SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJQ_D_ERYD1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 SER A 122
THR A 123
ILE A  65
PHE A 477
ARG A  75
 None
 1.48A 4zjqD-1c4oA:
0.0		 4zjqD-1c4oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus;
Bos taurus;
Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc)
PF05856
(ARPC4) 		5 SER A 133
ILE F 142
PHE D 273
GLU A 132
GLU A 128
 None
 1.34A 4zjqD-1u2vA:
0.0		 4zjqD-1u2vA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 THR A 398
ILE A 152
PHE A 193
ASP A 327
GLU A 387
 None
 1.43A 4zjqD-2eceA:
undetectable		 4zjqD-2eceA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 SER A 311
THR A 285
PHE A 146
GLU A 313
GLU A  86
 None
None
None
K  A 511 (-3.6A)
K  A 511 (-2.6A)
 1.35A 4zjqD-2i2xA:
0.3		 4zjqD-2i2xA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ASN A 109
MET A 119
ILE A 114
PHE A 175
ASP A 413
 None
None
None
None
BG6  A1002 (-2.6A)
 1.47A 4zjqD-2nztA:
0.0		 4zjqD-2nztA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		5 ASN A 285
MET A 208
ILE A 235
PHE A 204
GLU A 167
 None
 1.30A 4zjqD-3hk0A:
undetectable		 4zjqD-3hk0A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 THR A1321
SER A1228
MET A1446
ILE A1350
GLU A1333
 None
 1.45A 4zjqD-3k9bA:
undetectable		 4zjqD-3k9bA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 ASN A  81
SER A 134
MET A 573
PHE A 666
ARG A 815
GLU A 817
 None
 1.12A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  79
ASN A  81
THR A  91
PHE A 664
ARG A 815
 None
 1.28A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  79
ASN A  81
THR A  91
PHE A 664
ASP A 681
GLU A 826
 None
 0.92A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
ASN A  81
THR A  91
SER A 134
LYS A 292
MET A 573
ILE A 626
ARG A 815
 None
 1.09A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
THR A  91
SER A 134
LYS A 292
MET A 573
ILE A 626
ASP A 681
GLU A 826
 None
 0.96A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
ASN A  81
THR A  91
SER A 134
LYS A 292
MET A 573
PHE A 666
ARG A 815
 None
 1.15A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
THR A  91
SER A 134
LYS A 292
MET A 573
PHE A 666
ASP A 681
GLU A 826
 None
 0.94A 4zjqD-3w9hA:
58.3		 4zjqD-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 SER A  79
THR A  91
LYS A 292
ASP A 681
GLU A 816
 None
 1.03A 4zjqD-3w9iA:
51.4		 4zjqD-3w9iA:
69.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 SER A  79
THR A  91
LYS A 292
ASP A 681
GLU A 825
 None
 0.88A 4zjqD-3w9iA:
51.4		 4zjqD-3w9iA:
69.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ASN A  19
THR A  21
ILE A 147
GLU A 121
GLU A 242
 None
 1.44A 4zjqD-4fl3A:
0.5		 4zjqD-4fl3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 SER A 254
THR A 294
ILE A 223
PHE A 203
GLU A 253
 None
 1.50A 4zjqD-4gm6A:
undetectable		 4zjqD-4gm6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 PHE A 136
ASP A 198
ARG A 335
GLU A 333
GLU A 132
 None
PO4  A 504 ( 4.9A)
GLN  A 503 ( 4.8A)
MG  A 502 (-2.3A)
PO4  A 504 ( 2.3A)
 0.93A 4zjqD-4lnfA:
2.7		 4zjqD-4lnfA:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 SER A  89
THR A  44
SER A 134
ILE A 139
PHE A 623
 None
 1.19A 4zjqD-4mt1A:
51.4		 4zjqD-4mt1A:
49.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		5 MET A 249
ILE A  84
ARG A 179
GLU A 216
GLU A 241
 None
None
PYR  A 402 (-2.8A)
CA  A 403 ( 2.1A)
CA  A 403 ( 2.5A)
 1.38A 4zjqD-4petA:
undetectable		 4zjqD-4petA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A  99
THR A 100
SER A 198
MET A 295
PHE A 293
 None
 1.43A 4zjqD-4qn3A:
undetectable		 4zjqD-4qn3A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Pseudoalteromonas
atlantica) 		PF03480
(DctP) 		5 MET A 243
ILE A  78
ARG A 173
GLU A 210
GLU A 235
 None
None
PYR  A 401 (-2.9A)
NA  A 402 ( 3.2A)
NA  A 402 ( 2.5A)
 1.34A 4zjqD-5cm6A:
undetectable		 4zjqD-5cm6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		5 SER A  37
THR A  35
ILE A 312
ASP A 159
ARG A 405
 None
None
None
None
C8E  A 501 (-3.0A)
 1.21A 4zjqD-5dl5A:
undetectable		 4zjqD-5dl5A:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 ASN A  81
THR A  91
MET A 573
ILE A 626
PHE A 666
ASP A 681
ARG A 815
GLU A 817
 None
 0.96A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 ASN A  81
THR A  91
MET A 573
ILE A 626
PHE A 666
ASP A 681
GLU A 817
GLU A 826
 None
 0.94A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  79
ASN A  81
THR A  91
ILE A 277
ARG A 815
 None
 1.24A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
THR A  91
LYS A 292
MET A 573
ILE A 626
PHE A 666
ASP A 681
ARG A 815
 None
 0.98A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
THR A  91
LYS A 292
MET A 573
ILE A 626
PHE A 666
ASP A 681
GLU A 826
 None
 0.98A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  79
ASN A  81
THR A  91
PHE A 664
ASP A 681
ARG A 815
 None
 1.23A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  79
ASN A  81
THR A  91
PHE A 664
ASP A 681
GLU A 826
 None
 0.89A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
THR A  91
SER A 134
MET A 573
ILE A 626
PHE A 666
ASP A 681
GLU A 826
 None
 0.89A 4zjqD-5enoA:
44.8		 4zjqD-5enoA:
72.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		5 SER A 245
THR A 239
SER A 221
ILE A 449
ASP A 174
 None
 1.31A 4zjqD-5h0iA:
undetectable		 4zjqD-5h0iA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 5 THR B 598
SER B 506
MET B 696
ILE B 692
PHE B 762
 None
 1.24A 4zjqD-5kdjB:
0.5		 4zjqD-5kdjB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		5 THR A 598
SER A 506
MET A 696
ILE A 692
PHE A 762
 None
 1.29A 4zjqD-5kdsA:
undetectable		 4zjqD-5kdsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 ILE A 407
PHE A 497
ASP A 293
ARG A 374
GLU A 372
 None
None
None
SO4  A 601 (-4.0A)
SO4  A 601 (-3.2A)
 1.36A 4zjqD-5ntfA:
undetectable		 4zjqD-5ntfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 5 SER A 541
THR A 539
SER A 576
MET A 373
GLU A 232
 None
 1.44A 4zjqD-6coyA:
2.6		 4zjqD-6coyA:
undetectable