SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJ8_A_SUVA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 256
VAL A  96
VAL A  15
GLU A 314
ASN A 316
 None
 1.41A 4zj8A-1dm3A:
undetectable		 4zj8A-1dm3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ALA A 175
SER A 176
VAL A 257
GLN A  33
PHE A   5
 ACR  A 598 (-3.7A)
None
None
None
None
 1.28A 4zj8A-1kxhA:
undetectable		 4zj8A-1kxhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7s H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ALA A 153
GLN A 114
VAL A  97
PHE A  74
ASN A  70
 None
 1.42A 4zj8A-1s7sA:
undetectable		 4zj8A-1s7sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 ALA A 245
SER A 244
VAL A 344
VAL A 157
HIS A 492
 None
 1.50A 4zj8A-1thgA:
0.8		 4zj8A-1thgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		5 ALA A  30
VAL A  37
GLN A  24
MET A  63
GLU A  19
 None
 1.47A 4zj8A-1yloA:
3.4		 4zj8A-1yloA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 VAL A 682
VAL A 565
GLN A 645
GLU A 665
ASN A 457
 None
None
GAL  A 700 (-4.0A)
GAL  A 700 (-2.7A)
GAL  A 700 (-3.6A)
 1.41A 4zj8A-1z45A:
6.0		 4zj8A-1z45A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		5 ALA A 175
SER A 174
VAL A 172
VAL A 128
TYR A 282
 None
 1.29A 4zj8A-2anpA:
undetectable		 4zj8A-2anpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ALA A 676
VAL A 678
VAL A 352
GLU A 486
PHE A 479
 None
 1.27A 4zj8A-2c11A:
undetectable		 4zj8A-2c11A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 ALA A  18
VAL A 221
GLU A 253
HIS A 180
TYR A 176
 None
 1.39A 4zj8A-2cjeA:
2.4		 4zj8A-2cjeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 SER B 564
GLN B 522
VAL B 474
GLN B 593
TYR B 524
 None
 1.45A 4zj8A-2o8eB:
3.6		 4zj8A-2o8eB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 VAL A 156
GLN A 160
PHE A 308
ASN A 304
HIS A 217
 None
None
None
None
ZN  A 501 (-3.5A)
 1.50A 4zj8A-2qt3A:
undetectable		 4zj8A-2qt3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 SER A 635
VAL A 634
GLU A 144
HIS A 657
TYR A 621
 None
 1.08A 4zj8A-2x40A:
undetectable		 4zj8A-2x40A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ALA A 220
SER A 219
GLN A 247
MET A 249
GLU A 259
 None
 1.48A 4zj8A-3dlaA:
undetectable		 4zj8A-3dlaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 ALA A  21
GLN A  88
GLU A  50
HIS A  23
TYR A 297
 None
 1.34A 4zj8A-3emqA:
undetectable		 4zj8A-3emqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 ALA B 410
VAL B 436
GLU B 291
PHE B 273
TYR B 404
 None
 1.47A 4zj8A-3h32B:
undetectable		 4zj8A-3h32B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 SER A  86
GLN A  21
PHE A 409
ASN A 484
HIS A   7
 None
 1.33A 4zj8A-3h7lA:
undetectable		 4zj8A-3h7lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF13419
(HAD_2) 		5 ALA A 118
SER A 119
GLN A  79
VAL A  75
GLU A  84
 None
CL  A 232 (-3.4A)
None
None
None
 1.29A 4zj8A-3l5kA:
undetectable		 4zj8A-3l5kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A  80
SER A  84
GLU A  93
PHE A 126
TYR A 363
 None
None
None
FAD  A 400 ( 4.7A)
None
 1.19A 4zj8A-3mpiA:
4.5		 4zj8A-3mpiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  87
GLN A 159
GLU A 155
ASN A 110
TYR A 309
 LLP  A 185 ( 3.6A)
LLP  A 185 ( 3.6A)
None
None
None
 1.33A 4zj8A-3nu8A:
undetectable		 4zj8A-3nu8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 5 SER A  95
VAL A 120
VAL A   9
MET A  24
HIS A  91
 None
None
None
None
CA  A 501 (-3.5A)
 1.40A 4zj8A-3s4lA:
undetectable		 4zj8A-3s4lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 ALA A 148
VAL A 146
VAL A 199
PHE A 233
TYR A 171
 None
 1.44A 4zj8A-4effA:
2.3		 4zj8A-4effA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ALA A 273
VAL A 293
VAL A 249
MET A 260
PHE A 223
 None
None
None
None
AW2  A 502 (-3.4A)
 1.23A 4zj8A-4er6A:
4.2		 4zj8A-4er6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		5 ALA A  47
VAL A  53
VAL A  98
GLN A 217
PHE A 128
 None
 1.49A 4zj8A-4guzA:
undetectable		 4zj8A-4guzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 VAL A 176
GLN A 211
PHE A 209
HIS A 103
TYR A 105
 None
CR2  A  58 ( 3.4A)
CR2  A  58 ( 4.6A)
None
CR2  A  58 ( 4.6A)
 1.31A 4zj8A-4jgeA:
undetectable		 4zj8A-4jgeA:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		11 ALA A 110
VAL A 114
GLN A 134
VAL A 138
GLN A 187
MET A 191
GLU A 212
PHE A 227
ASN A 324
HIS A 350
TYR A 354
 SUV  A2001 ( 4.2A)
SUV  A2001 (-4.6A)
SUV  A2001 (-3.5A)
None
SUV  A2001 (-3.6A)
SUV  A2001 ( 4.6A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.5A)
SUV  A2001 (-3.0A)
SUV  A2001 ( 3.7A)
None
 0.52A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Geobacillus
kaustophilus) 		PF01680
(SOR_SNZ) 		5 ALA A 191
VAL A 193
GLN A 188
MET A 177
GLU A 181
 None
 1.35A 4zj8A-4wxzA:
undetectable		 4zj8A-4wxzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 ALA B  93
SER B  94
VAL B 105
VAL B 378
GLU B  84
 None
 1.26A 4zj8A-5c2vB:
undetectable		 4zj8A-5c2vB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 123
VAL A 127
VAL A 106
GLN A 185
PHE A 289
 None
 1.34A 4zj8A-5d6bA:
4.2		 4zj8A-5d6bA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ALA A 273
VAL A 293
VAL A 249
MET A 260
PHE A 223
 None
 1.23A 4zj8A-5dtrA:
4.1		 4zj8A-5dtrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 ALA B 295
SER B 296
VAL B 269
GLU B 277
PHE B  42
 None
 1.06A 4zj8A-5fbhB:
4.4		 4zj8A-5fbhB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 SER A 505
VAL A 199
MET A 547
PHE A 452
HIS A 507
 None
 1.47A 4zj8A-5hqnA:
undetectable		 4zj8A-5hqnA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 172
SER A 175
VAL A 174
GLN A 144
TYR A   2
 None
 1.43A 4zj8A-5loxA:
undetectable		 4zj8A-5loxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loy DESIGNED ANBU
PROTEIN

(synthetic
construct) 		PF00227
(Proteasome) 		5 ALA A 173
SER A 176
VAL A 175
GLN A 145
TYR A   2
 None
 1.46A 4zj8A-5loyA:
undetectable		 4zj8A-5loyA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 ALA F 202
VAL F 199
VAL F  89
GLU F 193
PHE F 152
 None
 1.47A 4zj8A-5mmiF:
undetectable		 4zj8A-5mmiF:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 ALA F 202
VAL F 199
VAL F 207
GLU F 193
PHE F 152
 None
 1.39A 4zj8A-5mmiF:
undetectable		 4zj8A-5mmiF:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ALA A 575
VAL A 406
GLN A 689
GLU A 320
HIS A 585
 None
None
AHR  A 901 (-3.6A)
AHR  A 901 (-2.7A)
None
 1.42A 4zj8A-5opjA:
undetectable		 4zj8A-5opjA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 158
VAL A 168
GLN A  86
GLU A  90
TYR A 416
 None
 1.26A 4zj8A-5u7qA:
undetectable		 4zj8A-5u7qA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 5 ALA A 236
SER A 235
VAL A 232
GLN A 325
TYR A 360
 None
 1.29A 4zj8A-5wm4A:
2.4		 4zj8A-5wm4A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5q DCN1-LIKE PROTEIN 1

(Homo sapiens) 		no annotation 5 ALA A  98
VAL A 102
GLN A 114
GLU A 121
TYR A 181
 None
 1.49A 4zj8A-6b5qA:
undetectable		 4zj8A-6b5qA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 5 ALA C  90
VAL C 340
GLN C 286
GLN C 290
GLU C 291
 None
 1.35A 4zj8A-6gbhC:
3.8		 4zj8A-6gbhC:
10.16