SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJQ_A_ERYA1101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE

(Homo sapiens) 		PF01182
(Glucosamine_iso) 		5 SER A 151
MET A  89
ASP A 141
GLU A 148
GLY A 142
 16G  A4299 (-3.6A)
None
None
None
None
 1.33A 4zjqA-1ne7A:
0.0		 4zjqA-1ne7A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 SER A 282
LEU A 665
ASN A 697
GLU A 435
GLY A 763
 None
 1.43A 4zjqA-1r8wA:
0.0		 4zjqA-1r8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		5 SER A  13
LEU A  77
GLU A  70
ASP A  53
GLY A  48
 None
None
None
CA  A 203 ( 2.4A)
CA  A 205 (-4.1A)
 1.19A 4zjqA-2ml3A:
undetectable		 4zjqA-2ml3A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 LEU A 321
GLU A 117
ASP A 124
GLY A 123
MET A 122
 None
 1.43A 4zjqA-2v6jA:
0.0		 4zjqA-2v6jA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 SER D 175
MET D 406
LEU D 224
GLU D   9
GLY D 132
 None
 1.25A 4zjqA-2ynmD:
0.0		 4zjqA-2ynmD:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 SER A 162
SER A 174
LYS A 211
ASP A 144
GLY A 145
 None
 1.24A 4zjqA-2zsuA:
0.7		 4zjqA-2zsuA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		5 SER A 274
SER A 188
GLU A 200
ASN A 277
GLY A 162
 None
None
None
GOL  A 402 (-2.9A)
None
 1.34A 4zjqA-3h75A:
0.2		 4zjqA-3h75A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 SER K 488
LEU K 591
GLU K 292
ASN K 518
GLY K 373
 None
 1.37A 4zjqA-3j2uK:
0.0		 4zjqA-3j2uK:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 SER A 452
LEU A 337
ASP A 273
GLY A 275
MET A 274
 None
None
EDO  A 503 (-3.9A)
None
None
 1.40A 4zjqA-3peiA:
undetectable		 4zjqA-3peiA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A 326
GLU A 319
ASP A 427
ASN A 421
GLU A 425
 None
FAD  A 801 (-4.7A)
FAD  A 801 (-3.5A)
FAD  A 801 (-3.0A)
None
 1.16A 4zjqA-3umvA:
undetectable		 4zjqA-3umvA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
LYS A 292
MET A 573
LEU A 668
ASP A 681
ASN A 719
GLU A 826
GLY A 861
MET A 862
 None
 0.86A 4zjqA-3w9hA:
58.7		 4zjqA-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
SER A 134
LYS A 292
MET A 573
LEU A 668
ASP A 681
ASN A 719
GLU A 826
GLY A 861
 None
 0.97A 4zjqA-3w9hA:
58.7		 4zjqA-3w9hA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		6 SER A  79
LYS A 292
ASP A 681
ASN A 718
GLU A 825
GLY A 860
 None
 0.82A 4zjqA-3w9iA:
51.6		 4zjqA-3w9iA:
69.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		5 SER A  35
SER A 132
LEU A 160
ASN A  32
GLY A 166
 None
 1.38A 4zjqA-4dpyA:
4.5		 4zjqA-4dpyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 SER A 511
GLU A 425
ASP A 370
GLU A 417
GLY A 414
 None
CA  A 803 (-2.2A)
None
ZN  A 801 (-1.8A)
None
 1.46A 4zjqA-4tweA:
0.5		 4zjqA-4tweA:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		7 SER A  79
LYS A 292
LEU A 668
ASP A 681
ASN A 719
GLU A 826
MET A 862
 None
 1.12A 4zjqA-5enoA:
46.0		 4zjqA-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
LYS A 292
MET A 573
ASP A 681
ASN A 719
GLU A 826
GLY A 861
MET A 862
 None
 0.84A 4zjqA-5enoA:
46.0		 4zjqA-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		7 SER A  79
SER A 134
LYS A 292
LEU A 668
ASP A 681
ASN A 719
GLU A 826
 None
 1.19A 4zjqA-5enoA:
46.0		 4zjqA-5enoA:
72.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
SER A 134
LYS A 292
MET A 573
ASP A 681
ASN A 719
GLU A 826
GLY A 861
 None
 0.92A 4zjqA-5enoA:
46.0		 4zjqA-5enoA:
72.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		5 SER A 229
LEU A  70
ASP A 370
GLY A 223
MET A 221
 None
 1.30A 4zjqA-5gneA:
0.4		 4zjqA-5gneA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 SER A 658
LEU A 436
GLU A 707
GLY A 732
MET A 503
 SYM  A 901 (-3.4A)
None
SYM  A 901 (-3.3A)
None
None
 1.24A 4zjqA-5kufA:
undetectable		 4zjqA-5kufA:
21.91