SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZE0_A_VORA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		5 THR B 396
ILE B 397
GLY B 402
LEU B 268
LEU B 267
 None
 1.39A 4ze0A-1e3dB:
0.0		 4ze0A-1e3dB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 ILE A 268
GLY A 475
THR A 183
LEU A 205
LEU A  38
 None
 1.16A 4ze0A-1f0iA:
undetectable		 4ze0A-1f0iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 THR A 379
ILE A 468
GLY A 269
LEU A 203
LEU A 190
 None
 1.27A 4ze0A-1gytA:
0.0		 4ze0A-1gytA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF

(Homo sapiens) 		PF09128
(RGS-like) 		5 TYR A 225
PHE A 103
GLY A  73
LEU A  63
LEU A  59
 None
 1.42A 4ze0A-1iapA:
undetectable		 4ze0A-1iapA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 ILE A 108
PHE A 205
GLY A 130
THR A 152
LEU A 172
 None
 1.16A 4ze0A-1imjA:
undetectable		 4ze0A-1imjA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 5 PHE B  97
ILE B  67
GLY B  46
THR B  17
LEU B  72
 None
 1.34A 4ze0A-1jmzB:
undetectable		 4ze0A-1jmzB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 362
PHE A 566
GLY A 533
LEU A 430
LEU A 427
 None
 1.39A 4ze0A-1kcwA:
0.0		 4ze0A-1kcwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksh ARF-LIKE PROTEIN 2

(Mus musculus) 		PF00025
(Arf) 		5 PHE A 123
ILE A  32
GLY A 168
LEU A 173
LEU A  62
 None
 1.34A 4ze0A-1kshA:
undetectable		 4ze0A-1kshA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 127
ILE A 115
PHE A 131
LEU A  66
LEU A  62
 None
 1.42A 4ze0A-1mldA:
0.0		 4ze0A-1mldA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 TYR A 229
THR A 261
ILE A 263
GLY A 301
THR A  23
 None
 1.43A 4ze0A-1ni3A:
undetectable		 4ze0A-1ni3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 TYR A 183
THR A 152
GLY A 130
THR A 356
LEU A 300
 None
POP  A1155 (-4.5A)
POP  A1155 ( 4.9A)
None
None
 1.33A 4ze0A-1ocmA:
undetectable		 4ze0A-1ocmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		5 THR A 261
GLY A 305
THR A  43
LEU A  40
LEU A  36
 None
 1.29A 4ze0A-1p8rA:
undetectable		 4ze0A-1p8rA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 PHE A 351
ILE A 423
PHE A 397
LEU A 257
LEU A 431
 None
 1.28A 4ze0A-1q15A:
undetectable		 4ze0A-1q15A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR A  59
GLY A  74
THR A  77
LEU A 260
LEU A 261
 None
 1.27A 4ze0A-1sb3A:
undetectable		 4ze0A-1sb3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF09128
(RGS-like) 		5 TYR C 225
PHE C 103
GLY C  73
LEU C  63
LEU C  59
 None
 1.40A 4ze0A-1shzC:
undetectable		 4ze0A-1shzC:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 THR C 158
PHE C 151
GLY C 112
THR C 110
LEU C  36
 None
None
FAD  C4931 ( 4.6A)
FAD  C4931 ( 2.9A)
FAD  C4931 (-4.2A)
 1.34A 4ze0A-1t3qC:
undetectable		 4ze0A-1t3qC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR B 141
ILE B 144
GLY B 186
LEU B 168
LEU B 236
 None
 1.18A 4ze0A-1tqyB:
undetectable		 4ze0A-1tqyB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		5 THR A 149
ILE A 144
GLY A 280
LEU A 285
LEU A 140
 None
 1.33A 4ze0A-1u6zA:
undetectable		 4ze0A-1u6zA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 TYR A 212
ILE A 288
PHE A  59
LEU A 172
LEU A 265
 None
 1.25A 4ze0A-1uwyA:
undetectable		 4ze0A-1uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 TYR A 758
ILE A 760
THR A 798
LEU A 675
LEU A 697
 None
 1.25A 4ze0A-1wkbA:
1.1		 4ze0A-1wkbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 THR A  38
ILE A 104
GLY A 108
LEU A 143
LEU A 160
 None
 1.22A 4ze0A-1wkrA:
undetectable		 4ze0A-1wkrA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 TYR A  76
PHE A  83
THR A 260
LEU A 321
LEU A 324
 ESL  A 471 ( 3.8A)
None
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
HEM  A 470 ( 3.9A)
 0.88A 4ze0A-1x8vA:
34.4		 4ze0A-1x8vA:
28.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PHE A 276
ILE A  16
GLY A 290
LEU A 253
LEU A 318
 None
 1.23A 4ze0A-1xi8A:
undetectable		 4ze0A-1xi8A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 THR A  84
ILE A  82
PHE A  91
LEU A 122
LEU A  69
 None
 1.40A 4ze0A-1xx4A:
undetectable		 4ze0A-1xx4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		5 TYR A 109
ILE A  62
THR A  67
LEU A  91
LEU A  95
 None
 1.27A 4ze0A-1ytlA:
undetectable		 4ze0A-1ytlA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 TYR A  74
ILE A 161
PHE A 183
GLY A  78
LEU A  40
 None
 1.08A 4ze0A-2a9vA:
undetectable		 4ze0A-2a9vA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		5 PHE A  41
GLY A  43
THR A  54
LEU A 106
LEU A 108
 None
 1.38A 4ze0A-2f91A:
undetectable		 4ze0A-2f91A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 PHE A 257
GLY A 241
THR A 214
LEU A 212
LEU A 434
 None
None
FAD  A1000 (-4.2A)
None
None
 1.36A 4ze0A-2fjaA:
undetectable		 4ze0A-2fjaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtp REGULATOR OF
G-PROTEIN SIGNALING
1

(Homo sapiens) 		PF00615
(RGS) 		5 PHE C 177
ILE C 182
GLY C  82
LEU C  61
LEU C 190
 None
 1.18A 4ze0A-2gtpC:
undetectable		 4ze0A-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 TYR A 149
THR A 146
GLY A 508
THR A 488
LEU A  54
 None
 1.28A 4ze0A-2i3oA:
undetectable		 4ze0A-2i3oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		5 THR A 193
PHE A 171
ILE A 142
GLY A 145
LEU A 224
 None
 1.34A 4ze0A-2jbwA:
undetectable		 4ze0A-2jbwA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjz ATC0852

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		6 THR A  18
PHE A  39
GLY A  48
THR A   7
LEU A  68
LEU A 115
 None
 1.49A 4ze0A-2kjzA:
undetectable		 4ze0A-2kjzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 ILE A 369
GLY A  54
THR A 336
LEU A 332
LEU A 328
 None
 1.34A 4ze0A-2p50A:
undetectable		 4ze0A-2p50A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 367
GLY A 323
THR A  94
LEU A 296
LEU A 112
 None
 1.22A 4ze0A-2qq6A:
undetectable		 4ze0A-2qq6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd2 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF01634
(HisG) 		5 THR A   6
ILE A  51
GLY A  70
LEU A  22
LEU A  29
 None
 1.22A 4ze0A-2vd2A:
undetectable		 4ze0A-2vd2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE C 177
PHE C 157
THR C 249
LEU C 286
LEU C 290
 None
 1.43A 4ze0A-2wtkC:
undetectable		 4ze0A-2wtkC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		5 PHE A 238
ILE A 272
GLY A 260
LEU A 175
LEU A 179
 None
 1.32A 4ze0A-2yzwA:
undetectable		 4ze0A-2yzwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 THR A 459
ILE A 454
GLY A 480
LEU A 508
LEU A 488
 None
 1.40A 4ze0A-2z63A:
undetectable		 4ze0A-2z63A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 THR A 459
ILE A 454
GLY A 480
LEU A 508
LEU A 488
 None
 1.36A 4ze0A-2z66A:
undetectable		 4ze0A-2z66A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 PHE A  48
ILE A  61
GLY A   9
THR A  15
LEU A  69
 None
 1.33A 4ze0A-2zskA:
undetectable		 4ze0A-2zskA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		5 PHE A  44
ILE A 101
GLY A 106
LEU A  86
LEU A  90
 None
None
EDO  A 300 (-4.3A)
None
EDO  A 296 ( 3.9A)
 1.38A 4ze0A-3bwxA:
undetectable		 4ze0A-3bwxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		5 TYR G 108
ILE G  63
THR G  68
LEU G  90
LEU G  94
 None
 1.28A 4ze0A-3cf4G:
undetectable		 4ze0A-3cf4G:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqy ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Shewanella
oneidensis) 		PF03702
(AnmK) 		5 ILE A 279
PHE A 234
GLY A 190
LEU A 195
LEU A 271
 None
 1.41A 4ze0A-3cqyA:
undetectable		 4ze0A-3cqyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		5 PHE A 289
ILE A 267
THR A  79
LEU A  81
LEU A  83
 None
 1.05A 4ze0A-3d5eA:
undetectable		 4ze0A-3d5eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		5 PHE A 364
ILE A 360
GLY A 346
LEU A 109
LEU A 120
 None
 1.21A 4ze0A-3e79A:
undetectable		 4ze0A-3e79A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 TYR A1266
THR A1267
PHE A1402
GLY A 730
LEU A 712
 None
 1.15A 4ze0A-3ecqA:
undetectable		 4ze0A-3ecqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A  20
ILE A  21
GLY A 332
THR A 303
LEU A  26
 None
None
None
MUC  A 383 (-4.6A)
None
 0.92A 4ze0A-3fj4A:
undetectable		 4ze0A-3fj4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 THR A 459
ILE A 454
GLY A 480
LEU A 508
LEU A 488
 None
 1.36A 4ze0A-3fxiA:
undetectable		 4ze0A-3fxiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		5 PHE A  59
ILE A 221
GLY A  89
LEU A 131
LEU A 101
 None
 1.31A 4ze0A-3h2yA:
undetectable		 4ze0A-3h2yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1

(Vitis vinifera) 		PF05368
(NmrA) 		5 THR A  90
PHE A 120
ILE A  22
GLY A 202
LEU A  57
 None
 1.39A 4ze0A-3i5mA:
undetectable		 4ze0A-3i5mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		5 THR A 266
ILE A 256
GLY A  32
THR A 159
LEU A 169
 None
 1.24A 4ze0A-3ibgA:
undetectable		 4ze0A-3ibgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		5 THR A 335
ILE A 426
GLY A 225
LEU A 165
LEU A 152
 None
None
None
None
PEG  A 469 (-4.9A)
 1.26A 4ze0A-3ij3A:
undetectable		 4ze0A-3ij3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 PHE A1122
ILE A1108
THR A1002
LEU A1193
LEU A1186
 None
 1.36A 4ze0A-3jb9A:
undetectable		 4ze0A-3jb9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 THR A 289
PHE A 288
ILE A 296
LEU A 313
LEU A 337
 None
 1.06A 4ze0A-3kdnA:
undetectable		 4ze0A-3kdnA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		5 PHE A 345
ILE A 335
PHE A 373
GLY A 343
LEU A 292
 None
 1.43A 4ze0A-3khzA:
0.6		 4ze0A-3khzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 THR A 287
ILE A 313
GLY A 224
LEU A 252
LEU A 303
 None
 1.29A 4ze0A-3lq1A:
undetectable		 4ze0A-3lq1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 THR A 228
ILE A 229
THR A 391
LEU A 372
LEU A  66
 None
 1.34A 4ze0A-3ncyA:
undetectable		 4ze0A-3ncyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 THR A 147
ILE A 148
GLY A 191
LEU A 403
LEU A 353
 None
 1.43A 4ze0A-3nd0A:
0.3		 4ze0A-3nd0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		5 THR A  72
ILE A  38
GLY A   9
LEU A   6
LEU A  82
 None
None
ATP  A 961 ( 3.7A)
None
None
 1.36A 4ze0A-3nd6A:
undetectable		 4ze0A-3nd6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 TYR A 259
ILE A 253
PHE A 359
LEU A 247
LEU A 217
 None
 1.33A 4ze0A-3ndaA:
undetectable		 4ze0A-3ndaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 TYR A 284
ILE A 288
GLY A 310
LEU A 383
LEU A  30
 None
 1.37A 4ze0A-3o80A:
undetectable		 4ze0A-3o80A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 PHE A  64
ILE A 111
GLY A 119
LEU A 155
LEU A 159
 None
 1.28A 4ze0A-3oc7A:
2.3		 4ze0A-3oc7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 THR B 293
PHE B 294
ILE B 289
PHE B 270
LEU B 241
 None
 1.20A 4ze0A-3ojaB:
undetectable		 4ze0A-3ojaB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		5 PHE A 173
PHE A 356
GLY A 215
LEU A 218
LEU A 197
 None
 1.36A 4ze0A-3oqqA:
undetectable		 4ze0A-3oqqA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		5 THR A 251
PHE A 250
PHE A 248
LEU A 270
LEU A 227
 PHE  A 980 ( 4.1A)
PHE  A 980 (-4.5A)
PHE  A 980 (-3.6A)
None
None
 1.43A 4ze0A-3pcoA:
undetectable		 4ze0A-3pcoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7a PHOSPHOGLYCERATE
MUTASE, PUTATIVE

(Bacillus
anthracis) 		PF00300
(His_Phos_1) 		5 PHE A  97
ILE A 136
THR A 184
LEU A 197
LEU A 125
 None
 1.42A 4ze0A-3r7aA:
undetectable		 4ze0A-3r7aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tej ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00550
(PP-binding)
PF00975
(Thioesterase) 		5 PHE A1081
ILE A1275
GLY A1140
THR A1142
LEU A1238
 None
 1.06A 4ze0A-3tejA:
undetectable		 4ze0A-3tejA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		5 PHE A  92
ILE A  97
GLY A  28
LEU A  34
LEU A  48
 None
 1.30A 4ze0A-3vmwA:
undetectable		 4ze0A-3vmwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 THR A 245
ILE A 230
GLY A 206
THR A 200
LEU A 189
 None
 1.34A 4ze0A-3vpzA:
undetectable		 4ze0A-3vpzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 PHE A 616
GLY A 653
THR A 639
LEU A 665
LEU A 709
 None
 1.24A 4ze0A-3wfaA:
undetectable		 4ze0A-3wfaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 TYR A 419
ILE A 405
GLY A 389
LEU A 349
LEU A 204
 None
 1.25A 4ze0A-3wstA:
undetectable		 4ze0A-3wstA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv7 HMD CO-OCCURRING
PROTEIN HCGE

(Methanothermobacter
marburgensis) 		PF00899
(ThiF) 		5 PHE A  58
ILE A  57
GLY A  22
LEU A  18
LEU A  32
 None
None
ADP  A 301 (-3.2A)
None
None
 1.42A 4ze0A-3wv7A:
undetectable		 4ze0A-3wv7A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		5 THR A 481
ILE A 480
GLY A  85
LEU A 384
LEU A 146
 None
 1.31A 4ze0A-4a0wA:
undetectable		 4ze0A-4a0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 THR A  64
GLY A  36
THR A  20
LEU A  33
LEU A  59
 None
 1.20A 4ze0A-4gq1A:
undetectable		 4ze0A-4gq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Staphylococcus
aureus) 		PF01255
(Prenyltransf) 		5 THR A 116
ILE A 150
THR A  61
LEU A 107
LEU A 104
 None
 1.28A 4ze0A-4h8eA:
undetectable		 4ze0A-4h8eA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		5 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.17A 4ze0A-4i3fA:
undetectable		 4ze0A-4i3fA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 THR A 299
ILE A 300
GLY A 318
LEU A 330
LEU A 241
 None
 1.25A 4ze0A-4kpuA:
undetectable		 4ze0A-4kpuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 PHE A 312
ILE A 356
GLY A 425
LEU A 399
LEU A 395
 None
 0.96A 4ze0A-4p7hA:
undetectable		 4ze0A-4p7hA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 5 THR H 409
PHE H 405
ILE H 343
GLY H 443
LEU H 456
 None
 1.44A 4ze0A-4qslH:
undetectable		 4ze0A-4qslH:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywn NADH-FMN
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF01613
(Flavin_Reduct) 		5 THR A 102
ILE A 112
THR A  63
LEU A  67
LEU A  73
 None
 1.37A 4ze0A-4ywnA:
undetectable		 4ze0A-4ywnA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 PHE A 308
ILE A 304
THR A 158
LEU A  86
LEU A  82
 None
 1.21A 4ze0A-5a0kA:
undetectable		 4ze0A-5a0kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 TYR A 603
THR A 574
THR A 119
LEU A 178
LEU A 695
 None
 1.22A 4ze0A-5a7mA:
undetectable		 4ze0A-5a7mA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffx MARR FAMILY
REGULATORY PROTEIN

(Staphylococcus
aureus) 		PF12802
(MarR_2) 		5 PHE A 104
ILE A  29
GLY A  97
THR A  94
LEU A  68
 None
 1.25A 4ze0A-5ffxA:
undetectable		 4ze0A-5ffxA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		8 TYR A 118
THR A 122
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
None
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.61A 4ze0A-5fsaA:
57.2		 4ze0A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		9 TYR A 126
THR A 130
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
LEU A 383
 VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-4.0A)
 0.44A 4ze0A-5hs1A:
63.6		 4ze0A-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 THR A 457
ILE A 452
GLY A 478
LEU A 506
LEU A 486
 None
 1.34A 4ze0A-5ijbA:
undetectable		 4ze0A-5ijbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 THR A 308
PHE A 275
ILE A 274
GLY A 312
THR A 383
 None
 0.97A 4ze0A-5jboA:
undetectable		 4ze0A-5jboA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		9 TYR A 127
THR A 131
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.58A 4ze0A-5jlcA:
59.2		 4ze0A-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 196
ILE A 200
GLY A 262
LEU A 227
LEU A 219
 None
 1.34A 4ze0A-5lhkA:
undetectable		 4ze0A-5lhkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 5 ILE A 121
GLY A 211
THR A 229
LEU A 103
LEU A 105
 None
 1.39A 4ze0A-5ms3A:
undetectable		 4ze0A-5ms3A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns3 50S RIBOSOMAL
PROTEIN L5

(Thermus
thermophilus) 		no annotation 5 PHE A 125
GLY A 129
THR A 161
LEU A 172
LEU A  19
 None
 1.43A 4ze0A-5ns3A:
undetectable		 4ze0A-5ns3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		5 THR A 273
PHE A 276
ILE A 277
PHE A 235
LEU A 356
 None
 1.31A 4ze0A-5x62A:
undetectable		 4ze0A-5x62A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 5 THR A  39
ILE A  18
THR A 211
LEU A  30
LEU A  57
 None
 1.23A 4ze0A-5z9yA:
undetectable		 4ze0A-5z9yA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zai -

(-) 		no annotation 5 PHE A  70
ILE A  67
PHE A  81
LEU A  33
LEU A  32
 COA  A 301 (-4.8A)
COA  A 301 (-4.0A)
None
None
None
 1.18A 4ze0A-5zaiA:
undetectable		 4ze0A-5zaiA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
PHE A 114
PHE A 292
THR A 297
LEU A 358
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
TPF  A 506 ( 4.0A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
 1.36A 4ze0A-6ay4A:
41.9		 4ze0A-6ay4A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 5 THR A  84
PHE A 262
ILE A 263
PHE A  30
GLY A  29
 None
 1.32A 4ze0A-6b4mA:
undetectable		 4ze0A-6b4mA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 THR C 147
ILE C 151
GLY C 329
LEU C 339
LEU C 274
 None
 1.12A 4ze0A-6cajC:
undetectable		 4ze0A-6cajC:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 5 TYR C 127
ILE C 105
PHE C  88
GLY C 108
LEU C 214
 None
 1.16A 4ze0A-6eicC:
undetectable		 4ze0A-6eicC:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 CAP-ASSOCIATED
PROTEIN CAF20
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 5 PHE B  22
ILE A  77
PHE B  27
LEU A  87
LEU A 154
 None
 1.34A 4ze0A-6fc3B:
undetectable		 4ze0A-6fc3B:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 PHE A 312
ILE A 356
GLY A 425
LEU A 399
LEU A 395
 None
 1.07A 4ze0A-6fsaA:
undetectable		 4ze0A-6fsaA:
undetectable