SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZE2_A_1YNA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A  26
LEU A 140
ILE A 256
PHE A 102
GLY A 259
 None
None
None
CU  A 556 ( 4.9A)
None
 1.16A 4ze2A-1asoA:
0.0		 4ze2A-1asoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 191
ILE A 149
PHE A 187
GLY A 207
LEU A 265
 None
 1.14A 4ze2A-1cqjA:
0.0		 4ze2A-1cqjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		6 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
MET A 517
 None
 1.28A 4ze2A-1d0nA:
0.1		 4ze2A-1d0nA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		5 GLY A 149
LEU A  81
ILE A  37
GLY A  32
LEU A  77
 None
 1.15A 4ze2A-1ds9A:
0.0		 4ze2A-1ds9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR B   4
PHE B  71
GLY B 102
HIS B  53
THR B  51
 None
 1.11A 4ze2A-1htrB:
0.0		 4ze2A-1htrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLY A   8
TYR A 265
LEU A 264
PHE A 341
THR A   6
 LLP  A 185 ( 3.5A)
None
None
None
None
 1.16A 4ze2A-1iugA:
0.0		 4ze2A-1iugA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 GLY A 259
LEU A  26
GLY A  16
THR A  92
LEU A 251
 None
 1.03A 4ze2A-1k27A:
0.0		 4ze2A-1k27A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 GLY A 359
TYR A 284
LEU A 274
PHE A 294
GLY A 317
 None
 1.15A 4ze2A-1lxyA:
0.0		 4ze2A-1lxyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		5 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.09A 4ze2A-1nphA:
0.0		 4ze2A-1nphA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		5 LEU E 915
PHE E 943
GLY E 891
LEU E 896
THR E 989
 None
 1.15A 4ze2A-1o7dE:
undetectable		 4ze2A-1o7dE:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 GLY A 237
PHE A 320
GLY A 307
THR A  98
THR A 239
 K  A 502 ( 4.7A)
None
None
None
None
 1.07A 4ze2A-1p9eA:
undetectable		 4ze2A-1p9eA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 GLY A 251
LEU A 326
ILE A 346
GLY A 339
THR A 354
 GLY  A 251 ( 0.0A)
LEU  A 326 ( 0.6A)
ILE  A 346 ( 0.7A)
GLY  A 339 ( 0.0A)
THR  A 354 ( 0.8A)
 1.16A 4ze2A-1rrvA:
undetectable		 4ze2A-1rrvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A 257
LEU A 109
PHE A 144
ILE A  62
LEU A 279
 None
 1.11A 4ze2A-1v0bA:
undetectable		 4ze2A-1v0bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys5 LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 GLY A 146
LEU A  94
ILE A  71
GLY A 126
LEU A 152
 None
 0.99A 4ze2A-1ys5A:
undetectable		 4ze2A-1ys5A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		5 GLY A  55
LEU A  24
ILE A  72
PHE A  28
THR A  58
 None
 1.11A 4ze2A-2fccA:
undetectable		 4ze2A-2fccA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 165
LEU A 314
GLY A 222
LEU A 229
THR A 190
 None
 1.15A 4ze2A-2hlpA:
undetectable		 4ze2A-2hlpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		5 LEU A 519
PHE A 524
GLY A 490
THR A 495
MET A 493
 None
 0.95A 4ze2A-2hwkA:
undetectable		 4ze2A-2hwkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		5 LEU A 519
PHE A 524
GLY A 580
THR A 495
MET A 493
 None
 1.10A 4ze2A-2hwkA:
undetectable		 4ze2A-2hwkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.87A 4ze2A-2jfwA:
undetectable		 4ze2A-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		5 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.02A 4ze2A-2ow4A:
undetectable		 4ze2A-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 PHE A 216
ILE A   7
LEU A 235
THR A 146
MET A 172
 None
 1.13A 4ze2A-2p17A:
undetectable		 4ze2A-2p17A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		5 GLY A 577
PHE A 646
ILE A 722
GLY A 671
THR A 727
 None
 1.14A 4ze2A-2wd6A:
undetectable		 4ze2A-2wd6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		5 GLY A  68
LEU A 280
ILE A 335
LEU A 344
HIS A 345
 None
 1.16A 4ze2A-2xhcA:
undetectable		 4ze2A-2xhcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 LEU A 351
PHE A  46
PHE A 333
GLY A 409
THR A 258
 None
 1.10A 4ze2A-2z00A:
undetectable		 4ze2A-2z00A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLY A1142
LEU A1116
GLY A1108
LEU A1235
THR A1141
 None
None
MN  A   3 (-3.8A)
None
None
 1.17A 4ze2A-2zxqA:
undetectable		 4ze2A-2zxqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.15A 4ze2A-3bs8A:
undetectable		 4ze2A-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		5 GLY A  36
PHE A 395
ILE A 386
GLY A 321
THR A 343
 None
 1.09A 4ze2A-3dmsA:
undetectable		 4ze2A-3dmsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		5 GLY A  88
PHE A 202
ILE A 177
GLY A 194
THR A  50
 None
 1.13A 4ze2A-3f4sA:
undetectable		 4ze2A-3f4sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum) 		PF01633
(Choline_kinase) 		5 GLY A 188
PHE A 353
ILE A 318
GLY A 210
LEU A 303
 None
 1.14A 4ze2A-3fi8A:
undetectable		 4ze2A-3fi8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5j PUTATIVE ATP/GTP
BINDING PROTEIN

(Clostridioides
difficile) 		PF00581
(Rhodanese) 		5 GLY A 119
TYR A  52
ILE A  51
PHE A  40
GLY A  64
 None
None
None
None
PGE  A 302 ( 4.0A)
 0.98A 4ze2A-3g5jA:
undetectable		 4ze2A-3g5jA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		5 GLY A 274
LEU A 120
PHE A 160
ILE A  74
LEU A 296
 None
 1.09A 4ze2A-3gbzA:
undetectable		 4ze2A-3gbzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		5 GLY A  32
ILE A  53
PHE A  58
GLY A  45
LEU A  13
 None
 1.17A 4ze2A-3h87A:
undetectable		 4ze2A-3h87A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.12A 4ze2A-3ihgA:
undetectable		 4ze2A-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 LEU W 843
THR W 894
LEU W 831
HIS W 830
MET W 854
 None
 1.12A 4ze2A-3iylW:
undetectable		 4ze2A-3iylW:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 GLY A 216
ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 1.02A 4ze2A-3jr3A:
undetectable		 4ze2A-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
 None
 1.13A 4ze2A-3n23B:
undetectable		 4ze2A-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 GLY A 498
ILE B 332
GLY B 465
THR A 489
LEU A 383
 None
 1.11A 4ze2A-3opyA:
undetectable		 4ze2A-3opyA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		5 GLY A 166
LEU A 402
ILE A 223
GLY A 212
THR A 393
 None
 1.14A 4ze2A-3oz7A:
undetectable		 4ze2A-3oz7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  41
TYR A   9
PHE A 102
GLY A  66
THR A  38
 None
 1.11A 4ze2A-3q4dA:
undetectable		 4ze2A-3q4dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 GLY B 217
LEU B 258
LEU B  52
HIS B 184
THR B 214
 None
 1.06A 4ze2A-3qkcB:
1.0		 4ze2A-3qkcB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.14A 4ze2A-3r44A:
undetectable		 4ze2A-3r44A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 295
ILE A 286
GLY A 246
LEU A 242
THR A 307
 None
 1.13A 4ze2A-3stjA:
undetectable		 4ze2A-3stjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		5 GLY A 240
LEU A 191
ILE A  70
GLY A  39
LEU A  82
 None
 1.11A 4ze2A-3tdpA:
undetectable		 4ze2A-3tdpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 355
PHE A 314
ILE A 339
GLY A 325
LEU A 361
 None
 1.06A 4ze2A-3tm5A:
undetectable		 4ze2A-3tm5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 398
ILE A  62
GLY A  82
HIS A  87
THR A 399
 None
 1.14A 4ze2A-3u4aA:
undetectable		 4ze2A-3u4aA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 GLY A 369
LEU A 222
ILE A 227
GLY A  95
THR A  92
 None
 1.10A 4ze2A-3vuoA:
0.6		 4ze2A-3vuoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 GLY A 178
LEU A 308
GLY A 269
LEU A 191
THR A 185
 None
 1.12A 4ze2A-3wh7A:
undetectable		 4ze2A-3wh7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		5 GLY A 330
LEU A 325
ILE A 348
GLY A 390
THR A 357
 None
 1.11A 4ze2A-3wj9A:
undetectable		 4ze2A-3wj9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		5 TYR A 385
ILE A 377
GLY A 372
THR A 312
THR A 318
 None
 1.16A 4ze2A-3wrfA:
undetectable		 4ze2A-3wrfA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 GLY A 186
LEU A 161
ILE A  12
GLY A 217
THR A 224
 None
None
NDP  A 999 (-3.8A)
None
None
 1.08A 4ze2A-4b4oA:
undetectable		 4ze2A-4b4oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.17A 4ze2A-4b6gA:
undetectable		 4ze2A-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 GLY A 442
LEU A 416
ILE A 422
GLY A 334
THR A 440
 None
 1.10A 4ze2A-4bb9A:
undetectable		 4ze2A-4bb9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 501
LEU A 149
ILE A 469
GLY A 218
THR A 494
 None
None
PGE  A1554 ( 4.7A)
None
None
 1.16A 4ze2A-4be9A:
undetectable		 4ze2A-4be9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cij GST REP

(Geobacillus
stearothermophilus) 		PF02486
(Rep_trans) 		5 GLY A  76
LEU A  36
GLY A  85
THR A  82
THR A  14
 None
 1.16A 4ze2A-4cijA:
undetectable		 4ze2A-4cijA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glr ANTI-PTAU HEAVY
CHAIN

(Gallus gallus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  60
LEU H  82
GLY H  10
THR H 107
LEU H  20
 None
 1.04A 4ze2A-4glrH:
undetectable		 4ze2A-4glrH:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 GLY A 206
LEU A 228
ILE A 122
THR A 187
THR A 208
 None
 1.13A 4ze2A-4idmA:
undetectable		 4ze2A-4idmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 FLG22
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(;
Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF00669
(Flagellin_N)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A 493
LEU A 484
ILE C  85
GLY A 439
THR A 470
 None
 1.15A 4ze2A-4mn8A:
undetectable		 4ze2A-4mn8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 LEU A 333
ILE A 325
PHE A 365
GLY A  78
LEU A 358
 None
 1.16A 4ze2A-4n7tA:
undetectable		 4ze2A-4n7tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 GLY A 420
LEU A 268
ILE A 256
GLY A 260
LEU A 431
 None
None
None
SO4  A 501 (-3.4A)
None
 1.16A 4ze2A-4npaA:
0.4		 4ze2A-4npaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcw FILAGGRIN

(Homo sapiens) 		PF01023
(S_100) 		5 LEU A  80
ILE A  10
PHE A  40
LEU A  60
HIS A  59
 2PE  A 103 (-4.3A)
None
None
2PE  A 103 ( 4.9A)
None
 0.97A 4ze2A-4pcwA:
undetectable		 4ze2A-4pcwA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		5 LEU A 235
ILE A 232
GLY A 298
THR A 300
LEU A 324
 None
 1.08A 4ze2A-4pvcA:
undetectable		 4ze2A-4pvcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 GLY A 990
ILE A1050
LEU A1026
HIS A1029
MET A1022
 None
 1.07A 4ze2A-4qmhA:
undetectable		 4ze2A-4qmhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		5 PHE A 228
ILE A 254
GLY A 142
THR A 137
THR A 101
 None
 1.10A 4ze2A-4rxtA:
undetectable		 4ze2A-4rxtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 GLY A  25
LEU A 167
PHE A 159
PHE A 142
GLY A  86
 None
None
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.0A)
 1.10A 4ze2A-4uy6A:
undetectable		 4ze2A-4uy6A:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		6 GLY A  69
TYR A 122
LEU A 125
PHE A 130
PHE A 229
HIS A 374
 None
VOR  A 590 (-3.8A)
None
VOR  A 590 (-4.6A)
None
None
 1.16A 4ze2A-4uymA:
52.3		 4ze2A-4uymA:
50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 GLY A 662
LEU A 398
ILE A 355
GLY A 351
THR A 408
 None
 1.06A 4ze2A-4uzsA:
undetectable		 4ze2A-4uzsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 5 GLY E 141
TYR E  83
LEU E  84
GLY E  77
THR E 142
 None
 1.03A 4ze2A-4whbE:
undetectable		 4ze2A-4whbE:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.14A 4ze2A-4x1zA:
undetectable		 4ze2A-4x1zA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 LEU A 362
ILE A 352
PHE A 366
LEU A 337
MET A 388
 None
 1.17A 4ze2A-4xzeA:
undetectable		 4ze2A-4xzeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydl HEAVY CHAIN OF
ANTIBODY
C38-VRC18.02

(Homo sapiens) 		no annotation 5 GLY H  85
LEU H  82
ILE H  34
GLY H 104
THR H  87
 None
 1.01A 4ze2A-4ydlH:
undetectable		 4ze2A-4ydlH:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		5 GLY A 189
LEU A 211
ILE A 299
GLY A 208
THR A 121
 None
 0.98A 4ze2A-4yj5A:
undetectable		 4ze2A-4yj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7a BARLEY STRIPE MOSAIC
VIRUS NARROW

(Barley stripe
mosaic virus) 		PF00721
(TMV_coat) 		5 GLY A  81
LEU A 188
GLY A  27
LEU A  71
THR A 178
 None
 1.14A 4ze2A-5a7aA:
undetectable		 4ze2A-5a7aA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  85
LEU H  80
ILE H  34
GLY H 104
THR H  87
 None
 0.98A 4ze2A-5awnH:
undetectable		 4ze2A-5awnH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 GLY A1091
LEU A 710
ILE A 389
GLY A 373
LEU A1029
 None
 1.03A 4ze2A-5fqdA:
undetectable		 4ze2A-5fqdA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 GLY A  65
TYR A 118
LEU A 121
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
HIS A 377
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.6A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.54A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.07A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5p NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.12A 4ze2A-5g5pA:
undetectable		 4ze2A-5g5pA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 PHE A  93
ILE A  76
GLY A 112
LEU A 151
THR A 169
 None
 1.11A 4ze2A-5gvaA:
undetectable		 4ze2A-5gvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.07A 4ze2A-5h7jA:
undetectable		 4ze2A-5h7jA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.12A 4ze2A-5h7kA:
undetectable		 4ze2A-5h7kA:
8.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		6 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.78A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 GLY A  73
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.60A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 GLY A 463
LEU A 284
ILE A 430
GLY A 425
THR A 446
 None
 1.08A 4ze2A-5j5uA:
undetectable		 4ze2A-5j5uA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 GLY A  74
TYR A 127
LEU A 130
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
HIS A 382
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.69A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 GLY A 316
THR A 319
LEU A 381
HIS A 382
THR A 510
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
 0.98A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kai CYTOCHROME C-550

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
 0.98A 4ze2A-5kaiV:
undetectable		 4ze2A-5kaiV:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.12A 4ze2A-5l3tA:
undetectable		 4ze2A-5l3tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.09A 4ze2A-5m7rA:
undetectable		 4ze2A-5m7rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqf APICAL MEMBRANE
ANTIGEN 1

(Plasmodium
falciparum) 		PF02430
(AMA-1) 		5 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.16A 4ze2A-5nqfA:
undetectable		 4ze2A-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.15A 4ze2A-5ubpA:
undetectable		 4ze2A-5ubpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 GLY 2 421
PHE 2 677
ILE 2 673
THR 2 567
LEU 2 576
 None
 1.05A 4ze2A-5udb2:
undetectable		 4ze2A-5udb2:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.00A 4ze2A-5uhkA:
undetectable		 4ze2A-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 GLY A 223
LEU A 252
ILE A 390
LEU A 239
THR A 231
 None
 1.00A 4ze2A-5vsjA:
undetectable		 4ze2A-5vsjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.16A 4ze2A-5vvoA:
undetectable		 4ze2A-5vvoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 GLY C1089
TYR C1165
LEU C1129
ILE C1166
GLY C1159
 None
 1.17A 4ze2A-5zyaC:
1.0		 4ze2A-5zyaC:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzn -

(-) 		no annotation 5 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.03A 4ze2A-5zznV:
undetectable		 4ze2A-5zznV:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
PHE A 114
THR A 297
LEU A 358
THR A 465
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
None
 0.90A 4ze2A-6ay4A:
42.6		 4ze2A-6ay4A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 GLY A  61
LEU A  93
PHE A 104
ILE A  85
THR A  63
 None
 1.04A 4ze2A-6bbpA:
undetectable		 4ze2A-6bbpA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 5 GLY A 177
ILE A  63
GLY A  81
LEU A 157
HIS A 180
 None
None
None
SAM  A 901 (-3.8A)
SAM  A 901 (-4.2A)
 0.82A 4ze2A-6bxnA:
undetectable		 4ze2A-6bxnA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 5 LEU B  47
ILE B   2
GLY C  12
THR C  16
THR B  39
 None
 1.10A 4ze2A-6cfwB:
undetectable		 4ze2A-6cfwB:
11.48