SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZF8_A_MYTA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)


(Geobacillus
stearothermophilus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
4 LEU A 326
ILE A 257
ALA A 256
ALA A 246
None
None
None
CA  A3001 (-4.6A)
0.76A 4zf8A-1brwA:
0.0
4zf8A-1brwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans)
PF00463
(ICL)
4 VAL A 127
LEU A 238
ILE A 194
ALA A 167
None
0.66A 4zf8A-1dquA:
0.0
4zf8A-1dquA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1


(Homo sapiens)
PF02263
(GBP)
PF02841
(GBP_C)
5 LEU A 118
ILE A 304
ALA A 303
THR A 299
ALA A 315
None
1.01A 4zf8A-1f5nA:
0.0
4zf8A-1f5nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
4 VAL C 275
ILE C 251
ALA C 250
ALA C 232
None
0.71A 4zf8A-1ffvC:
0.0
4zf8A-1ffvC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK


(Thermococcus
litoralis)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
4 VAL 1  86
LEU 1 127
ILE 1 154
ALA 1 153
None
0.79A 4zf8A-1g291:
0.0
4zf8A-1g291:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4m NAMN
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF01467
(CTP_transf_like)
4 VAL A  15
LEU A  72
ILE A  64
ALA A  63
None
0.73A 4zf8A-1k4mA:
0.0
4zf8A-1k4mA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE


(Archaeoglobus
fulgidus)
PF01913
(FTR)
PF02741
(FTR_C)
4 LEU A 296
ILE A 291
ALA A  13
THR A  11
None
0.70A 4zf8A-1m5hA:
undetectable
4zf8A-1m5hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m76 3-HYDROXYACYL-COA
DEHYDROGENASE


(Homo sapiens)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 LEU A 118
ILE A 108
ALA A 107
ALA A 133
None
NAD  A 350 (-3.7A)
NAD  A 350 (-4.3A)
None
0.70A 4zf8A-1m76A:
0.0
4zf8A-1m76A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 VAL A 241
LEU A 276
ILE A 230
ALA A 231
None
0.74A 4zf8A-1muuA:
0.0
4zf8A-1muuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrx SEQA PROTEIN

(Escherichia
coli)
PF17206
(SeqA_N)
4 LEU A  29
ILE A  14
ALA A  15
THR A  18
None
0.76A 4zf8A-1xrxA:
undetectable
4zf8A-1xrxA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE


(Saccharomyces
cerevisiae)
PF00155
(Aminotran_1_2)
4 VAL A 379
LEU A 337
ILE A 404
ALA A 403
None
0.55A 4zf8A-1yaaA:
undetectable
4zf8A-1yaaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF13603
(tRNA-synt_1_2)
4 VAL A 230
LEU A 313
ILE A 399
ALA A 400
None
0.78A 4zf8A-2ajhA:
undetectable
4zf8A-2ajhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)


(Bluetongue
virus)
PF01700
(Orbi_VP3)
4 LEU A 406
ILE A 429
ALA A 506
ALA A 513
None
0.77A 4zf8A-2btvA:
undetectable
4zf8A-2btvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwf UBIQUITIN-LIKE
PROTEIN DSK2


(Saccharomyces
cerevisiae)
PF00240
(ubiquitin)
4 VAL A  18
LEU A  44
ILE A  31
ALA A  30
None
0.70A 4zf8A-2bwfA:
undetectable
4zf8A-2bwfA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
4 VAL A 313
LEU A 251
ILE A 336
ALA A 340
None
0.76A 4zf8A-2d62A:
undetectable
4zf8A-2d62A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE


(Pyrococcus
horikoshii)
PF00266
(Aminotran_5)
4 LEU A 178
ILE A 228
ALA A 229
ALA A  86
None
0.75A 4zf8A-2dr1A:
undetectable
4zf8A-2dr1A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis)
PF00440
(TetR_N)
4 LEU A 104
ILE A  20
ALA A  16
ALA A  57
None
0.79A 4zf8A-2f07A:
undetectable
4zf8A-2f07A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE


(Methanopyrus
kandleri)
PF01913
(FTR)
PF02741
(FTR_C)
4 LEU A 295
ILE A 290
ALA A  13
THR A  11
None
0.68A 4zf8A-2fhkA:
undetectable
4zf8A-2fhkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Mycobacterium
tuberculosis)
PF00275
(EPSP_synthase)
4 VAL A 244
LEU A 306
ILE A 276
ALA A 318
None
0.79A 4zf8A-2o0xA:
undetectable
4zf8A-2o0xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE


(Geobacillus
kaustophilus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 LEU A  99
ILE A  23
ALA A  24
THR A  28
None
0.59A 4zf8A-2oejA:
undetectable
4zf8A-2oejA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 VAL A 234
LEU A 326
ILE A 277
ALA A 210
None
0.72A 4zf8A-2panA:
undetectable
4zf8A-2panA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkp HOMOACONITASE SMALL
SUBUNIT


(Methanocaldococcus
jannaschii)
PF00694
(Aconitase_C)
4 VAL A  54
LEU A 120
ILE A 101
ALA A 105
None
0.78A 4zf8A-2pkpA:
undetectable
4zf8A-2pkpA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens)
PF00067
(p450)
5 LEU A 219
ILE A 301
ALA A 302
THR A 306
ALA A 367
None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
0.83A 4zf8A-2q9gA:
43.4
4zf8A-2q9gA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens)
PF00067
(p450)
5 VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
0.49A 4zf8A-2q9gA:
43.4
4zf8A-2q9gA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE


(Trypanosoma
cruzi)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 VAL A 253
LEU A 268
ILE A 180
THR A 201
None
0.77A 4zf8A-2qaeA:
undetectable
4zf8A-2qaeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 VAL A  80
LEU A  37
ILE A  63
ALA A  64
ALA A  71
None
0.93A 4zf8A-2qkxA:
undetectable
4zf8A-2qkxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay8 GLUTATHIONE
S-TRANSFERASE


(Bombyx mori)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 LEU A   6
ILE A  71
ALA A  72
ALA A  24
None
0.49A 4zf8A-3ay8A:
undetectable
4zf8A-3ay8A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA

(Perca
flavescens)
PF00042
(Globin)
4 LEU A 110
ILE A  17
ALA A  21
ALA A  26
None
0.77A 4zf8A-3bj1A:
undetectable
4zf8A-3bj1A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
4 VAL A 215
LEU A 289
ILE A 271
ALA A  76
None
0.78A 4zf8A-3caiA:
undetectable
4zf8A-3caiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A 143
ILE A 128
ALA A 125
ALA A 174
None
0.70A 4zf8A-3cmtA:
undetectable
4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A1143
ILE A1128
ALA A1125
ALA A1174
None
0.70A 4zf8A-3cmtA:
undetectable
4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A2143
ILE A2128
ALA A2125
ALA A2174
None
0.69A 4zf8A-3cmtA:
undetectable
4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A3143
ILE A3128
ALA A3125
ALA A3174
None
0.70A 4zf8A-3cmtA:
undetectable
4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A4143
ILE A4128
ALA A4125
ALA A4174
None
0.69A 4zf8A-3cmtA:
undetectable
4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A 143
ILE A 128
ALA A 125
ALA A 174
None
0.74A 4zf8A-3cmuA:
undetectable
4zf8A-3cmuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A1143
ILE A1128
ALA A1125
ALA A1174
None
0.75A 4zf8A-3cmuA:
undetectable
4zf8A-3cmuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A2143
ILE A2128
ALA A2125
ALA A2174
None
0.74A 4zf8A-3cmuA:
undetectable
4zf8A-3cmuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A3143
ILE A3128
ALA A3125
ALA A3174
None
0.74A 4zf8A-3cmuA:
undetectable
4zf8A-3cmuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A4143
ILE A4128
ALA A4125
ALA A4174
None
0.74A 4zf8A-3cmuA:
undetectable
4zf8A-3cmuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 VAL A5143
ILE A5128
ALA A5125
ALA A5174
None
0.74A 4zf8A-3cmuA:
undetectable
4zf8A-3cmuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 LEU A 100
ILE A  24
ALA A  25
THR A  29
None
0.67A 4zf8A-3fk4A:
undetectable
4zf8A-3fk4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6e 50S RIBOSOMAL
PROTEIN L22P


(Haloarcula
marismortui)
PF00237
(Ribosomal_L22)
4 VAL R 143
LEU R  47
ILE R  31
ALA R  32
None
0.63A 4zf8A-3g6eR:
undetectable
4zf8A-3g6eR:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Mus musculus)
PF00155
(Aminotran_1_2)
4 VAL A 400
LEU A 358
ILE A 425
ALA A 424
None
0.55A 4zf8A-3hlmA:
undetectable
4zf8A-3hlmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
4 LEU A   7
ILE A  29
ALA A  30
ALA A 108
None
0.69A 4zf8A-3k4yA:
undetectable
4zf8A-3k4yA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
4 VAL A 251
LEU A   5
ILE A 243
THR A 179
None
None
None
SO4  A 262 (-4.3A)
0.79A 4zf8A-3k4yA:
undetectable
4zf8A-3k4yA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE


(Mesorhizobium
loti)
PF12697
(Abhydrolase_6)
4 VAL A 225
LEU A  51
ILE A 272
ALA A 271
None
0.49A 4zf8A-3kxpA:
undetectable
4zf8A-3kxpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnq HOMEOBOX PROTEIN
ARISTALESS


(Drosophila
melanogaster)
PF00046
(Homeobox)
5 LEU A 100
ILE A 122
ALA A 119
THR A 125
ALA A 127
None
1.45A 4zf8A-3lnqA:
undetectable
4zf8A-3lnqA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m63 UBIQUITIN
DOMAIN-CONTAINING
PROTEIN DSK2


(Saccharomyces
cerevisiae)
PF00240
(ubiquitin)
4 VAL B  18
LEU B  44
ILE B  31
ALA B  30
None
0.79A 4zf8A-3m63B:
undetectable
4zf8A-3m63B:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE


(Amycolatopsis
balhimycina)
PF00067
(p450)
4 VAL A  88
ILE A 234
THR A 239
ALA A 282
HEM  A 397 ( 3.8A)
GOL  A 400 ( 4.0A)
HEM  A 397 (-3.5A)
HEM  A 397 ( 3.8A)
0.67A 4zf8A-3mgxA:
28.5
4zf8A-3mgxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes)
PF01212
(Beta_elim_lyase)
4 VAL A 335
LEU A 347
ALA A 265
ALA A 270
None
0.77A 4zf8A-3pj0A:
undetectable
4zf8A-3pj0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1


(Mus musculus)
PF00784
(MyTH4)
4 LEU A1260
ILE A1323
ALA A1322
ALA A1280
None
0.76A 4zf8A-3pvlA:
undetectable
4zf8A-3pvlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN


(Salmonella
enterica)
PF07470
(Glyco_hydro_88)
5 LEU A 370
ILE A 322
ALA A 321
THR A 294
ALA A 291
None
1.33A 4zf8A-3qwtA:
undetectable
4zf8A-3qwtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II


(Mycolicibacterium
smegmatis)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 VAL A 123
LEU A  69
ILE A  77
ALA A  76
None
0.73A 4zf8A-3rd8A:
0.3
4zf8A-3rd8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE


(Wolinella
succinogenes)
PF01053
(Cys_Met_Meta_PP)
4 VAL A 200
LEU A 114
ILE A  91
ALA A  90
None
0.79A 4zf8A-3ri6A:
undetectable
4zf8A-3ri6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjz N-TYPE ATP
PYROPHOSPHATASE
SUPERFAMILY


(Pyrococcus
furiosus)
PF01902
(Diphthami_syn_2)
4 VAL A   9
LEU A 196
ILE A  25
ALA A  24
None
0.74A 4zf8A-3rjzA:
undetectable
4zf8A-3rjzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE


(Avian
avulavirus 1)
PF00423
(HN)
4 LEU A 542
ILE A 544
ALA A 545
THR A 489
None
0.78A 4zf8A-3t1eA:
undetectable
4zf8A-3t1eA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
4 LEU A  94
ILE A  71
ALA A  72
ALA A  24
None
0.74A 4zf8A-3t7cA:
undetectable
4zf8A-3t7cA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE


(Mycobacteroides
abscessus)
PF01182
(Glucosamine_iso)
4 VAL A 143
LEU A  54
ILE A  27
ALA A  26
None
0.64A 4zf8A-3tx2A:
undetectable
4zf8A-3tx2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 LEU A 887
ILE A 744
ALA A 745
ALA A 879
None
0.74A 4zf8A-3va7A:
undetectable
4zf8A-3va7A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zig SEPF-LIKE PROTEIN

(Pyrococcus
furiosus)
PF04472
(SepF)
4 VAL A 119
LEU A  64
ILE A  94
ALA A  95
None
0.79A 4zf8A-3zigA:
undetectable
4zf8A-3zigA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN


(Prochloron
didemni)
PF00082
(Peptidase_S8)
4 VAL A 168
LEU A 101
ILE A 118
ALA A 149
None
0.73A 4zf8A-3zxyA:
undetectable
4zf8A-3zxyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Mycobacterium
tuberculosis)
PF01116
(F_bP_aldolase)
4 LEU A 102
ILE A 143
ALA A 144
ALA A 151
None
0.70A 4zf8A-4a22A:
undetectable
4zf8A-4a22A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE


(Staphylococcus
aureus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 VAL A 452
ILE A 445
ALA A 442
ALA A 482
None
0.80A 4zf8A-4c13A:
undetectable
4zf8A-4c13A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu5 ENDOLYSIN

(Clostridium
virus phiCD27)
no annotation 4 LEU A 230
ILE A 241
ALA A 237
ALA A 202
None
0.80A 4zf8A-4cu5A:
undetectable
4zf8A-4cu5A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7s STHK_CNBD_CGMP

(Spirochaeta
thermophila)
PF00027
(cNMP_binding)
4 LEU A 301
ILE A 407
ALA A 408
ALA A 415
None
0.76A 4zf8A-4d7sA:
undetectable
4zf8A-4d7sA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY


(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 VAL A  51
LEU A 113
ILE A  40
ALA A  41
None
0.76A 4zf8A-4ewtA:
undetectable
4zf8A-4ewtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE


(Avian
avulavirus 1)
PF00423
(HN)
4 LEU A 543
ILE A 545
ALA A 546
THR A 490
None
0.75A 4zf8A-4fzhA:
undetectable
4zf8A-4fzhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE


(Staphylococcus
aureus)
PF02423
(OCD_Mu_crystall)
4 LEU A 226
ILE A 232
THR A 143
ALA A 203
None
0.79A 4zf8A-4mp3A:
undetectable
4zf8A-4mp3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE


(Alicyclobacillus
acidocaldarius)
PF00016
(RuBisCO_large)
4 LEU A 101
ILE A  32
ALA A  33
THR A  37
None
0.76A 4zf8A-4nasA:
undetectable
4zf8A-4nasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA


(Campylobacter
jejuni)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
4 LEU A  85
ILE A  59
ALA A  58
ALA A 171
None
0.65A 4zf8A-4noiA:
undetectable
4zf8A-4noiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzk UNCHARACTERIZED
PROTEIN


([Eubacterium]
siraeum)
PF14286
(DHHW)
4 VAL A 138
LEU A 361
ALA A 204
ALA A 324
None
0.61A 4zf8A-4nzkA:
undetectable
4zf8A-4nzkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE


(Ruegeria
pomeroyi)
PF03480
(DctP)
4 VAL A 293
LEU A 164
ILE A 152
THR A 226
None
0.67A 4zf8A-4pafA:
undetectable
4zf8A-4pafA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
no annotation 4 LEU A  32
ILE A  60
ALA A  61
ALA A 147
None
0.76A 4zf8A-4po6A:
undetectable
4zf8A-4po6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb1 XYN30D

(Paenibacillus
barcinonensis)
PF03422
(CBM_6)
4 ILE A  53
ALA A  52
THR A 125
ALA A  47
None
0.79A 4zf8A-4qb1A:
undetectable
4zf8A-4qb1A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE


(Sphaerobacter
thermophilus)
no annotation 4 ILE B  72
ALA B  71
THR B  67
ALA B  63
None
0.79A 4zf8A-4ritB:
undetectable
4zf8A-4ritB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE


(Streptococcus
pneumoniae)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
4 VAL A  83
LEU A  43
ILE A  17
ALA A  16
None
0.75A 4zf8A-4rl6A:
undetectable
4zf8A-4rl6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE


(Streptomyces
avermitilis)
PF00067
(p450)
4 LEU A 178
ILE A 240
ALA A 241
ALA A 288
None
DIF  A 502 (-3.3A)
HEM  A 501 ( 3.8A)
HEM  A 501 ( 3.7A)
0.63A 4zf8A-4ubsA:
31.8
4zf8A-4ubsA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Oceanimonas
doudoroffii)
PF00171
(Aldedh)
4 ILE A  46
ALA A  45
THR A  41
ALA A  37
None
0.79A 4zf8A-4zz7A:
undetectable
4zf8A-4zz7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA


(Pseudomonas
protegens)
no annotation 4 VAL E 312
LEU E  24
ALA E 339
ALA E  16
None
None
None
FAD  E 501 (-3.2A)
0.68A 4zf8A-5dbjE:
undetectable
4zf8A-5dbjE:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 LEU A 181
ILE A 263
ALA A 264
THR A 268
ALA A 328
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
0.73A 4zf8A-5e78A:
57.9
4zf8A-5e78A:
98.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae)
PF00463
(ICL)
4 VAL A 136
LEU A 247
ILE A 203
ALA A 176
None
0.71A 4zf8A-5e9gA:
undetectable
4zf8A-5e9gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum)
PF00463
(ICL)
4 VAL A 136
LEU A 247
ILE A 203
ALA A 176
None
0.74A 4zf8A-5e9hA:
undetectable
4zf8A-5e9hA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
4 VAL A 226
LEU A  90
ILE A 302
ALA A 301
None
0.76A 4zf8A-5ee0A:
undetectable
4zf8A-5ee0A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT


(Escherichia
coli)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 VAL C 130
LEU C  63
ILE C 112
ALA C 113
None
0.68A 4zf8A-5g5gC:
undetectable
4zf8A-5g5gC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL


(Homo sapiens)
PF00180
(Iso_dh)
4 VAL B  50
LEU B  96
ILE B  68
ALA B  67
None
0.75A 4zf8A-5grhB:
undetectable
4zf8A-5grhB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 LEU A 887
ILE A 744
ALA A 745
ALA A 879
None
0.73A 4zf8A-5i8iA:
undetectable
4zf8A-5i8iA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium)
PF00561
(Abhydrolase_1)
4 LEU A 160
ILE A 109
THR A  68
ALA A 181
None
0.79A 4zf8A-5jkjA:
undetectable
4zf8A-5jkjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3


(Branchiostoma
lanceolatum)
PF01353
(GFP)
4 LEU A 206
ILE A  57
THR A 197
ALA A 136
None
CR2  A  59 ( 4.2A)
CR2  A  59 ( 4.7A)
None
0.78A 4zf8A-5ltqA:
undetectable
4zf8A-5ltqA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 4 VAL A 200
LEU A 247
ILE A 230
ALA A 229
None
0.66A 4zf8A-5n3uA:
undetectable
4zf8A-5n3uA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n41 POLB1 BINDING
PROTEIN 2


(Sulfolobus
solfataricus)
no annotation 4 VAL A  49
ILE A  18
ALA A  19
ALA A  34
None
0.65A 4zf8A-5n41A:
undetectable
4zf8A-5n41A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE


(Leishmania
major)
PF00883
(Peptidase_M17)
4 VAL A  51
LEU A 138
ALA A 124
ALA A 155
None
0.71A 4zf8A-5nthA:
undetectable
4zf8A-5nthA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA


(Mycobacterium
tuberculosis)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
4 VAL A 136
LEU A  83
ILE A 110
ALA A 126
None
0.71A 4zf8A-5uhdA:
undetectable
4zf8A-5uhdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
4 LEU A 194
ILE A 247
ALA A 246
ALA A 242
None
0.68A 4zf8A-5v1wA:
undetectable
4zf8A-5v1wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1)
no annotation 4 VAL A 724
LEU A 622
ILE A 686
ALA A 695
None
0.63A 4zf8A-5wmmA:
undetectable
4zf8A-5wmmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A)
no annotation 4 VAL A 405
LEU A 418
ILE A 387
ALA A 388
None
0.65A 4zf8A-5wsoA:
undetectable
4zf8A-5wsoA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Campylobacter
jejuni)
no annotation 4 LEU A 139
ILE A 141
ALA A 142
ALA A 182
None
0.73A 4zf8A-6bmaA:
undetectable
4zf8A-6bmaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE


(Entamoeba
histolytica)
no annotation 4 LEU A  42
ILE A 189
ALA A 188
ALA A 204
None
0.63A 4zf8A-6cc2A:
undetectable
4zf8A-6cc2A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Moorella
thermoacetica)
no annotation 4 LEU A 606
ILE A 576
ALA A 575
ALA A 567
None
0.77A 4zf8A-6cipA:
undetectable
4zf8A-6cipA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE


(Bacteroides
thetaiotaomicron)
no annotation 4 VAL A 374
LEU A 476
ILE A 413
ALA A 412
None
0.62A 4zf8A-6f8zA:
undetectable
4zf8A-6f8zA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpd PROTEIN AB21

(Agaricus
bisporus)
no annotation 4 LEU A 169
ILE A 152
ALA A 153
ALA A 157
None
0.78A 4zf8A-6fpdA:
undetectable
4zf8A-6fpdA:
11.20