SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJL_A_ERYA1101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		4 ASN A 118
SER A  36
ASP A  77
GLU A 111
 None
 1.48A 4zjlA-1izeA:
0.4		 4zjlA-1izeA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a62 CADHERIN-8

(Mus musculus) 		PF00028
(Cadherin) 		4 ASN A 247
SER A 307
ASP A 172
GLU A 117
 None
None
CA  A 328 ( 4.9A)
CA  A 328 ( 2.6A)
 1.46A 4zjlA-2a62A:
0.0		 4zjlA-2a62A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASN A 489
SER A 496
ASP A 461
GLU A 457
 None
 1.28A 4zjlA-2xf2A:
1.3		 4zjlA-2xf2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 ASN A 278
SER A  16
ASP A 171
GLU A 200
 None
 1.47A 4zjlA-3dhuA:
0.0		 4zjlA-3dhuA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 ASN B 376
SER B  14
ASP B  46
GLU B 382
 None
 1.33A 4zjlA-3q75B:
0.0		 4zjlA-3q75B:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ASN A  81
SER A 134
LYS A 292
ASP A 681
GLU A 826
 None
 0.79A 4zjlA-3w9hA:
59.1		 4zjlA-3w9hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Salmonella
enterica) 		PF12710
(HAD) 		4 ASN A 251
SER A 133
ASP A 104
GLU A 101
 None
 1.29A 4zjlA-4ezeA:
3.5		 4zjlA-4ezeA:
15.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ASN A  81
LYS A 292
ASP A 681
GLU A 826
 None
 0.56A 4zjlA-5enoA:
47.0		 4zjlA-5enoA:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 SER A 134
LYS A 292
ASP A 681
GLU A 826
 None
 0.65A 4zjlA-5enoA:
47.0		 4zjlA-5enoA:
73.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocd -

(-) 		no annotation 4 ASN A 147
SER A 199
ASP A  64
GLU A 180
 None
 1.23A 4zjlA-5ocdA:
0.0		 4zjlA-5ocdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASN A 345
SER A  96
ASP A 227
GLU A 223
 None
 1.10A 4zjlA-5opjA:
0.0		 4zjlA-5opjA:
undetectable