
ALA A 713
ARG A 140
LEU A 137
PHE A 693
 None
 1.42A 4zo1X-4wgkA:
undetectable		 4zo1X-4wgkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 ILE A 474
ALA A 477
ALA A 397
LEU A 394
PHE A 429
 None
 1.36A 4zo1X-5a2oA:
undetectable		 4zo1X-5a2oA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		5 ILE A 288
ALA A 337
ALA A 240
ARG A 207
PHE A 226
 None
None
None
None
EDO  A 503 (-3.6A)
 1.24A 4zo1X-5dldA:
undetectable		 4zo1X-5dldA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 ILE A 249
ALA A 149
ARG A 247
ALA A 174
PHE A 274
 None
 1.39A 4zo1X-5dp2A:
undetectable		 4zo1X-5dp2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 ILE A 374
ALA A 393
ARG A 390
LEU A 376
PHE A 372
 None
 1.46A 4zo1X-5f1qA:
undetectable		 4zo1X-5f1qA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h69 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF06470
(SMC_hinge) 		5 ILE A 538
ALA A 541
ARG A 645
ALA A 545
LEU A 620
 None
 1.44A 4zo1X-5h69A:
undetectable		 4zo1X-5h69A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ALA B 155
LEU B 177
ASN B 180
MET B 144
PHE B 116
 None
 1.33A 4zo1X-5hzlB:
undetectable		 4zo1X-5hzlB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 ALA A 281
ARG A 435
LEU A 431
ASN A 428
PHE A 275
 None
 1.43A 4zo1X-5i5hA:
undetectable		 4zo1X-5i5hA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		5 ALA A  43
MET A  96
MET A  82
ALA A  84
PHE A  38
 None
 1.44A 4zo1X-5k1gA:
undetectable		 4zo1X-5k1gA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 225
ALA A 226
ARG A 230
ALA A 162
ASN A 492
 None
None
EDO  A 607 (-3.6A)
None
None
 1.46A 4zo1X-5kxjA:
undetectable		 4zo1X-5kxjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A1135
MET A1113
ALA A1119
LEU A1123
PHE A1138
 None
 1.21A 4zo1X-5m3cA:
undetectable		 4zo1X-5m3cA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 469
ALA A 468
ALA A 506
ASN A 174
PHE A 459
 None
 1.31A 4zo1X-5nd5A:
undetectable		 4zo1X-5nd5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nri D-ALANINE--D-ALANINE
LIGASE

(Burkholderia
pseudomallei) 		no annotation 5 ILE A 197
ALA A 195
ALA A 291
LEU A 203
PHE A 250
 None
 1.44A 4zo1X-5nriA:
undetectable		 4zo1X-5nriA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 ILE A 141
ALA A 342
ARG A 347
ALA A 300
MET A  74
 None
 1.49A 4zo1X-5tu0A:
undetectable		 4zo1X-5tu0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ILE A 186
ALA A 217
LEU A 190
ASN A 188
PHE A 184
 None
 1.30A 4zo1X-5tufA:
undetectable		 4zo1X-5tufA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ILE A 186
ALA A 217
LEU A 190
ASN A 188
PHE A 184
 None
GOL  A 401 ( 4.8A)
None
None
None
 1.33A 4zo1X-5tukA:
undetectable		 4zo1X-5tukA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ILE A 186
ALA A 217
LEU A 190
ASN A 188
PHE A 184
 None
 1.18A 4zo1X-5tulA:
undetectable		 4zo1X-5tulA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		5 ILE A 272
MET A  45
MET A 357
ALA A 335
ASN A 275
 None
None
IMP  A 500 ( 3.8A)
None
IMP  A 500 (-4.0A)
 1.47A 4zo1X-5uzeA:
undetectable		 4zo1X-5uzeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		5 ILE A 229
ALA A 261
ALA A   9
ARG A 118
LEU A 259
 None
 1.36A 4zo1X-5wqkA:
undetectable		 4zo1X-5wqkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1x MUTATOR MUTT PROTEIN

(Staphylococcus
aureus) 		PF00293
(NUDIX) 		5 ILE A  11
ALA A  10
ALA A  21
ARG A  23
PHE A  13
 None
 1.45A 4zo1X-5x1xA:
undetectable		 4zo1X-5x1xA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE B1212
ALA B1213
ARG B1215
HIS A  92
PHE A1413
 None
 1.37A 4zo1X-5xogB:
undetectable		 4zo1X-5xogB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqh PROTEIN ROGDI
HOMOLOG

(Homo sapiens) 		PF10259
(Rogdi_lz) 		5 ILE A 251
ALA A 116
ARG A 159
LEU A 160
PHE A  61
 None
 1.44A 4zo1X-5xqhA:
undetectable		 4zo1X-5xqhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 5 ILE A 246
ALA A 189
ALA A 157
ARG A 343
LEU A 185
 None
 1.18A 4zo1X-5yatA:
undetectable		 4zo1X-5yatA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 5 ALA A 529
ARG A 445
LEU A 506
ASN A 530
HIS A 564
 None
 1.20A 4zo1X-5zibA:
undetectable		 4zo1X-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 ILE A 172
ALA A 175
ALA A 147
LEU A  99
PHE A 159
 None
 1.18A 4zo1X-6cn1A:
undetectable		 4zo1X-6cn1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxo BLDN
RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR

(Streptomyces
venezuelae) 		no annotation 5 ILE A  55
ALA A   7
MET D  77
MET D  74
ARG D  67
 None
 1.35A 4zo1X-6dxoA:
undetectable		 4zo1X-6dxoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek7 YAXA

(Yersinia
enterocolitica) 		no annotation 5 ILE A  96
ALA A 100
ALA A 336
LEU A 204
PHE A  93
 None
 1.20A 4zo1X-6ek7A:
undetectable		 4zo1X-6ek7A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 ILE J  59
ALA J  58
ALA J 732
ASN J  73
PHE J 140
 None
 1.29A 4zo1X-6fhsJ:
undetectable		 4zo1X-6fhsJ:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 5 ALA A 200
ALA A 118
ARG A 121
LEU A 198
HIS A 107
 None
 1.47A 4zo1X-6g3dA:
undetectable		 4zo1X-6g3dA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-) 		no annotation 5 ALA A 276
ALA A 246
ARG A 245
HIS A 264
MET A 410
 None
 1.42A 4zo1X-6grwA:
undetectable		 4zo1X-6grwA:
undetectable