SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZE1_A_X2NA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana)
PF01261
(AP_endonuc_2)
4 VAL A  45
ILE A 431
PRO A 311
THR A 277
None
1.16A 4ze1A-1a0eA:
0.0
4ze1A-1a0eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bey CAMPATH-1H ANTIBODY

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL H 177
ILE H  48
PRO H  41
THR H  89
None
1.17A 4ze1A-1beyH:
0.0
4ze1A-1beyH:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT


(Desulfovibrio
desulfuricans)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 VAL A 242
TYR A 117
ILE A 133
THR A 160
SF4  A 268 ( 4.6A)
None
None
None
1.31A 4ze1A-1e3dA:
0.0
4ze1A-1e3dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE


(Escherichia
coli)
PF00343
(Phosphorylase)
4 VAL A 411
TYR A 273
ILE A 197
PRO A 310
None
1.16A 4ze1A-1e4oA:
0.0
4ze1A-1e4oA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN


(Escherichia
virus T4)
PF13597
(NRDD)
4 VAL A 135
TYR A 266
ILE A 575
THR A 192
None
1.22A 4ze1A-1h79A:
0.0
4ze1A-1h79A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
4 VAL A 563
TYR A 452
ILE A 311
THR A 464
None
1.25A 4ze1A-1j0nA:
0.0
4ze1A-1j0nA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster)
PF02469
(Fasciclin)
4 VAL A 432
TYR A 598
ILE A 612
PRO A 478
None
None
None
NAG  A1624 ( 4.8A)
1.29A 4ze1A-1o70A:
0.0
4ze1A-1o70A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE


(Rattus
norvegicus)
PF00248
(Aldo_ket_red)
4 VAL A 255
ILE A  79
PRO A 267
THR A  23
None
1.19A 4ze1A-1ralA:
0.0
4ze1A-1ralA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)


(Thermoproteus
tenax)
PF00171
(Aldedh)
4 VAL A 444
TYR A 180
ILE A 183
PRO A 461
None
1.11A 4ze1A-1uxtA:
0.2
4ze1A-1uxtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkw PUTATIVE
NITROREDUCTASE


(Thermotoga
maritima)
PF14512
(TM1586_NiRdase)
4 VAL A 102
ILE A 118
PRO A 144
THR A 181
None
None
SO4  A 208 ( 4.6A)
None
1.33A 4ze1A-1vkwA:
undetectable
4ze1A-1vkwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE


(Clostridium
acetobutylicum)
PF04029
(2-ph_phosp)
4 VAL A 123
TYR A 229
PRO A 227
THR A  97
None
1.11A 4ze1A-1vr0A:
undetectable
4ze1A-1vr0A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 VAL A1154
ILE A1264
PRO A1314
THR A1127
None
1.14A 4ze1A-1wueA:
undetectable
4ze1A-1wueA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]


(Anaerobiospirillum
succiniciproducens)
PF01293
(PEPCK_ATP)
4 VAL A 502
ILE A 456
PRO A 490
THR A 466
None
0.98A 4ze1A-1ytmA:
undetectable
4ze1A-1ytmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus)
PF02171
(Piwi)
PF12212
(PAZ_siRNAbind)
4 TYR A 678
ILE A 319
PRO A 681
THR A 690
None
1.26A 4ze1A-1z26A:
undetectable
4ze1A-1z26A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3


(Saccharomyces
cerevisiae)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 TYR A 133
ILE A  46
PRO A 188
THR A 172
None
1.33A 4ze1A-1zpuA:
undetectable
4ze1A-1zpuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Synechococcus
sp.)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 VAL A 101
TYR A 316
ILE A 296
THR A 239
NAP  A1341 (-4.9A)
None
None
None
1.27A 4ze1A-2d2iA:
undetectable
4ze1A-2d2iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)


(Mus musculus)
PF00248
(Aldo_ket_red)
4 VAL A 234
TYR A  55
PRO A  26
THR A  38
None
FFA  A   3 ( 4.5A)
None
None
1.24A 4ze1A-2ipfA:
undetectable
4ze1A-2ipfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio)
PF03372
(Exo_endo_phos)
4 TYR A 107
ILE A 101
PRO A 132
THR A 162
None
1.26A 4ze1A-2o3cA:
undetectable
4ze1A-2o3cA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE


(Infectious
bursal disease
virus)
PF04197
(Birna_RdRp)
4 VAL A 697
TYR A 405
ILE A 406
THR A 209
None
1.33A 4ze1A-2pggA:
undetectable
4ze1A-2pggA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 455
TYR A 410
PRO A 438
THR A 361
None
None
None
SO4  A   2 ( 4.2A)
1.03A 4ze1A-2qluA:
undetectable
4ze1A-2qluA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
4 VAL A 133
TYR A  65
ILE A 195
PRO A  46
None
1.22A 4ze1A-2rb5A:
undetectable
4ze1A-2rb5A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE


(Escherichia
coli)
PF01715
(IPPT)
4 VAL A 268
TYR A  47
ILE A  72
THR A 108
None
None
None
A  C  37 ( 2.9A)
1.03A 4ze1A-2zm5A:
undetectable
4ze1A-2zm5A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
4 TYR A  51
ILE A  48
PRO A 186
THR A 210
None
1.10A 4ze1A-2zncA:
undetectable
4ze1A-2zncA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like)
4 VAL A 468
TYR A 381
ILE A 371
THR A 350
None
1.19A 4ze1A-3abzA:
undetectable
4ze1A-3abzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)


(Synechococcus
elongatus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 VAL A 101
TYR A 316
ILE A 296
THR A 239
None
1.32A 4ze1A-3b20A:
undetectable
4ze1A-3b20A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli)
PF03934
(T2SSK)
4 VAL K 113
TYR K 277
ILE K 297
THR K 210
None
1.25A 4ze1A-3ci0K:
undetectable
4ze1A-3ci0K:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN


(Bacteroides
fragilis)
PF12741
(SusD-like)
4 VAL A  75
ILE A 451
PRO A 460
THR A 304
None
None
ACT  A   8 ( 4.1A)
None
1.29A 4ze1A-3gzsA:
undetectable
4ze1A-3gzsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE


(Bordetella
bronchiseptica)
no annotation 4 VAL A 168
ILE A  12
PRO A 213
THR A 106
None
1.18A 4ze1A-3ixlA:
undetectable
4ze1A-3ixlA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]


(Escherichia
coli)
PF00171
(Aldedh)
4 TYR A 110
ILE A 108
PRO A 168
THR A 153
None
1.24A 4ze1A-3jz4A:
0.0
4ze1A-3jz4A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 VAL A 584
ILE A 479
PRO A 534
THR A 472
None
1.34A 4ze1A-3mosA:
undetectable
4ze1A-3mosA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae)
PF02126
(PTE)
4 VAL A 243
TYR A 282
ILE A  50
THR A  66
None
1.34A 4ze1A-3ovgA:
undetectable
4ze1A-3ovgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC


(Escherichia
coli)
PF01266
(DAO)
PF05430
(Methyltransf_30)
4 VAL A 588
ILE A 629
PRO A 581
THR A 570
None
1.12A 4ze1A-3ps9A:
undetectable
4ze1A-3ps9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9s DNA-BINDING RESPONSE
REGULATOR


(Deinococcus
radiodurans)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
4 VAL A  79
ILE A 161
PRO A 151
THR A 122
None
1.19A 4ze1A-3q9sA:
undetectable
4ze1A-3q9sA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR


(Pseudomonas
fluorescens)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 VAL A 102
TYR A 494
PRO A 483
THR A 441
None
1.29A 4ze1A-3qlbA:
undetectable
4ze1A-3qlbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN


(Bordetella
bronchiseptica)
PF13379
(NMT1_2)
4 TYR A  47
ILE A 253
PRO A 116
THR A  96
CIT  A 347 (-4.4A)
None
None
None
1.22A 4ze1A-3qslA:
undetectable
4ze1A-3qslA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)


(Archaeoglobus
fulgidus)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
4 VAL A 382
ILE A 207
PRO A 369
THR A 200
None
None
None
NAD  A 396 (-3.9A)
1.08A 4ze1A-3qw2A:
undetectable
4ze1A-3qw2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 VAL A 256
TYR A 138
PRO A  40
THR A 187
None
1.34A 4ze1A-3redA:
undetectable
4ze1A-3redA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
4 VAL A 178
TYR A 400
ILE A 501
THR A 486
None
1.32A 4ze1A-3sutA:
undetectable
4ze1A-3sutA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE


(Mycobacteroides
abscessus)
PF00557
(Peptidase_M24)
4 VAL A 237
TYR A  69
ILE A 108
THR A 250
None
LMR  A 271 ( 4.9A)
None
None
1.22A 4ze1A-3tavA:
undetectable
4ze1A-3tavA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uif SULFONATE ABC
TRANSPORTER,
PERIPLASMIC
SULFONATE-BINDING
PROTEIN SSUA


(Methylobacillus
flagellatus)
PF09084
(NMT1)
4 VAL A 298
ILE A  91
PRO A 116
THR A 240
None
1.31A 4ze1A-3uifA:
undetectable
4ze1A-3uifA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE


(Geobacter
sulfurreducens)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
4 VAL A 135
ILE A  36
PRO A 103
THR A 231
None
None
HEC  A 423 (-4.2A)
None
1.33A 4ze1A-4aalA:
undetectable
4ze1A-4aalA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
4 VAL A 524
ILE A 388
PRO A 379
THR A 474
None
1.14A 4ze1A-4ainA:
undetectable
4ze1A-4ainA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1


(Homo sapiens)
PF00514
(Arm)
PF16186
(Arm_3)
4 TYR A 503
ILE A 481
PRO A 467
THR A 408
None
1.24A 4ze1A-4b18A:
undetectable
4ze1A-4b18A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyz CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES


(Ruminococcus
flavefaciens)
no annotation 4 TYR A 219
ILE A 192
PRO A 249
THR A  61
None
1.17A 4ze1A-4eyzA:
1.0
4ze1A-4eyzA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT


(Synechococcus
elongatus)
PF00502
(Phycobilisome)
4 VAL A  32
TYR B 165
ILE B 169
THR B 140
None
1.33A 4ze1A-4f0uA:
1.4
4ze1A-4f0uA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
4 TYR A  24
ILE A 120
PRO A 128
THR A  53
None
1.15A 4ze1A-4gp1A:
undetectable
4ze1A-4gp1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR L  87
ILE L  21
PRO L  40
THR H 194
None
1.31A 4ze1A-4hjjL:
undetectable
4ze1A-4hjjL:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN


(Pseudomonas)
PF01804
(Penicil_amidase)
4 VAL B 374
ILE A 201
PRO B 260
THR B  69
None
1.31A 4ze1A-4hstB:
undetectable
4ze1A-4hstB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME


(Rickettsia
typhi)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
4 VAL A 647
TYR A 485
ILE A 516
PRO A 591
None
1.26A 4ze1A-4hvtA:
3.3
4ze1A-4hvtA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium)
PF00144
(Beta-lactamase)
4 VAL A 376
TYR A 218
ILE A 170
THR A 106
None
1.29A 4ze1A-4iviA:
undetectable
4ze1A-4iviA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium)
PF00144
(Beta-lactamase)
4 VAL A 412
TYR A 172
ILE A 170
THR A 106
None
1.33A 4ze1A-4iviA:
undetectable
4ze1A-4iviA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 VAL A  52
TYR A 457
ILE A 454
THR A 379
None
1.15A 4ze1A-4jzyA:
undetectable
4ze1A-4jzyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis)
PF16103
(DUF4822)
4 VAL A 237
TYR A 300
ILE A 295
THR A 274
None
1.33A 4ze1A-4kh8A:
undetectable
4ze1A-4kh8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB


(Macaca mulatta)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL H 107
ILE L  33
PRO L  44
THR L 102
None
1.24A 4ze1A-4ktdH:
undetectable
4ze1A-4ktdH:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus)
PF01764
(Lipase_3)
4 VAL A 121
ILE A 290
PRO A 205
THR A 106
None
1.18A 4ze1A-4l3wA:
undetectable
4ze1A-4l3wA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE


(Mycoplasma
synoviae)
PF00701
(DHDPS)
4 TYR A 103
ILE A  83
PRO A  12
THR A  16
None
1.32A 4ze1A-4n4pA:
undetectable
4ze1A-4n4pA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7i 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE


(Entamoeba
histolytica)
PF00459
(Inositol_P)
4 VAL A 201
ILE A 102
PRO A  41
THR A  21
None
1.15A 4ze1A-4o7iA:
undetectable
4ze1A-4o7iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae)
PF08787
(Alginate_lyase2)
4 TYR A 280
ILE A 160
PRO A  39
THR A 147
None
1.29A 4ze1A-4ozxA:
undetectable
4ze1A-4ozxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A


(Pseudomonas
mendocina)
PF02332
(Phenol_Hydrox)
4 VAL A 407
ILE A 459
PRO A 403
THR A 340
None
1.17A 4ze1A-4p1cA:
undetectable
4ze1A-4p1cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC


(Trypanosoma
brucei)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 VAL A 186
ILE A 284
PRO A 234
THR A 175
None
1.27A 4ze1A-4p8rA:
undetectable
4ze1A-4p8rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1


(Homo sapiens;
synthetic
construct)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 VAL A3791
ILE A3506
PRO A3819
THR A3393
None
1.26A 4ze1A-4rh7A:
undetectable
4ze1A-4rh7A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
4 VAL P 384
TYR P  43
ILE P 218
THR P 422
None
1.29A 4ze1A-4s2tP:
undetectable
4ze1A-4s2tP:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2x IMPORTIN SUBUNIT
ALPHA-6


(Homo sapiens)
PF00514
(Arm)
PF16186
(Arm_3)
4 TYR D 504
ILE D 482
PRO D 468
THR D 409
None
1.27A 4ze1A-4u2xD:
undetectable
4ze1A-4u2xD:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7


(Homo sapiens)
PF00514
(Arm)
PF16186
(Arm_3)
4 TYR A 501
ILE A 479
PRO A 465
THR A 406
None
1.15A 4ze1A-4uadA:
undetectable
4ze1A-4uadA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L


(Human
metapneumovirus)
no annotation 4 VAL A1615
TYR A1717
ILE A1695
THR A1670
None
1.32A 4ze1A-4uclA:
undetectable
4ze1A-4uclA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 VAL A 144
TYR A  44
ILE A  36
THR A 238
None
1.28A 4ze1A-4xeuA:
0.0
4ze1A-4xeuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 VAL A 144
TYR A  44
ILE A 224
THR A 238
None
1.33A 4ze1A-4xeuA:
0.0
4ze1A-4xeuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
4 VAL A  45
ILE A 571
PRO A 323
THR A 535
NA  A 601 (-4.8A)
None
None
None
1.09A 4ze1A-4xnuA:
undetectable
4ze1A-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ


(Escherichia
coli)
PF03180
(Lipoprotein_9)
4 VAL X  70
TYR X 117
ILE X 218
PRO X 136
None
1.24A 4ze1A-4yahX:
undetectable
4ze1A-4yahX:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B


(Pseudomonas
putida)
PF12706
(Lactamase_B_2)
4 TYR A   2
ILE A   3
PRO A 152
THR A 190
None
None
None
NA  A 403 (-2.9A)
1.18A 4ze1A-4z5yA:
undetectable
4ze1A-4z5yA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z D4-10 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL D 184
ILE D  50
PRO D  43
THR D  88
None
1.30A 4ze1A-5d1zD:
undetectable
4ze1A-5d1zD:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE


(Pseudomonas
putida)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 VAL A 106
TYR A 155
ILE A  93
PRO A 159
None
1.20A 4ze1A-5dgtA:
undetectable
4ze1A-5dgtA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 VAL A 256
TYR A 138
PRO A  40
THR A 187
None
1.32A 4ze1A-5eb5A:
undetectable
4ze1A-5eb5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801)
PF00305
(Lipoxygenase)
4 VAL A 483
TYR A 466
ILE A 462
THR A 566
None
1.33A 4ze1A-5ek8A:
0.0
4ze1A-5ek8A:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans)
PF00067
(p450)
4 TYR A 118
ILE A 131
PRO A 230
THR A 311
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.2A)
HEM  A 580 (-3.6A)
0.30A 4ze1A-5fsaA:
56.9
4ze1A-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22)
no annotation 4 VAL Y 294
ILE Y 205
PRO Y 299
THR Y 260
None
1.19A 4ze1A-5gaiY:
undetectable
4ze1A-5gaiY:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385)
4 VAL A2044
ILE A2017
PRO A2053
THR A1983
None
0.94A 4ze1A-5h64A:
undetectable
4ze1A-5h64A:
11.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
5 VAL A  70
TYR A 126
ILE A 139
PRO A 238
THR A 318
None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
None
HEM  A 601 (-3.4A)
0.50A 4ze1A-5hs1A:
undetectable
4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
5 VAL A  71
TYR A 126
ILE A 139
PRO A 238
THR A 318
None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
None
HEM  A 601 (-3.4A)
1.32A 4ze1A-5hs1A:
undetectable
4ze1A-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis)
PF13354
(Beta-lactamase2)
4 VAL A 176
ILE A 120
PRO A 146
THR A 134
None
1.27A 4ze1A-5hw3A:
undetectable
4ze1A-5hw3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
4 VAL A1190
TYR A1304
ILE A1352
PRO A1326
None
1.32A 4ze1A-5i6hA:
undetectable
4ze1A-5i6hA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00180
(Iso_dh)
4 VAL A 281
ILE A 376
PRO A 147
THR A 338
None
1.29A 4ze1A-5j32A:
undetectable
4ze1A-5j32A:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
4 TYR A 127
ILE A 140
PRO A 239
THR A 319
1YN  A 602 ( 3.8A)
1YN  A 602 (-4.4A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
0.37A 4ze1A-5jlcA:
undetectable
4ze1A-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE


(Cryptococcus
neoformans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
4 VAL A  84
TYR A 343
ILE A 341
THR A 441
None
None
None
ATP  A 703 ( 3.7A)
1.06A 4ze1A-5k8fA:
undetectable
4ze1A-5k8fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2


(Homo sapiens)
PF01094
(ANF_receptor)
PF07562
(NCD3G)
4 VAL A 381
TYR A 216
ILE A 221
PRO A 186
None
1.27A 4ze1A-5kznA:
undetectable
4ze1A-5kznA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni)
PF00873
(ACR_tran)
4 VAL A 841
TYR A 859
ILE A  97
THR A 867
None
1.32A 4ze1A-5lq3A:
undetectable
4ze1A-5lq3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE


(Hordeum vulgare)
PF00343
(Phosphorylase)
4 VAL A 575
TYR A 346
ILE A 269
PRO A 386
None
1.23A 4ze1A-5lrbA:
undetectable
4ze1A-5lrbA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH


(Eremococcus
coleocola)
PF01566
(Nramp)
4 VAL A  25
ILE A 233
PRO A  41
THR A 350
None
1.30A 4ze1A-5m8jA:
undetectable
4ze1A-5m8jA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster)
no annotation 4 VAL A 609
ILE A 564
PRO A 600
THR A 287
None
1.28A 4ze1A-5n94A:
undetectable
4ze1A-5n94A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG


(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii)
PF00384
(Molybdopterin)
PF12838
(Fer4_7)
4 VAL G  52
TYR B 148
ILE B 182
PRO G  72
None
1.30A 4ze1A-5t5iG:
undetectable
4ze1A-5t5iG:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis)
no annotation 4 VAL A 133
TYR A 342
ILE A 340
THR A  27
None
1.33A 4ze1A-5uj1A:
undetectable
4ze1A-5uj1A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4p NADPH DEHYDROGENASE
3


(Saccharomyces
cerevisiae)
no annotation 4 VAL A 113
TYR A 265
ILE A 262
THR A 293
None
1.25A 4ze1A-5v4pA:
undetectable
4ze1A-5v4pA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-)
no annotation 4 VAL A1535
ILE A 150
PRO A 360
THR A1456
None
1.27A 4ze1A-5xyaA:
undetectable
4ze1A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus)
no annotation 4 TYR A 466
ILE A 356
PRO A 235
THR A 343
None
1.32A 4ze1A-5zu5A:
undetectable
4ze1A-5zu5A:
10.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE


(Naegleria
fowleri)
no annotation 4 VAL A  51
TYR A 107
PRO A 213
THR A 297
None
TPF  A 506 (-4.2A)
None
HEM  A 501 (-3.4A)
0.87A 4ze1A-6ay4A:
undetectable
4ze1A-6ay4A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S10E
RIBOSOMAL PROTEIN
S12E


(Leishmania
donovani)
no annotation 4 VAL Q  44
TYR N  45
ILE N  54
PRO N  39
None
1.12A 4ze1A-6az1Q:
undetectable
4ze1A-6az1Q:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S10E
RIBOSOMAL PROTEIN
S12E


(Leishmania
donovani)
no annotation 4 VAL Q  44
TYR N  45
PRO N  39
THR N  34
None
None
None
G  11569 ( 3.1A)
1.26A 4ze1A-6az1Q:
undetectable
4ze1A-6az1Q:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
no annotation 4 VAL M  68
TYR A 486
ILE A 415
THR A 395
None
1.06A 4ze1A-6c66M:
undetectable
4ze1A-6c66M:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
IGG2B FAB HEAVY
CHAIN


(Homo sapiens;
Mus musculus)
no annotation 4 VAL B 212
TYR J  33
ILE J  29
THR B 126
None
1.27A 4ze1A-6d6uB:
undetectable
4ze1A-6d6uB:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus)
no annotation 4 VAL A 456
TYR A 351
ILE A 401
PRO A 354
None
None
None
HEM  A 501 ( 4.1A)
1.25A 4ze1A-6giiA:
undetectable
4ze1A-6giiA:
9.51