SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZE1_A_X2NA602_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0e | XYLOSE ISOMERASE (Thermotoganeapolitana) |
PF01261(AP_endonuc_2) | 4 | VAL A 45ILE A 431PRO A 311THR A 277 | None | 1.16A | 4ze1A-1a0eA:0.0 | 4ze1A-1a0eA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bey | CAMPATH-1H ANTIBODY (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | VAL H 177ILE H 48PRO H 41THR H 89 | None | 1.17A | 4ze1A-1beyH:0.0 | 4ze1A-1beyH:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASESMALL SUBUNIT (Desulfovibriodesulfuricans) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 4 | VAL A 242TYR A 117ILE A 133THR A 160 | SF4 A 268 ( 4.6A)NoneNoneNone | 1.31A | 4ze1A-1e3dA:0.0 | 4ze1A-1e3dA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e4o | MALTODEXTRINPHOSPHORYLASE (Escherichiacoli) |
PF00343(Phosphorylase) | 4 | VAL A 411TYR A 273ILE A 197PRO A 310 | None | 1.16A | 4ze1A-1e4oA:0.0 | 4ze1A-1e4oA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h79 | ANAEROBICRIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASELARGE CHAIN (Escherichiavirus T4) |
PF13597(NRDD) | 4 | VAL A 135TYR A 266ILE A 575THR A 192 | None | 1.22A | 4ze1A-1h79A:0.0 | 4ze1A-1h79A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0n | XANTHAN LYASE (Bacillus sp.GL1) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | VAL A 563TYR A 452ILE A 311THR A 464 | None | 1.25A | 4ze1A-1j0nA:0.0 | 4ze1A-1j0nA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o70 | FASCICLIN I (Drosophilamelanogaster) |
PF02469(Fasciclin) | 4 | VAL A 432TYR A 598ILE A 612PRO A 478 | NoneNoneNoneNAG A1624 ( 4.8A) | 1.29A | 4ze1A-1o70A:0.0 | 4ze1A-1o70A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ral | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Rattusnorvegicus) |
PF00248(Aldo_ket_red) | 4 | VAL A 255ILE A 79PRO A 267THR A 23 | None | 1.19A | 4ze1A-1ralA:0.0 | 4ze1A-1ralA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uxt | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE(NADP+) (Thermoproteustenax) |
PF00171(Aldedh) | 4 | VAL A 444TYR A 180ILE A 183PRO A 461 | None | 1.11A | 4ze1A-1uxtA:0.2 | 4ze1A-1uxtA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkw | PUTATIVENITROREDUCTASE (Thermotogamaritima) |
PF14512(TM1586_NiRdase) | 4 | VAL A 102ILE A 118PRO A 144THR A 181 | NoneNoneSO4 A 208 ( 4.6A)None | 1.33A | 4ze1A-1vkwA:undetectable | 4ze1A-1vkwA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vr0 | PROBABLE2-PHOSPHOSULFOLACTATE PHOSPHATASE (Clostridiumacetobutylicum) |
PF04029(2-ph_phosp) | 4 | VAL A 123TYR A 229PRO A 227THR A 97 | None | 1.11A | 4ze1A-1vr0A:undetectable | 4ze1A-1vr0A:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wue | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | VAL A1154ILE A1264PRO A1314THR A1127 | None | 1.14A | 4ze1A-1wueA:undetectable | 4ze1A-1wueA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytm | PHOSPHOENOLPYRUVATECARBOXYKINASE [ATP] (Anaerobiospirillumsucciniciproducens) |
PF01293(PEPCK_ATP) | 4 | VAL A 502ILE A 456PRO A 490THR A 466 | None | 0.98A | 4ze1A-1ytmA:undetectable | 4ze1A-1ytmA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z26 | ARGONAUTE (Pyrococcusfuriosus) |
PF02171(Piwi)PF12212(PAZ_siRNAbind) | 4 | TYR A 678ILE A 319PRO A 681THR A 690 | None | 1.26A | 4ze1A-1z26A:undetectable | 4ze1A-1z26A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zpu | IRON TRANSPORTMULTICOPPER OXIDASEFET3 (Saccharomycescerevisiae) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | TYR A 133ILE A 46PRO A 188THR A 172 | None | 1.33A | 4ze1A-1zpuA:undetectable | 4ze1A-1zpuA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2i | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Synechococcussp.) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | VAL A 101TYR A 316ILE A 296THR A 239 | NAP A1341 (-4.9A)NoneNoneNone | 1.27A | 4ze1A-2d2iA:undetectable | 4ze1A-2d2iA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipf | (3(17)ALPHA-HYDROXYSTEROIDDEHYDROGENASE) (Mus musculus) |
PF00248(Aldo_ket_red) | 4 | VAL A 234TYR A 55PRO A 26THR A 38 | NoneFFA A 3 ( 4.5A)NoneNone | 1.24A | 4ze1A-2ipfA:undetectable | 4ze1A-2ipfA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3c | APEX NUCLEASE 1 (Danio rerio) |
PF03372(Exo_endo_phos) | 4 | TYR A 107ILE A 101PRO A 132THR A 162 | None | 1.26A | 4ze1A-2o3cA:undetectable | 4ze1A-2o3cA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgg | RNA-DIRECTED RNAPOLYMERASE (Infectiousbursal diseasevirus) |
PF04197(Birna_RdRp) | 4 | VAL A 697TYR A 405ILE A 406THR A 209 | None | 1.33A | 4ze1A-2pggA:undetectable | 4ze1A-2pggA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 455TYR A 410PRO A 438THR A 361 | NoneNoneNoneSO4 A 2 ( 4.2A) | 1.03A | 4ze1A-2qluA:undetectable | 4ze1A-2qluA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb5 | PUTATIVEUNCHARACTERIZEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF08282(Hydrolase_3) | 4 | VAL A 133TYR A 65ILE A 195PRO A 46 | None | 1.22A | 4ze1A-2rb5A:undetectable | 4ze1A-2rb5A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zm5 | TRNADELTA(2)-ISOPENTENYLPYROPHOSPHATETRANSFERASE (Escherichiacoli) |
PF01715(IPPT) | 4 | VAL A 268TYR A 47ILE A 72THR A 108 | NoneNoneNone A C 37 ( 2.9A) | 1.03A | 4ze1A-2zm5A:undetectable | 4ze1A-2zm5A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2znc | CARBONIC ANHYDRASEIV (Mus musculus) |
PF00194(Carb_anhydrase) | 4 | TYR A 51ILE A 48PRO A 186THR A 210 | None | 1.10A | 4ze1A-2zncA:undetectable | 4ze1A-2zncA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abz | BETA-GLUCOSIDASE I (Kluyveromycesmarxianus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF07691(PA14)PF14310(Fn3-like) | 4 | VAL A 468TYR A 381ILE A 371THR A 350 | None | 1.19A | 4ze1A-3abzA:undetectable | 4ze1A-3abzA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b20 | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE(NADP+) (Synechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | VAL A 101TYR A 316ILE A 296THR A 239 | None | 1.32A | 4ze1A-3b20A:undetectable | 4ze1A-3b20A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ci0 | PSEUDOPILIN GSPK (Escherichiacoli) |
PF03934(T2SSK) | 4 | VAL K 113TYR K 277ILE K 297THR K 210 | None | 1.25A | 4ze1A-3ci0K:undetectable | 4ze1A-3ci0K:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzs | UNCHARACTERIZED SUSDSUPERFAMILY PROTEIN (Bacteroidesfragilis) |
PF12741(SusD-like) | 4 | VAL A 75ILE A 451PRO A 460THR A 304 | NoneNoneACT A 8 ( 4.1A)None | 1.29A | 4ze1A-3gzsA:undetectable | 4ze1A-3gzsA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixl | ARYLMALONATEDECARBOXYLASE (Bordetellabronchiseptica) |
no annotation | 4 | VAL A 168ILE A 12PRO A 213THR A 106 | None | 1.18A | 4ze1A-3ixlA:undetectable | 4ze1A-3ixlA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jz4 | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE[NADP+] (Escherichiacoli) |
PF00171(Aldedh) | 4 | TYR A 110ILE A 108PRO A 168THR A 153 | None | 1.24A | 4ze1A-3jz4A:0.0 | 4ze1A-3jz4A:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mos | TRANSKETOLASE (Homo sapiens) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | VAL A 584ILE A 479PRO A 534THR A 472 | None | 1.34A | 4ze1A-3mosA:undetectable | 4ze1A-3mosA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ovg | AMIDOHYDROLASE (Mycoplasmasynoviae) |
PF02126(PTE) | 4 | VAL A 243TYR A 282ILE A 50THR A 66 | None | 1.34A | 4ze1A-3ovgA:undetectable | 4ze1A-3ovgA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ps9 | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Escherichiacoli) |
PF01266(DAO)PF05430(Methyltransf_30) | 4 | VAL A 588ILE A 629PRO A 581THR A 570 | None | 1.12A | 4ze1A-3ps9A:undetectable | 4ze1A-3ps9A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9s | DNA-BINDING RESPONSEREGULATOR (Deinococcusradiodurans) |
PF00072(Response_reg)PF00486(Trans_reg_C) | 4 | VAL A 79ILE A 161PRO A 151THR A 122 | None | 1.19A | 4ze1A-3q9sA:undetectable | 4ze1A-3q9sA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qlb | ENANTIO-PYOCHELINRECEPTOR (Pseudomonasfluorescens) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | VAL A 102TYR A 494PRO A 483THR A 441 | None | 1.29A | 4ze1A-3qlbA:undetectable | 4ze1A-3qlbA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsl | PUTATIVE EXPORTEDPROTEIN (Bordetellabronchiseptica) |
PF13379(NMT1_2) | 4 | TYR A 47ILE A 253PRO A 116THR A 96 | CIT A 347 (-4.4A)NoneNoneNone | 1.22A | 4ze1A-3qslA:undetectable | 4ze1A-3qslA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qw2 | MYO-INOSITOL-1-PHOSPHATE SYNTHASE (INO1) (Archaeoglobusfulgidus) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 4 | VAL A 382ILE A 207PRO A 369THR A 200 | NoneNoneNoneNAD A 396 (-3.9A) | 1.08A | 4ze1A-3qw2A:undetectable | 4ze1A-3qw2A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | VAL A 256TYR A 138PRO A 40THR A 187 | None | 1.34A | 4ze1A-3redA:undetectable | 4ze1A-3redA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sut | BETA-HEXOSAMINIDASE (Paenibacillussp. TS12) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b) | 4 | VAL A 178TYR A 400ILE A 501THR A 486 | None | 1.32A | 4ze1A-3sutA:undetectable | 4ze1A-3sutA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tav | METHIONINEAMINOPEPTIDASE (Mycobacteroidesabscessus) |
PF00557(Peptidase_M24) | 4 | VAL A 237TYR A 69ILE A 108THR A 250 | NoneLMR A 271 ( 4.9A)NoneNone | 1.22A | 4ze1A-3tavA:undetectable | 4ze1A-3tavA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uif | SULFONATE ABCTRANSPORTER,PERIPLASMICSULFONATE-BINDINGPROTEIN SSUA (Methylobacillusflagellatus) |
PF09084(NMT1) | 4 | VAL A 298ILE A 91PRO A 116THR A 240 | None | 1.31A | 4ze1A-3uifA:undetectable | 4ze1A-3uifA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aal | CYTOCHROME C551PEROXIDASE (Geobactersulfurreducens) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | VAL A 135ILE A 36PRO A 103THR A 231 | NoneNoneHEC A 423 (-4.2A)None | 1.33A | 4ze1A-4aalA:undetectable | 4ze1A-4aalA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ain | GLYCINE BETAINETRANSPORTER BETP (Corynebacteriumglutamicum) |
PF02028(BCCT) | 4 | VAL A 524ILE A 388PRO A 379THR A 474 | None | 1.14A | 4ze1A-4ainA:undetectable | 4ze1A-4ainA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b18 | IMPORTIN SUBUNITALPHA-1 (Homo sapiens) |
PF00514(Arm)PF16186(Arm_3) | 4 | TYR A 503ILE A 481PRO A 467THR A 408 | None | 1.24A | 4ze1A-4b18A:undetectable | 4ze1A-4b18A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyz | CELLULOSOME-RELATEDPROTEIN MODULE FROMRUMINOCOCCUSFLAVEFACIENS THATRESEMBLESPAPAIN-LIKE CYSTEINEPEPTIDASES (Ruminococcusflavefaciens) |
no annotation | 4 | TYR A 219ILE A 192PRO A 249THR A 61 | None | 1.17A | 4ze1A-4eyzA:1.0 | 4ze1A-4eyzA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0u | ALLOPHYCOCYANINALPHA CHAINALLOPHYCOCYANIN,BETA SUBUNIT (Synechococcuselongatus) |
PF00502(Phycobilisome) | 4 | VAL A 32TYR B 165ILE B 169THR B 140 | None | 1.33A | 4ze1A-4f0uA:1.4 | 4ze1A-4f0uA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 4 | TYR A 24ILE A 120PRO A 128THR A 53 | None | 1.15A | 4ze1A-4gp1A:undetectable | 4ze1A-4gp1A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjj | ANTI-IL12 ANTI-IL18DFAB HEAVY CHAINANTI-IL12 ANTI-IL18DFAB LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR L 87ILE L 21PRO L 40THR H 194 | None | 1.31A | 4ze1A-4hjjL:undetectable | 4ze1A-4hjjL:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hst | GLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE ALPHA CHAINGLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE BETA CHAIN (Pseudomonas) |
PF01804(Penicil_amidase) | 4 | VAL B 374ILE A 201PRO B 260THR B 69 | None | 1.31A | 4ze1A-4hstB:undetectable | 4ze1A-4hstB:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvt | POST-PROLINECLEAVING ENZYME (Rickettsiatyphi) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | VAL A 647TYR A 485ILE A 516PRO A 591 | None | 1.26A | 4ze1A-4hvtA:3.3 | 4ze1A-4hvtA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivi | CARBOXYLESTERASE (unculturedbacterium) |
PF00144(Beta-lactamase) | 4 | VAL A 376TYR A 218ILE A 170THR A 106 | None | 1.29A | 4ze1A-4iviA:undetectable | 4ze1A-4iviA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivi | CARBOXYLESTERASE (unculturedbacterium) |
PF00144(Beta-lactamase) | 4 | VAL A 412TYR A 172ILE A 170THR A 106 | None | 1.33A | 4ze1A-4iviA:undetectable | 4ze1A-4iviA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jzy | CRYPTOCHROME-1 (Drosophilamelanogaster) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | VAL A 52TYR A 457ILE A 454THR A 379 | None | 1.15A | 4ze1A-4jzyA:undetectable | 4ze1A-4jzyA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kh8 | HYPOTHETICAL PROTEIN (Enterococcusfaecalis) |
PF16103(DUF4822) | 4 | VAL A 237TYR A 300ILE A 295THR A 274 | None | 1.33A | 4ze1A-4kh8A:undetectable | 4ze1A-4kh8A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ktd | GE136 HEAVY CHAINFABGE136 LIGHT CHAINFAB (Macaca mulatta) |
PF07654(C1-set)PF07686(V-set) | 4 | VAL H 107ILE L 33PRO L 44THR L 102 | None | 1.24A | 4ze1A-4ktdH:undetectable | 4ze1A-4ktdH:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l3w | LIPASE (Rhizopusmicrosporus) |
PF01764(Lipase_3) | 4 | VAL A 121ILE A 290PRO A 205THR A 106 | None | 1.18A | 4ze1A-4l3wA:undetectable | 4ze1A-4l3wA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n4p | ACYLNEURAMINATELYASE (Mycoplasmasynoviae) |
PF00701(DHDPS) | 4 | TYR A 103ILE A 83PRO A 12THR A 16 | None | 1.32A | 4ze1A-4n4pA:undetectable | 4ze1A-4n4pA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7i | 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE,PUTATIVE (Entamoebahistolytica) |
PF00459(Inositol_P) | 4 | VAL A 201ILE A 102PRO A 41THR A 21 | None | 1.15A | 4ze1A-4o7iA:undetectable | 4ze1A-4o7iA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozx | ALGINATE LYASE (Klebsiellapneumoniae) |
PF08787(Alginate_lyase2) | 4 | TYR A 280ILE A 160PRO A 39THR A 147 | None | 1.29A | 4ze1A-4ozxA:undetectable | 4ze1A-4ozxA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1c | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonasmendocina) |
PF02332(Phenol_Hydrox) | 4 | VAL A 407ILE A 459PRO A 403THR A 340 | None | 1.17A | 4ze1A-4p1cA:undetectable | 4ze1A-4p1cA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p8r | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomabrucei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | VAL A 186ILE A 284PRO A 234THR A 175 | None | 1.27A | 4ze1A-4p8rA:undetectable | 4ze1A-4p8rA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rh7 | GREEN FLUORESCENTPROTEIN/CYTOPLASMICDYNEIN 2 HEAVY CHAIN1 (Homo sapiens;syntheticconstruct) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | VAL A3791ILE A3506PRO A3819THR A3393 | None | 1.26A | 4ze1A-4rh7A:undetectable | 4ze1A-4rh7A:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2t | PROTEIN APP-1 (Caenorhabditiselegans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 4 | VAL P 384TYR P 43ILE P 218THR P 422 | None | 1.29A | 4ze1A-4s2tP:undetectable | 4ze1A-4s2tP:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u2x | IMPORTIN SUBUNITALPHA-6 (Homo sapiens) |
PF00514(Arm)PF16186(Arm_3) | 4 | TYR D 504ILE D 482PRO D 468THR D 409 | None | 1.27A | 4ze1A-4u2xD:undetectable | 4ze1A-4u2xD:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uad | IMPORTIN SUBUNITALPHA-7 (Homo sapiens) |
PF00514(Arm)PF16186(Arm_3) | 4 | TYR A 501ILE A 479PRO A 465THR A 406 | None | 1.15A | 4ze1A-4uadA:undetectable | 4ze1A-4uadA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ucl | RNA-DIRECTED RNAPOLYMERASE L (Humanmetapneumovirus) |
no annotation | 4 | VAL A1615TYR A1717ILE A1695THR A1670 | None | 1.32A | 4ze1A-4uclA:undetectable | 4ze1A-4uclA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeu | TRANSKETOLASE (Pseudomonasaeruginosa) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | VAL A 144TYR A 44ILE A 36THR A 238 | None | 1.28A | 4ze1A-4xeuA:0.0 | 4ze1A-4xeuA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeu | TRANSKETOLASE (Pseudomonasaeruginosa) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | VAL A 144TYR A 44ILE A 224THR A 238 | None | 1.33A | 4ze1A-4xeuA:0.0 | 4ze1A-4xeuA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnu | INTEGRAL MEMBRANEPROTEIN-DOPAMINETRANSPORTER (Drosophilamelanogaster) |
PF00209(SNF) | 4 | VAL A 45ILE A 571PRO A 323THR A 535 | NA A 601 (-4.8A)NoneNoneNone | 1.09A | 4ze1A-4xnuA:undetectable | 4ze1A-4xnuA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yah | D-METHIONINE-BINDINGLIPOPROTEIN METQ (Escherichiacoli) |
PF03180(Lipoprotein_9) | 4 | VAL X 70TYR X 117ILE X 218PRO X 136 | None | 1.24A | 4ze1A-4yahX:undetectable | 4ze1A-4yahX:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5y | COENZYME PQQSYNTHESIS PROTEIN B (Pseudomonasputida) |
PF12706(Lactamase_B_2) | 4 | TYR A 2ILE A 3PRO A 152THR A 190 | NoneNoneNone NA A 403 (-2.9A) | 1.18A | 4ze1A-4z5yA:undetectable | 4ze1A-4z5yA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d1z | D4-10 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | VAL D 184ILE D 50PRO D 43THR D 88 | None | 1.30A | 4ze1A-5d1zD:undetectable | 4ze1A-5d1zD:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dgt | BENZOYLFORMATEDECARBOXYLASE (Pseudomonasputida) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | VAL A 106TYR A 155ILE A 93PRO A 159 | None | 1.20A | 4ze1A-5dgtA:undetectable | 4ze1A-5dgtA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eb5 | HNL ISOENZYME 5 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | VAL A 256TYR A 138PRO A 40THR A 187 | None | 1.32A | 4ze1A-5eb5A:undetectable | 4ze1A-5eb5A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ek8 | LIPOXYGENASE (Cyanothece sp.PCC 8801) |
PF00305(Lipoxygenase) | 4 | VAL A 483TYR A 466ILE A 462THR A 566 | None | 1.33A | 4ze1A-5ek8A:0.0 | 4ze1A-5ek8A:20.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 4 | TYR A 118ILE A 131PRO A 230THR A 311 | X2N A 590 ( 4.0A)X2N A 590 (-4.2A)X2N A 590 (-4.2A)HEM A 580 (-3.6A) | 0.30A | 4ze1A-5fsaA:56.9 | 4ze1A-5fsaA:59.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gai | TAIL FIBER PROTEIN (Salmonellavirus P22) |
no annotation | 4 | VAL Y 294ILE Y 205PRO Y 299THR Y 260 | None | 1.19A | 4ze1A-5gaiY:undetectable | 4ze1A-5gaiY:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h64 | SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08771(FRB_dom)PF11865(DUF3385) | 4 | VAL A2044ILE A2017PRO A2053THR A1983 | None | 0.94A | 4ze1A-5h64A:undetectable | 4ze1A-5h64A:11.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 5 | VAL A 70TYR A 126ILE A 139PRO A 238THR A 318 | NoneVOR A 602 ( 3.8A)VOR A 602 (-4.3A)NoneHEM A 601 (-3.4A) | 0.50A | 4ze1A-5hs1A:undetectable | 4ze1A-5hs1A:99.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 5 | VAL A 71TYR A 126ILE A 139PRO A 238THR A 318 | NoneVOR A 602 ( 3.8A)VOR A 602 (-4.3A)NoneHEM A 601 (-3.4A) | 1.32A | 4ze1A-5hs1A:undetectable | 4ze1A-5hs1A:99.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hw3 | BETA-LACTAMASE (Burkholderiavietnamiensis) |
PF13354(Beta-lactamase2) | 4 | VAL A 176ILE A 120PRO A 146THR A 134 | None | 1.27A | 4ze1A-5hw3A:undetectable | 4ze1A-5hw3A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6h | ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 4 | VAL A1190TYR A1304ILE A1352PRO A1326 | None | 1.32A | 4ze1A-5i6hA:undetectable | 4ze1A-5i6hA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j32 | 3-ISOPROPYLMALATEDEHYDROGENASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00180(Iso_dh) | 4 | VAL A 281ILE A 376PRO A 147THR A 338 | None | 1.29A | 4ze1A-5j32A:undetectable | 4ze1A-5j32A:22.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 4 | TYR A 127ILE A 140PRO A 239THR A 319 | 1YN A 602 ( 3.8A)1YN A 602 (-4.4A)1YN A 602 ( 4.8A)HEM A 601 ( 3.5A) | 0.37A | 4ze1A-5jlcA:undetectable | 4ze1A-5jlcA:83.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8f | ACETYL-COENZYME ASYNTHETASE (Cryptococcusneoformans) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 4 | VAL A 84TYR A 343ILE A 341THR A 441 | NoneNoneNoneATP A 703 ( 3.7A) | 1.06A | 4ze1A-5k8fA:undetectable | 4ze1A-5k8fA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzn | METABOTROPICGLUTAMATE RECEPTOR 2 (Homo sapiens) |
PF01094(ANF_receptor)PF07562(NCD3G) | 4 | VAL A 381TYR A 216ILE A 221PRO A 186 | None | 1.27A | 4ze1A-5kznA:undetectable | 4ze1A-5kznA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 4 | VAL A 841TYR A 859ILE A 97THR A 867 | None | 1.32A | 4ze1A-5lq3A:undetectable | 4ze1A-5lq3A:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lrb | ALPHA-1,4 GLUCANPHOSPHORYLASE (Hordeum vulgare) |
PF00343(Phosphorylase) | 4 | VAL A 575TYR A 346ILE A 269PRO A 386 | None | 1.23A | 4ze1A-5lrbA:undetectable | 4ze1A-5lrbA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8j | DIVALENT METALCATION TRANSPORTERMNTH (Eremococcuscoleocola) |
PF01566(Nramp) | 4 | VAL A 25ILE A 233PRO A 41THR A 350 | None | 1.30A | 4ze1A-5m8jA:undetectable | 4ze1A-5m8jA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n94 | CG9323, ISOFORM A (Drosophilamelanogaster) |
no annotation | 4 | VAL A 609ILE A 564PRO A 600THR A 287 | None | 1.28A | 4ze1A-5n94A:undetectable | 4ze1A-5n94A:10.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT BTUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT FWDG (Methanothermobactersp. CaT2;Methanothermobacterwolfeii) |
PF00384(Molybdopterin)PF12838(Fer4_7) | 4 | VAL G 52TYR B 148ILE B 182PRO G 72 | None | 1.30A | 4ze1A-5t5iG:undetectable | 4ze1A-5t5iG:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj1 | DNA TOPOISOMERASE 1 (Mycobacteriumtuberculosis) |
no annotation | 4 | VAL A 133TYR A 342ILE A 340THR A 27 | None | 1.33A | 4ze1A-5uj1A:undetectable | 4ze1A-5uj1A:9.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4p | NADPH DEHYDROGENASE3 (Saccharomycescerevisiae) |
no annotation | 4 | VAL A 113TYR A 265ILE A 262THR A 293 | None | 1.25A | 4ze1A-5v4pA:undetectable | 4ze1A-5v4pA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xya | - (-) |
no annotation | 4 | VAL A1535ILE A 150PRO A 360THR A1456 | None | 1.27A | 4ze1A-5xyaA:undetectable | 4ze1A-5xyaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zu5 | ALGINATE LYASE (Vibriosplendidus) |
no annotation | 4 | TYR A 466ILE A 356PRO A 235THR A 343 | None | 1.32A | 4ze1A-5zu5A:undetectable | 4ze1A-5zu5A:10.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ay4 | CYP51, STEROL14ALPHA-DEMETHYLASE (Naegleriafowleri) |
no annotation | 4 | VAL A 51TYR A 107PRO A 213THR A 297 | NoneTPF A 506 (-4.2A)NoneHEM A 501 (-3.4A) | 0.87A | 4ze1A-6ay4A:undetectable | 4ze1A-6ay4A:33.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az1 | RIBOSOMAL PROTEINS10ERIBOSOMAL PROTEINS12E (Leishmaniadonovani) |
no annotation | 4 | VAL Q 44TYR N 45ILE N 54PRO N 39 | None | 1.12A | 4ze1A-6az1Q:undetectable | 4ze1A-6az1Q:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az1 | RIBOSOMAL PROTEINS10ERIBOSOMAL PROTEINS12E (Leishmaniadonovani) |
no annotation | 4 | VAL Q 44TYR N 45PRO N 39THR N 34 | NoneNoneNone G 11569 ( 3.1A) | 1.26A | 4ze1A-6az1Q:undetectable | 4ze1A-6az1Q:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CAS5EFAMILYCRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 4 | VAL M 68TYR A 486ILE A 415THR A 395 | None | 1.06A | 4ze1A-6c66M:undetectable | 4ze1A-6c66M:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6u | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1IGG2B FAB HEAVYCHAIN (Homo sapiens;Mus musculus) |
no annotation | 4 | VAL B 212TYR J 33ILE J 29THR B 126 | None | 1.27A | 4ze1A-6d6uB:undetectable | 4ze1A-6d6uB:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gii | CYTOCHROME P450 (Tepidiphilusthermophilus) |
no annotation | 4 | VAL A 456TYR A 351ILE A 401PRO A 354 | NoneNoneNoneHEM A 501 ( 4.1A) | 1.25A | 4ze1A-6giiA:undetectable | 4ze1A-6giiA:9.51 |