SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZME_A_ADNA1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3y ODORANT BINDING
PROTEIN

(Sus scrofa) 		PF00061
(Lipocalin) 		5 PHE A  44
GLY A  70
VAL A  90
LEU A  98
LEU A 118
 None
 1.11A 4zmeA-1a3yA:
0.2		 4zmeA-1a3yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 ALA D 138
GLY D 158
VAL D 135
GLU D 128
LEU D 131
 None
 1.16A 4zmeA-1dkgD:
undetectable		 4zmeA-1dkgD:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A  86
LEU A 104
LEU A 105
PHE A  51
THR A 241
 None
 0.91A 4zmeA-1fujA:
0.0		 4zmeA-1fujA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ALA A 178
GLY A 147
LEU A  24
LEU A 215
LEU A 182
 None
 1.06A 4zmeA-1i7qA:
undetectable		 4zmeA-1i7qA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		6 GLY A1618
LYS A1646
LEU A1701
GLU A1718
PHE A1725
THR A1774
 ADP  A2002 ( 4.2A)
ADP  A2002 (-2.8A)
None
ADP  A2002 (-3.6A)
ADP  A2002 ( 3.8A)
ADP  A2002 ( 4.1A)
 0.84A 4zmeA-1iahA:
23.2		 4zmeA-1iahA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		6 GLY A1619
LYS A1646
LEU A1701
GLU A1718
PHE A1725
THR A1774
 ADP  A2002 (-3.1A)
ADP  A2002 (-2.8A)
None
ADP  A2002 (-3.6A)
ADP  A2002 ( 3.8A)
ADP  A2002 ( 4.1A)
 0.46A 4zmeA-1iahA:
23.2		 4zmeA-1iahA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 161
VAL A 188
LEU A 127
LEU A  87
PHE A 159
 None
 1.13A 4zmeA-1ig8A:
0.0		 4zmeA-1ig8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		5 PHE A  95
GLY A  49
LEU A 159
LEU A 156
PHE A 152
 None
 1.17A 4zmeA-1j5xA:
undetectable		 4zmeA-1j5xA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jod OLFACTORY MARKER
PROTEIN

(Mus musculus) 		PF06554
(Olfactory_mark) 		5 ALA A 204
GLY A 226
VAL A 170
LEU A 254
PHE A 241
 None
 1.00A 4zmeA-1jodA:
0.0		 4zmeA-1jodA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		5 GLY A 107
VAL A  58
LEU A  75
LEU A  49
THR A  71
 SAH  A 801 (-4.6A)
None
None
None
None
 1.15A 4zmeA-1l3iA:
undetectable		 4zmeA-1l3iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		5 PHE A 593
ALA A 588
LEU A 613
LEU A 616
PHE A 621
 None
 1.12A 4zmeA-1lvaA:
undetectable		 4zmeA-1lvaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 296
VAL A 308
LEU A 313
LEU A 334
LEU A 331
 None
 1.13A 4zmeA-1n5xA:
undetectable		 4zmeA-1n5xA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or5 ACYL CARRIER PROTEIN

(Streptomyces
roseofulvus) 		PF00550
(PP-binding) 		5 GLY A  36
LEU A  49
LEU A  72
LEU A   8
THR A  45
 None
 1.13A 4zmeA-1or5A:
undetectable		 4zmeA-1or5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		5 PHE A 250
ALA A 246
GLY A 207
VAL A 160
LEU A 270
 None
None
None
None
4TP  A 332 (-4.8A)
 1.12A 4zmeA-1ps6A:
undetectable		 4zmeA-1ps6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		5 PHE A 250
GLY A 207
VAL A 160
LEU A 273
LEU A 270
 None
None
None
None
4TP  A 332 (-4.8A)
 1.17A 4zmeA-1ps6A:
undetectable		 4zmeA-1ps6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		5 ALA A 232
GLY A 236
LEU A  98
GLU A 243
LEU A 247
 None
 0.97A 4zmeA-1q5dA:
undetectable		 4zmeA-1q5dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		5 ALA A  99
GLY A  32
LEU A  58
LEU A  61
THR A  12
 None
 1.07A 4zmeA-1sh8A:
undetectable		 4zmeA-1sh8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		5 ALA A 120
GLY A 118
LEU A 213
LEU A 188
LEU A 178
 None
 1.16A 4zmeA-1txzA:
undetectable		 4zmeA-1txzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		5 ALA A 120
GLY A 118
VAL A  76
LEU A 188
LEU A 178
 None
 1.12A 4zmeA-1txzA:
undetectable		 4zmeA-1txzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ALA A 259
GLY A 257
VAL A  26
LEU A  24
LEU A  68
 ANP  A 700 (-3.3A)
None
ANP  A 700 (-4.1A)
ANP  A 700 (-4.5A)
None
 1.13A 4zmeA-1w5tA:
undetectable		 4zmeA-1w5tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsu SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09107
(SelB-wing_3) 		5 PHE A 593
ALA A 588
LEU A 613
LEU A 616
PHE A 621
 None
 1.15A 4zmeA-1wsuA:
undetectable		 4zmeA-1wsuA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3v SITE-SPECIFIC
RECOMBINASE INTI4

(Vibrio cholerae) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		5 ALA A  58
GLY A  61
LEU A  72
LEU A  75
PHE A  53
 None
 1.16A 4zmeA-2a3vA:
undetectable		 4zmeA-2a3vA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 ALA A 183
GLY A 179
LEU A  83
LEU A  43
THR A 108
 None
 0.93A 4zmeA-2ad1A:
undetectable		 4zmeA-2ad1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 ALA A 413
GLY A 392
LEU A 163
LEU A 138
LEU A 135
 None
FAD  A1485 (-3.4A)
None
None
None
 1.08A 4zmeA-2braA:
undetectable		 4zmeA-2braA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf5 FADD PROTEIN

(Homo sapiens) 		PF00531
(Death)
PF01335
(DED) 		5 GLY A  85
LEU A  63
LEU A   8
PHE A   4
THR A  60
 None
 1.11A 4zmeA-2gf5A:
undetectable		 4zmeA-2gf5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		5 GLY A 213
VAL A  43
LEU A  15
LEU A   8
THR A  14
 None
 1.15A 4zmeA-2i54A:
undetectable		 4zmeA-2i54A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ALA A 103
GLY A 107
LEU A 176
LEU A 119
THR A 179
 None
 1.14A 4zmeA-2j66A:
undetectable		 4zmeA-2j66A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		5 PHE X 150
GLY X 181
VAL X 133
LEU X 115
PHE X 184
 None
 1.06A 4zmeA-2p5zX:
undetectable		 4zmeA-2p5zX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbp ENOYL-COA HYDRATASE
SUBUNIT I

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 ALA A 126
VAL A 177
LEU A 150
LEU A 115
PHE A 111
 None
 1.17A 4zmeA-2pbpA:
undetectable		 4zmeA-2pbpA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		5 PHE A 550
ALA A 676
VAL A 668
LEU A 653
LEU A 635
 None
CL  A 504 ( 4.2A)
None
None
None
 1.17A 4zmeA-2pfiA:
undetectable		 4zmeA-2pfiA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 ALA A  76
LEU A 212
LEU A 111
LEU A 112
PHE A 114
 NAD  A 401 (-3.5A)
None
None
None
NAD  A 401 (-4.9A)
 1.13A 4zmeA-2pzkA:
undetectable		 4zmeA-2pzkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 GLY A  10
LEU A 212
LEU A 111
LEU A 112
PHE A 114
 NAD  A 401 (-3.1A)
None
None
None
NAD  A 401 (-4.9A)
 1.09A 4zmeA-2pzkA:
undetectable		 4zmeA-2pzkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 146
LYS A 148
GLU A 190
LEU A 192
LEU A 193
 None
ATP  A 501 ( 3.8A)
ATP  A 501 (-3.5A)
ATP  A 501 ( 4.7A)
ATP  A 501 (-4.2A)
 0.54A 4zmeA-2qk4A:
1.1		 4zmeA-2qk4A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 PHE A  41
GLY A 340
LEU A 216
LEU A 351
PHE A 113
 None
 0.96A 4zmeA-2r7mA:
0.0		 4zmeA-2r7mA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		5 GLY A 119
VAL A  92
LEU A  97
LEU A 100
PHE A 132
 None
 1.00A 4zmeA-2wf7A:
undetectable		 4zmeA-2wf7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 PHE A 625
ALA A 614
GLY A 610
LEU A 529
THR A 526
 None
 1.15A 4zmeA-2y6iA:
undetectable		 4zmeA-2y6iA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		5 ALA A  14
GLY A 268
LEU A 229
LEU A 171
LEU A 174
 None
 1.14A 4zmeA-2yzwA:
undetectable		 4zmeA-2yzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		5 PHE A 199
ALA A 203
GLY A 207
LYS A 210
LEU A 177
 None
 1.14A 4zmeA-3a8rA:
undetectable		 4zmeA-3a8rA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		5 PHE A  45
ALA A  43
GLY A  12
LEU A  56
LEU A  67
 None
None
None
None
EDO  A 265 ( 4.4A)
 1.17A 4zmeA-3adrA:
undetectable		 4zmeA-3adrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 PHE A 707
VAL A 716
LEU A 680
PHE A 577
THR A 559
 None
 1.13A 4zmeA-3ahiA:
undetectable		 4zmeA-3ahiA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		6 PHE A 707
VAL A 716
LEU A 563
LEU A 680
PHE A 577
THR A 559
 None
 1.18A 4zmeA-3ai7A:
undetectable		 4zmeA-3ai7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A 347
GLY A 188
VAL A 327
LEU A 325
THR A 277
 None
 1.16A 4zmeA-3d46A:
undetectable		 4zmeA-3d46A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		5 ALA A 748
GLY A 750
VAL A 541
LYS A 537
PHE A 743
 None
 1.12A 4zmeA-3ebbA:
undetectable		 4zmeA-3ebbA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		5 PHE A 356
ALA A 351
LEU A 417
LEU A 521
LEU A 433
 None
 1.14A 4zmeA-3fhaA:
undetectable		 4zmeA-3fhaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 PHE A1392
ALA A1391
VAL A1360
LEU A1304
LEU A1356
 None
 0.78A 4zmeA-3gd7A:
undetectable		 4zmeA-3gd7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 GLY A  50
VAL A  38
LEU A  72
LEU A 108
PHE A 110
 None
 1.05A 4zmeA-3ibrA:
undetectable		 4zmeA-3ibrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibz PUTATIVE TELLURIUM
RESISTANT LIKE
PROTEIN TERD

(Streptomyces
coelicolor) 		PF02342
(TerD) 		5 PHE A 187
GLY A  51
VAL A 106
LYS A 104
GLU A 159
 None
 0.99A 4zmeA-3ibzA:
undetectable		 4zmeA-3ibzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 PHE A 499
ALA A 332
VAL A 495
LEU A 348
THR A 391
 None
 1.18A 4zmeA-3iveA:
undetectable		 4zmeA-3iveA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 PHE A 243
GLY A 201
LEU A  65
LEU A  64
THR A 300
 None
 0.97A 4zmeA-3k1jA:
undetectable		 4zmeA-3k1jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 ALA B 850
GLY B 506
VAL B 833
LEU B 838
LEU B 842
 None
 1.15A 4zmeA-3k70B:
undetectable		 4zmeA-3k70B:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 194
GLY A 178
LEU A 362
LEU A   9
THR A 361
 None
 1.07A 4zmeA-3kzuA:
undetectable		 4zmeA-3kzuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Yersinia pestis) 		PF04166
(PdxA) 		5 PHE A 251
ALA A 247
GLY A 208
VAL A 161
LEU A 271
 None
 1.10A 4zmeA-3lxyA:
undetectable		 4zmeA-3lxyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mam OSMOPROTECTION
PROTEIN (PROX)

(Archaeoglobus
fulgidus) 		PF04069
(OpuAC) 		5 PHE A 164
ALA A 135
VAL A 186
LEU A 113
LEU A 204
 None
 1.16A 4zmeA-3mamA:
undetectable		 4zmeA-3mamA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n77 NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		5 PHE A 111
GLY A  38
LEU A 127
LEU A  19
THR A 131
 None
 1.16A 4zmeA-3n77A:
undetectable		 4zmeA-3n77A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 PHE A 606
ALA A 276
GLY A 274
LEU A 164
LEU A 144
 None
 1.11A 4zmeA-3ne5A:
undetectable		 4zmeA-3ne5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyf D-ARGININE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 ALA A1198
GLY A1012
LEU A1061
LEU A1313
THR A1337
 None
FAD  A1500 (-3.5A)
None
None
None
 1.14A 4zmeA-3nyfA:
undetectable		 4zmeA-3nyfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oga NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		5 PHE A 111
GLY A  38
LEU A 127
LEU A  19
THR A 131
 None
 1.13A 4zmeA-3ogaA:
undetectable		 4zmeA-3ogaA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pdt MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		10 ALA A 587
GLY A 589
VAL A 643
LYS A 645
LEU A 689
GLU A 713
LEU A 715
LEU A 716
PHE A 720
THR A 765
 ADP  A 811 (-3.3A)
ADP  A 811 (-2.9A)
None
ADP  A 811 (-2.7A)
None
None
ADP  A 811 ( 4.8A)
ADP  A 811 (-3.8A)
ADP  A 811 (-3.5A)
ADP  A 811 (-4.1A)
 0.67A 4zmeA-3pdtA:
40.2		 4zmeA-3pdtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pdt MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		10 PHE A 586
ALA A 587
GLY A 589
VAL A 643
LYS A 645
LEU A 689
LEU A 715
LEU A 716
PHE A 720
THR A 765
 ADP  A 811 (-4.8A)
ADP  A 811 (-3.3A)
ADP  A 811 (-2.9A)
None
ADP  A 811 (-2.7A)
None
ADP  A 811 ( 4.8A)
ADP  A 811 (-3.8A)
ADP  A 811 (-3.5A)
ADP  A 811 (-4.1A)
 0.32A 4zmeA-3pdtA:
40.2		 4zmeA-3pdtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 249
GLU A 244
LEU A 242
PHE A  24
THR A 260
 None
 1.10A 4zmeA-3pwzA:
undetectable		 4zmeA-3pwzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A  60
VAL A 246
GLU A 250
LEU A 247
LEU A  54
 None
 0.90A 4zmeA-3rd8A:
undetectable		 4zmeA-3rd8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ALA A 256
GLY A 272
VAL A 210
LEU A 249
THR A 298
 None
 1.08A 4zmeA-3tbhA:
undetectable		 4zmeA-3tbhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 285
GLY A 311
VAL A 316
LEU A 349
LEU A 360
 None
TPO  A 312 ( 2.5A)
None
None
None
 1.09A 4zmeA-3ulzA:
4.8		 4zmeA-3ulzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 ALA A  78
VAL A 117
LEU A 100
LEU A 269
LEU A 266
 None
 1.15A 4zmeA-3wafA:
undetectable		 4zmeA-3wafA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 GLY A 660
LEU A 630
GLU A 631
LEU A 665
THR A 639
 None
 1.16A 4zmeA-3wfaA:
undetectable		 4zmeA-3wfaA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 ALA A 165
GLY A 169
LEU A 158
LEU A 159
THR A  71
 None
 1.17A 4zmeA-3wrtA:
undetectable		 4zmeA-3wrtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		5 ALA A  77
GLY A  75
VAL A 123
LEU A 112
THR A 116
 None
 1.08A 4zmeA-3wwhA:
undetectable		 4zmeA-3wwhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		5 PHE A  70
ALA A  77
GLY A  75
LEU A 112
THR A 116
 None
 1.05A 4zmeA-3wwhA:
undetectable		 4zmeA-3wwhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 PHE A 644
ALA A 686
LEU A 784
LEU A 655
LEU A 756
 None
 1.07A 4zmeA-4e93A:
5.3		 4zmeA-4e93A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f47 ENOYL-COA HYDRATASE
ECHA19

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 PHE A 144
GLY A 191
VAL A 118
LEU A  66
THR A 133
 None
 1.13A 4zmeA-4f47A:
undetectable		 4zmeA-4f47A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN

(Arabidopsis
thaliana) 		PF00225
(Kinesin) 		5 GLY A 982
LEU A 954
LEU A1182
PHE A1184
THR A 951
 None
 1.13A 4zmeA-4frzA:
undetectable		 4zmeA-4frzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcu 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Deinococcus
radiodurans) 		PF02962
(CHMI) 		5 GLY A  72
LEU A  85
LEU A  28
PHE A  35
THR A  81
 None
 1.13A 4zmeA-4jcuA:
undetectable		 4zmeA-4jcuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyj ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 PHE A  62
ALA A 113
VAL A 103
LEU A  53
PHE A  38
 None
 1.11A 4zmeA-4jyjA:
undetectable		 4zmeA-4jyjA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 PHE A  42
GLY A  47
LEU A 137
LEU A 122
THR A 134
 None
 1.09A 4zmeA-4kf6A:
undetectable		 4zmeA-4kf6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		5 GLY A  66
LEU A 126
GLU A 164
PHE A 171
THR A 222
 PEG  A 302 (-4.7A)
None
PEG  A 302 (-4.3A)
None
None
 1.03A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		5 GLY A  67
LEU A 126
GLU A 164
PHE A 171
THR A 222
 None
None
PEG  A 302 (-4.3A)
None
None
 1.12A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		7 GLY A  67
VAL A  83
LYS A  85
LEU A 126
GLU A 164
LEU A 167
THR A 222
 None
None
PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 1.23A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		9 PHE A  63
ALA A  64
GLY A  66
VAL A  83
LYS A  85
LEU A 126
GLU A 164
LEU A 167
THR A 222
 None
PEG  A 302 ( 3.9A)
PEG  A 302 (-4.7A)
None
PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 0.79A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 175
GLY A 179
VAL A 155
LEU A 100
LEU A 153
 None
 1.06A 4zmeA-4qdiA:
undetectable		 4zmeA-4qdiA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		5 ALA A  34
GLY A  36
LEU A 390
LEU A  41
THR A 394
 None
 1.14A 4zmeA-4wb0A:
undetectable		 4zmeA-4wb0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		5 GLY A 281
LEU A 301
LEU A 274
PHE A 273
THR A 305
 None
 1.18A 4zmeA-4wxpA:
undetectable		 4zmeA-4wxpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 ALA A 130
GLY A 134
VAL A 164
LEU A 100
LEU A 139
 None
 1.10A 4zmeA-4x3mA:
undetectable		 4zmeA-4x3mA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA A  58
GLY A  63
VAL A  51
LEU A 124
PHE A 126
 None
 1.16A 4zmeA-4y5fA:
undetectable		 4zmeA-4y5fA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dyj MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		11 PHE A 586
ALA A 587
GLY A 589
VAL A 643
LYS A 645
LEU A 689
GLU A 713
LEU A 715
LEU A 716
PHE A 720
THR A 765
 AMP  A 904 (-4.8A)
AMP  A 904 (-3.3A)
AMP  A 904 (-3.2A)
None
AMP  A 904 (-2.9A)
None
AMP  A 904 (-3.9A)
AMP  A 904 ( 4.8A)
AMP  A 904 (-3.8A)
AMP  A 904 (-3.6A)
AMP  A 904 ( 4.4A)
 0.23A 4zmeA-5dyjA:
41.2		 4zmeA-5dyjA:
98.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 PHE A 120
GLY A 125
VAL A 280
LEU A 274
THR A 252
 None
 1.12A 4zmeA-5esrA:
undetectable		 4zmeA-5esrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13355
(DUF4101) 		5 GLY A 695
LEU A 756
GLU A 758
LEU A 734
LEU A 733
 None
EDO  A 901 ( 4.7A)
EDO  A 901 ( 3.8A)
None
None
 1.16A 4zmeA-5hadA:
undetectable		 4zmeA-5hadA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 GLY A 340
VAL A 364
LEU A 411
GLU A 365
THR A 413
 None
 1.17A 4zmeA-5hucA:
undetectable		 4zmeA-5hucA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 ALA B 622
GLY B 624
VAL B 770
LEU B 749
LEU B 767
 None
 1.12A 4zmeA-5my0B:
undetectable		 4zmeA-5my0B:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 PHE A1352
GLY A1607
LEU A1598
LEU A1638
THR A1297
 None
 1.09A 4zmeA-5mznA:
undetectable		 4zmeA-5mznA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 PHE A 217
VAL A 265
LYS A 270
GLU A 266
LEU A 261
 ACT  A 504 (-4.5A)
None
None
None
None
 0.97A 4zmeA-5n72A:
undetectable		 4zmeA-5n72A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLY B 163
LEU B 360
LEU B 157
LEU B 422
PHE B 578
 None
 1.08A 4zmeA-5nd1B:
undetectable		 4zmeA-5nd1B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o98 ALCOHOL
DEHYDROGENASE 1

(Catharanthus
roseus) 		no annotation 5 GLY A  45
VAL A  35
LEU A  57
LEU A  28
PHE A  22
 None
 0.98A 4zmeA-5o98A:
undetectable		 4zmeA-5o98A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		5 GLY A 219
VAL A  48
LEU A  21
LEU A  14
THR A  20
 None
 1.15A 4zmeA-5ue7A:
undetectable		 4zmeA-5ue7A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		PF10418
(DHODB_Fe-S_bind) 		5 PHE B 193
GLY B 248
VAL B 195
GLU B 113
THR B  48
 None
None
None
FAD  B 301 (-3.3A)
FAD  B 301 (-3.4A)
 1.13A 4zmeA-5vj7B:
undetectable		 4zmeA-5vj7B:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 5 PHE A 170
LEU A  64
LEU A  22
PHE A 175
THR A  80
 None
 1.17A 4zmeA-5w4aA:
undetectable		 4zmeA-5w4aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 ALA A 248
GLY A 264
VAL A 202
LEU A 241
THR A 290
 None
 1.13A 4zmeA-5xa2A:
undetectable		 4zmeA-5xa2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL C  24
LEU A  12
LEU C  10
LEU C   7
PHE C   3
 None
 1.15A 4zmeA-5xynC:
undetectable		 4zmeA-5xynC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 PHE E1495
ALA E1494
VAL E1523
LEU E1519
THR E1534
 None
 1.12A 4zmeA-6c3pE:
undetectable		 4zmeA-6c3pE:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfs PHOSPHOMANNOMUTASE 1

(Homo sapiens) 		no annotation 5 GLY A 224
VAL A  51
LEU A  24
LEU A  17
THR A  23
 None
 1.17A 4zmeA-6cfsA:
undetectable		 4zmeA-6cfsA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1

(Saccharomyces
cerevisiae) 		no annotation 5 PHE i 318
GLY j 367
LEU i 382
LEU i 356
THR i 386
 None
 1.15A 4zmeA-6faii:
undetectable		 4zmeA-6faii:
13.82