SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZME_B_ADNB902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 PHE A 260
VAL A 272
GLU A 276
LEU A 318
PHE A  11
 None
 1.34A 4zmeB-1bhwA:
undetectable		 4zmeB-1bhwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PHE A 234
ALA A 233
VAL A 356
LEU A 305
PHE A 332
 None
 1.31A 4zmeB-1br2A:
0.0		 4zmeB-1br2A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A  86
LEU A 104
LEU A 105
PHE A  51
THR A 241
 None
 0.91A 4zmeB-1fujA:
0.0		 4zmeB-1fujA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		5 LYS A1646
LEU A1701
GLU A1718
PHE A1725
THR A1774
 ADP  A2002 (-2.8A)
None
ADP  A2002 (-3.6A)
ADP  A2002 ( 3.8A)
ADP  A2002 ( 4.1A)
 0.36A 4zmeB-1iahA:
23.2		 4zmeB-1iahA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 161
VAL A 188
LEU A 127
LEU A  87
PHE A 159
 None
 1.13A 4zmeB-1ig8A:
undetectable		 4zmeB-1ig8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		5 PHE A 111
ALA A  50
VAL A 180
LEU A 193
LEU A 176
 None
 1.26A 4zmeB-1jneA:
undetectable		 4zmeB-1jneA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 ALA C 113
VAL C 141
LEU C 157
LEU C 179
LEU C 176
 None
 1.19A 4zmeB-1l7vC:
0.0		 4zmeB-1l7vC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		5 PHE A 593
ALA A 588
LEU A 577
LEU A 616
PHE A 621
 None
 1.27A 4zmeB-1lvaA:
undetectable		 4zmeB-1lvaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		5 PHE A 593
ALA A 588
LEU A 613
LEU A 616
PHE A 621
 None
 1.12A 4zmeB-1lvaA:
undetectable		 4zmeB-1lvaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 165
LEU A 160
LEU A 169
LEU A 172
PHE A  98
 None
 1.24A 4zmeB-1nowA:
undetectable		 4zmeB-1nowA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogd HIGH AFFINITY RIBOSE
TRANSPORT PROTEIN
RBSD

(Bacillus
subtilis) 		PF05025
(RbsD_FucU) 		5 PHE A  88
VAL A  64
LEU A  15
LEU A 125
LEU A  58
 None
 1.18A 4zmeB-1ogdA:
undetectable		 4zmeB-1ogdA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 PHE A 381
VAL A 486
LEU A 513
LEU A 449
PHE A 453
 None
 1.30A 4zmeB-1qxpA:
undetectable		 4zmeB-1qxpA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r94 PROTEIN YFHF

(Escherichia
coli) 		PF01521
(Fe-S_biosyn) 		5 ALA A  11
VAL A  60
LEU A  28
LEU A  77
PHE A  88
 None
 1.33A 4zmeB-1r94A:
undetectable		 4zmeB-1r94A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlj NRDI PROTEIN

(Bacillus
subtilis) 		PF07972
(Flavodoxin_NdrI) 		5 ALA A  -1
VAL A 119
LEU A  96
LEU A  66
PHE A  22
 None
 1.19A 4zmeB-1rljA:
undetectable		 4zmeB-1rljA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 ALA A 237
LEU A 205
LEU A 228
LEU A 230
THR A 203
 None
 1.32A 4zmeB-1smrA:
undetectable		 4zmeB-1smrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		5 ALA A  43
VAL A   6
GLU A   9
LEU A  10
LEU A  13
 None
 1.31A 4zmeB-1t06A:
undetectable		 4zmeB-1t06A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		5 PHE A 276
LEU A 209
LEU A 261
LEU A 264
PHE A 225
 None
 1.34A 4zmeB-1vfgA:
undetectable		 4zmeB-1vfgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 PHE C 598
ALA C 597
LEU C 634
LEU C 460
LEU C 458
 None
 1.35A 4zmeB-1w36C:
undetectable		 4zmeB-1w36C:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsu SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09107
(SelB-wing_3) 		5 PHE A 593
ALA A 588
LEU A 577
LEU A 616
PHE A 621
 None
 1.27A 4zmeB-1wsuA:
undetectable		 4zmeB-1wsuA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsu SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09107
(SelB-wing_3) 		5 PHE A 593
ALA A 588
LEU A 613
LEU A 616
PHE A 621
 None
 1.15A 4zmeB-1wsuA:
undetectable		 4zmeB-1wsuA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		5 PHE A 145
ALA A 149
VAL A 128
LEU A  99
LEU A  73
 None
 1.35A 4zmeB-1yx1A:
undetectable		 4zmeB-1yx1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bap DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		no annotation 5 ALA B 278
VAL B 236
LEU B 308
LEU B 289
PHE B 286
 None
 1.23A 4zmeB-2bapB:
undetectable		 4zmeB-2bapB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnx DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 ALA A 278
VAL A 236
LEU A 308
LEU A 289
PHE A 286
 None
 1.17A 4zmeB-2bnxA:
undetectable		 4zmeB-2bnxA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		5 PHE A 142
VAL A 150
LEU A  65
LEU A 104
PHE A  48
 None
 1.31A 4zmeB-2citA:
undetectable		 4zmeB-2citA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 ALA A 209
LEU A 162
LEU A 165
PHE A 183
THR A 168
 None
 1.27A 4zmeB-2cxnA:
undetectable		 4zmeB-2cxnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 VAL A 121
LEU A 176
GLU A 110
LEU A 106
THR A 204
 None
 1.20A 4zmeB-2d4eA:
undetectable		 4zmeB-2d4eA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 ALA A 278
VAL A 236
LEU A 308
LEU A 289
PHE A 286
 None
 1.30A 4zmeB-2f31A:
undetectable		 4zmeB-2f31A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 PHE A 312
ALA A 255
VAL A 239
LEU A 183
PHE A 201
 None
 1.29A 4zmeB-2gjxA:
undetectable		 4zmeB-2gjxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 PHE I 312
ALA I 255
VAL I 239
LEU I 183
PHE I 201
 None
 1.27A 4zmeB-2gk1I:
undetectable		 4zmeB-2gk1I:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		5 PHE A 209
ALA A 218
VAL A 173
LEU A 199
PHE A 220
 None
 1.35A 4zmeB-2gk3A:
undetectable		 4zmeB-2gk3A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		5 PHE A 190
VAL A 212
LEU A 255
LEU A 243
THR A 253
 None
 1.29A 4zmeB-2mbgA:
undetectable		 4zmeB-2mbgA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 PHE B 573
LEU B 601
GLU B 544
LEU B 542
THR B 605
 None
 1.23A 4zmeB-2o8eB:
undetectable		 4zmeB-2o8eB:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbp ENOYL-COA HYDRATASE
SUBUNIT I

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 ALA A 126
VAL A 177
LEU A 150
LEU A 115
PHE A 111
 None
 1.18A 4zmeB-2pbpA:
undetectable		 4zmeB-2pbpA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		5 PHE A 550
ALA A 676
VAL A 668
LEU A 653
LEU A 635
 None
CL  A 504 ( 4.2A)
None
None
None
 1.18A 4zmeB-2pfiA:
undetectable		 4zmeB-2pfiA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 ALA A  76
LEU A 212
LEU A 111
LEU A 112
PHE A 114
 NAD  A 401 (-3.5A)
None
None
None
NAD  A 401 (-4.9A)
 1.14A 4zmeB-2pzkA:
undetectable		 4zmeB-2pzkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 146
LYS A 148
GLU A 190
LEU A 192
LEU A 193
 None
ATP  A 501 ( 3.8A)
ATP  A 501 (-3.5A)
ATP  A 501 ( 4.7A)
ATP  A 501 (-4.2A)
 0.52A 4zmeB-2qk4A:
0.1		 4zmeB-2qk4A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 PHE A 632
VAL A 890
LEU A 859
LEU A 868
LEU A 867
 None
 1.26A 4zmeB-2r6fA:
undetectable		 4zmeB-2r6fA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 PHE A 192
ALA A 191
VAL A 341
LEU A 263
PHE A 317
 None
 1.33A 4zmeB-2v26A:
undetectable		 4zmeB-2v26A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 PHE A 551
ALA A 541
LEU A 369
LEU A 405
PHE A 536
 None
 1.29A 4zmeB-2x6kA:
3.0		 4zmeB-2x6kA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A  86
ALA A 112
LEU A 197
LEU A  76
LEU A  77
 None
 1.29A 4zmeB-2yxzA:
undetectable		 4zmeB-2yxzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		5 PHE A  17
ALA A  46
VAL A  15
LEU A 116
LEU A 127
 None
 1.30A 4zmeB-2zg6A:
undetectable		 4zmeB-2zg6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 PHE A 707
VAL A 716
LEU A 680
PHE A 577
THR A 559
 None
 1.13A 4zmeB-3ahiA:
undetectable		 4zmeB-3ahiA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 LEU A 563
LEU A 680
LEU A 677
PHE A 577
THR A 559
 None
 1.30A 4zmeB-3ai7A:
undetectable		 4zmeB-3ai7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		6 PHE A 707
VAL A 716
LEU A 563
LEU A 680
PHE A 577
THR A 559
 None
 1.18A 4zmeB-3ai7A:
undetectable		 4zmeB-3ai7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 ALA B 278
VAL B 236
LEU B 308
LEU B 289
PHE B 286
 None
 1.27A 4zmeB-3eg5B:
undetectable		 4zmeB-3eg5B:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		5 PHE A 356
ALA A 351
LEU A 417
LEU A 521
LEU A 433
 None
 1.12A 4zmeB-3fhaA:
undetectable		 4zmeB-3fhaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 PHE A1392
ALA A1391
VAL A1360
LEU A1304
LEU A1356
 None
 0.77A 4zmeB-3gd7A:
undetectable		 4zmeB-3gd7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4p PROTEASOME SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA a 167
LEU a  40
LEU a 184
LEU a  20
THR a  50
 None
 1.25A 4zmeB-3h4pa:
undetectable		 4zmeB-3h4pa:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 PHE A 499
ALA A 332
VAL A 495
LEU A 348
THR A 391
 None
 1.18A 4zmeB-3iveA:
undetectable		 4zmeB-3iveA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00202
(Aminotran_3) 		5 LEU A 246
GLU A 234
LEU A 259
PHE A 230
THR A 248
 None
 1.28A 4zmeB-3lg0A:
undetectable		 4zmeB-3lg0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mam OSMOPROTECTION
PROTEIN (PROX)

(Archaeoglobus
fulgidus) 		PF04069
(OpuAC) 		5 PHE A 164
ALA A 135
VAL A 186
LEU A 113
LEU A 204
 None
 1.16A 4zmeB-3mamA:
undetectable		 4zmeB-3mamA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 VAL A 592
LEU A 624
LEU A 581
LEU A 578
PHE A 546
 None
 1.24A 4zmeB-3opbA:
undetectable		 4zmeB-3opbA:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pdt MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		9 ALA A 587
VAL A 643
LYS A 645
LEU A 689
GLU A 713
LEU A 715
LEU A 716
PHE A 720
THR A 765
 ADP  A 811 (-3.3A)
None
ADP  A 811 (-2.7A)
None
None
ADP  A 811 ( 4.8A)
ADP  A 811 (-3.8A)
ADP  A 811 (-3.5A)
ADP  A 811 (-4.1A)
 0.67A 4zmeB-3pdtA:
40.1		 4zmeB-3pdtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pdt MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		9 PHE A 586
ALA A 587
VAL A 643
LYS A 645
LEU A 689
LEU A 715
LEU A 716
PHE A 720
THR A 765
 ADP  A 811 (-4.8A)
ADP  A 811 (-3.3A)
None
ADP  A 811 (-2.7A)
None
ADP  A 811 ( 4.8A)
ADP  A 811 (-3.8A)
ADP  A 811 (-3.5A)
ADP  A 811 (-4.1A)
 0.25A 4zmeB-3pdtA:
40.1		 4zmeB-3pdtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 249
GLU A 244
LEU A 242
PHE A  24
THR A 260
 None
 1.10A 4zmeB-3pwzA:
undetectable		 4zmeB-3pwzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 PHE A  78
ALA A  44
VAL A  82
LEU A 124
THR A  16
 None
 1.21A 4zmeB-3rd5A:
undetectable		 4zmeB-3rd5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A  60
VAL A 246
GLU A 250
LEU A 247
LEU A  54
 None
 0.90A 4zmeB-3rd8A:
undetectable		 4zmeB-3rd8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 LYS A 281
GLU A 233
LEU A 234
LEU A 237
THR A 289
 None
 1.35A 4zmeB-3tviA:
undetectable		 4zmeB-3tviA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 ALA A  78
VAL A 117
LEU A 100
LEU A 269
LEU A 266
 None
 1.15A 4zmeB-3wafA:
undetectable		 4zmeB-3wafA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A 192
ALA A 191
VAL A 341
LEU A 263
PHE A 317
 None
 1.32A 4zmeB-4anjA:
undetectable		 4zmeB-4anjA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		5 ALA A 844
VAL A 881
GLU A 885
LEU A 882
LEU A 887
 None
 1.27A 4zmeB-4b9wA:
undetectable		 4zmeB-4b9wA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 PHE A 644
ALA A 686
LEU A 784
LEU A 655
LEU A 756
 None
 1.07A 4zmeB-4e93A:
5.3		 4zmeB-4e93A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		5 ALA A  48
GLU A  55
LEU A  58
LEU A  59
THR A 254
 None
 1.14A 4zmeB-4g76A:
undetectable		 4zmeB-4g76A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyj ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 PHE A  62
ALA A 113
VAL A 103
LEU A  53
PHE A  38
 None
 1.12A 4zmeB-4jyjA:
undetectable		 4zmeB-4jyjA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 PHE A  42
LEU A 137
LEU A 122
LEU A 125
THR A 134
 None
 1.18A 4zmeB-4kf6A:
undetectable		 4zmeB-4kf6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Salmonella
enterica) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 ALA A 165
VAL A  72
LEU A  23
LEU A  84
PHE A 159
 None
 1.21A 4zmeB-4kh7A:
undetectable		 4zmeB-4kh7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ALA A  60
VAL A  76
LEU A  50
LEU A 118
PHE A 120
 None
 1.29A 4zmeB-4krgA:
undetectable		 4zmeB-4krgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		5 LYS A  85
LEU A 126
GLU A 164
PHE A 171
THR A 222
 PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 1.06A 4zmeB-4kujA:
22.8		 4zmeB-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		8 PHE A  63
ALA A  64
VAL A  83
LYS A  85
LEU A 126
GLU A 164
LEU A 167
THR A 222
 None
PEG  A 302 ( 3.9A)
None
PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 0.81A 4zmeB-4kujA:
22.8		 4zmeB-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF02557
(VanY) 		5 ALA A 153
VAL A  65
GLU A 159
LEU A  71
THR A 165
 None
 1.33A 4zmeB-4mphA:
undetectable		 4zmeB-4mphA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mso SERINE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
cenocepacia) 		PF00464
(SHMT) 		5 PHE A 282
ALA A 277
LEU A 208
PHE A  87
THR A 226
 None
 1.33A 4zmeB-4msoA:
undetectable		 4zmeB-4msoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnp LIPOPROTEIN

(Staphylococcus
aureus) 		PF01297
(ZnuA) 		5 PHE A 209
ALA A 208
VAL A 278
LEU A 252
LEU A 253
 None
 1.26A 4zmeB-4nnpA:
undetectable		 4zmeB-4nnpA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 VAL A 116
LEU A  11
GLU A 106
LEU A 110
THR A  15
 None
 1.28A 4zmeB-4o5hA:
undetectable		 4zmeB-4o5hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opa NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		no annotation 5 ALA B 107
VAL B 169
LEU B 193
LEU B 139
LEU B 142
 None
 1.33A 4zmeB-4opaB:
undetectable		 4zmeB-4opaB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		5 VAL A 198
LEU A  57
LEU A  54
PHE A  50
THR A 271
 None
 1.33A 4zmeB-4oyeA:
undetectable		 4zmeB-4oyeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		5 PHE X 105
VAL X 133
GLU X 136
LEU X 134
PHE X  96
 None
 1.28A 4zmeB-4pkaX:
undetectable		 4zmeB-4pkaX:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q37 RADICAL SAM PROTEIN

(Thermotoga
maritima) 		PF02310
(B12-binding) 		5 PHE A  94
ALA A  77
VAL A  61
GLU A  64
LEU A  68
 None
 1.29A 4zmeB-4q37A:
undetectable		 4zmeB-4q37A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 PHE A 577
ALA A 590
VAL A 557
LEU A 538
LEU A 560
 None
 1.21A 4zmeB-4uozA:
undetectable		 4zmeB-4uozA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 PHE A 259
VAL A 271
GLU A 275
LEU A 316
PHE A  10
 None
 1.33A 4zmeB-4xiaA:
undetectable		 4zmeB-4xiaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 PHE A 259
VAL A 271
GLU A 275
LEU A 318
PHE A  10
 None
 1.32A 4zmeB-4xiaA:
undetectable		 4zmeB-4xiaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkb YCF53-LIKE PROTEIN

(Synechocystis
sp. PCC 6803) 		PF05419
(GUN4)
PF16416
(GUN4_N) 		5 ALA A 219
VAL A 135
LEU A 119
LEU A 143
PHE A 160
 None
 1.35A 4zmeB-4xkbA:
undetectable		 4zmeB-4xkbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA A  84
VAL A 115
LEU A  42
LEU A 122
LEU A  74
 None
 1.22A 4zmeB-4y5fA:
undetectable		 4zmeB-4y5fA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 PHE A  13
VAL A  15
LEU A  91
LEU A 107
THR A  88
 None
 1.19A 4zmeB-5ah4A:
undetectable		 4zmeB-5ah4A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dyj MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		10 PHE A 586
ALA A 587
VAL A 643
LYS A 645
LEU A 689
GLU A 713
LEU A 715
LEU A 716
PHE A 720
THR A 765
 AMP  A 904 (-4.8A)
AMP  A 904 (-3.3A)
None
AMP  A 904 (-2.9A)
None
AMP  A 904 (-3.9A)
AMP  A 904 ( 4.8A)
AMP  A 904 (-3.8A)
AMP  A 904 (-3.6A)
AMP  A 904 ( 4.4A)
 0.17A 4zmeB-5dyjA:
41.0		 4zmeB-5dyjA:
98.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dyj MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		6 PHE A 586
ALA A 594
LEU A 715
LEU A 716
PHE A 720
THR A 765
 AMP  A 904 (-4.8A)
AMP  A 904 ( 4.0A)
AMP  A 904 ( 4.8A)
AMP  A 904 (-3.8A)
AMP  A 904 (-3.6A)
AMP  A 904 ( 4.4A)
 1.39A 4zmeB-5dyjA:
41.0		 4zmeB-5dyjA:
98.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 PHE A 739
VAL A 766
LEU A 725
PHE A 733
THR A 483
 None
 1.35A 4zmeB-5hzrA:
undetectable		 4zmeB-5hzrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 PHE A 248
ALA A 247
VAL A 369
LEU A 319
PHE A 345
 None
 1.29A 4zmeB-5i4eA:
undetectable		 4zmeB-5i4eA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1

(Reovirus sp.) 		PF01664
(Reo_sigma1) 		5 PHE A 355
VAL A 324
LEU A 426
LEU A 366
LEU A 428
 None
 1.34A 4zmeB-5mhrA:
1.1		 4zmeB-5mhrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 PHE A 217
VAL A 265
LYS A 270
GLU A 266
LEU A 261
 ACT  A 504 (-4.5A)
None
None
None
None
 0.98A 4zmeB-5n72A:
undetectable		 4zmeB-5n72A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 5 PHE A 170
LEU A  64
LEU A  22
PHE A 175
THR A  80
 None
 1.17A 4zmeB-5w4aA:
undetectable		 4zmeB-5w4aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL C  24
LEU A  12
LEU C  10
LEU C   7
PHE C   3
 None
 1.16A 4zmeB-5xynC:
undetectable		 4zmeB-5xynC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B  75
LYS B  36
LEU B  72
PHE B   8
THR B   6
 None
 1.33A 4zmeB-5y58B:
undetectable		 4zmeB-5y58B:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 5 PHE A 352
ALA A 367
VAL A 330
GLU A 332
LEU A 316
 None
 1.31A 4zmeB-5yp3A:
undetectable		 4zmeB-5yp3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 PHE A 317
ALA A 318
VAL A  68
LEU A 357
THR A 335
 None
 1.18A 4zmeB-5ysmA:
undetectable		 4zmeB-5ysmA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 5 VAL A  80
LEU A 115
LEU A 100
PHE A  96
THR A 113
 None
 1.35A 4zmeB-5ze8A:
undetectable		 4zmeB-5ze8A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 PHE A 308
ALA A 309
VAL A 340
LEU A 379
THR A 382
 None
 1.23A 4zmeB-6bk7A:
undetectable		 4zmeB-6bk7A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 5 PHE P 152
ALA P 151
VAL P 275
LEU P 223
PHE P 251
 None
 1.19A 4zmeB-6c1dP:
undetectable		 4zmeB-6c1dP:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 PHE E1495
ALA E1494
VAL E1523
LEU E1519
THR E1534
 None
 1.13A 4zmeB-6c3pE:
undetectable		 4zmeB-6c3pE:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 PHE A 476
ALA A 417
VAL A 474
LEU A 427
PHE A 488
 None
 1.34A 4zmeB-6evgA:
undetectable		 4zmeB-6evgA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 269
VAL A 241
LEU A 245
LEU A 259
THR A 227
 None
 1.35A 4zmeB-6fbtA:
undetectable		 4zmeB-6fbtA:
13.73