SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZN7_A_DESA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 108
ALA A 112
LEU A   5
HIS A 131
LEU A 180
 None
 1.09A 4zn7A-1bxkA:
0.0		 4zn7A-1bxkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  50
LEU A  95
LEU A  59
LEU A  62
LEU A  88
 NAP  A 386 (-4.9A)
None
None
None
None
 1.21A 4zn7A-1civA:
0.0		 4zn7A-1civA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 375
LEU A 362
LEU A 361
MET A 100
LEU A  93
 None
 1.21A 4zn7A-1dm3A:
0.0		 4zn7A-1dm3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 107
ALA A 111
LEU A   4
HIS A 130
LEU A 187
 None
 1.10A 4zn7A-1g1aA:
0.0		 4zn7A-1g1aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 MET A 160
LEU A 213
ALA A 216
MET A 239
MET A 198
 None
None
None
HEM  A1414 (-4.3A)
None
 1.09A 4zn7A-1gwiA:
0.0		 4zn7A-1gwiA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ALA A 226
LEU A 212
LEU A 186
LEU A 183
LEU A 245
 None
None
None
None
FAD  A 421 ( 4.6A)
 1.06A 4zn7A-1iqrA:
0.0		 4zn7A-1iqrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLU A 229
LEU A 212
LEU A 186
LEU A 183
LEU A 245
 None
None
None
None
FAD  A 421 ( 4.6A)
 1.21A 4zn7A-1iqrA:
0.0		 4zn7A-1iqrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.16A 4zn7A-1loxA:
0.0		 4zn7A-1loxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 628
ALA A 630
LEU A 652
LEU A 640
LEU A 564
 None
 1.19A 4zn7A-1lufA:
undetectable		 4zn7A-1lufA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		5 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.11A 4zn7A-1mumA:
undetectable		 4zn7A-1mumA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 LEU A 141
ALA A 139
LEU A  73
LEU A  77
LEU A  78
 None
 0.98A 4zn7A-1mxfA:
undetectable		 4zn7A-1mxfA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		5 LEU A 238
LEU A 235
LEU A 231
HIS A 384
LEU A 194
 None
 1.19A 4zn7A-1nw1A:
2.3		 4zn7A-1nw1A:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
HIS A 524
MET A 528
LEU A 540
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.8A)
None
None
 0.47A 4zn7A-1pcgA:
37.9		 4zn7A-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		5 ALA A 143
GLU A 136
LEU A 151
LEU A 134
HIS A 157
 None
 1.22A 4zn7A-1sg4A:
undetectable		 4zn7A-1sg4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU C  59
ALA C  57
GLU C 190
LEU C 172
LEU C 197
 None
 1.23A 4zn7A-1shzC:
undetectable		 4zn7A-1shzC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU C  76
LEU C  59
LEU C  62
MET C  83
LEU C  49
 None
 1.22A 4zn7A-1shzC:
undetectable		 4zn7A-1shzC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A 143
GLU A 142
LEU A 196
LEU A 137
LEU A 176
 None
 1.08A 4zn7A-1ulzA:
undetectable		 4zn7A-1ulzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve2 UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 ALA A  46
LEU A  84
LEU A  23
HIS A  39
LEU A  50
 None
 0.99A 4zn7A-1ve2A:
undetectable		 4zn7A-1ve2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 5 LEU A 130
ALA A 161
LEU A 182
LEU A 164
LEU A 142
 None
 1.23A 4zn7A-1wwlA:
undetectable		 4zn7A-1wwlA:
26.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.48A 4zn7A-1xb7A:
28.8		 4zn7A-1xb7A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13420
(Acetyltransf_4) 		5 MET A 105
LEU A 108
ALA A 112
HIS A 135
LEU A 166
 None
 1.18A 4zn7A-1yr0A:
undetectable		 4zn7A-1yr0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
 None
 0.94A 4zn7A-1zklA:
undetectable		 4zn7A-1zklA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 LEU A 893
ALA A 897
LEU A 934
LEU A 942
LEU A 910
 None
 1.08A 4zn7A-2c3oA:
undetectable		 4zn7A-2c3oA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 299
ALA A 302
LEU A 340
HIS A 325
LEU A 306
 None
 1.17A 4zn7A-2ctzA:
undetectable		 4zn7A-2ctzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		5 LEU A 327
ALA A 330
LEU A 338
LEU A 337
MET A 362
 None
 1.13A 4zn7A-2dqbA:
undetectable		 4zn7A-2dqbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06345
(Drf_DAD)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 179
LEU A 182
LEU A 186
MET B   6
LEU A 163
 None
 1.04A 4zn7A-2f31A:
undetectable		 4zn7A-2f31A:
24.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 268
ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.55A 4zn7A-2gpvA:
27.3		 4zn7A-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		6 LEU A  43
ALA A  46
LEU A 149
LEU A  26
LEU A  27
LEU A  50
 None
 1.43A 4zn7A-2j3mA:
undetectable		 4zn7A-2j3mA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2my2 U2 SNRNP COMPONENT
IST3

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 LEU A  57
ALA A  55
LEU A  22
LEU A  18
LEU A  42
 None
 1.01A 4zn7A-2my2A:
undetectable		 4zn7A-2my2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 120
LEU A  59
LEU A  57
LEU A  50
LEU A 118
 None
 1.20A 4zn7A-2nadA:
undetectable		 4zn7A-2nadA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
HIS A 524
MET A 528
LEU A 540
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-4.2A)
None
None
 0.55A 4zn7A-2ocfA:
37.1		 4zn7A-2ocfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 346
MET A 421
HIS A 524
LEU A 536
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 (-4.5A)
EST  A 596 (-4.2A)
None
 1.23A 4zn7A-2ocfA:
37.1		 4zn7A-2ocfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ALA A  36
LEU A  77
ARG A  80
MET A 108
LEU A 223
 1CA  A 247 (-4.0A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
None
 0.70A 4zn7A-2q3yA:
28.2		 4zn7A-2q3yA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		5 ALA A 233
LEU A 231
LEU A  37
LEU A  38
LEU A 221
 None
 1.17A 4zn7A-2qjcA:
undetectable		 4zn7A-2qjcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 307
LEU A 281
LEU A 280
MET A 243
LEU A 324
 None
 1.20A 4zn7A-2vbiA:
undetectable		 4zn7A-2vbiA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		5 LEU A 229
ALA A  57
LEU A 243
LEU A 246
LEU A  61
 None
 1.20A 4zn7A-2wamA:
undetectable		 4zn7A-2wamA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 LEU A 113
ALA A 116
LEU A 159
LEU A 158
LEU A 148
 None
 1.16A 4zn7A-2z23A:
undetectable		 4zn7A-2z23A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5

(Homo sapiens) 		PF13869
(NUDIX_2) 		5 LEU A  84
LEU A  96
LEU A 193
MET A 125
LEU A 215
 None
 1.15A 4zn7A-3bhoA:
undetectable		 4zn7A-3bhoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3b 30S RIBOSOMAL
PROTEIN S10

(Escherichia
coli) 		PF00338
(Ribosomal_S10) 		5 LEU J  17
ALA J  21
GLU J  24
LEU J  71
LEU J  10
 None
 1.16A 4zn7A-3d3bJ:
undetectable		 4zn7A-3d3bJ:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 ALA A 167
LEU A  86
ARG A 173
HIS A 159
LEU A 370
 None
 1.09A 4zn7A-3djdA:
undetectable		 4zn7A-3djdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 407
GLU A 476
LEU A 402
MET A 418
LEU A 469
 None
 1.15A 4zn7A-3dljA:
undetectable		 4zn7A-3dljA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 120
LEU A  59
LEU A  57
LEU A  50
LEU A 118
 None
 1.23A 4zn7A-3fn4A:
undetectable		 4zn7A-3fn4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		5 LEU A 109
ALA A 130
LEU A 149
LEU A 158
LEU A 121
 None
 1.16A 4zn7A-3gc2A:
undetectable		 4zn7A-3gc2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 5 ALA A 206
GLU A 209
LEU A 239
ARG A 162
LEU A 203
 None
 1.20A 4zn7A-3gjyA:
undetectable		 4zn7A-3gjyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 289
ALA A 292
GLU A 291
MET A 233
LEU A 296
 None
 1.05A 4zn7A-3h5qA:
undetectable		 4zn7A-3h5qA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 306
GLU A 307
LEU A 302
ARG A 281
LEU A 337
 None
 1.21A 4zn7A-3k17A:
undetectable		 4zn7A-3k17A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		5 MET A 796
LEU A 812
GLU A 902
LEU A 889
LEU A 906
 None
 1.17A 4zn7A-3kz1A:
undetectable		 4zn7A-3kz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3leo LEUKOTRIENE C4
SYNTHASE

(Homo sapiens) 		PF01124
(MAPEG) 		5 LEU A  81
ALA A  79
LEU A   8
LEU A   7
LEU A 118
 PAM  A 215 ( 4.5A)
None
None
PAM  A 215 ( 4.1A)
None
 1.13A 4zn7A-3leoA:
undetectable		 4zn7A-3leoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 LEU A 834
ALA A 838
LEU A 806
LEU A 803
LEU A 857
 None
 0.78A 4zn7A-3m62A:
undetectable		 4zn7A-3m62A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 406
LEU A 420
MET A 365
HIS A 368
LEU A 483
 IBM  A   1 ( 4.7A)
IBM  A   1 (-4.8A)
None
None
None
 1.08A 4zn7A-3n3zA:
undetectable		 4zn7A-3n3zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhm RESPONSE REGULATOR

(Myxococcus
xanthus) 		PF00072
(Response_reg) 		5 ALA A  57
LEU A  65
LEU A  22
MET A  74
LEU A  89
 None
 1.19A 4zn7A-3nhmA:
undetectable		 4zn7A-3nhmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		5 LEU A 205
LEU A 216
LEU A 219
LEU A 223
MET A 231
 None
 1.13A 4zn7A-3p52A:
undetectable		 4zn7A-3p52A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		5 LEU A 240
ALA A 173
LEU A 126
LEU A 123
MET A  45
 None
 0.97A 4zn7A-3pl0A:
undetectable		 4zn7A-3pl0A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 210
ALA A 233
LEU A 224
LEU A 235
LEU A 205
 None
 1.13A 4zn7A-3pwzA:
undetectable		 4zn7A-3pwzA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ALA A 147
GLU A 146
LEU A 139
LEU A 143
LEU A 178
 None
 1.19A 4zn7A-3rb9A:
undetectable		 4zn7A-3rb9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcc SORTASE SRTA

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 LEU A  94
ALA A  98
LEU A 181
LEU A 115
LEU A  83
 None
 1.22A 4zn7A-3rccA:
undetectable		 4zn7A-3rccA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		5 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.12A 4zn7A-3rdeA:
undetectable		 4zn7A-3rdeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  32
LEU A  77
ARG A  80
MET A 108
LEU A 223
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
None
 0.65A 4zn7A-3ry9A:
27.8		 4zn7A-3ry9A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 166
ALA A 201
LEU A 180
LEU A 177
HIS A 136
 None
 1.12A 4zn7A-3shoA:
undetectable		 4zn7A-3shoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		5 ALA A  19
LEU A 145
LEU A  50
LEU A  54
LEU A 237
 None
 1.00A 4zn7A-3tx2A:
undetectable		 4zn7A-3tx2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 LEU A 333
ALA A 332
LEU A 361
MET A 347
LEU A 237
 None
 1.20A 4zn7A-3ue9A:
undetectable		 4zn7A-3ue9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uho GLUTAMATE RACEMASE

(Campylobacter
jejuni) 		PF01177
(Asp_Glu_race) 		5 ALA A 241
LEU A  16
LEU A  13
HIS A 227
LEU A 247
 None
 1.20A 4zn7A-3uhoA:
undetectable		 4zn7A-3uhoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A 300
ALA A 302
LEU A 253
LEU A 261
LEU A 320
 None
None
None
None
FAD  A 801 (-4.6A)
 1.20A 4zn7A-3umvA:
undetectable		 4zn7A-3umvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		5 ALA A  81
LEU A 141
MET A 193
HIS A 173
LEU A 109
 None
 1.17A 4zn7A-3vaxA:
undetectable		 4zn7A-3vaxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)

(Geobacillus
stearothermophilus) 		PF01281
(Ribosomal_L9_N)
PF03948
(Ribosomal_L9_C) 		5 LEU K 141
ALA K 139
LEU K  68
LEU K 133
HIS K 106
 None
 1.17A 4zn7A-487dK:
undetectable		 4zn7A-487dK:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6y BACTERIAL
REGULATORY, FIS
FAMILY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg) 		5 LEU A  39
ALA A  38
LEU A  52
LEU A  61
LEU A   6
 None
 1.23A 4zn7A-4d6yA:
undetectable		 4zn7A-4d6yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 LEU A 289
LEU A 286
LEU A 282
HIS A 417
LEU A 249
 None
 0.96A 4zn7A-4da5A:
undetectable		 4zn7A-4da5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		5 LEU A 348
ALA A 293
LEU A 325
LEU A 328
LEU A 289
 None
 1.22A 4zn7A-4dx2A:
undetectable		 4zn7A-4dx2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geq KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 210
ALA A 213
LEU A 196
LEU A 200
LEU A 217
 None
 1.15A 4zn7A-4geqA:
undetectable		 4zn7A-4geqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 303
LEU A 321
MET A 316
HIS A 289
LEU A 272
 None
 1.19A 4zn7A-4h2hA:
undetectable		 4zn7A-4h2hA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		5 ALA A 143
LEU A 189
LEU A 139
LEU A 138
LEU A 115
 None
 1.03A 4zn7A-4k3fA:
undetectable		 4zn7A-4k3fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 LEU A 213
ALA A 217
LEU A 133
LEU A 134
LEU A 231
 None
 1.11A 4zn7A-4lmvA:
undetectable		 4zn7A-4lmvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj7 RRNA-PROCESSING
PROTEIN UTP23

(Saccharomyces
cerevisiae) 		PF04900
(Fcf1) 		5 MET A  60
LEU A  29
ALA A 120
LEU A 130
LEU A  49
 None
 1.08A 4zn7A-4mj7A:
undetectable		 4zn7A-4mj7A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 283
ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
LEU A 466
 None
 0.69A 4zn7A-4n1yA:
32.0		 4zn7A-4n1yA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 771
GLU A 770
LEU A 705
LEU A 702
ARG A 813
 None
 1.16A 4zn7A-4n5cA:
undetectable		 4zn7A-4n5cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntb LEUKOTRIENE C4
SYNTHASE

(Mus musculus) 		PF01124
(MAPEG) 		5 LEU A  81
ALA A  79
LEU A   8
LEU A   7
LEU A 118
 None
 1.08A 4zn7A-4ntbA:
undetectable		 4zn7A-4ntbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opa NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		no annotation 5 MET B  99
ALA B 144
LEU B 142
LEU B 141
LEU B 180
 None
 1.06A 4zn7A-4opaB:
undetectable		 4zn7A-4opaB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 LEU A 133
ALA A 131
LEU A 157
LEU A 154
LEU A 150
 None
None
None
None
EDO  A 508 (-3.2A)
 1.21A 4zn7A-4pzvA:
undetectable		 4zn7A-4pzvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		5 LEU A 310
ALA A 314
GLU A 323
LEU A 331
LEU A 327
 None
 1.20A 4zn7A-4r89A:
undetectable		 4zn7A-4r89A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
ALA A 773
LEU A 810
LEU A 814
ARG A 817
LEU A 960
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
None
 0.57A 4zn7A-4udbA:
27.6		 4zn7A-4udbA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 121
LEU A  60
LEU A  58
LEU A  51
LEU A 119
 None
 1.18A 4zn7A-4xybA:
undetectable		 4zn7A-4xybA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 1.00A 4zn7A-4zz7A:
undetectable		 4zn7A-4zz7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ALA A 119
LEU A  11
LEU A  16
LEU A  93
HIS A  30
 None
 1.14A 4zn7A-5cnxA:
undetectable		 4zn7A-5cnxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 289
ALA A 292
GLU A 291
MET A 233
LEU A 296
 LEU  A 289 ( 0.6A)
ALA  A 292 ( 0.0A)
GLU  A 291 ( 0.6A)
MET  A 233 ( 0.0A)
LEU  A 296 ( 0.5A)
 1.02A 4zn7A-5ep8A:
undetectable		 4zn7A-5ep8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fej COPM

(Synechocystis
sp. PCC 6803) 		PF03713
(DUF305) 		5 MET A  63
LEU A 128
ALA A 130
HIS A 148
MET A 145
 None
None
None
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 1.13A 4zn7A-5fejA:
undetectable		 4zn7A-5fejA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 MET A 131
LEU A 221
LEU A 321
LEU A 318
LEU A 314
 None
 1.18A 4zn7A-5fqlA:
undetectable		 4zn7A-5fqlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftg CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 LEU A 289
LEU A 286
LEU A 282
HIS A 417
LEU A 249
 None
None
None
EDO  A1468 (-4.0A)
None
 0.96A 4zn7A-5ftgA:
undetectable		 4zn7A-5ftgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 ALA A 207
GLU A 210
LEU A  41
LEU A  38
LEU A 215
 None
 1.23A 4zn7A-5gkxA:
undetectable		 4zn7A-5gkxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A 176
ALA A 180
GLU A 183
LEU A 582
LEU A 568
 None
 0.94A 4zn7A-5gveA:
undetectable		 4zn7A-5gveA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF06444
(NADH_dehy_S2_C) 		5 ALA K  44
LEU N  27
LEU K  63
LEU K  64
LEU N  78
 None
 1.21A 4zn7A-5lc5K:
undetectable		 4zn7A-5lc5K:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Bos taurus) 		PF00420
(Oxidored_q2)
PF00507
(Oxidored_q4) 		5 LEU K  73
ALA K  71
LEU A  63
LEU A  64
LEU K  30
 None
 0.98A 4zn7A-5lc5K:
undetectable		 4zn7A-5lc5K:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 769
ALA A 773
LEU A 814
ARG A 817
MET A 845
LEU A 960
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
None
 0.62A 4zn7A-5mwpA:
27.5		 4zn7A-5mwpA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 338
ALA B 230
LEU B 184
LEU B 233
LEU B  82
 None
 1.17A 4zn7A-5my0B:
undetectable		 4zn7A-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 5 MET A 288
LEU A 260
ALA A 273
HIS A 228
LEU A 159
 None
 1.12A 4zn7A-5oatA:
undetectable		 4zn7A-5oatA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcs KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 210
ALA D 213
LEU D 196
LEU D 200
LEU D 217
 None
 1.21A 4zn7A-5tcsD:
undetectable		 4zn7A-5tcsD:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td8 KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 210
ALA D 213
LEU D 196
LEU D 200
LEU D 217
 None
None
None
None
HG  D 301 (-3.0A)
 1.20A 4zn7A-5td8D:
undetectable		 4zn7A-5td8D:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
LEU A 298
ALA A 302
GLU A 305
LEU A 339
LEU A 343
ARG A 346
HIS A 475
MET A 479
LEU A 490
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
None
None
 0.50A 4zn7A-5toaA:
31.4		 4zn7A-5toaA:
57.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 MET A  29
LEU A  32
LEU A  77
ARG A  80
MET A 108
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.21A 4zn7A-5ufsA:
28.1		 4zn7A-5ufsA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0w SHARPIN

(Homo sapiens) 		no annotation 5 LEU B 297
ALA B 295
LEU B 283
LEU B 221
LEU B 242
 None
 0.93A 4zn7A-5x0wB:
undetectable		 4zn7A-5x0wB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcb RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 18

(Mus musculus) 		no annotation 5 LEU A 340
LEU A 367
LEU A 368
LEU A 359
HIS A 435
 None
 1.11A 4zn7A-6bcbA:
undetectable		 4zn7A-6bcbA:
20.70