SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZN7_B_DESB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 MET A 160
LEU A 213
ALA A 216
MET A 239
MET A 198
 None
None
None
HEM  A1414 (-4.3A)
None
 1.15A 4zn7B-1gwiA:
2.0		 4zn7B-1gwiA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		5 LEU P  61
LEU P 101
LEU P 102
MET P 165
LEU P 127
 None
 1.32A 4zn7B-1ikoP:
undetectable		 4zn7B-1ikoP:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		5 MET A 242
LEU A 245
ALA A 249
GLU A 254
MET A 283
 None
 1.34A 4zn7B-1jbkA:
0.0		 4zn7B-1jbkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		5 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.08A 4zn7B-1mumA:
undetectable		 4zn7B-1mumA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 MET A 648
ARG A 660
HIS A 782
LEU A 783
MET A 786
 None
 0.95A 4zn7B-1nl3A:
0.0		 4zn7B-1nl3A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU D 278
LEU D 257
LEU D 292
HIS D 246
LEU D 245
 None
 1.31A 4zn7B-1oy3D:
undetectable		 4zn7B-1oy3D:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 384
LEU A 387
ARG A 394
MET A 421
HIS A 524
LEU A 525
MET A 528
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
None
 0.42A 4zn7B-1pcgA:
38.0		 4zn7B-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		5 ALA A 287
LEU A 292
LEU A 307
MET A 253
HIS A 249
 None
 1.31A 4zn7B-1r8gA:
undetectable		 4zn7B-1r8gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		5 LEU A  66
ALA A  68
LEU A  84
LEU A  80
LEU A  93
 None
 1.22A 4zn7B-1uc7A:
undetectable		 4zn7B-1uc7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 140
ALA A 143
GLU A 142
LEU A 196
LEU A 137
 None
 1.34A 4zn7B-1ulzA:
undetectable		 4zn7B-1ulzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 223
GLU A 221
LEU A 199
ARG A 247
MET A 230
 None
 1.35A 4zn7B-1v3tA:
undetectable		 4zn7B-1v3tA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.49A 4zn7B-1xb7A:
29.1		 4zn7B-1xb7A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		5 LEU A  59
ALA A 242
LEU A 257
LEU A 258
LEU A  10
 None
 1.11A 4zn7B-1y9uA:
undetectable		 4zn7B-1y9uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 ALA A 286
GLU A 288
LEU A 277
LEU A 274
LEU A 182
 None
 1.35A 4zn7B-1yniA:
undetectable		 4zn7B-1yniA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.25A 4zn7B-1yrwA:
undetectable		 4zn7B-1yrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.24A 4zn7B-1z7eA:
undetectable		 4zn7B-1z7eA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0o UPLC1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 LEU E 659
LEU E 638
LEU E 673
HIS E 627
LEU E 626
 None
 1.32A 4zn7B-2b0oE:
undetectable		 4zn7B-2b0oE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.17A 4zn7B-2bbzA:
undetectable		 4zn7B-2bbzA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 LEU A 355
ALA A 357
LEU A  84
LEU A  90
ARG A  96
 None
 1.33A 4zn7B-2cyaA:
undetectable		 4zn7B-2cyaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di3 BACTERIAL REGULATORY
PROTEINS, GNTR
FAMILY

(Corynebacterium
glutamicum) 		PF00392
(GntR)
PF07729
(FCD) 		5 ALA A 123
GLU A 124
LEU A 203
LEU A 200
MET A 164
 None
 1.32A 4zn7B-2di3A:
undetectable		 4zn7B-2di3A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		5 LEU X 198
ALA X 175
GLU X 178
LEU X 206
LEU X 203
 None
 1.25A 4zn7B-2dlcX:
undetectable		 4zn7B-2dlcX:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		5 LEU A 327
ALA A 330
LEU A 338
LEU A 337
MET A 362
 None
 1.18A 4zn7B-2dqbA:
undetectable		 4zn7B-2dqbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebe HYPOTHETICAL PROTEIN
TTHA0061

(Thermus
thermophilus) 		PF11482
(DUF3208) 		5 LEU A  65
ALA A  32
LEU A   6
LEU A  62
LEU A  73
 None
 1.29A 4zn7B-2ebeA:
undetectable		 4zn7B-2ebeA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.10A 4zn7B-2f1sA:
undetectable		 4zn7B-2f1sA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		5 LEU A  36
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.22A 4zn7B-2fe1A:
undetectable		 4zn7B-2fe1A:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 268
ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.52A 4zn7B-2gpvA:
27.8		 4zn7B-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx0 PUTATIVE DNA-BINDING
PROTEIN

(Salmonella
enterica) 		PF03479
(DUF296) 		5 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.26A 4zn7B-2hx0A:
undetectable		 4zn7B-2hx0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3d HYPOTHETICAL PROTEIN
ATU1826

(Agrobacterium
fabrum) 		PF02129
(Peptidase_S15) 		5 LEU A 150
ALA A 105
LEU A  52
LEU A  49
LEU A 207
 None
 1.28A 4zn7B-2i3dA:
undetectable		 4zn7B-2i3dA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6g PUTATIVE
METHYLTRANSFERASE

(Salmonella
enterica) 		PF03848
(TehB) 		5 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
MLY  A 167 ( 4.2A)
None
None
None
 1.18A 4zn7B-2i6gA:
undetectable		 4zn7B-2i6gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 MET A 291
LEU A 292
ALA A 294
LEU A 406
LEU A 251
 None
 1.17A 4zn7B-2nlxA:
undetectable		 4zn7B-2nlxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A 135
ALA A 374
LEU A 310
LEU A 375
ARG A  93
 None
 1.30A 4zn7B-2o4cA:
undetectable		 4zn7B-2o4cA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 384
LEU A 387
ARG A 394
MET A 421
HIS A 524
LEU A 525
MET A 528
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
None
 0.49A 4zn7B-2ocfA:
37.5		 4zn7B-2ocfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 None
 1.22A 4zn7B-2rfaA:
undetectable		 4zn7B-2rfaA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 ALA A 346
LEU A 319
LEU A 401
LEU A 327
MET A 330
 None
 0.91A 4zn7B-2rkoA:
undetectable		 4zn7B-2rkoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		5 LEU A 203
ALA A 206
GLU A 209
LEU A 261
LEU A 281
 None
 1.29A 4zn7B-2vl7A:
undetectable		 4zn7B-2vl7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 ALA A  77
LEU A 211
LEU A 127
MET A 186
LEU A 193
 None
 1.18A 4zn7B-2wyxA:
undetectable		 4zn7B-2wyxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
 1.17A 4zn7B-2xvaA:
undetectable		 4zn7B-2xvaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		5 ALA A 288
GLU A 291
LEU A 257
LEU A 265
LEU A 273
 None
 1.31A 4zn7B-2yy5A:
undetectable		 4zn7B-2yy5A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 GLU A  73
LEU A  87
LEU A  82
ARG A  28
MET A  67
 None
 1.35A 4zn7B-2zwvA:
undetectable		 4zn7B-2zwvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjd TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Jannaschia sp.
CCS1) 		PF00440
(TetR_N)
PF13305
(WHG) 		5 ALA A  34
LEU A  58
LEU A  55
HIS A  51
LEU A  16
 None
 1.18A 4zn7B-3cjdA:
undetectable		 4zn7B-3cjdA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		6 LEU A  29
ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.37A 4zn7B-3ec4A:
undetectable		 4zn7B-3ec4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF00270
(DEAD)
PF12894
(ANAPC4_WD40) 		5 ALA B 197
LEU B 168
ARG A 348
MET B 263
LEU B 166
 None
 1.32A 4zn7B-3fhcB:
undetectable		 4zn7B-3fhcB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		5 MET A 124
ALA A  91
LEU A 133
LEU A 128
LEU A  60
 None
 1.16A 4zn7B-3gd9A:
undetectable		 4zn7B-3gd9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r USHER SYNDROME
TYPE-1G PROTEIN

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU B 440
ALA B 442
LEU B 396
LEU B 399
LEU B 418
 None
 1.34A 4zn7B-3k1rB:
undetectable		 4zn7B-3k1rB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 133
ALA A 136
GLU A 135
ARG A 176
LEU A  94
 None
 1.34A 4zn7B-3kn1A:
undetectable		 4zn7B-3kn1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 133
ALA A 136
GLU A 135
LEU A 170
LEU A  94
 None
 1.23A 4zn7B-3kn1A:
undetectable		 4zn7B-3kn1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		5 LEU A  33
ALA A  36
LEU A  43
LEU A  42
LEU A  99
 None
 1.23A 4zn7B-3ky9A:
undetectable		 4zn7B-3ky9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		6 MET A 796
LEU A 812
GLU A 902
LEU A 889
LEU A 906
LEU A 742
 None
 1.37A 4zn7B-3kz1A:
undetectable		 4zn7B-3kz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 GLU A 210
LEU A 182
LEU A 206
MET A 261
LEU A 218
 None
 1.33A 4zn7B-3nzpA:
undetectable		 4zn7B-3nzpA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		5 GLU A 161
LEU A 158
ARG A  49
HIS A  80
LEU A  83
 None
 1.31A 4zn7B-3o7jA:
undetectable		 4zn7B-3o7jA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		5 LEU A 301
LEU A 242
LEU A 241
LEU A 304
MET A 315
 None
 1.34A 4zn7B-3rdeA:
undetectable		 4zn7B-3rdeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 MET K  61
LEU K  64
LEU N 118
LEU N 134
HIS N 124
 None
 1.30A 4zn7B-3rkoK:
undetectable		 4zn7B-3rkoK:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 166
ALA A 201
LEU A 180
LEU A 177
HIS A 136
 None
 1.11A 4zn7B-3shoA:
undetectable		 4zn7B-3shoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 LEU A 383
ALA A 387
LEU A 300
LEU A 309
LEU A 353
 None
 1.31A 4zn7B-3sqnA:
undetectable		 4zn7B-3sqnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdb PROBABLE
ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT

(Mycobacterium
tuberculosis) 		PF02861
(Clp_N) 		5 LEU A 127
ALA A 129
LEU A  49
LEU A  52
LEU A  34
 None
 1.30A 4zn7B-3wdbA:
undetectable		 4zn7B-3wdbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.18A 4zn7B-3zlbA:
undetectable		 4zn7B-3zlbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)

(Geobacillus
stearothermophilus) 		PF01281
(Ribosomal_L9_N)
PF03948
(Ribosomal_L9_C) 		5 LEU K 141
ALA K 139
LEU K  68
LEU K 133
HIS K 106
 None
 1.17A 4zn7B-487dK:
undetectable		 4zn7B-487dK:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 ALA B 122
LEU B 109
LEU B 374
LEU B 151
MET B 155
 None
 1.02A 4zn7B-4akxB:
undetectable		 4zn7B-4akxB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7l FILAMIN-B

(Homo sapiens) 		PF00307
(CH)
PF00630
(Filamin) 		5 ALA A  83
LEU A  94
LEU A  84
HIS A 120
LEU A 117
 None
 1.28A 4zn7B-4b7lA:
undetectable		 4zn7B-4b7lA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 MET A1710
LEU A1714
LEU A1729
LEU A1725
LEU A1467
 None
 1.24A 4zn7B-4c6oA:
undetectable		 4zn7B-4c6oA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL17

(Sus scrofa) 		PF01196
(Ribosomal_L17) 		5 LEU R  36
GLU R  40
LEU R  89
LEU R  93
LEU R  80
 None
 1.34A 4zn7B-4ce4R:
undetectable		 4zn7B-4ce4R:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 LEU A  98
ALA A  90
LEU A 269
LEU A 273
LEU A 281
 None
 1.31A 4zn7B-4gr4A:
undetectable		 4zn7B-4gr4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 LEU A  98
ALA A  90
LEU A 269
LEU A 273
LEU A 281
 None
 1.35A 4zn7B-4gr5A:
undetectable		 4zn7B-4gr5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS) 		5 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
 None
 1.26A 4zn7B-4hzuT:
undetectable		 4zn7B-4hzuT:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		5 LEU A 371
GLU A 217
LEU A 168
LEU A 373
LEU A 381
 None
 1.14A 4zn7B-4impA:
undetectable		 4zn7B-4impA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 116
ALA A 119
LEU A 140
LEU A  18
LEU A 157
 None
 1.33A 4zn7B-4m0mA:
2.7		 4zn7B-4m0mA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 380
ALA A 382
LEU A 294
LEU A 340
LEU A 176
 None
 1.25A 4zn7B-4mx2A:
undetectable		 4zn7B-4mx2A:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
 None
 0.61A 4zn7B-4n1yA:
32.4		 4zn7B-4n1yA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 130
GLU A 232
LEU A 156
LEU A 160
LEU A  68
 None
 1.34A 4zn7B-4n83A:
3.4		 4zn7B-4n83A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 LEU B 432
LEU B 315
LEU B 440
LEU B 289
MET B 288
 None
 1.32A 4zn7B-4o9uB:
undetectable		 4zn7B-4o9uB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 MET E 316
ALA E 279
LEU E 283
LEU E 282
LEU E 308
 None
 1.16A 4zn7B-4obuE:
undetectable		 4zn7B-4obuE:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 639
LEU A 614
LEU A 611
ARG A 466
LEU A 632
 None
 1.29A 4zn7B-4on9A:
undetectable		 4zn7B-4on9A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  10
ALA A  12
LEU A  25
LEU A  24
LEU A  57
 None
 1.16A 4zn7B-4qfvA:
undetectable		 4zn7B-4qfvA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		5 LEU A 318
ALA A 322
GLU A 325
LEU A 331
LEU A 328
 None
None
None
EDO  A1002 (-4.3A)
EDO  A1002 (-4.8A)
 1.27A 4zn7B-4r10A:
undetectable		 4zn7B-4r10A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		5 LEU A 310
ALA A 314
GLU A 323
LEU A 331
LEU A 327
 None
 1.22A 4zn7B-4r89A:
undetectable		 4zn7B-4r89A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 LEU A 175
LEU A 154
LEU A 157
ARG A 164
LEU A 149
 None
 1.32A 4zn7B-4s38A:
undetectable		 4zn7B-4s38A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm3 KTZI

(Kutzneria sp.
744) 		PF13434
(K_oxygenase) 		5 LEU A  24
ALA A  22
LEU A 405
LEU A 408
HIS A 108
 None
FAD  A 501 (-3.2A)
BR  A 505 ( 4.0A)
None
None
 1.35A 4zn7B-4tm3A:
undetectable		 4zn7B-4tm3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.19A 4zn7B-4zfhA:
undetectable		 4zn7B-4zfhA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 1.04A 4zn7B-4zz7A:
undetectable		 4zn7B-4zz7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 138
ALA A 136
LEU A  21
LEU A  33
LEU A 171
 None
 1.31A 4zn7B-5co8A:
undetectable		 4zn7B-5co8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fej COPM

(Synechocystis
sp. PCC 6803) 		PF03713
(DUF305) 		5 MET A  63
LEU A 128
ALA A 130
HIS A 148
MET A 145
 None
None
None
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 1.13A 4zn7B-5fejA:
undetectable		 4zn7B-5fejA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 LEU A 143
LEU A 183
LEU A 179
HIS A 296
LEU A 297
 None
 1.21A 4zn7B-5fjnA:
undetectable		 4zn7B-5fjnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 MET A2088
LEU A2091
LEU A2128
LEU A2096
LEU A2079
 None
 1.30A 4zn7B-5fu7A:
2.8		 4zn7B-5fu7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 MET A 508
LEU A 487
LEU A   3
HIS A 465
LEU A 467
 None
 1.18A 4zn7B-5h42A:
undetectable		 4zn7B-5h42A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4s L-RHAMNOSE-BINDING
LECTIN

(Toxopneustes
pileolus) 		PF02140
(Gal_Lectin) 		5 LEU A 280
ALA A 218
LEU A 203
LEU A 277
LEU A 205
 None
 1.15A 4zn7B-5h4sA:
undetectable		 4zn7B-5h4sA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le4 DD_D12_11_D12

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.15A 4zn7B-5le4A:
undetectable		 4zn7B-5le4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.10A 4zn7B-5lebA:
undetectable		 4zn7B-5lebA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw2 DARPIN_5M3_D12

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.17A 4zn7B-5lw2A:
undetectable		 4zn7B-5lw2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 MET B  75
LEU B 116
LEU B 150
LEU B 153
LEU B 109
 None
 1.35A 4zn7B-5mkgB:
undetectable		 4zn7B-5mkgB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 293
LEU A 285
LEU A 290
ARG A 109
LEU A 163
 None
 1.29A 4zn7B-5nccA:
undetectable		 4zn7B-5nccA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ALA A 797
GLU A 798
LEU A 764
LEU A 803
LEU A 742
 None
 1.15A 4zn7B-5o1pA:
undetectable		 4zn7B-5o1pA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		5 LEU C1517
ALA C1484
LEU C1436
LEU C1433
LEU C1407
 None
 1.28A 4zn7B-5swvC:
undetectable		 4zn7B-5swvC:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 295
LEU A 298
ALA A 302
GLU A 305
LEU A 339
ARG A 346
HIS A 475
LEU A 476
MET A 479
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
None
 0.35A 4zn7B-5toaA:
31.6		 4zn7B-5toaA:
57.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 5 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.34A 4zn7B-5ux2A:
undetectable		 4zn7B-5ux2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 665
ALA A 667
LEU A 680
LEU A 679
LEU A 712
 None
 1.23A 4zn7B-5vkqA:
undetectable		 4zn7B-5vkqA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  65 ( 0.5A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.14A 4zn7B-5wo6A:
undetectable		 4zn7B-5wo6A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 386
ALA A 395
LEU A 491
LEU A 383
HIS A 287
 None
 1.31A 4zn7B-5xqoA:
undetectable		 4zn7B-5xqoA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 MET C1403
LEU C1406
MET C1369
HIS C1418
LEU C1419
 None
 1.23A 4zn7B-5y3rC:
undetectable		 4zn7B-5y3rC:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.10A 4zn7B-6f5eA:
undetectable		 4zn7B-6f5eA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 5 ALA A 347
LEU A 337
LEU A 341
LEU A 423
MET A 426
 BCR  A4007 ( 4.9A)
CLA  A1122 ( 4.4A)
CLA  A1123 (-3.8A)
BCR  A4007 ( 4.7A)
CLA  A1129 (-3.4A)
 1.36A 4zn7B-6fosA:
1.9		 4zn7B-6fosA:
18.14