SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJL_A_ERYA1101
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjy | PROTEIN (CYTOSOLICPHOSPHOLIPASE A2) (Homo sapiens) |
PF00168(C2)PF01735(PLA2_B) | 5 | SER A 140SER A 147LEU A 367THR A 376GLY A 375 | None | 1.43A | 4zjlA-1cjyA:0.0 | 4zjlA-1cjyA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gwc | GLUTATHIONES-TRANSFERASE TSI-1 (Aegilopstauschii) |
PF00043(GST_C)PF02798(GST_N) | 5 | SER A 69SER A 170PHE A 184PHE A 199LEU A 27 | GTX A1225 (-2.7A)NoneNoneNoneNone | 1.39A | 4zjlA-1gwcA:0.0 | 4zjlA-1gwcA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0h | FORMATEDEHYDROGENASESUBUNIT ALPHA (Desulfovibriogigas) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | SER A 853PHE A 836LEU A 236GLY A 192MET A 191 | MGD A1002 ( 4.0A)NoneNoneMGD A1002 (-3.7A)None | 1.39A | 4zjlA-1h0hA:0.0 | 4zjlA-1h0hA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lcs | FELINE LEUKEMIAVIRUSRECEPTOR-BINDINGDOMAIN (Feline leukemiavirus) |
PF00429(TLV_coat) | 5 | SER A 115PHE A 197LEU A 165THR A 168GLY A 171 | None | 1.09A | 4zjlA-1lcsA:undetectable | 4zjlA-1lcsA:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt4 | GLUCOSE-1-PHOSPHATASE (Escherichiacoli) |
PF00328(His_Phos_2) | 5 | MET A 379MET A 335PHE A 322LEU A 296THR A 126 | None | 1.28A | 4zjlA-1nt4A:2.3 | 4zjlA-1nt4A:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1orr | CDP-TYVELOSE-2-EPIMERASE (Salmonellaenterica) |
PF16363(GDP_Man_Dehyd) | 5 | SER A 123PHE A 250LEU A 4THR A 7GLY A 8 | NAD A1200 (-3.1A)NoneNoneNoneNAD A1200 (-3.2A) | 1.36A | 4zjlA-1orrA:undetectable | 4zjlA-1orrA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1squ | CHEX PROTEIN (Thermotogamaritima) |
PF13690(CheX) | 5 | SER A 61PHE A 140LEU A 21THR A 96GLY A 93 | None | 1.34A | 4zjlA-1squA:undetectable | 4zjlA-1squA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9q | TRANSCRIPTIONALREGULATOR, HTH_3FAMILY (Vibrio cholerae) |
PF01381(HTH_3) | 5 | SER A 120PHE A 8PHE A 70LEU A 63GLY A 35 | None | 1.41A | 4zjlA-1y9qA:undetectable | 4zjlA-1y9qA:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zx5 | MANNOSEPHOSPHATEISOMERASE, PUTATIVE (Archaeoglobusfulgidus) |
PF01238(PMI_typeI) | 5 | SER A 59PHE A 82PHE A 41GLU A 264GLY A 55 | None | 1.39A | 4zjlA-1zx5A:0.0 | 4zjlA-1zx5A:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2g | THREONINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | SER A 220MET A 391MET A 388THR A 192GLY A 193 | NoneNoneNoneNonePLP A1163 ( 3.9A) | 1.12A | 4zjlA-2c2gA:undetectable | 4zjlA-2c2gA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxj | S100 CALCIUM-BINDINGPROTEIN A13 (Mus musculus) |
PF01023(S_100) | 5 | SER A 32PHE A 23GLU A 86LEU A 41GLY A 81 | None | 1.49A | 4zjlA-2cxjA:undetectable | 4zjlA-2cxjA:7.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d52 | PENTAKETIDE CHROMONESYNTHASE (Aloearborescens) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | SER A 145GLU A 205LEU A 140THR A 120GLY A 119 | None | 1.10A | 4zjlA-2d52A:undetectable | 4zjlA-2d52A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dyk | GTP-BINDING PROTEIN (Thermusthermophilus) |
PF01926(MMR_HSR1) | 5 | PHE A 51GLU A 154LEU A 21THR A 141GLY A 148 | None | 1.40A | 4zjlA-2dykA:undetectable | 4zjlA-2dykA:10.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6p | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Aquifexaeolicus) |
PF02348(CTP_transf_3) | 5 | PHE A 108GLU A 195LEU A 199GLY A 181MET A 183 | NoneIPA A1236 (-3.9A)NoneNoneNone | 1.37A | 4zjlA-2y6pA:undetectable | 4zjlA-2y6pA:11.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yg6 | PUTRESCINE OXIDASE (Rhodococcuserythropolis) |
PF01593(Amino_oxidase) | 5 | SER A 343SER A 182GLU A 324LEU A 199GLY A 166 | None | 1.14A | 4zjlA-2yg6A:undetectable | 4zjlA-2yg6A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | SER A 374PHE A 215GLU A 364LEU A 383GLY A 163 | None | 1.44A | 4zjlA-2ylzA:1.0 | 4zjlA-2ylzA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3j | HISTONE-ARGININEMETHYLTRANSFERASECARM1 (Rattusnorvegicus) |
PF06325(PrmA) | 5 | PHE A 336PHE A 423LEU A 435THR A 460GLY A 461 | None | 1.16A | 4zjlA-3b3jA:undetectable | 4zjlA-3b3jA:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d23 | 3C-LIKE PROTEINASE (HumancoronavirusHKU1) |
no annotation | 5 | SER B 240PHE B 273GLU B 287LEU B 248GLY B 109 | None | 1.48A | 4zjlA-3d23B:undetectable | 4zjlA-3d23B:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6s | PUTATIVEENDONUCLEASE/EXONUCLEASE/PHOSPHATASEFAMILY PROTEIN (Bacteroidesvulgatus) |
PF03372(Exo_endo_phos) | 5 | PHE A 33GLU A 242LEU A 255THR A 203GLY A 204 | None | 1.48A | 4zjlA-3g6sA:undetectable | 4zjlA-3g6sA:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzt | CALCIUM-DEPENDENTPROTEIN KINASE 3 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 5 | SER A 465MET A 527PHE A 520GLU A 160GLY A 83 | NoneNoneNoneGOL A 542 (-3.8A)J60 A 540 ( 4.3A) | 1.45A | 4zjlA-3hztA:undetectable | 4zjlA-3hztA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j23 | CAPSID PROTEIN VP1CAPSID PROTEIN VP3 (Enterovirus A;Enterovirus A) |
PF00073(Rhv)PF00073(Rhv) | 5 | MET A 129PHE A 204PHE A 126LEU C 43GLY C 106 | None | 0.96A | 4zjlA-3j23A:undetectable | 4zjlA-3j23A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9v | FAD-DEPENDENTOXIDOREDUCTASE (Actinomadurakijaniata) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | MET A 327GLU A 113LEU A 79THR A 66GLY A 107 | NoneTYD A 901 (-3.8A)NoneNoneNone | 1.33A | 4zjlA-3m9vA:undetectable | 4zjlA-3m9vA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot4 | PUTATIVEISOCHORISMATASE (Bordetellabronchiseptica) |
PF00857(Isochorismatase) | 5 | SER A 154SER A 84PHE A 40THR A 126GLY A 125 | CSO A 150 ( 2.6A)NoneNoneNoneNone | 1.28A | 4zjlA-3ot4A:undetectable | 4zjlA-3ot4A:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t95 | AUTOINDUCER2-BINDING PROTEINLSRB (Yersinia pestis) |
PF13407(Peripla_BP_4) | 5 | SER A 90MET A 142MET A 138LEU A 323GLY A 44 | PAV A 400 ( 4.5A)NoneNoneNoneNone | 1.39A | 4zjlA-3t95A:1.6 | 4zjlA-3t95A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tw5 | TRANSGLUTAMINASEELICITOR (Phytophthorasojae) |
PF16683(TGase_elicitor) | 5 | SER A 197SER A 290GLU A 444LEU A 439THR A 461 | None | 1.44A | 4zjlA-3tw5A:undetectable | 4zjlA-3tw5A:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v98 | ARACHIDONATE5-LIPOXYGENASE (Homo sapiens) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | PHE A 151GLU A 417LEU A 368THR A 427GLY A 428 | None | 1.19A | 4zjlA-3v98A:undetectable | 4zjlA-3v98A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwa | CYTOPLASMIC EXPORTPROTEIN 1 (Saccharomycescerevisiae) |
no annotation | 5 | SER A 139PHE A 167LEU A 182GLY A 194MET A 193 | None | 1.36A | 4zjlA-3vwaA:undetectable | 4zjlA-3vwaA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6o | DYNAMIN-1-LIKEPROTEIN (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M) | 5 | SER A 40GLU A 89LEU A 67GLY A -1MET A 1 | GCP A 801 (-2.6A)NoneNoneNoneNone | 1.44A | 4zjlA-3w6oA:undetectable | 4zjlA-3w6oA:16.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 6 | SER A 79MET A 573GLU A 673GLU A 683LEU A 828THR A 860 | None | 1.10A | 4zjlA-3w9hA:59.1 | 4zjlA-3w9hA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 8 | SER A 79MET A 575PHE A 615GLU A 683LEU A 828THR A 860GLY A 861MET A 862 | None | 1.13A | 4zjlA-3w9hA:59.1 | 4zjlA-3w9hA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 6 | SER A 79SER A 133GLU A 683THR A 860GLY A 861MET A 862 | None | 1.03A | 4zjlA-3w9hA:59.1 | 4zjlA-3w9hA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 9 | SER A 79SER A 135MET A 573PHE A 615GLU A 683LEU A 828THR A 860GLY A 861MET A 862 | None | 0.86A | 4zjlA-3w9hA:59.1 | 4zjlA-3w9hA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 5 | SER A 79MET A 626LEU A 827THR A 859GLY A 860 | None | 1.05A | 4zjlA-3w9iA:52.1 | 4zjlA-3w9iA:69.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zu4 | PUTATIVE REDUCTASEYPO4104/Y4119/YP_4011 (Yersinia pestis) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 5 | SER A 86SER A 280GLU A 75THR A 51GLY A 52 | NoneNoneNAI A1400 (-3.7A)NAI A1400 ( 3.6A)NAI A1400 (-3.5A) | 1.43A | 4zjlA-3zu4A:undetectable | 4zjlA-3zu4A:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ar9 | COLLAGENASE COLT (Clostridiumtetani) |
PF01752(Peptidase_M9) | 5 | SER A 653PHE A 467GLU A 651THR A 658GLY A 725 | None | 1.38A | 4zjlA-4ar9A:3.4 | 4zjlA-4ar9A:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3k | BETA-GLUCOSIDASE (Streptococcuspyogenes) |
PF00232(Glyco_hydro_1) | 5 | SER A 314PHE A 243GLU A 171LEU A 269GLY A 186 | None | 1.29A | 4zjlA-4b3kA:undetectable | 4zjlA-4b3kA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqn | PUTATIVEBRANCHED-CHAIN AMINOACIDAMINOTRANSFERASEILVE (Streptococcusmutans) |
PF01063(Aminotran_4) | 5 | PHE A 149PHE A 57LEU A 244THR A 248GLY A 284 | None | 1.49A | 4zjlA-4dqnA:undetectable | 4zjlA-4dqnA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxq | PUTATIVEADP-RIBOSYLTRANSFERASE CERTHRAX (Bacillus cereus) |
PF03496(ADPrib_exo_Tox)PF07737(ATLF) | 5 | SER A 331PHE A 440LEU A 244THR A 260GLY A 257 | None | 1.34A | 4zjlA-4fxqA:undetectable | 4zjlA-4fxqA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhz | BETA-GLUCURONIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | SER A 50SER A 329LEU A 138THR A 92GLY A 110 | None | 1.32A | 4zjlA-4jhzA:undetectable | 4zjlA-4jhzA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jkl | BETA-GLUCURONIDASE (Streptococcusagalactiae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | SER A 43SER A 328LEU A 131THR A 85GLY A 103 | None | 1.33A | 4zjlA-4jklA:undetectable | 4zjlA-4jklA:21.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mt1 | DRUG EFFLUX PROTEIN (Neisseriagonorrhoeae) |
PF00873(ACR_tran) | 5 | SER A 79MET A 570PHE A 610PHE A 612GLY A 857 | None | 1.21A | 4zjlA-4mt1A:50.8 | 4zjlA-4mt1A:49.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8m | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Actinobacillussuccinogenes) |
PF03480(DctP) | 5 | SER A 301MET A 96PHE A 310GLU A 209GLY A 186 | None | 1.41A | 4zjlA-4o8mA:undetectable | 4zjlA-4o8mA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6g | PYRROLYSINE--TRNALIGASE (Methanosarcinamazei) |
PF01409(tRNA-synt_2d) | 5 | PHE A 366GLU A 261GLU A 425THR A 343GLY A 326 | None | 1.34A | 4zjlA-4q6gA:1.6 | 4zjlA-4q6gA:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woq | N-ACETYLNEURAMINATELYASE (Clostridioidesdifficile) |
PF00701(DHDPS) | 5 | SER A 158PHE A 191PHE A 176THR A 153GLY A 154 | None | 1.49A | 4zjlA-4woqA:undetectable | 4zjlA-4woqA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsb | POLYMERASE PB2 (Influenza Avirus) |
PF00604(Flu_PB2) | 5 | SER C 653SER C 688PHE C 600PHE C 595GLY C 727 | None | 1.44A | 4zjlA-4wsbC:undetectable | 4zjlA-4wsbC:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xox | 3-OXOACYL-ACPSYNTHASE (Vibrio cholerae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | SER A 156SER A 109GLU A 190THR A 163GLY A 333 | None | 1.40A | 4zjlA-4xoxA:undetectable | 4zjlA-4xoxA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zz7 | METHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Oceanimonasdoudoroffii) |
PF00171(Aldedh) | 5 | SER A 284PHE A 148PHE A 150GLY A 411MET A 433 | NoneNAD A 501 (-4.1A)NoneNoneNone | 1.47A | 4zjlA-4zz7A:undetectable | 4zjlA-4zz7A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7i | CRISPR-ASSOCIATEDNUCLEASE/HELICASECAS3 SUBTYPEI-F/YPEST (Pseudomonasaeruginosa) |
no annotation | 5 | PHE A 973GLU A 779LEU A 772THR A 459GLY A 460 | None | 1.16A | 4zjlA-5b7iA:undetectable | 4zjlA-5b7iA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bop | NANOBODYOCTARELLIN V.1 (Lama glama;syntheticconstruct) |
PF07686(V-set)no annotation | 5 | PHE A 37GLU B 146GLU B 119LEU A 102GLY B 141 | None | 1.27A | 4zjlA-5bopA:undetectable | 4zjlA-5bopA:9.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eno | MULTIDRUG EFFLUXPUMP SUBUNITACRB,MULTIDRUGEFFLUX PUMP SUBUNITACRB (Escherichiacoli) |
PF00873(ACR_tran) | 7 | SER A 79MET A 575GLU A 683LEU A 828THR A 860GLY A 861MET A 862 | None | 0.86A | 4zjlA-5enoA:47.0 | 4zjlA-5enoA:73.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eno | MULTIDRUG EFFLUXPUMP SUBUNITACRB,MULTIDRUGEFFLUX PUMP SUBUNITACRB (Escherichiacoli) |
PF00873(ACR_tran) | 6 | SER A 79SER A 133GLU A 683THR A 860GLY A 861MET A 862 | None | 1.08A | 4zjlA-5enoA:47.0 | 4zjlA-5enoA:73.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eno | MULTIDRUG EFFLUXPUMP SUBUNITACRB,MULTIDRUGEFFLUX PUMP SUBUNITACRB (Escherichiacoli) |
PF00873(ACR_tran) | 9 | SER A 79SER A 135MET A 573PHE A 615GLU A 683LEU A 828THR A 860GLY A 861MET A 862 | None | 0.80A | 4zjlA-5enoA:47.0 | 4zjlA-5enoA:73.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ep8 | PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (Bacillussubtilis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | SER A 347GLU A 348GLU A 211THR A 202GLY A 203 | SER A 347 ( 0.0A)GLU A 348 ( 0.6A)GLU A 211 ( 0.6A)THR A 202 ( 0.8A)GLY A 203 ( 0.0A) | 1.45A | 4zjlA-5ep8A:undetectable | 4zjlA-5ep8A:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgn | LIPOOLIGOSACCHARIDEPHOSPHOETHANOLAMINETRANSFERASE A (Neisseriameningitidis) |
PF00884(Sulfatase)PF08019(DUF1705) | 5 | SER A 325SER A 102GLU A 298GLU A 322GLY A 329 | LMT A 602 (-3.3A)NoneNoneNoneNone | 1.46A | 4zjlA-5fgnA:undetectable | 4zjlA-5fgnA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | DNA DAMAGE-BINDINGPROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | SER A1011GLU A1002LEU A 974THR A1032GLY A1031 | None | 1.40A | 4zjlA-5fqdA:undetectable | 4zjlA-5fqdA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdj | NFRA1 (Bacillusmegaterium) |
PF00881(Nitroreductase) | 5 | PHE A 159PHE A 77LEU A 22GLY A 129MET A 128 | FMN A 400 ( 4.6A)NoneNoneNoneNone | 1.33A | 4zjlA-5hdjA:undetectable | 4zjlA-5hdjA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihr | PROBABLEBETA-GALACTOSIDASE A (Aspergillusniger) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | SER A 751SER A 361MET A 343GLU A 803GLY A 801 | None | 1.41A | 4zjlA-5ihrA:undetectable | 4zjlA-5ihrA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k04 | UNCHARACTERIZEDPROTEINN-TERMINALACETYLTRANSFERASE BCOMPLEX SUBUNIT NAT3 (Candidaalbicans;Candidaalbicans) |
PF09797(NatB_MDM20)PF08445(FR47) | 5 | SER A 115PHE A 128PHE A 121GLU A 117GLU B 10 | None | 1.19A | 4zjlA-5k04A:undetectable | 4zjlA-5k04A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kni | TANKYRASE-1 (Homo sapiens) |
PF07647(SAM_2) | 5 | SER A1037MET A1029PHE A1047LEU A1065GLY A1074 | None | 1.11A | 4zjlA-5kniA:undetectable | 4zjlA-5kniA:5.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m42 | PROLINEDEHYDROGENASE (Thermusthermophilus) |
PF01619(Pro_dh) | 5 | PHE A 253PHE A 224LEU A 216GLY A 243MET A 242 | None | 1.23A | 4zjlA-5m42A:undetectable | 4zjlA-5m42A:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 5 | SER B 178GLU B 183GLU B 71THR B 145GLY B 144 | NoneNoneNoneG2P B 501 (-3.2A)G2P B 501 ( 4.6A) | 1.24A | 4zjlA-5n5nB:undetectable | 4zjlA-5n5nB:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o7e | COLH PROTEIN (Hathewayahistolytica) |
no annotation | 5 | SER A 643PHE A 435GLU A 376THR A 648GLY A 715 | None | 1.28A | 4zjlA-5o7eA:2.4 | 4zjlA-5o7eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 5 | SER B 603PHE B 317PHE B 272THR B 14GLY B 13 | None | 1.48A | 4zjlA-5swiB:undetectable | 4zjlA-5swiB:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d2l | HISTONE-ARGININEMETHYLTRANSFERASECARM1 (Homo sapiens) |
no annotation | 5 | PHE A 335PHE A 422LEU A 434THR A 459GLY A 460 | None | 1.33A | 4zjlA-6d2lA:undetectable | 4zjlA-6d2lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6em0 | 2-HYDROXYBIPHENYL-3-MONOOXYGENASE (Pseudomonasnitroreducens) |
no annotation | 5 | SER A 129PHE A 140GLU A 130LEU A 118THR A 54 | None | 1.47A | 4zjlA-6em0A:undetectable | 4zjlA-6em0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 4 | ASN A 118SER A 36ASP A 77GLU A 111 | None | 1.48A | 4zjlA-1izeA:0.4 | 4zjlA-1izeA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a62 | CADHERIN-8 (Mus musculus) |
PF00028(Cadherin) | 4 | ASN A 247SER A 307ASP A 172GLU A 117 | NoneNone CA A 328 ( 4.9A) CA A 328 ( 2.6A) | 1.46A | 4zjlA-2a62A:0.0 | 4zjlA-2a62A:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xf2 | CATALASE (Penicilliumjanthinellum) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | ASN A 489SER A 496ASP A 461GLU A 457 | None | 1.28A | 4zjlA-2xf2A:1.3 | 4zjlA-2xf2A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhu | ALPHA-AMYLASE (Lactobacillusplantarum) |
PF00128(Alpha-amylase) | 4 | ASN A 278SER A 16ASP A 171GLU A 200 | None | 1.47A | 4zjlA-3dhuA:0.0 | 4zjlA-3dhuA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q75 | FARNESYLTRANSFERASEBETA SUBUNIT (Cryptococcusneoformans) |
PF00432(Prenyltrans) | 4 | ASN B 376SER B 14ASP B 46GLU B 382 | None | 1.33A | 4zjlA-3q75B:0.0 | 4zjlA-3q75B:19.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 5 | ASN A 81SER A 134LYS A 292ASP A 681GLU A 826 | None | 0.79A | 4zjlA-3w9hA:59.1 | 4zjlA-3w9hA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eze | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Salmonellaenterica) |
PF12710(HAD) | 4 | ASN A 251SER A 133ASP A 104GLU A 101 | None | 1.29A | 4zjlA-4ezeA:3.5 | 4zjlA-4ezeA:15.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eno | MULTIDRUG EFFLUXPUMP SUBUNITACRB,MULTIDRUGEFFLUX PUMP SUBUNITACRB (Escherichiacoli) |
PF00873(ACR_tran) | 4 | ASN A 81LYS A 292ASP A 681GLU A 826 | None | 0.56A | 4zjlA-5enoA:47.0 | 4zjlA-5enoA:73.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eno | MULTIDRUG EFFLUXPUMP SUBUNITACRB,MULTIDRUGEFFLUX PUMP SUBUNITACRB (Escherichiacoli) |
PF00873(ACR_tran) | 4 | SER A 134LYS A 292ASP A 681GLU A 826 | None | 0.65A | 4zjlA-5enoA:47.0 | 4zjlA-5enoA:73.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocd | - (-) |
no annotation | 4 | ASN A 147SER A 199ASP A 64GLU A 180 | None | 1.23A | 4zjlA-5ocdA:0.0 | 4zjlA-5ocdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opj | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | ASN A 345SER A 96ASP A 227GLU A 223 | None | 1.10A | 4zjlA-5opjA:0.0 | 4zjlA-5opjA:undetectable |