SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZJ8_A_SUVA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 256
VAL A  96
VAL A  15
GLU A 314
ASN A 316
 None
 1.41A 4zj8A-1dm3A:
undetectable		 4zj8A-1dm3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ALA A 175
SER A 176
VAL A 257
GLN A  33
PHE A   5
 ACR  A 598 (-3.7A)
None
None
None
None
 1.28A 4zj8A-1kxhA:
undetectable		 4zj8A-1kxhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7s H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ALA A 153
GLN A 114
VAL A  97
PHE A  74
ASN A  70
 None
 1.42A 4zj8A-1s7sA:
undetectable		 4zj8A-1s7sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 ALA A 245
SER A 244
VAL A 344
VAL A 157
HIS A 492
 None
 1.50A 4zj8A-1thgA:
0.8		 4zj8A-1thgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		5 ALA A  30
VAL A  37
GLN A  24
MET A  63
GLU A  19
 None
 1.47A 4zj8A-1yloA:
3.4		 4zj8A-1yloA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 VAL A 682
VAL A 565
GLN A 645
GLU A 665
ASN A 457
 None
None
GAL  A 700 (-4.0A)
GAL  A 700 (-2.7A)
GAL  A 700 (-3.6A)
 1.41A 4zj8A-1z45A:
6.0		 4zj8A-1z45A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		5 ALA A 175
SER A 174
VAL A 172
VAL A 128
TYR A 282
 None
 1.29A 4zj8A-2anpA:
undetectable		 4zj8A-2anpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ALA A 676
VAL A 678
VAL A 352
GLU A 486
PHE A 479
 None
 1.27A 4zj8A-2c11A:
undetectable		 4zj8A-2c11A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 ALA A  18
VAL A 221
GLU A 253
HIS A 180
TYR A 176
 None
 1.39A 4zj8A-2cjeA:
2.4		 4zj8A-2cjeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 SER B 564
GLN B 522
VAL B 474
GLN B 593
TYR B 524
 None
 1.45A 4zj8A-2o8eB:
3.6		 4zj8A-2o8eB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 VAL A 156
GLN A 160
PHE A 308
ASN A 304
HIS A 217
 None
None
None
None
ZN  A 501 (-3.5A)
 1.50A 4zj8A-2qt3A:
undetectable		 4zj8A-2qt3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 SER A 635
VAL A 634
GLU A 144
HIS A 657
TYR A 621
 None
 1.08A 4zj8A-2x40A:
undetectable		 4zj8A-2x40A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ALA A 220
SER A 219
GLN A 247
MET A 249
GLU A 259
 None
 1.48A 4zj8A-3dlaA:
undetectable		 4zj8A-3dlaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 ALA A  21
GLN A  88
GLU A  50
HIS A  23
TYR A 297
 None
 1.34A 4zj8A-3emqA:
undetectable		 4zj8A-3emqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 ALA B 410
VAL B 436
GLU B 291
PHE B 273
TYR B 404
 None
 1.47A 4zj8A-3h32B:
undetectable		 4zj8A-3h32B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 SER A  86
GLN A  21
PHE A 409
ASN A 484
HIS A   7
 None
 1.33A 4zj8A-3h7lA:
undetectable		 4zj8A-3h7lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF13419
(HAD_2) 		5 ALA A 118
SER A 119
GLN A  79
VAL A  75
GLU A  84
 None
CL  A 232 (-3.4A)
None
None
None
 1.29A 4zj8A-3l5kA:
undetectable		 4zj8A-3l5kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A  80
SER A  84
GLU A  93
PHE A 126
TYR A 363
 None
None
None
FAD  A 400 ( 4.7A)
None
 1.19A 4zj8A-3mpiA:
4.5		 4zj8A-3mpiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  87
GLN A 159
GLU A 155
ASN A 110
TYR A 309
 LLP  A 185 ( 3.6A)
LLP  A 185 ( 3.6A)
None
None
None
 1.33A 4zj8A-3nu8A:
undetectable		 4zj8A-3nu8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 5 SER A  95
VAL A 120
VAL A   9
MET A  24
HIS A  91
 None
None
None
None
CA  A 501 (-3.5A)
 1.40A 4zj8A-3s4lA:
undetectable		 4zj8A-3s4lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 ALA A 148
VAL A 146
VAL A 199
PHE A 233
TYR A 171
 None
 1.44A 4zj8A-4effA:
2.3		 4zj8A-4effA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ALA A 273
VAL A 293
VAL A 249
MET A 260
PHE A 223
 None
None
None
None
AW2  A 502 (-3.4A)
 1.23A 4zj8A-4er6A:
4.2		 4zj8A-4er6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		5 ALA A  47
VAL A  53
VAL A  98
GLN A 217
PHE A 128
 None
 1.49A 4zj8A-4guzA:
undetectable		 4zj8A-4guzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 VAL A 176
GLN A 211
PHE A 209
HIS A 103
TYR A 105
 None
CR2  A  58 ( 3.4A)
CR2  A  58 ( 4.6A)
None
CR2  A  58 ( 4.6A)
 1.31A 4zj8A-4jgeA:
undetectable		 4zj8A-4jgeA:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		11 ALA A 110
VAL A 114
GLN A 134
VAL A 138
GLN A 187
MET A 191
GLU A 212
PHE A 227
ASN A 324
HIS A 350
TYR A 354
 SUV  A2001 ( 4.2A)
SUV  A2001 (-4.6A)
SUV  A2001 (-3.5A)
None
SUV  A2001 (-3.6A)
SUV  A2001 ( 4.6A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.5A)
SUV  A2001 (-3.0A)
SUV  A2001 ( 3.7A)
None
 0.52A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Geobacillus
kaustophilus) 		PF01680
(SOR_SNZ) 		5 ALA A 191
VAL A 193
GLN A 188
MET A 177
GLU A 181
 None
 1.35A 4zj8A-4wxzA:
undetectable		 4zj8A-4wxzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 ALA B  93
SER B  94
VAL B 105
VAL B 378
GLU B  84
 None
 1.26A 4zj8A-5c2vB:
undetectable		 4zj8A-5c2vB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 123
VAL A 127
VAL A 106
GLN A 185
PHE A 289
 None
 1.34A 4zj8A-5d6bA:
4.2		 4zj8A-5d6bA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ALA A 273
VAL A 293
VAL A 249
MET A 260
PHE A 223
 None
 1.23A 4zj8A-5dtrA:
4.1		 4zj8A-5dtrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 ALA B 295
SER B 296
VAL B 269
GLU B 277
PHE B  42
 None
 1.06A 4zj8A-5fbhB:
4.4		 4zj8A-5fbhB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 SER A 505
VAL A 199
MET A 547
PHE A 452
HIS A 507
 None
 1.47A 4zj8A-5hqnA:
undetectable		 4zj8A-5hqnA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 172
SER A 175
VAL A 174
GLN A 144
TYR A   2
 None
 1.43A 4zj8A-5loxA:
undetectable		 4zj8A-5loxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loy DESIGNED ANBU
PROTEIN

(synthetic
construct) 		PF00227
(Proteasome) 		5 ALA A 173
SER A 176
VAL A 175
GLN A 145
TYR A   2
 None
 1.46A 4zj8A-5loyA:
undetectable		 4zj8A-5loyA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 ALA F 202
VAL F 199
VAL F  89
GLU F 193
PHE F 152
 None
 1.47A 4zj8A-5mmiF:
undetectable		 4zj8A-5mmiF:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 ALA F 202
VAL F 199
VAL F 207
GLU F 193
PHE F 152
 None
 1.39A 4zj8A-5mmiF:
undetectable		 4zj8A-5mmiF:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ALA A 575
VAL A 406
GLN A 689
GLU A 320
HIS A 585
 None
None
AHR  A 901 (-3.6A)
AHR  A 901 (-2.7A)
None
 1.42A 4zj8A-5opjA:
undetectable		 4zj8A-5opjA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 158
VAL A 168
GLN A  86
GLU A  90
TYR A 416
 None
 1.26A 4zj8A-5u7qA:
undetectable		 4zj8A-5u7qA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 5 ALA A 236
SER A 235
VAL A 232
GLN A 325
TYR A 360
 None
 1.29A 4zj8A-5wm4A:
2.4		 4zj8A-5wm4A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5q DCN1-LIKE PROTEIN 1

(Homo sapiens) 		no annotation 5 ALA A  98
VAL A 102
GLN A 114
GLU A 121
TYR A 181
 None
 1.49A 4zj8A-6b5qA:
undetectable		 4zj8A-6b5qA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 5 ALA C  90
VAL C 340
GLN C 286
GLN C 290
GLU C 291
 None
 1.35A 4zj8A-6gbhC:
3.8		 4zj8A-6gbhC:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ILE A 192
PRO A 221
ILE A  16
VAL A  93
 NAI  A 302 (-4.1A)
None
None
None
 1.00A 4zj8A-1ahiA:
6.1		 4zj8A-1ahiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		4 ILE A 113
PRO A 114
ILE A 125
VAL A 124
 None
 0.72A 4zj8A-1cbkA:
undetectable		 4zj8A-1cbkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gji C-REL PROTO-ONCOGENE
PROTEIN

(Gallus gallus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 TRP A 224
PRO A 246
ILE A 205
VAL A 190
 None
 0.93A 4zj8A-1gjiA:
undetectable		 4zj8A-1gjiA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		4 TRP A  62
ILE A  50
ILE A 155
VAL A  77
 None
 0.93A 4zj8A-1ii2A:
undetectable		 4zj8A-1ii2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ILE A  31
HIS A  39
ILE A  41
VAL A  21
 None
 0.99A 4zj8A-1ksiA:
undetectable		 4zj8A-1ksiA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 TRP A 678
ILE A 533
ILE A 497
VAL A 460
 None
 0.98A 4zj8A-1q3xA:
undetectable		 4zj8A-1q3xA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		4 ILE A  64
PRO A  65
ILE A  13
VAL A 163
 None
 1.01A 4zj8A-1qnhA:
undetectable		 4zj8A-1qnhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ILE A 181
PRO A 209
ILE A  10
VAL A  82
 None
 0.96A 4zj8A-1ulsA:
4.9		 4zj8A-1ulsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		4 ILE A 190
PRO A 219
ILE A  11
VAL A  87
 NAI  A1270 (-4.6A)
None
None
None
 1.01A 4zj8A-1zjyA:
5.3		 4zj8A-1zjyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 TRP A 334
ILE A 345
ILE A 211
VAL A 189
 None
 0.93A 4zj8A-2ac5A:
undetectable		 4zj8A-2ac5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 ILE A 169
PRO A 171
HIS A 179
ILE A 151
 None
 0.98A 4zj8A-2aynA:
undetectable		 4zj8A-2aynA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Schistosoma
mansoni) 		PF00160
(Pro_isomerase) 		4 ILE A  64
PRO A  65
ILE A  19
VAL A 163
 None
 0.99A 4zj8A-2cmtA:
undetectable		 4zj8A-2cmtA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3u HYPOTHETICAL PROTEIN
PH1566

(Pyrococcus
horikoshii) 		PF00013
(KH_1) 		4 ILE A 128
HIS A 194
ILE A 144
VAL A 164
 None
 0.99A 4zj8A-2e3uA:
undetectable		 4zj8A-2e3uA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		4 ILE A 203
PRO A 204
HIS A   9
ILE A  53
 None
None
MN  A 402 (-3.5A)
None
 0.96A 4zj8A-2f6kA:
undetectable		 4zj8A-2f6kA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fei CD2-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF14604
(SH3_9) 		4 ILE A  11
PRO A  12
ILE A  26
VAL A   6
 None
 0.91A 4zj8A-2feiA:
undetectable		 4zj8A-2feiA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fei CD2-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF14604
(SH3_9) 		4 ILE A  11
PRO A  12
ILE A  26
VAL A  53
 None
 1.01A 4zj8A-2feiA:
undetectable		 4zj8A-2feiA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzl DNA REPAIR PROTEIN
RAD25, XPB

(Archaeoglobus
fulgidus) 		PF16203
(ERCC3_RAD25_C) 		4 ILE A 418
HIS A 376
ILE A 408
VAL A 410
 None
 0.93A 4zj8A-2fzlA:
3.0		 4zj8A-2fzlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TRP A 299
ILE A 310
ILE A 176
VAL A 154
 None
 0.97A 4zj8A-2hw6A:
2.3		 4zj8A-2hw6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		4 ILE A 229
PRO A 230
ILE A 207
VAL A 219
 None
 0.96A 4zj8A-2i0sA:
undetectable		 4zj8A-2i0sA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5

(Arabidopsis
thaliana) 		PF00071
(Ras) 		4 ILE C 154
PRO C 153
ILE C 101
VAL C  96
 None
 1.00A 4zj8A-2ntyC:
4.4		 4zj8A-2ntyC:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE

(Pyrococcus
furiosus) 		PF10120
(ThiP_synth) 		4 ILE A 292
PRO A 293
HIS A 423
ILE A 369
 None
 0.98A 4zj8A-2pb9A:
undetectable		 4zj8A-2pb9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ILE A 185
PRO A 213
ILE A   6
VAL A  85
 None
 0.98A 4zj8A-2ph3A:
6.1		 4zj8A-2ph3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Cryptosporidium
parvum) 		PF00160
(Pro_isomerase) 		4 ILE A  80
PRO A  81
ILE A  28
VAL A 179
 None
 0.97A 4zj8A-2poyA:
undetectable		 4zj8A-2poyA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 ILE A 571
HIS A 581
ILE A 525
VAL A 547
 None
 0.98A 4zj8A-2v26A:
2.1		 4zj8A-2v26A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		4 ILE A 144
PRO A 136
ILE A 151
VAL A 102
 None
 1.00A 4zj8A-2xhcA:
undetectable		 4zj8A-2xhcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		4 ILE A 190
PRO A 230
ILE A  12
VAL A  90
 NDP  A 270 (-4.3A)
None
None
None
 1.00A 4zj8A-3ai2A:
6.0		 4zj8A-3ai2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		4 TRP A  66
ILE A  39
ILE A  85
VAL A  17
 GAL  A 133 (-3.7A)
None
None
None
 0.93A 4zj8A-3ajzA:
undetectable		 4zj8A-3ajzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ILE A 227
HIS A  10
ILE A  48
VAL A  46
 None
 0.91A 4zj8A-3anxA:
undetectable		 4zj8A-3anxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 297
PRO A 298
ILE A 264
VAL A 266
 None
NAD  A 818 (-4.0A)
None
None
 0.81A 4zj8A-3cgdA:
4.2		 4zj8A-3cgdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		4 ILE A  71
PRO A  72
ILE A 281
VAL A 284
 None
 0.89A 4zj8A-3e9mA:
7.3		 4zj8A-3e9mA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		4 ILE A 181
PRO A 209
ILE A  11
VAL A  81
 None
 0.95A 4zj8A-3f9iA:
6.0		 4zj8A-3f9iA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 407
PRO A 408
HIS A 258
ILE A 339
 None
 0.85A 4zj8A-3gdeA:
undetectable		 4zj8A-3gdeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		4 TRP A 221
ILE A  91
ILE A  54
VAL A  18
 None
 0.82A 4zj8A-3h7oA:
undetectable		 4zj8A-3h7oA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		4 TRP A 221
ILE A  91
ILE A  56
VAL A  16
 None
 0.90A 4zj8A-3h7oA:
undetectable		 4zj8A-3h7oA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 TRP A 140
ILE A 175
HIS A  20
VAL A 117
 None
 0.86A 4zj8A-3htzA:
3.0		 4zj8A-3htzA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		4 PRO A 299
HIS A 220
ILE A  47
VAL A  75
 None
 0.83A 4zj8A-3ipwA:
undetectable		 4zj8A-3ipwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 TRP A1478
PRO A 971
ILE A1254
VAL A1219
 None
 0.94A 4zj8A-3jb9A:
undetectable		 4zj8A-3jb9A:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		4 ILE A 134
HIS A 171
ILE A 203
VAL A 207
 None
 0.90A 4zj8A-3k4hA:
5.9		 4zj8A-3k4hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A   5
HIS A 234
ILE A 243
VAL A 218
 None
 0.94A 4zj8A-3komA:
undetectable		 4zj8A-3komA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE A  72
HIS A 109
ILE A  92
VAL A   2
 None
 1.01A 4zj8A-3pymA:
7.3		 4zj8A-3pymA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1o ODORANT BINDING
PROTEIN, ANTENNAL

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		4 ILE A 118
HIS A  18
ILE A  50
VAL A 107
 None
None
PLM  A 128 ( 4.9A)
PLM  A 128 ( 4.7A)
 0.96A 4zj8A-3r1oA:
undetectable		 4zj8A-3r1oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA

(Daboia
siamensis) 		PF00089
(Trypsin) 		4 TRP A 237
ILE A 103
ILE A  66
VAL A  31
 None
 0.99A 4zj8A-3s9bA:
undetectable		 4zj8A-3s9bA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tju GRANZYME H

(Homo sapiens) 		PF00089
(Trypsin) 		4 TRP A 233
ILE A 104
ILE A  65
VAL A  33
 None
 0.86A 4zj8A-3tjuA:
undetectable		 4zj8A-3tjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw1 BAMBL LECTIN

(Burkholderia
ambifaria) 		PF07938
(Fungal_lectin) 		4 TRP A  34
ILE A  14
ILE A  24
VAL A  46
 None
 0.94A 4zj8A-3zw1A:
undetectable		 4zj8A-3zw1A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 ILE A 571
HIS A 581
ILE A 525
VAL A 547
 None
 1.00A 4zj8A-4anjA:
3.6		 4zj8A-4anjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		5 ILE A  66
PRO A  67
HIS A 106
ILE A 127
VAL A 145
 None
 1.49A 4zj8A-4bzgA:
undetectable		 4zj8A-4bzgA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 ILE A 192
PRO A 193
ILE A 151
VAL A 397
 None
 0.85A 4zj8A-4cp8A:
undetectable		 4zj8A-4cp8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csd FUCOSE-BINDING
LECTIN PROTEIN

(Ralstonia
solanacearum) 		PF07938
(Fungal_lectin) 		4 TRP A  36
ILE A  16
ILE A  26
VAL A  48
 MFU  A 304 (-3.9A)
None
None
None
 0.93A 4zj8A-4csdA:
undetectable		 4zj8A-4csdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csd FUCOSE-BINDING
LECTIN PROTEIN

(Ralstonia
solanacearum) 		PF07938
(Fungal_lectin) 		4 TRP A 127
ILE A 107
ILE A 117
VAL A 139
 MFU  A 306 (-3.9A)
None
None
None
 0.91A 4zj8A-4csdA:
undetectable		 4zj8A-4csdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csd FUCOSE-BINDING
LECTIN PROTEIN

(Ralstonia
solanacearum) 		PF07938
(Fungal_lectin) 		4 TRP A 218
ILE A 198
ILE A 208
VAL A 230
 MFU  A 302 (-4.0A)
None
None
None
 0.94A 4zj8A-4csdA:
undetectable		 4zj8A-4csdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		4 TRP A 237
ILE A 103
ILE A  66
VAL A  31
 None
 0.95A 4zj8A-4e7nA:
undetectable		 4zj8A-4e7nA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyv PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Serendipita
indica) 		PF00160
(Pro_isomerase) 		4 ILE A  57
PRO A  58
ILE A  12
VAL A 156
 None
 0.94A 4zj8A-4eyvA:
undetectable		 4zj8A-4eyvA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 TRP A 193
PRO A 276
ILE A  15
VAL A 110
 None
 1.00A 4zj8A-4fn5A:
5.5		 4zj8A-4fn5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 TRP H 678
ILE H 533
ILE H 497
VAL H 460
 None
 1.00A 4zj8A-4fxgH:
undetectable		 4zj8A-4fxgH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ILE A 184
PRO A 226
ILE A  14
VAL A  81
 None
 1.01A 4zj8A-4h16A:
2.5		 4zj8A-4h16A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		4 ILE A 319
HIS A 369
ILE A 375
VAL A 381
 None
 0.89A 4zj8A-4l22A:
18.5		 4zj8A-4l22A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		4 ILE A 382
HIS A 409
ILE A 440
VAL A 465
 None
 0.87A 4zj8A-4mboA:
undetectable		 4zj8A-4mboA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		4 ILE A 103
PRO A 102
ILE A  64
VAL A  88
 None
 1.01A 4zj8A-4mptA:
5.3		 4zj8A-4mptA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 158
HIS A 236
ILE A 287
VAL A 131
 None
ACP  A 501 ( 3.9A)
ACP  A 501 ( 4.3A)
ACP  A 501 ( 4.5A)
 1.01A 4zj8A-4mv3A:
undetectable		 4zj8A-4mv3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 ILE A 205
PRO A 233
ILE A  24
VAL A  99
 None
 0.93A 4zj8A-4nbrA:
5.6		 4zj8A-4nbrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		4 ILE A 181
PRO A 209
ILE A  11
VAL A  79
 NAD  A 301 (-4.4A)
None
None
None
 0.96A 4zj8A-4nbtA:
5.4		 4zj8A-4nbtA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		4 ILE A 203
PRO A 231
ILE A  17
VAL A  94
 NAD  A 301 (-4.2A)
None
None
None
 0.99A 4zj8A-4nbwA:
5.5		 4zj8A-4nbwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		4 TRP A 125
ILE A 105
ILE A 138
VAL A 240
 None
 0.91A 4zj8A-4o8mA:
undetectable		 4zj8A-4o8mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9a POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 TRP A 317
ILE A 545
ILE A 505
VAL A 521
 None
 0.95A 4zj8A-4p9aA:
undetectable		 4zj8A-4p9aA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 663
PRO A 656
ILE A 741
VAL A 729
 None
 0.95A 4zj8A-4q73A:
3.6		 4zj8A-4q73A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 332
HIS A 507
ILE A 501
VAL A 487
 None
 1.01A 4zj8A-4qiwA:
5.1		 4zj8A-4qiwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		4 ILE A 126
PRO A  48
HIS A  68
ILE A 277
 None
 1.01A 4zj8A-4qlzA:
undetectable		 4zj8A-4qlzA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Clostridium
butyricum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A  89
HIS A 138
ILE A  16
VAL A   6
 None
 1.00A 4zj8A-4r1nA:
4.9		 4zj8A-4r1nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ILE A 107
HIS A  62
ILE A  14
VAL A  85
 None
 0.96A 4zj8A-4rncA:
undetectable		 4zj8A-4rncA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		4 ILE A  50
PRO A  51
ILE A 108
VAL A  83
 None
 0.98A 4zj8A-4rpcA:
3.3		 4zj8A-4rpcA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		4 PRO A  54
HIS A  58
ILE A 111
VAL A 109
 None
 0.98A 4zj8A-4rvpA:
undetectable		 4zj8A-4rvpA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		6 TRP A 120
ILE A 130
PRO A 131
HIS A 224
ILE A 320
VAL A 353
 None
SUV  A2001 (-4.8A)
SUV  A2001 (-4.0A)
SUV  A2001 ( 4.8A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.9A)
 0.38A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		4 ILE A 172
PRO A 171
ILE A   7
VAL A 183
 None
 1.01A 4zj8A-4s12A:
undetectable		 4zj8A-4s12A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ILE A 224
HIS A 511
ILE A 514
VAL A 519
 None
 1.00A 4zj8A-4wd9A:
undetectable		 4zj8A-4wd9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1v CD2-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF14604
(SH3_9) 		4 ILE A 120
PRO A 121
ILE A 135
VAL A 115
 None
 0.97A 4zj8A-4x1vA:
undetectable		 4zj8A-4x1vA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2

(Homo sapiens) 		PF00622
(SPRY) 		4 PRO A 470
HIS A 292
ILE A 300
VAL A 307
 None
 0.97A 4zj8A-4x8nA:
undetectable		 4zj8A-4x8nA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 PRO B 327
HIS B 205
ILE B 294
VAL B 316
 None
 0.98A 4zj8A-4xsrB:
9.9		 4zj8A-4xsrB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 ILE A 481
PRO A 478
HIS A 542
ILE A 502
 None
 0.91A 4zj8A-4z38A:
undetectable		 4zj8A-4z38A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		4 ILE A 984
HIS A 977
ILE A 961
VAL A1007
 None
SO4  A1103 (-3.9A)
U  C   4 ( 4.6A)
None
 0.92A 4zj8A-4zlrA:
undetectable		 4zj8A-4zlrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 ILE W 337
PRO W 336
ILE W 287
VAL A  21
 None
 0.99A 4zj8A-4zxcW:
undetectable		 4zj8A-4zxcW:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		4 ILE A  72
HIS A  65
ILE A  84
VAL A 208
 None
PCA  A 403 (-3.9A)
None
None
 0.79A 4zj8A-5cadA:
undetectable		 4zj8A-5cadA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb0 UNIVERSAL STRESS
PROTEIN E

(Escherichia
coli) 		PF00582
(Usp) 		4 TRP A 150
ILE A 265
HIS A 244
ILE A 238
 Z6X  A 401 (-4.0A)
Z6X  A 401 ( 4.1A)
None
None
 0.97A 4zj8A-5cb0A:
undetectable		 4zj8A-5cb0A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ILE A 155
HIS A 237
ILE A 175
VAL A 138
 None
 0.97A 4zj8A-5cvvA:
undetectable		 4zj8A-5cvvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 TRP A 246
ILE A 271
ILE A  97
VAL A  93
 None
 0.89A 4zj8A-5djsA:
14.6		 4zj8A-5djsA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 586
PRO A 583
ILE A 531
VAL A 617
 None
 1.01A 4zj8A-5ip9A:
5.8		 4zj8A-5ip9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 712
PRO A 705
ILE A 790
VAL A 778
 None
NAD  A2002 (-4.3A)
None
None
 1.01A 4zj8A-5kf7A:
undetectable		 4zj8A-5kf7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 929
HIS A 869
ILE A 833
VAL A 832
 None
 1.01A 4zj8A-5kf7A:
undetectable		 4zj8A-5kf7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 ILE A  98
PRO A  99
ILE A  94
VAL A  19
 None
 0.86A 4zj8A-5kh0A:
2.1		 4zj8A-5kh0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5p PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		no annotation 4 TRP A 748
ILE A 853
ILE B 717
VAL B 720
 None
 0.94A 4zj8A-5n5pA:
undetectable		 4zj8A-5n5pA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A  59
PRO A  86
ILE A 282
VAL A  95
 None
 0.94A 4zj8A-5nd5A:
undetectable		 4zj8A-5nd5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 4 ILE A 278
PRO A 279
ILE A 108
VAL A 112
 None
 0.99A 4zj8A-5omsA:
undetectable		 4zj8A-5omsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora) 		no annotation 4 TRP A 279
PRO A 256
ILE A 128
VAL A  20
 TRP  A 279 ( 0.5A)
PRO  A 256 ( 1.1A)
ILE  A 128 ( 0.7A)
VAL  A  20 ( 0.6A)
 0.94A 4zj8A-5wpiA:
undetectable		 4zj8A-5wpiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 PRO A 301
HIS A 260
ILE A 214
VAL A 226
 None
 0.97A 4zj8A-5wugA:
3.4		 4zj8A-5wugA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 ILE A 386
PRO A 387
ILE A 336
VAL A 339
 None
 0.87A 4zj8A-5xdrA:
2.4		 4zj8A-5xdrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 TRP 2 875
ILE 2 909
HIS 2 932
ILE 2 918
 None
 0.95A 4zj8A-5zvs2:
undetectable		 4zj8A-5zvs2:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 4 ILE I 571
HIS I 581
ILE I 525
VAL I 547
 None
 0.93A 4zj8A-6bnpI:
undetectable		 4zj8A-6bnpI:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejb XYLOSYLTRANSFERASE 1

(Homo sapiens) 		no annotation 4 TRP A 555
HIS A 335
ILE A 568
VAL A 569
 None
 0.87A 4zj8A-6ejbA:
4.5		 4zj8A-6ejbA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 ILE B 200
HIS B  83
ILE B  62
VAL B 182
 None
 0.85A 4zj8A-6fd2B:
undetectable		 4zj8A-6fd2B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 ILE A 500
HIS A 431
ILE A 456
VAL A 459
 None
 0.92A 4zj8A-6g9oA:
3.4		 4zj8A-6g9oA:
8.43