SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZGF_A_BEZA210_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 183
ASN 2 180
GLN 2 173
 None
 1.48A 4zgfA-1bev2:
0.0		 4zgfA-1bev2:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 198
ASN 2 195
GLN 2 188
 None
 1.44A 4zgfA-1c8m2:
0.0		 4zgfA-1c8m2:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 VAL B 396
ALA B 392
ASN B   5
GLN B 195
 None
 1.49A 4zgfA-1ccwB:
0.0		 4zgfA-1ccwB:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 VAL A 389
ALA A 388
ASN A 384
GLN A 345
 None
 1.21A 4zgfA-1d2fA:
undetectable		 4zgfA-1d2fA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 198
ASN 2 195
GLN 2 188
 None
 1.44A 4zgfA-1ev12:
undetectable		 4zgfA-1ev12:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		4 VAL B  68
ALA B  64
ASN B  58
GLN B  57
 None
 1.22A 4zgfA-1ezvB:
0.0		 4zgfA-1ezvB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 VAL A 303
ALA A 239
ASN A 237
GLN A 320
 None
 1.45A 4zgfA-1ileA:
0.0		 4zgfA-1ileA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38) 		4 VAL A  97
ALA A  95
ASN A  90
GLN A  93
 None
 1.38A 4zgfA-1o7dA:
0.0		 4zgfA-1o7dA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 4 VAL B 248
ALA B 247
ASN B 286
GLN B 191
 None
 1.47A 4zgfA-1pbyB:
0.3		 4zgfA-1pbyB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puo MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 2, CHAIN 1

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		4 VAL A  13
ALA A  16
ASN A  21
GLN A  46
 None
 0.85A 4zgfA-1puoA:
undetectable		 4zgfA-1puoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgu AMYLOID BETA (A4)
PRECURSOR
PROTEIN-BINDING,
FAMILY B, MEMBER 2

(Mus musculus) 		PF00640
(PID) 		4 VAL A 126
ALA A 125
ASN A 121
GLN A  16
 None
 1.40A 4zgfA-1wguA:
1.9		 4zgfA-1wguA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yix DEOXYRIBONUCLEASE
YCFH

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 VAL A 180
ALA A 185
ASN A 184
GLN A 187
 None
 1.40A 4zgfA-1yixA:
undetectable		 4zgfA-1yixA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		4 VAL A 190
ALA A 191
ASN A 192
GLN A 234
 None
 1.30A 4zgfA-1z05A:
undetectable		 4zgfA-1z05A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 206
ASN 2 203
GLN 2 196
 None
 1.44A 4zgfA-1z7s2:
undetectable		 4zgfA-1z7s2:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		4 VAL A 228
ALA A 194
ASN A 295
GLN A 294
 None
 1.48A 4zgfA-1zgdA:
undetectable		 4zgfA-1zgdA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkr MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 1, CHAIN 2

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		4 VAL A  83
ALA A  86
ASN A  91
GLN A 116
 None
 0.82A 4zgfA-1zkrA:
undetectable		 4zgfA-1zkrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8k RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD) 		4 VAL A  54
ALA A  44
ASN A  45
GLN A  41
 None
 1.30A 4zgfA-2o8kA:
undetectable		 4zgfA-2o8kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb4 ATP-DEPENDENT RNA
HELICASE DDX25

(Homo sapiens) 		PF00271
(Helicase_C) 		4 VAL A 410
ALA A 444
ASN A 446
GLN A 314
 None
 1.40A 4zgfA-2rb4A:
undetectable		 4zgfA-2rb4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 VAL A  83
ALA A  86
ASN A  89
GLN A  92
 HEC  A 401 ( 4.8A)
HEC  A 401 ( 4.3A)
HEC  A 401 ( 4.9A)
HEC  A 401 (-4.5A)
 1.18A 4zgfA-2vhdA:
undetectable		 4zgfA-2vhdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 VAL A 362
ALA A 360
ASN A 359
GLN A 284
 None
 1.27A 4zgfA-2y0kA:
undetectable		 4zgfA-2y0kA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus musculus) 		PF00640
(PID)
PF10515
(APP_amyloid) 		4 VAL A 172
ALA A 171
ASN A 167
GLN A  62
 None
 1.32A 4zgfA-2yt0A:
undetectable		 4zgfA-2yt0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 VAL A 280
ALA A 279
ASN A 317
GLN A 315
 None
SPM  A 501 ( 4.5A)
None
SPM  A 501 ( 4.0A)
 1.43A 4zgfA-3c6mA:
undetectable		 4zgfA-3c6mA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL B 110
ALA B 200
ASN B 197
GLN B 190
 None
 1.38A 4zgfA-3dprB:
undetectable		 4zgfA-3dprB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 133
ALA A 149
ASN A 101
GLN A 103
 None
 1.31A 4zgfA-3efmA:
undetectable		 4zgfA-3efmA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A 131
ALA A 148
ASN A 150
GLN A 154
 None
None
UPG  A 342 ( 4.3A)
None
 1.32A 4zgfA-3enkA:
undetectable		 4zgfA-3enkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 206
ASN 2 203
GLN 2 196
 None
 1.49A 4zgfA-3epc2:
undetectable		 4zgfA-3epc2:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 205
ASN 2 202
GLN 2 195
 None
 1.47A 4zgfA-3epd2:
undetectable		 4zgfA-3epd2:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gek PUTATIVE
THIOESTERASE YHDA

(Lactococcus
lactis) 		PF03061
(4HBT) 		4 VAL A 131
ALA A 129
ASN A 128
GLN A  77
 None
 1.47A 4zgfA-3gekA:
undetectable		 4zgfA-3gekA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		4 VAL A 231
ALA A 228
ASN A 170
GLN A 226
 None
None
DGI  A 369 (-3.9A)
None
 1.34A 4zgfA-3h2yA:
undetectable		 4zgfA-3h2yA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		4 VAL A 161
ALA A  66
ASN A  65
GLN A 167
 None
 1.20A 4zgfA-3hl1A:
undetectable		 4zgfA-3hl1A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		4 VAL A  32
ALA A  30
ASN A  29
GLN A 396
 None
None
GOL  A 522 (-2.8A)
None
 0.95A 4zgfA-3ik2A:
undetectable		 4zgfA-3ik2A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 VAL A 214
ALA A 216
ASN A 186
GLN A 218
 None
 1.45A 4zgfA-3nraA:
undetectable		 4zgfA-3nraA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 VAL A 125
ALA A 129
ASN A 132
GLN A 133
 None
3HC  A 310 (-3.4A)
3HC  A 310 (-3.0A)
3HC  A 310 (-3.4A)
 1.45A 4zgfA-3pvtA:
undetectable		 4zgfA-3pvtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 VAL A  88
ALA A  89
ASN A 111
GLN A 104
 None
 1.50A 4zgfA-3qmlA:
undetectable		 4zgfA-3qmlA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qrq PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB192

(Thermus
thermophilus) 		PF08798
(CRISPR_assoc) 		4 VAL A 114
ALA A 115
ASN A 102
GLN A 172
 U  B   5 ( 4.3A)
U  B   5 ( 3.4A)
U  B   5 ( 3.0A)
G  B   4 ( 4.1A)
 1.43A 4zgfA-3qrqA:
undetectable		 4zgfA-3qrqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9j SEPTUM
SITE-DETERMINING
PROTEIN MIND

(Escherichia
coli) 		PF01656
(CbiA) 		4 VAL A 227
ALA A 220
ASN A 222
GLN A 223
 None
 1.45A 4zgfA-3r9jA:
undetectable		 4zgfA-3r9jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A  61
ALA A 265
ASN A 264
GLN A 268
 None
 1.26A 4zgfA-3ri6A:
undetectable		 4zgfA-3ri6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 VAL A 194
ALA A 193
ASN A 189
GLN A 190
 None
None
CL  A 614 ( 4.1A)
None
 1.41A 4zgfA-3sghA:
undetectable		 4zgfA-3sghA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t36 ENDO-TYPE
MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF01464
(SLT) 		4 VAL A  33
ALA A  29
ASN A  28
GLN A 198
 None
 1.15A 4zgfA-3t36A:
undetectable		 4zgfA-3t36A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 VAL A 101
ALA A 105
ASN A 108
GLN A 109
 None
None
P6G  A 401 ( 4.0A)
None
 1.35A 4zgfA-3tdgA:
undetectable		 4zgfA-3tdgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 VAL A 310
ALA A 312
ASN A 313
GLN A 314
 None
 1.30A 4zgfA-3tg9A:
undetectable		 4zgfA-3tg9A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 VAL A 127
ALA A  89
ASN A  88
GLN A 150
 None
 1.40A 4zgfA-3vrbA:
undetectable		 4zgfA-3vrbA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 VAL A 128
ALA A 127
ASN A 125
GLN A  70
 None
 1.47A 4zgfA-4bf7A:
undetectable		 4zgfA-4bf7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		4 VAL A2214
ALA A2217
ASN A2220
GLN A2161
 None
 1.26A 4zgfA-4f6cA:
undetectable		 4zgfA-4f6cA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 4 VAL B2214
ALA B2217
ASN B2220
GLN B2161
 None
 1.34A 4zgfA-4f6lB:
undetectable		 4zgfA-4f6lB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 VAL A 235
ALA A 239
ASN A 238
GLN A 243
 None
 1.48A 4zgfA-4fnqA:
undetectable		 4zgfA-4fnqA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		4 VAL A  10
ALA A  11
ASN A 149
GLN A 146
 None
 1.29A 4zgfA-4htpA:
undetectable		 4zgfA-4htpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		4 VAL A 387
ALA A 391
ASN A 390
GLN A 394
 None
 1.46A 4zgfA-4ijmA:
undetectable		 4zgfA-4ijmA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 VAL A 124
ALA A 100
ASN A  45
GLN A  82
 None
 1.36A 4zgfA-4irxA:
undetectable		 4zgfA-4irxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		4 VAL A  91
ALA A  92
ASN A 115
GLN A 108
 None
 1.43A 4zgfA-4kboA:
undetectable		 4zgfA-4kboA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 VAL A 156
ALA A 191
ASN A 192
GLN A 482
 None
None
NAG  A 701 (-1.9A)
None
 1.41A 4zgfA-4l37A:
undetectable		 4zgfA-4l37A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 VAL A 100
ALA A  99
ASN A  96
GLN A  95
 None
 1.32A 4zgfA-4maeA:
undetectable		 4zgfA-4maeA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		4 VAL A 127
ALA A 126
ASN A  71
GLN A  74
 None
 1.33A 4zgfA-4mupA:
undetectable		 4zgfA-4mupA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 VAL A 216
ALA A 217
ASN A 223
GLN A 224
 None
 1.34A 4zgfA-4ovkA:
undetectable		 4zgfA-4ovkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 VAL A  44
ALA A  42
ASN A  41
GLN A  35
 None
 1.35A 4zgfA-4q48A:
undetectable		 4zgfA-4q48A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 VAL 2 110
ALA 2 205
ASN 2 202
GLN 2 195
 None
 1.46A 4zgfA-4q4y2:
undetectable		 4zgfA-4q4y2:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tse E3 UBIQUITIN-PROTEIN
LIGASE MIB1

(Homo sapiens) 		no annotation 4 VAL A 341
ALA A 396
ASN A 393
GLN A 352
 None
 1.36A 4zgfA-4tseA:
undetectable		 4zgfA-4tseA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 VAL B 106
ALA B  88
ASN B  70
GLN B  90
 None
 1.36A 4zgfA-4um8B:
undetectable		 4zgfA-4um8B:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyb SEC14-LIKE PROTEIN 3

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 VAL A 372
ALA A 374
ASN A 285
GLN A 283
 None
None
EDO  A1406 (-4.8A)
None
 1.48A 4zgfA-4uybA:
undetectable		 4zgfA-4uybA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs TATA-BINDING
PROTEIN-ASSOCIATED
PHOSPHOPROTEIN
ECU04_1440 PROTEIN

(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi) 		PF00808
(CBFD_NFYB_HMF)
PF00352
(TBP) 		4 VAL D 191
ALA B 129
ASN B 128
GLN B 132
 None
 1.26A 4zgfA-4wzsD:
undetectable		 4zgfA-4wzsD:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 VAL A1033
ALA A1029
ASN A1026
GLN A1098
 None
 0.97A 4zgfA-4xa2A:
undetectable		 4zgfA-4xa2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1

(Homo sapiens) 		PF00569
(ZZ)
PF06701
(MIB_HERC2) 		4 VAL A 325
ALA A 380
ASN A 377
GLN A 336
 None
 1.42A 4zgfA-4xibA:
undetectable		 4zgfA-4xibA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvs CAPSID PROTEIN VP0

(Enterovirus A) 		PF00073
(Rhv) 		4 VAL C 110
ALA C 191
ASN C  30
GLN C 181
 None
 1.37A 4zgfA-4yvsC:
undetectable		 4zgfA-4yvsC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvs CAPSID PROTEIN VP0

(Enterovirus A) 		PF00073
(Rhv) 		4 VAL C 110
ALA C 191
ASN C 188
GLN C 181
 None
 1.27A 4zgfA-4yvsC:
undetectable		 4zgfA-4yvsC:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zgf UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF16139
(DUF4847) 		4 VAL A 144
ALA A 159
ASN A 161
GLN A 163
 None
BEZ  A 210 (-3.4A)
BEZ  A 210 (-3.9A)
BEZ  A 210 (-3.2A)
 0.00A 4zgfA-4zgfA:
30.6		 4zgfA-4zgfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhy YFIR

(Pseudomonas
aeruginosa) 		PF13689
(DUF4154) 		4 VAL A  51
ALA A  47
ASN A  46
GLN A  43
 None
 1.43A 4zgfA-4zhyA:
undetectable		 4zgfA-4zhyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abj VP2

(Enterovirus A) 		PF00073
(Rhv) 		4 VAL B 110
ALA B 191
ASN B 188
GLN B 181
 None
 1.46A 4zgfA-5abjB:
undetectable		 4zgfA-5abjB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 VAL 2 109
ALA 2 156
ASN 2 153
GLN 2 146
 None
 1.44A 4zgfA-5aca2:
undetectable		 4zgfA-5aca2:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 VAL A  66
ALA A  67
ASN A  90
GLN A  83
 None
 1.42A 4zgfA-5e84A:
undetectable		 4zgfA-5e84A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		4 VAL A 134
ALA A 131
ASN A 127
GLN A 140
 None
 1.43A 4zgfA-5loaA:
undetectable		 4zgfA-5loaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 VAL A  64
ALA A  60
ASN A  59
GLN A  81
 None
None
None
MLR  A 401 (-3.9A)
 1.45A 4zgfA-5m28A:
undetectable		 4zgfA-5m28A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 VAL A 870
ALA A 871
ASN A 660
GLN A 659
 None
 1.34A 4zgfA-5nd1A:
undetectable		 4zgfA-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 VAL B 103
ALA B  85
ASN B  67
GLN B  87
 None
 1.39A 4zgfA-5nemB:
undetectable		 4zgfA-5nemB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ner O PANASIA VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 VAL 2 109
ALA 2 156
ASN 2 153
GLN 2 146
 None
 1.46A 4zgfA-5ner2:
undetectable		 4zgfA-5ner2:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 VAL A 569
ALA A 482
ASN A 481
GLN A 229
 None
 1.44A 4zgfA-5ohsA:
undetectable		 4zgfA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		4 VAL B 108
ALA B 181
ASN B 178
GLN B 171
 None
 1.45A 4zgfA-5osnB:
undetectable		 4zgfA-5osnB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owx GENOME POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 VAL 2 109
ALA 2 156
ASN 2 153
GLN 2 146
 None
 1.36A 4zgfA-5owx2:
undetectable		 4zgfA-5owx2:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 VAL A 729
ALA A 695
ASN A 694
GLN A 838
 None
 1.34A 4zgfA-5ux5A:
undetectable		 4zgfA-5ux5A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ale -

(-) 		no annotation 4 VAL B 420
ALA B 423
ASN B 426
GLN B 462
 None
 1.40A 4zgfA-6aleB:
undetectable		 4zgfA-6aleB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 VAL A  66
ALA A  67
ASN A  90
GLN A  83
 None
 1.42A 4zgfA-6eoeA:
undetectable		 4zgfA-6eoeA:
14.18