SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZE2_A_1YNA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A  26
LEU A 140
ILE A 256
PHE A 102
GLY A 259
 None
None
None
CU  A 556 ( 4.9A)
None
 1.16A 4ze2A-1asoA:
0.0		 4ze2A-1asoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 191
ILE A 149
PHE A 187
GLY A 207
LEU A 265
 None
 1.14A 4ze2A-1cqjA:
0.0		 4ze2A-1cqjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		6 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
MET A 517
 None
 1.28A 4ze2A-1d0nA:
0.1		 4ze2A-1d0nA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		5 GLY A 149
LEU A  81
ILE A  37
GLY A  32
LEU A  77
 None
 1.15A 4ze2A-1ds9A:
0.0		 4ze2A-1ds9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR B   4
PHE B  71
GLY B 102
HIS B  53
THR B  51
 None
 1.11A 4ze2A-1htrB:
0.0		 4ze2A-1htrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLY A   8
TYR A 265
LEU A 264
PHE A 341
THR A   6
 LLP  A 185 ( 3.5A)
None
None
None
None
 1.16A 4ze2A-1iugA:
0.0		 4ze2A-1iugA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 GLY A 259
LEU A  26
GLY A  16
THR A  92
LEU A 251
 None
 1.03A 4ze2A-1k27A:
0.0		 4ze2A-1k27A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 GLY A 359
TYR A 284
LEU A 274
PHE A 294
GLY A 317
 None
 1.15A 4ze2A-1lxyA:
0.0		 4ze2A-1lxyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		5 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.09A 4ze2A-1nphA:
0.0		 4ze2A-1nphA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		5 LEU E 915
PHE E 943
GLY E 891
LEU E 896
THR E 989
 None
 1.15A 4ze2A-1o7dE:
undetectable		 4ze2A-1o7dE:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 GLY A 237
PHE A 320
GLY A 307
THR A  98
THR A 239
 K  A 502 ( 4.7A)
None
None
None
None
 1.07A 4ze2A-1p9eA:
undetectable		 4ze2A-1p9eA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 GLY A 251
LEU A 326
ILE A 346
GLY A 339
THR A 354
 GLY  A 251 ( 0.0A)
LEU  A 326 ( 0.6A)
ILE  A 346 ( 0.7A)
GLY  A 339 ( 0.0A)
THR  A 354 ( 0.8A)
 1.16A 4ze2A-1rrvA:
undetectable		 4ze2A-1rrvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A 257
LEU A 109
PHE A 144
ILE A  62
LEU A 279
 None
 1.11A 4ze2A-1v0bA:
undetectable		 4ze2A-1v0bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys5 LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 GLY A 146
LEU A  94
ILE A  71
GLY A 126
LEU A 152
 None
 0.99A 4ze2A-1ys5A:
undetectable		 4ze2A-1ys5A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		5 GLY A  55
LEU A  24
ILE A  72
PHE A  28
THR A  58
 None
 1.11A 4ze2A-2fccA:
undetectable		 4ze2A-2fccA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 165
LEU A 314
GLY A 222
LEU A 229
THR A 190
 None
 1.15A 4ze2A-2hlpA:
undetectable		 4ze2A-2hlpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		5 LEU A 519
PHE A 524
GLY A 490
THR A 495
MET A 493
 None
 0.95A 4ze2A-2hwkA:
undetectable		 4ze2A-2hwkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		5 LEU A 519
PHE A 524
GLY A 580
THR A 495
MET A 493
 None
 1.10A 4ze2A-2hwkA:
undetectable		 4ze2A-2hwkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.87A 4ze2A-2jfwA:
undetectable		 4ze2A-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		5 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.02A 4ze2A-2ow4A:
undetectable		 4ze2A-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 PHE A 216
ILE A   7
LEU A 235
THR A 146
MET A 172
 None
 1.13A 4ze2A-2p17A:
undetectable		 4ze2A-2p17A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		5 GLY A 577
PHE A 646
ILE A 722
GLY A 671
THR A 727
 None
 1.14A 4ze2A-2wd6A:
undetectable		 4ze2A-2wd6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		5 GLY A  68
LEU A 280
ILE A 335
LEU A 344
HIS A 345
 None
 1.16A 4ze2A-2xhcA:
undetectable		 4ze2A-2xhcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 LEU A 351
PHE A  46
PHE A 333
GLY A 409
THR A 258
 None
 1.10A 4ze2A-2z00A:
undetectable		 4ze2A-2z00A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLY A1142
LEU A1116
GLY A1108
LEU A1235
THR A1141
 None
None
MN  A   3 (-3.8A)
None
None
 1.17A 4ze2A-2zxqA:
undetectable		 4ze2A-2zxqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.15A 4ze2A-3bs8A:
undetectable		 4ze2A-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		5 GLY A  36
PHE A 395
ILE A 386
GLY A 321
THR A 343
 None
 1.09A 4ze2A-3dmsA:
undetectable		 4ze2A-3dmsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		5 GLY A  88
PHE A 202
ILE A 177
GLY A 194
THR A  50
 None
 1.13A 4ze2A-3f4sA:
undetectable		 4ze2A-3f4sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum) 		PF01633
(Choline_kinase) 		5 GLY A 188
PHE A 353
ILE A 318
GLY A 210
LEU A 303
 None
 1.14A 4ze2A-3fi8A:
undetectable		 4ze2A-3fi8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5j PUTATIVE ATP/GTP
BINDING PROTEIN

(Clostridioides
difficile) 		PF00581
(Rhodanese) 		5 GLY A 119
TYR A  52
ILE A  51
PHE A  40
GLY A  64
 None
None
None
None
PGE  A 302 ( 4.0A)
 0.98A 4ze2A-3g5jA:
undetectable		 4ze2A-3g5jA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		5 GLY A 274
LEU A 120
PHE A 160
ILE A  74
LEU A 296
 None
 1.09A 4ze2A-3gbzA:
undetectable		 4ze2A-3gbzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		5 GLY A  32
ILE A  53
PHE A  58
GLY A  45
LEU A  13
 None
 1.17A 4ze2A-3h87A:
undetectable		 4ze2A-3h87A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.12A 4ze2A-3ihgA:
undetectable		 4ze2A-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 LEU W 843
THR W 894
LEU W 831
HIS W 830
MET W 854
 None
 1.12A 4ze2A-3iylW:
undetectable		 4ze2A-3iylW:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 GLY A 216
ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 1.02A 4ze2A-3jr3A:
undetectable		 4ze2A-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
 None
 1.13A 4ze2A-3n23B:
undetectable		 4ze2A-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 GLY A 498
ILE B 332
GLY B 465
THR A 489
LEU A 383
 None
 1.11A 4ze2A-3opyA:
undetectable		 4ze2A-3opyA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		5 GLY A 166
LEU A 402
ILE A 223
GLY A 212
THR A 393
 None
 1.14A 4ze2A-3oz7A:
undetectable		 4ze2A-3oz7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  41
TYR A   9
PHE A 102
GLY A  66
THR A  38
 None
 1.11A 4ze2A-3q4dA:
undetectable		 4ze2A-3q4dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 GLY B 217
LEU B 258
LEU B  52
HIS B 184
THR B 214
 None
 1.06A 4ze2A-3qkcB:
1.0		 4ze2A-3qkcB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.14A 4ze2A-3r44A:
undetectable		 4ze2A-3r44A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 295
ILE A 286
GLY A 246
LEU A 242
THR A 307
 None
 1.13A 4ze2A-3stjA:
undetectable		 4ze2A-3stjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		5 GLY A 240
LEU A 191
ILE A  70
GLY A  39
LEU A  82
 None
 1.11A 4ze2A-3tdpA:
undetectable		 4ze2A-3tdpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 355
PHE A 314
ILE A 339
GLY A 325
LEU A 361
 None
 1.06A 4ze2A-3tm5A:
undetectable		 4ze2A-3tm5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 398
ILE A  62
GLY A  82
HIS A  87
THR A 399
 None
 1.14A 4ze2A-3u4aA:
undetectable		 4ze2A-3u4aA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 GLY A 369
LEU A 222
ILE A 227
GLY A  95
THR A  92
 None
 1.10A 4ze2A-3vuoA:
0.6		 4ze2A-3vuoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 GLY A 178
LEU A 308
GLY A 269
LEU A 191
THR A 185
 None
 1.12A 4ze2A-3wh7A:
undetectable		 4ze2A-3wh7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		5 GLY A 330
LEU A 325
ILE A 348
GLY A 390
THR A 357
 None
 1.11A 4ze2A-3wj9A:
undetectable		 4ze2A-3wj9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		5 TYR A 385
ILE A 377
GLY A 372
THR A 312
THR A 318
 None
 1.16A 4ze2A-3wrfA:
undetectable		 4ze2A-3wrfA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 GLY A 186
LEU A 161
ILE A  12
GLY A 217
THR A 224
 None
None
NDP  A 999 (-3.8A)
None
None
 1.08A 4ze2A-4b4oA:
undetectable		 4ze2A-4b4oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.17A 4ze2A-4b6gA:
undetectable		 4ze2A-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 GLY A 442
LEU A 416
ILE A 422
GLY A 334
THR A 440
 None
 1.10A 4ze2A-4bb9A:
undetectable		 4ze2A-4bb9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 501
LEU A 149
ILE A 469
GLY A 218
THR A 494
 None
None
PGE  A1554 ( 4.7A)
None
None
 1.16A 4ze2A-4be9A:
undetectable		 4ze2A-4be9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cij GST REP

(Geobacillus
stearothermophilus) 		PF02486
(Rep_trans) 		5 GLY A  76
LEU A  36
GLY A  85
THR A  82
THR A  14
 None
 1.16A 4ze2A-4cijA:
undetectable		 4ze2A-4cijA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glr ANTI-PTAU HEAVY
CHAIN

(Gallus gallus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  60
LEU H  82
GLY H  10
THR H 107
LEU H  20
 None
 1.04A 4ze2A-4glrH:
undetectable		 4ze2A-4glrH:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 GLY A 206
LEU A 228
ILE A 122
THR A 187
THR A 208
 None
 1.13A 4ze2A-4idmA:
undetectable		 4ze2A-4idmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 FLG22
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(;
Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF00669
(Flagellin_N)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A 493
LEU A 484
ILE C  85
GLY A 439
THR A 470
 None
 1.15A 4ze2A-4mn8A:
undetectable		 4ze2A-4mn8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 LEU A 333
ILE A 325
PHE A 365
GLY A  78
LEU A 358
 None
 1.16A 4ze2A-4n7tA:
undetectable		 4ze2A-4n7tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 GLY A 420
LEU A 268
ILE A 256
GLY A 260
LEU A 431
 None
None
None
SO4  A 501 (-3.4A)
None
 1.16A 4ze2A-4npaA:
0.4		 4ze2A-4npaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcw FILAGGRIN

(Homo sapiens) 		PF01023
(S_100) 		5 LEU A  80
ILE A  10
PHE A  40
LEU A  60
HIS A  59
 2PE  A 103 (-4.3A)
None
None
2PE  A 103 ( 4.9A)
None
 0.97A 4ze2A-4pcwA:
undetectable		 4ze2A-4pcwA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		5 LEU A 235
ILE A 232
GLY A 298
THR A 300
LEU A 324
 None
 1.08A 4ze2A-4pvcA:
undetectable		 4ze2A-4pvcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 GLY A 990
ILE A1050
LEU A1026
HIS A1029
MET A1022
 None
 1.07A 4ze2A-4qmhA:
undetectable		 4ze2A-4qmhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		5 PHE A 228
ILE A 254
GLY A 142
THR A 137
THR A 101
 None
 1.10A 4ze2A-4rxtA:
undetectable		 4ze2A-4rxtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 GLY A  25
LEU A 167
PHE A 159
PHE A 142
GLY A  86
 None
None
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.0A)
 1.10A 4ze2A-4uy6A:
undetectable		 4ze2A-4uy6A:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		6 GLY A  69
TYR A 122
LEU A 125
PHE A 130
PHE A 229
HIS A 374
 None
VOR  A 590 (-3.8A)
None
VOR  A 590 (-4.6A)
None
None
 1.16A 4ze2A-4uymA:
52.3		 4ze2A-4uymA:
50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 GLY A 662
LEU A 398
ILE A 355
GLY A 351
THR A 408
 None
 1.06A 4ze2A-4uzsA:
undetectable		 4ze2A-4uzsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 5 GLY E 141
TYR E  83
LEU E  84
GLY E  77
THR E 142
 None
 1.03A 4ze2A-4whbE:
undetectable		 4ze2A-4whbE:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.14A 4ze2A-4x1zA:
undetectable		 4ze2A-4x1zA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 LEU A 362
ILE A 352
PHE A 366
LEU A 337
MET A 388
 None
 1.17A 4ze2A-4xzeA:
undetectable		 4ze2A-4xzeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydl HEAVY CHAIN OF
ANTIBODY
C38-VRC18.02

(Homo sapiens) 		no annotation 5 GLY H  85
LEU H  82
ILE H  34
GLY H 104
THR H  87
 None
 1.01A 4ze2A-4ydlH:
undetectable		 4ze2A-4ydlH:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		5 GLY A 189
LEU A 211
ILE A 299
GLY A 208
THR A 121
 None
 0.98A 4ze2A-4yj5A:
undetectable		 4ze2A-4yj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7a BARLEY STRIPE MOSAIC
VIRUS NARROW

(Barley stripe
mosaic virus) 		PF00721
(TMV_coat) 		5 GLY A  81
LEU A 188
GLY A  27
LEU A  71
THR A 178
 None
 1.14A 4ze2A-5a7aA:
undetectable		 4ze2A-5a7aA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  85
LEU H  80
ILE H  34
GLY H 104
THR H  87
 None
 0.98A 4ze2A-5awnH:
undetectable		 4ze2A-5awnH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 GLY A1091
LEU A 710
ILE A 389
GLY A 373
LEU A1029
 None
 1.03A 4ze2A-5fqdA:
undetectable		 4ze2A-5fqdA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 GLY A  65
TYR A 118
LEU A 121
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
HIS A 377
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.6A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.54A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.07A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5p NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.12A 4ze2A-5g5pA:
undetectable		 4ze2A-5g5pA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 PHE A  93
ILE A  76
GLY A 112
LEU A 151
THR A 169
 None
 1.11A 4ze2A-5gvaA:
undetectable		 4ze2A-5gvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.07A 4ze2A-5h7jA:
undetectable		 4ze2A-5h7jA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.12A 4ze2A-5h7kA:
undetectable		 4ze2A-5h7kA:
8.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		6 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.78A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 GLY A  73
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.60A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 GLY A 463
LEU A 284
ILE A 430
GLY A 425
THR A 446
 None
 1.08A 4ze2A-5j5uA:
undetectable		 4ze2A-5j5uA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 GLY A  74
TYR A 127
LEU A 130
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
HIS A 382
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.69A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 GLY A 316
THR A 319
LEU A 381
HIS A 382
THR A 510
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
 0.98A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kai CYTOCHROME C-550

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
 0.98A 4ze2A-5kaiV:
undetectable		 4ze2A-5kaiV:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.12A 4ze2A-5l3tA:
undetectable		 4ze2A-5l3tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.09A 4ze2A-5m7rA:
undetectable		 4ze2A-5m7rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqf APICAL MEMBRANE
ANTIGEN 1

(Plasmodium
falciparum) 		PF02430
(AMA-1) 		5 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.16A 4ze2A-5nqfA:
undetectable		 4ze2A-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.15A 4ze2A-5ubpA:
undetectable		 4ze2A-5ubpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 GLY 2 421
PHE 2 677
ILE 2 673
THR 2 567
LEU 2 576
 None
 1.05A 4ze2A-5udb2:
undetectable		 4ze2A-5udb2:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.00A 4ze2A-5uhkA:
undetectable		 4ze2A-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 GLY A 223
LEU A 252
ILE A 390
LEU A 239
THR A 231
 None
 1.00A 4ze2A-5vsjA:
undetectable		 4ze2A-5vsjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.16A 4ze2A-5vvoA:
undetectable		 4ze2A-5vvoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 GLY C1089
TYR C1165
LEU C1129
ILE C1166
GLY C1159
 None
 1.17A 4ze2A-5zyaC:
1.0		 4ze2A-5zyaC:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzn -

(-) 		no annotation 5 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.03A 4ze2A-5zznV:
undetectable		 4ze2A-5zznV:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
PHE A 114
THR A 297
LEU A 358
THR A 465
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
None
 0.90A 4ze2A-6ay4A:
42.6		 4ze2A-6ay4A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 GLY A  61
LEU A  93
PHE A 104
ILE A  85
THR A  63
 None
 1.04A 4ze2A-6bbpA:
undetectable		 4ze2A-6bbpA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 5 GLY A 177
ILE A  63
GLY A  81
LEU A 157
HIS A 180
 None
None
None
SAM  A 901 (-3.8A)
SAM  A 901 (-4.2A)
 0.82A 4ze2A-6bxnA:
undetectable		 4ze2A-6bxnA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 5 LEU B  47
ILE B   2
GLY C  12
THR C  16
THR B  39
 None
 1.10A 4ze2A-6cfwB:
undetectable		 4ze2A-6cfwB:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 ALA A 186
TYR A 185
HIS A 166
PHE A 319
 None
 1.39A 4ze2A-1aj8A:
0.2		 4ze2A-1aj8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ALA A  15
TYR A  35
HIS A 293
PHE A  23
 None
 1.37A 4ze2A-1e5dA:
0.2		 4ze2A-1e5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzc ERYTHRINA
CRISTA-GALLI LECTIN

(Erythrina
crista-galli) 		PF00139
(Lectin_legB) 		4 ALA A 190
TYR A 185
PRO A 141
PHE A  76
 None
 1.22A 4ze2A-1gzcA:
0.0		 4ze2A-1gzcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 ALA A 151
HIS A  72
PRO A 301
PHE A 309
 None
 1.25A 4ze2A-1js6A:
0.0		 4ze2A-1js6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ALA A 202
TYR A 201
PRO A  45
PHE A 131
 None
 1.31A 4ze2A-1lnlA:
0.0		 4ze2A-1lnlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
METHYLAMINE
DEHYDROGENASE (LIGHT
SUBUNIT)

(Paracoccus
denitrificans) 		PF02975
(Me-amine-dh_L)
PF06433
(Me-amine-dh_H) 		4 ALA L 102
HIS H 178
PRO H 184
PHE H 141
 None
 1.28A 4ze2A-1mdaL:
0.0		 4ze2A-1mdaL:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa3 ENDO-BETA-1-4-GLUCAN
ASE

(Trichoderma
citrinoviride) 		PF01670
(Glyco_hydro_12) 		4 ALA A  83
TYR A 168
PRO A  80
PHE A 175
 None
 1.39A 4ze2A-1oa3A:
0.0		 4ze2A-1oa3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 ALA A 349
TYR A 350
PRO A 283
PHE A 405
 None
 1.29A 4ze2A-1pbyA:
0.0		 4ze2A-1pbyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP3)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 ALA 3 171
TYR 3 169
HIS 1  49
PRO 1  90
 None
 1.10A 4ze2A-1qgc3:
undetectable		 4ze2A-1qgc3:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ALA A  85
HIS A 293
PRO A  11
PHE A  45
 None
 1.20A 4ze2A-1rqgA:
undetectable		 4ze2A-1rqgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ALA A 113
TYR A 115
HIS A 363
PHE A 366
 None
 0.97A 4ze2A-1su7A:
undetectable		 4ze2A-1su7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 4 TYR A  47
HIS A 217
PRO A 221
PHE A 135
 None
 1.31A 4ze2A-1ufoA:
undetectable		 4ze2A-1ufoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ALA A 573
TYR A 574
HIS A 435
PRO A 512
 None
None
None
MAN  A3008 (-4.3A)
 1.06A 4ze2A-1xc6A:
undetectable		 4ze2A-1xc6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 ALA A 161
TYR A 160
PRO A 190
PHE A 197
 None
NDP  A1278 (-4.9A)
NDP  A1278 (-4.1A)
NDP  A1278 (-4.2A)
 1.37A 4ze2A-1xhlA:
undetectable		 4ze2A-1xhlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as5 FORKHEAD BOX PROTEIN
P2

(Homo sapiens) 		PF00250
(Forkhead) 		4 ALA F 510
TYR F 509
PRO F 506
PHE F 541
 None
 1.41A 4ze2A-2as5F:
2.1		 4ze2A-2as5F:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bn5 PSI
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA

(Drosophila
melanogaster) 		PF09005
(DUF1897)
no annotation 		4 ALA A 656
TYR A 654
PRO B 419
PHE B 414
 None
 1.41A 4ze2A-2bn5A:
undetectable		 4ze2A-2bn5A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 ALA A 514
TYR A 515
PRO A 521
PHE A 580
 None
 1.19A 4ze2A-2btvA:
undetectable		 4ze2A-2btvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		4 ALA A 153
TYR A 152
HIS A 198
PRO A 135
 None
CR2  A  56 ( 4.7A)
None
None
 1.29A 4ze2A-2dd7A:
undetectable		 4ze2A-2dd7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ALA A 305
TYR A 304
HIS A 340
PHE A 276
 None
GOL  A 761 ( 4.9A)
None
None
 1.25A 4ze2A-2e8yA:
undetectable		 4ze2A-2e8yA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 ALA A 371
TYR A  90
HIS A 412
PRO A 395
 None
 1.23A 4ze2A-2fafA:
undetectable		 4ze2A-2fafA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ALA A 673
HIS A 207
PRO A 679
PHE A  94
 None
 1.26A 4ze2A-2hauA:
undetectable		 4ze2A-2hauA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		4 ALA A  65
TYR A 115
PRO A 181
PHE A 119
 None
 1.22A 4ze2A-2if6A:
undetectable		 4ze2A-2if6A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 ALA A 200
HIS A 243
PRO A 254
PHE A 221
 None
 1.40A 4ze2A-2j7cA:
undetectable		 4ze2A-2j7cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ALA A 380
TYR A 381
PRO A 325
PHE A 335
 None
 1.23A 4ze2A-2o1bA:
undetectable		 4ze2A-2o1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		4 ALA A 263
TYR A 198
PRO A 279
PHE A 215
 None
 1.22A 4ze2A-2o69A:
undetectable		 4ze2A-2o69A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxg OUTER MEMBRANE
PROTEIN

(Xanthomonas
citri) 		PF04355
(SmpA_OmlA) 		4 ALA A  37
HIS A  49
PRO A  45
PHE A  76
 None
 1.16A 4ze2A-2pxgA:
undetectable		 4ze2A-2pxgA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		4 ALA A 153
TYR A 154
PRO A 298
PHE A 207
 None
 1.33A 4ze2A-2q0fA:
undetectable		 4ze2A-2q0fA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ALA A 141
TYR A  19
PRO A  60
PHE A  64
 None
 1.39A 4ze2A-2qytA:
undetectable		 4ze2A-2qytA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8)
PF13927
(Ig_3) 		4 ALA A 161
TYR A 145
HIS B 426
PHE A 129
 None
 1.04A 4ze2A-2v9tA:
undetectable		 4ze2A-2v9tA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ALA A 522
TYR A 521
HIS A 556
PHE A 494
 None
None
CSX  A 588 ( 4.0A)
None
 1.21A 4ze2A-2wanA:
undetectable		 4ze2A-2wanA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ALA A 234
TYR A 233
HIS A 266
PHE A 204
 None
 1.21A 4ze2A-2wskA:
undetectable		 4ze2A-2wskA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 ALA A 128
TYR A 127
HIS A 243
PRO A 180
 None
 1.34A 4ze2A-2x4gA:
undetectable		 4ze2A-2x4gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00578
(AhpC-TSA) 		4 ALA A 126
TYR A 124
PRO A  17
PHE A 135
 None
 1.21A 4ze2A-2ywiA:
undetectable		 4ze2A-2ywiA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N

(Thermus
thermophilus) 		PF00578
(AhpC-TSA) 		4 ALA A 114
TYR A 112
PRO A   8
PHE A 123
 None
 1.15A 4ze2A-2ywoA:
undetectable		 4ze2A-2ywoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bge PREDICTED ATPASE

(Haemophilus
influenzae) 		PF12002
(MgsA_C) 		4 ALA A 351
TYR A 414
HIS A 370
PHE A 405
 None
None
None
SO4  A   1 (-4.8A)
 1.21A 4ze2A-3bgeA:
undetectable		 4ze2A-3bgeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ALA A 143
TYR A 146
HIS A  66
PHE A  63
 None
 1.35A 4ze2A-3d1jA:
undetectable		 4ze2A-3d1jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0u GLUTATHIONE
PEROXIDASE

(Trypanosoma
cruzi) 		PF00255
(GSHPx) 		4 TYR A  55
HIS A  34
PRO A  76
PHE A 103
 None
 1.31A 4ze2A-3e0uA:
undetectable		 4ze2A-3e0uA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A  20
TYR A  93
PRO A 102
PHE A 234
 None
 1.29A 4ze2A-3g7sA:
undetectable		 4ze2A-3g7sA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsr ALL0216 PROTEIN

(Nostoc sp. PCC
7120) 		PF10674
(Ycf54) 		4 ALA A  69
TYR A   8
PRO A 103
PHE A  56
 None
 1.37A 4ze2A-3jsrA:
undetectable		 4ze2A-3jsrA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		4 ALA A  61
TYR A  62
PRO A  68
PHE A  97
 None
 1.42A 4ze2A-3k11A:
undetectable		 4ze2A-3k11A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		4 ALA A 162
TYR A 163
HIS A 105
PRO A 169
 None
 1.36A 4ze2A-3kxpA:
undetectable		 4ze2A-3kxpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l20 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF06983
(3-dmu-9_3-mt) 		4 ALA A  29
TYR A  23
PRO A   9
PHE A  13
 None
 1.11A 4ze2A-3l20A:
undetectable		 4ze2A-3l20A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ALA A  41
TYR A  40
HIS A 259
PRO A 318
 None
 1.03A 4ze2A-3mn8A:
undetectable		 4ze2A-3mn8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		4 ALA A 334
TYR A 337
HIS A  57
PRO A  98
 None
None
GOL  A1001 ( 4.7A)
None
 1.23A 4ze2A-3n9iA:
0.8		 4ze2A-3n9iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ALA A1064
TYR A1067
HIS A 962
PHE A 940
 None
 1.23A 4ze2A-3nzuA:
undetectable		 4ze2A-3nzuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A

(Escherichia
coli) 		PF00004
(AAA)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		4 ALA A 352
TYR A 415
HIS A 371
PHE A 406
 None
 1.17A 4ze2A-3pvsA:
undetectable		 4ze2A-3pvsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ALA A 278
HIS A 269
PRO A 367
PHE A 354
 None
 1.21A 4ze2A-3rb9A:
undetectable		 4ze2A-3rb9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		4 ALA A 200
TYR A 199
HIS A 226
PRO A 211
 None
 1.36A 4ze2A-3rvaA:
undetectable		 4ze2A-3rvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ALA A 434
TYR A 437
HIS A 485
PHE A 399
 None
 1.32A 4ze2A-3rx8A:
undetectable		 4ze2A-3rx8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		4 ALA A  56
HIS A 456
PRO A 292
PHE A 239
 None
 1.19A 4ze2A-3t66A:
undetectable		 4ze2A-3t66A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ALA A 257
TYR A 258
PRO A 210
PHE A 215
 None
 1.18A 4ze2A-3vabA:
undetectable		 4ze2A-3vabA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ALA A 312
TYR A 311
HIS A 347
PHE A 283
 None
None
MTT  A 802 (-4.4A)
None
 1.15A 4ze2A-3wdjA:
undetectable		 4ze2A-3wdjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		4 ALA A 362
HIS A 322
PRO A 313
PHE A 331
 None
 1.42A 4ze2A-3zytA:
undetectable		 4ze2A-3zytA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 ALA A 370
TYR A 369
HIS A 404
PHE A 312
 None
None
GOL  A1888 (-4.1A)
None
 1.24A 4ze2A-4aioA:
undetectable		 4ze2A-4aioA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		4 ALA B 400
TYR B 398
HIS B 368
PHE B 226
 None
 1.31A 4ze2A-4c9bB:
undetectable		 4ze2A-4c9bB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		4 ALA A 224
TYR A 225
PRO A 210
PHE A  81
 None
 1.28A 4ze2A-4fwbA:
undetectable		 4ze2A-4fwbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 ALA C 172
TYR C 170
HIS A  49
PRO A  90
 None
 1.16A 4ze2A-4gh4C:
undetectable		 4ze2A-4gh4C:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 ALA B 213
TYR B 212
HIS A 199
PRO B 172
 None
 1.17A 4ze2A-4hzuB:
undetectable		 4ze2A-4hzuB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ALA A 570
TYR A 571
HIS A 432
PRO A 509
 SEP  A 569 ( 3.7A)
NAG  A1138 (-4.9A)
None
None
 1.10A 4ze2A-4iugA:
undetectable		 4ze2A-4iugA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4x NP PROTEIN

(Sandfly fever
Naples
phlebovirus) 		PF05733
(Tenui_N) 		4 ALA A  31
TYR A  32
HIS A 152
PRO A  37
 None
 1.38A 4ze2A-4j4xA:
undetectable		 4ze2A-4j4xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 ALA A  97
TYR A  95
HIS A 259
PRO A  88
 None
 1.29A 4ze2A-4ofwA:
undetectable		 4ze2A-4ofwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 ALA A 290
TYR A 288
HIS A  66
PRO A 281
 None
 1.30A 4ze2A-4ofwA:
undetectable		 4ze2A-4ofwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 ALA A 200
HIS A  31
PRO A 208
PHE A 233
 None
 1.36A 4ze2A-4onoA:
undetectable		 4ze2A-4onoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 4 ALA A 127
HIS A  40
PRO A 155
PHE A  47
 None
 1.41A 4ze2A-4p8iA:
undetectable		 4ze2A-4p8iA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 4 ALA A 237
TYR A 221
HIS A 169
PHE A 211
 None
 1.34A 4ze2A-4rkmA:
undetectable		 4ze2A-4rkmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		4 ALA A  27
TYR A  30
PRO A 149
PHE A  66
 None
BFS  A 173 (-4.5A)
BFS  A 173 (-4.5A)
None
 0.91A 4ze2A-4stdA:
undetectable		 4ze2A-4stdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 ALA A 237
TYR A 233
HIS A   7
PRO A   0
 PG4  A 704 ( 4.0A)
None
None
PG4  A 704 (-4.3A)
 1.29A 4ze2A-4xwlA:
1.5		 4ze2A-4xwlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		4 ALA A 200
TYR A 168
HIS A  92
PHE A  50
 None
 1.15A 4ze2A-4yt2A:
undetectable		 4ze2A-4yt2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 4 ALA A  26
TYR A  29
PRO A 127
PHE A  41
 None
 1.38A 4ze2A-4yubA:
undetectable		 4ze2A-4yubA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 ALA W  75
HIS W  87
PRO W 253
PHE W  85
 None
 1.39A 4ze2A-4zxcW:
undetectable		 4ze2A-4zxcW:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		4 ALA I 309
HIS I 279
PRO I 247
PHE I 277
 None
 1.38A 4ze2A-5a5uI:
undetectable		 4ze2A-5a5uI:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 ALA A 417
TYR A 406
HIS A 115
PHE A 446
 None
 1.15A 4ze2A-5ah1A:
undetectable		 4ze2A-5ah1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 ALA K1037
HIS K1056
PRO K1029
PHE K1054
 None
 1.36A 4ze2A-5anbK:
undetectable		 4ze2A-5anbK:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 ALA A 212
TYR A 213
HIS A 193
PRO A 216
 None
 1.25A 4ze2A-5c2zA:
undetectable		 4ze2A-5c2zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE

(Penicillium
cyclopium) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 ALA A  93
HIS A 196
PRO A 174
PHE A 256
 None
CL  A 305 ( 4.6A)
None
None
 1.42A 4ze2A-5ch8A:
undetectable		 4ze2A-5ch8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 ALA A 170
TYR A 169
HIS A 156
PHE A 189
 None
MLY  A 181 ( 3.9A)
None
None
 1.03A 4ze2A-5czwA:
undetectable		 4ze2A-5czwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 ALA B 212
TYR B 211
HIS A 202
PRO B 172
 None
None
ANP  A 301 (-4.6A)
None
 1.06A 4ze2A-5d3mB:
undetectable		 4ze2A-5d3mB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 ALA A 342
HIS A 455
PRO A 278
PHE A 325
 None
ZN  A 702 ( 3.1A)
None
None
 1.42A 4ze2A-5ficA:
undetectable		 4ze2A-5ficA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 ALA A  61
TYR A  64
PRO A 230
PHE A 380
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
X2N  A 590 ( 4.8A)
 0.41A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ALA B 496
HIS B 534
PRO B 506
PHE B 514
 None
 1.28A 4ze2A-5gqrB:
undetectable		 4ze2A-5gqrB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hha PVDO

(Pseudomonas
aeruginosa) 		PF03781
(FGE-sulfatase) 		4 ALA A 161
TYR A 157
PRO A  27
PHE A  75
 None
 1.11A 4ze2A-5hhaA:
undetectable		 4ze2A-5hhaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 ALA A 342
HIS A 455
PRO A 278
PHE A 325
 None
ZN  A 702 ( 3.1A)
None
None
 1.34A 4ze2A-5hqnA:
undetectable		 4ze2A-5hqnA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 ALA A  69
TYR A  72
PRO A 238
PHE A 384
 None
 0.40A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 ALA A 344
HIS A 457
PRO A 280
PHE A 327
 None
ZN  A 714 (-3.2A)
None
None
 1.30A 4ze2A-5i85A:
undetectable		 4ze2A-5i85A:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 ALA A  70
TYR A  73
PRO A 239
PHE A 385
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
1YN  A 602 (-4.8A)
 0.26A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kef PHNB PROTEIN

(Staphylococcus
aureus) 		PF06983
(3-dmu-9_3-mt) 		4 ALA A  29
TYR A  23
PRO A   9
PHE A  13
 None
 1.10A 4ze2A-5kefA:
undetectable		 4ze2A-5kefA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 438
TYR A 437
HIS A 323
PRO A 310
 None
 0.97A 4ze2A-5lewA:
2.9		 4ze2A-5lewA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 4 ALA B  74
HIS B  86
PRO B 255
PHE B  84
 None
 1.24A 4ze2A-5m22B:
0.9		 4ze2A-5m22B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6p TYROCIDINE SYNTHASE
2

(Brevibacillus
parabrevis) 		no annotation 4 ALA A3297
HIS A3255
PRO A3130
PHE A3414
 None
 1.38A 4ze2A-5m6pA:
1.3		 4ze2A-5m6pA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		4 ALA A 156
HIS A  99
PRO A 152
PHE A 104
 None
 1.34A 4ze2A-5mb4A:
undetectable		 4ze2A-5mb4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II
PROTEIN D1

(Arabidopsis
thaliana) 		PF00124
(Photo_RC) 		4 ALA A 153
HIS A 332
PRO A 162
PHE A 186
 CLA  A 402 ( 3.7A)
None
None
CLA  A 402 (-4.4A)
 1.35A 4ze2A-5mdxA:
undetectable		 4ze2A-5mdxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE

(Mus musculus) 		no annotation 4 ALA A  29
HIS A 136
PRO A 118
PHE A  74
 None
 1.29A 4ze2A-5mzeA:
undetectable		 4ze2A-5mzeA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 ALA A  40
TYR A  43
HIS A 191
PRO A 186
 None
None
None
OLC  A 606 (-4.4A)
 1.16A 4ze2A-5n6mA:
undetectable		 4ze2A-5n6mA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 4 ALA A 172
TYR A 322
PRO A 508
PHE A 312
 None
 1.23A 4ze2A-5nf2A:
undetectable		 4ze2A-5nf2A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		4 ALA A 221
TYR A 223
HIS A  40
PRO A 113
 CA  A 302 ( 4.4A)
None
None
None
 1.06A 4ze2A-5twtA:
undetectable		 4ze2A-5twtA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u32 TRNA LIGASE

(Candida
albicans) 		no annotation 4 ALA A 479
TYR A 559
HIS A 574
PRO A 417
 None
 1.22A 4ze2A-5u32A:
undetectable		 4ze2A-5u32A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae) 		no annotation 4 ALA A 226
TYR A 225
PRO A 231
PHE A 127
 None
 1.25A 4ze2A-5y4kA:
undetectable		 4ze2A-5y4kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Burkholderia
cenocepacia) 		no annotation 4 ALA A 213
TYR A 212
PRO A 290
PHE A 285
 None
 1.31A 4ze2A-5y89A:
undetectable		 4ze2A-5y89A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 4 ALA A 322
TYR A 325
HIS A  45
PRO A  86
 None
None
TRP  A 501 (-4.0A)
None
 1.28A 4ze2A-6dfuA:
undetectable		 4ze2A-6dfuA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ALA A 664
TYR A 768
PRO A 755
PHE A 751
 None
 0.97A 4ze2A-6eonA:
undetectable		 4ze2A-6eonA:
20.23