SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJO_A_ERYA1101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 SER A 126
ALA A 100
ASP A 387
GLU A 239
THR A 388
 None
None
None
None
SF4  A 466 ( 4.1A)
 1.42A 4zjoA-1ao0A:
0.6		 4zjoA-1ao0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ASN A 424
ALA A 218
GLU A 428
GLU A 240
LEU A 241
 LYS  A 505 (-4.0A)
None
LYS  A 505 (-3.0A)
LYS  A 505 (-2.9A)
None
 1.29A 4zjoA-1bbuA:
0.0		 4zjoA-1bbuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ASN A 350
MET A 396
ALA A 450
ASP A 293
GLU A 354
 None
None
None
ZN  A 601 (-2.2A)
ZN  A 602 (-2.3A)
 1.29A 4zjoA-1gytA:
undetectable		 4zjoA-1gytA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		5 SER A 154
ASN A 596
ALA A 160
LEU A 469
THR A 434
 None
 1.45A 4zjoA-1pemA:
0.0		 4zjoA-1pemA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 SER A 330
ALA A  61
ASP A 354
GLU A 305
LEU A  54
 None
 1.46A 4zjoA-1w5dA:
0.0		 4zjoA-1w5dA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanopyrus
kandleri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ALA A 112
ASP A  57
GLU A 194
THR A  74
MET A  76
 None
K  A 701 (-4.2A)
None
None
None
 1.30A 4zjoA-2fhkA:
4.3		 4zjoA-2fhkA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 ASP A 529
GLU A 540
GLU A 709
LEU A 510
THR A 531
 None
 1.50A 4zjoA-2fuqA:
undetectable		 4zjoA-2fuqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 SER A 266
ALA A 368
GLU A 350
LEU A 360
THR A 261
 None
 1.18A 4zjoA-2hjhA:
undetectable		 4zjoA-2hjhA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 SER A 162
MET A 340
GLU A 164
GLU A  84
THR A 218
 None
None
ZN  A 501 ( 2.3A)
None
ZN  A 501 ( 4.7A)
 1.30A 4zjoA-2i2xA:
0.0		 4zjoA-2i2xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0t SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00790
(VHS) 		5 ASN B  14
SER B  45
ALA B  50
GLU B  17
LEU B  75
 None
 1.48A 4zjoA-2l0tB:
undetectable		 4zjoA-2l0tB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		5 ASN A 158
SER A 219
ALA A 244
GLU A 157
LEU A 152
 AHB  A7002 (-3.5A)
None
None
FE2  A5001 (-2.5A)
None
 1.16A 4zjoA-2og7A:
undetectable		 4zjoA-2og7A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ASN A 414
ALA A 209
GLU A 418
GLU A 231
LEU A 232
 B4P  A 494 (-3.8A)
None
LYN  A 495 (-2.9A)
LYN  A 495 (-3.0A)
None
 1.35A 4zjoA-3a74A:
1.7		 4zjoA-3a74A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 SER A 267
ALA A 273
GLU A 280
LEU A 281
THR A  43
 None
 1.49A 4zjoA-3h14A:
undetectable		 4zjoA-3h14A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hps 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF08502
(LeuA_dimer) 		5 ASN A 250
SER A 173
ALA A 253
GLU A 111
GLU A 309
 COI  A 702 (-4.5A)
None
None
None
None
 1.34A 4zjoA-3hpsA:
undetectable		 4zjoA-3hpsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpx 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like) 		5 ASN A 250
SER A 173
ALA A 253
GLU A 111
GLU A 309
 None
 1.38A 4zjoA-3hpxA:
undetectable		 4zjoA-3hpxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ALA A 140
ASP A  74
GLU A 114
LEU A  95
THR A  73
 None
 1.42A 4zjoA-3kyoA:
undetectable		 4zjoA-3kyoA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 618
ASP A 681
GLU A 826
LEU A 828
MET A 862
 None
 1.01A 4zjoA-3w9hA:
59.9		 4zjoA-3w9hA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  79
ASN A  81
GLU A 683
GLU A 817
LEU A 828
THR A 860
 None
 0.87A 4zjoA-3w9hA:
59.9		 4zjoA-3w9hA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
ASN A  81
SER A 133
ASP A 681
GLU A 683
GLU A 826
THR A 860
MET A 862
 None
 1.33A 4zjoA-3w9hA:
59.9		 4zjoA-3w9hA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
SER A 135
ASP A 681
GLU A 683
GLU A 826
LEU A 828
THR A 860
MET A 862
 None
 0.96A 4zjoA-3w9hA:
59.9		 4zjoA-3w9hA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
SER A 135
MET A 573
ASP A 681
GLU A 826
LEU A 828
THR A 860
MET A 862
 None
 0.95A 4zjoA-3w9hA:
59.9		 4zjoA-3w9hA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 SER A  79
ASP A 681
GLU A 816
LEU A 827
THR A 859
 None
 0.85A 4zjoA-3w9iA:
52.6		 4zjoA-3w9iA:
69.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 SER A  79
ASP A 681
GLU A 825
LEU A 827
THR A 859
 None
 0.75A 4zjoA-3w9iA:
52.6		 4zjoA-3w9iA:
69.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis) 		PF00210
(Ferritin) 		5 SER A  17
GLU A  51
GLU A 127
GLU A  94
LEU A 134
 None
FE  A1161 ( 2.4A)
FE  A1161 ( 2.6A)
FE  A1162 (-2.0A)
None
 1.49A 4zjoA-4am2A:
1.8		 4zjoA-4am2A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		5 ASN A 195
ASP A 479
GLU A 194
GLU A 273
THR A 534
 ACP  A1589 (-3.4A)
CA  A1592 (-2.1A)
FEO  A1595 ( 2.5A)
FEO  A1595 ( 2.4A)
None
 1.45A 4zjoA-4amfA:
undetectable		 4zjoA-4amfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		5 ASN A 195
ASP A 479
GLU A 273
GLU A 194
GLU A 387
 ACP  A1589 (-3.4A)
CA  A1592 (-2.1A)
FEO  A1595 ( 2.4A)
FEO  A1595 ( 2.5A)
CA  A1593 ( 2.3A)
 1.48A 4zjoA-4amfA:
undetectable		 4zjoA-4amfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		5 SER A 539
ALA A 533
GLU A 587
LEU A 565
THR A 572
 None
 1.32A 4zjoA-4ar9A:
3.3		 4zjoA-4ar9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ALA D 264
ASP D 256
GLU D 193
GLU D 189
THR D 164
 None
None
MG  D1477 ( 4.1A)
MG  D1477 (-4.1A)
MG  D1477 ( 3.4A)
 1.48A 4zjoA-4b2qD:
0.0		 4zjoA-4b2qD:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		5 SER A 152
ALA A 209
GLU A  97
GLU A 164
LEU A  90
 None
None
MN  A 401 ( 2.3A)
MN  A 401 (-1.7A)
None
 1.49A 4zjoA-4dr0A:
undetectable		 4zjoA-4dr0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 458
ALA A 123
GLU A 508
GLU A 460
LEU A 110
 None
 1.24A 4zjoA-4epaA:
undetectable		 4zjoA-4epaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex5 LYSINE--TRNA LIGASE

(Burkholderia
thailandensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ASN A 428
ALA A 218
GLU A 432
GLU A 240
LEU A 241
 LYS  A 601 (-3.1A)
None
LYS  A 601 (-2.7A)
LYS  A 601 (-2.8A)
None
 1.40A 4zjoA-4ex5A:
1.0		 4zjoA-4ex5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		5 MET A 280
ALA A 284
GLU A 252
LEU A 266
THR A 251
 None
 1.13A 4zjoA-4gb7A:
undetectable		 4zjoA-4gb7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 SER A 911
ALA A 589
ASP A 673
GLU A 633
GLU A 602
 None
 1.33A 4zjoA-4gl2A:
undetectable		 4zjoA-4gl2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		5 SER A 145
SER A 315
ASP A 298
GLU A 184
GLU A 183
 None
 1.35A 4zjoA-4mhpA:
undetectable		 4zjoA-4mhpA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 SER A  76
ALA A  29
GLU A  36
LEU A  44
THR A 116
 None
 1.39A 4zjoA-5by3A:
undetectable		 4zjoA-5by3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyj MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		5 SER A 691
ALA A 655
ASP A 766
GLU A 713
THR A 765
 None
None
AMP  A 904 (-3.1A)
AMP  A 904 (-3.9A)
AMP  A 904 ( 4.4A)
 1.25A 4zjoA-5dyjA:
undetectable		 4zjoA-5dyjA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 SER A 233
ASN A 246
SER A 222
ASP A  86
GLU A 241
 MG  A 402 ( 2.5A)
None
None
MG  A 401 (-2.5A)
MG  A 403 ( 4.3A)
 1.22A 4zjoA-5dz2A:
undetectable		 4zjoA-5dz2A:
15.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 618
ASP A 681
GLU A 826
LEU A 828
MET A 862
 None
 1.01A 4zjoA-5enoA:
46.2		 4zjoA-5enoA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		10 SER A  79
ASN A  81
MET A 573
ASP A 681
GLU A 683
GLU A 817
GLU A 826
LEU A 828
THR A 860
MET A 862
 None
 0.93A 4zjoA-5enoA:
46.2		 4zjoA-5enoA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  79
ASN A  81
SER A 133
ASP A 681
GLU A 683
THR A 860
 None
 1.09A 4zjoA-5enoA:
46.2		 4zjoA-5enoA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		10 SER A  79
ASN A  81
SER A 135
MET A 573
ASP A 681
GLU A 683
GLU A 826
LEU A 828
THR A 860
MET A 862
 None
 0.87A 4zjoA-5enoA:
46.2		 4zjoA-5enoA:
72.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ALA D 295
ASP D 287
GLU D 224
GLU D 220
THR D 195
 None
MG  D 601 ( 4.8A)
MG  D 601 ( 3.8A)
MG  D 601 ( 4.9A)
MG  D 601 ( 3.1A)
 1.48A 4zjoA-5fl7D:
undetectable		 4zjoA-5fl7D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE
PROTEOSOME SUBUNIT
ALPHA TYPE 1,
PUTATIVE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 SER F  54
ALA E 200
GLU E 180
LEU E 144
THR E 165
 None
 1.30A 4zjoA-5fmgF:
undetectable		 4zjoA-5fmgF:
12.61