SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJL_D_ERYD1101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 SER A  80
PHE A 165
LEU A 235
ASN A 229
GLU A 222
 None
 1.42A 4zjlD-1ckmA:
0.0		 4zjlD-1ckmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 SER A 173
PHE A 405
PHE A 206
LEU A 467
ASP A  92
 None
None
SWA  A1103 (-4.4A)
None
SWA  A1103 ( 2.4A)
 1.31A 4zjlD-1hwwA:
0.0		 4zjlD-1hwwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 SER A 248
LEU A 373
ASP A  24
ARG A 317
GLU A  32
 None
 1.41A 4zjlD-3bdzA:
0.5		 4zjlD-3bdzA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 SER A 333
LEU A 323
ASN A 553
GLU A 245
MET A 324
 None
 1.29A 4zjlD-3i04A:
0.4		 4zjlD-3i04A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 ASN A 492
SER A 415
PHE A 487
ASP A 220
GLU A 493
 None
 1.36A 4zjlD-3ttsA:
0.0		 4zjlD-3ttsA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  79
ASN A  81
PHE A 615
PHE A 617
GLU A 826
 None
 1.09A 4zjlD-3w9hA:
59.1		 4zjlD-3w9hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  79
ASN A  81
SER A 133
ASP A 681
GLU A 826
MET A 862
 None
 1.33A 4zjlD-3w9hA:
59.1		 4zjlD-3w9hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
ASN A  81
SER A 135
PHE A 615
ASN A 719
GLU A 817
GLU A 826
MET A 862
 None
 0.92A 4zjlD-3w9hA:
59.1		 4zjlD-3w9hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		8 SER A  79
ASN A  81
SER A 135
PHE A 615
ASP A 681
ASN A 719
GLU A 826
MET A 862
 None
 0.92A 4zjlD-3w9hA:
59.1		 4zjlD-3w9hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 SER A  88
LEU A 246
ASP A  46
ARG A 145
GLU A  87
 None
 1.40A 4zjlD-4dg8A:
0.0		 4zjlD-4dg8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ASN A 327
SER A 322
PHE A 360
PHE A 167
GLU A 329
 None
 1.32A 4zjlD-4ga7A:
undetectable		 4zjlD-4ga7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 SER A  28
LEU A  22
ASP A 249
ASN A  99
GLU A 100
 None
 1.48A 4zjlD-4po0A:
2.4		 4zjlD-4po0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE

(Bacteroides
fragilis) 		PF13472
(Lipase_GDSL_2) 		5 ASN A 174
PHE A 157
LEU A  92
ASN A 110
MET A 135
 None
 1.43A 4zjlD-4ppyA:
1.1		 4zjlD-4ppyA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 SER A 403
SER A  59
PHE A 286
LEU A  62
ASN A 251
 None
 1.45A 4zjlD-4zchA:
undetectable		 4zjlD-4zchA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X

(synthetic
construct) 		PF01498
(HTH_Tnp_Tc3_2)
PF13358
(DDE_3) 		5 LEU A  96
ASP A  43
ASN A 166
ARG A 216
GLU A 169
 None
GOL  A 317 (-4.2A)
GOL  A 317 (-3.9A)
None
GOL  A 317 (-4.0A)
 1.42A 4zjlD-5cr4A:
1.3		 4zjlD-5cr4A:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  79
ASN A  81
SER A 133
ASP A 681
GLU A 826
 None
 1.12A 4zjlD-5enoA:
46.0		 4zjlD-5enoA:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		9 SER A  79
ASN A  81
SER A 135
PHE A 615
ASP A 681
ASN A 719
GLU A 817
GLU A 826
MET A 862
 None
 0.96A 4zjlD-5enoA:
46.0		 4zjlD-5enoA:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A 135
PHE A 615
ASN A 719
ARG A 815
GLU A 826
MET A 862
 None
 1.11A 4zjlD-5enoA:
46.0		 4zjlD-5enoA:
73.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 SER A 258
PHE A 312
LEU A 128
ASP A 150
GLU A 152
 None
None
None
MN  A 505 (-4.0A)
MN  A 505 ( 2.4A)
 1.36A 4zjlD-5ks1A:
2.6		 4zjlD-5ks1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 SER A  28
LEU A  22
ASP A 248
ASN A  99
GLU A 100
 None
 1.46A 4zjlD-5oriA:
undetectable		 4zjlD-5oriA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 SER A 722
ASN A 681
LEU A 814
ASN A 650
GLU A 685
 None
 1.42A 4zjlD-5u1sA:
1.0		 4zjlD-5u1sA:
21.06