SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZDZ_A_TPFA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.82A 4zdzA-1a2oA:
undetectable		 4zdzA-1a2oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.91A 4zdzA-1c30A:
0.0		 4zdzA-1c30A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		4 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.81A 4zdzA-1chdA:
undetectable		 4zdzA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A  21
ILE A  53
PHE A 146
THR A 370
 None
 0.95A 4zdzA-1d1tA:
0.0		 4zdzA-1d1tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 ILE A 180
GLY A 234
LEU A 172
MET A 148
 None
 0.88A 4zdzA-1gz6A:
0.0		 4zdzA-1gz6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		4 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.91A 4zdzA-1l0qA:
undetectable		 4zdzA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 PHE A 609
ILE A 199
GLY A 613
THR A 644
 None
 0.95A 4zdzA-1mqsA:
0.0		 4zdzA-1mqsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 PHE A  61
ILE A  41
GLY A  65
THR A  69
 None
 0.95A 4zdzA-1oa1A:
undetectable		 4zdzA-1oa1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 PHE A 238
ILE A 316
PHE A 417
GLY A 387
LEU A   3
 None
 1.44A 4zdzA-1rf5A:
0.0		 4zdzA-1rf5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ILE A 210
GLY A 213
THR A 216
LEU A 184
 None
 0.83A 4zdzA-1tisA:
undetectable		 4zdzA-1tisA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ueb ELONGATION FACTOR P

(Thermus
thermophilus) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		4 GLY A 107
THR A 109
LEU A  85
MET A  83
 None
 0.86A 4zdzA-1uebA:
undetectable		 4zdzA-1uebA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 PHE A  97
GLY A 141
THR A 139
LEU A 176
 None
 0.94A 4zdzA-1urjA:
undetectable		 4zdzA-1urjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 PHE A  41
ILE A  21
GLY A 262
LEU A 214
 None
 0.87A 4zdzA-1womA:
undetectable		 4zdzA-1womA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 ILE A 133
PHE A  49
GLY A 141
LEU A 122
 None
 0.91A 4zdzA-1xx4A:
undetectable		 4zdzA-1xx4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b71 CYCLOPHILIN-LIKE
PROTEIN

(Plasmodium
yoelii) 		PF00160
(Pro_isomerase) 		4 PHE A  66
ILE A  41
PHE A 139
THR A  78
 None
 0.95A 4zdzA-2b71A:
undetectable		 4zdzA-2b71A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 ILE X 618
GLY X 342
THR X 344
LEU X 495
 None
 0.87A 4zdzA-2epkX:
undetectable		 4zdzA-2epkX:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtp REGULATOR OF
G-PROTEIN SIGNALING
1

(Homo sapiens) 		PF00615
(RGS) 		4 PHE C 177
ILE C 182
GLY C  82
LEU C  61
 None
 0.86A 4zdzA-2gtpC:
undetectable		 4zdzA-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.85A 4zdzA-2jfwA:
undetectable		 4zdzA-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5j HASR PROTEIN

(Serratia
marcescens) 		PF07660
(STN) 		4 PHE A  16
PHE A  30
GLY A  62
LEU A  76
 None
 0.92A 4zdzA-2m5jA:
undetectable		 4zdzA-2m5jA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.70A 4zdzA-2o7rA:
undetectable		 4zdzA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ILE A  53
GLY A  46
THR A 630
LEU A 640
 None
SF4  A1764 (-3.7A)
MGD  A1766 (-4.0A)
None
 0.94A 4zdzA-2vpwA:
undetectable		 4zdzA-2vpwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9y FATTY ACID/RETINOL
BINDING PROTEIN
PROTEIN 7, ISOFORM
A, CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF05823
(Gp-FAR-1) 		4 PHE A  21
ILE A  25
GLY A  61
MET A  49
 None
 0.92A 4zdzA-2w9yA:
undetectable		 4zdzA-2w9yA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PHE A 529
GLY A 417
THR A 303
MET A 420
 None
 0.86A 4zdzA-2wdaA:
undetectable		 4zdzA-2wdaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 ILE A 260
PHE A 208
GLY A 210
LEU A 219
 None
 0.88A 4zdzA-2wedA:
undetectable		 4zdzA-2wedA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus
subtilis) 		PF02156
(Glyco_hydro_26) 		5 PHE A 243
ILE A 249
PHE A 276
GLY A 268
LEU A 313
 None
 1.42A 4zdzA-2whkA:
undetectable		 4zdzA-2whkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		4 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.82A 4zdzA-2wlcA:
undetectable		 4zdzA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 ILE A 362
GLY A 299
THR A 282
MET A 374
 None
 0.95A 4zdzA-2yjgA:
undetectable		 4zdzA-2yjgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 PHE A 307
PHE A  27
GLY A 170
LEU A 145
 None
HEM  A 354 (-4.4A)
HEM  A 354 (-3.5A)
BXO  A 355 ( 4.7A)
 0.95A 4zdzA-3a18A:
undetectable		 4zdzA-3a18A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 ILE A 344
GLY A 280
THR A 231
LEU A 296
 None
 0.95A 4zdzA-3a9gA:
undetectable		 4zdzA-3a9gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.92A 4zdzA-3c8eA:
undetectable		 4zdzA-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 PHE A 486
ILE A 491
GLY A 462
LEU A 505
 None
 0.95A 4zdzA-3d3kA:
undetectable		 4zdzA-3d3kA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.89A 4zdzA-3d8bA:
undetectable		 4zdzA-3d8bA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 217
ILE A 193
GLY A 223
MET A 237
 None
 0.76A 4zdzA-3e9mA:
undetectable		 4zdzA-3e9mA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 PHE A 126
GLY A  86
THR A  59
LEU A 259
 None
SAH  A 901 (-3.1A)
None
None
 0.92A 4zdzA-3evcA:
undetectable		 4zdzA-3evcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD

(Bacteroides
fragilis) 		PF07876
(Dabb) 		4 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.65A 4zdzA-3fmbA:
2.2		 4zdzA-3fmbA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 PHE C  77
ILE C  80
GLY C 112
LEU C 148
 FAD  C 900 (-4.2A)
None
FAD  C 900 ( 4.3A)
None
 0.83A 4zdzA-3hrdC:
undetectable		 4zdzA-3hrdC:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrw HEMOGLOBIN SUBUNIT
BETA-1

(Mus musculus) 		PF00042
(Globin) 		4 ILE B 110
GLY B  64
LEU B  32
MET B  55
 None
 0.88A 4zdzA-3hrwB:
undetectable		 4zdzA-3hrwB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 PHE A 154
ILE A 320
PHE A 351
GLY A  54
 None
 0.74A 4zdzA-3i3vA:
undetectable		 4zdzA-3i3vA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 ILE 1 149
PHE 1 169
GLY 1 130
LEU 1 224
 None
 0.94A 4zdzA-3i9v1:
undetectable		 4zdzA-3i9v1:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 4 PHE D  31
ILE D  19
PHE D 179
THR D 233
 None
 0.85A 4zdzA-3iz3D:
0.5		 4zdzA-3iz3D:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US19

(Plasmodium
falciparum) 		PF00203
(Ribosomal_S19) 		4 PHE X  37
ILE X 112
PHE X  45
LEU X  57
 None
 0.94A 4zdzA-3j7aX:
undetectable		 4zdzA-3j7aX:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		4 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.82A 4zdzA-3jr3A:
undetectable		 4zdzA-3jr3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 PHE A  32
ILE A  28
GLY A 405
LEU A  56
 None
 0.95A 4zdzA-3k1tA:
undetectable		 4zdzA-3k1tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 PHE A 129
ILE A 168
GLY A  56
LEU A 189
 None
 0.95A 4zdzA-3kt4A:
0.9		 4zdzA-3kt4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 189
ILE A 185
PHE A  74
THR A 164
 None
 0.94A 4zdzA-3l8kA:
2.9		 4zdzA-3l8kA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.83A 4zdzA-3lppA:
undetectable		 4zdzA-3lppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		4 PHE A 144
ILE A 146
GLY A 172
LEU A 128
 None
 0.94A 4zdzA-3m3pA:
undetectable		 4zdzA-3m3pA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides) 		PF00072
(Response_reg) 		4 PHE A  60
GLY A  28
THR A  22
LEU A  89
 None
 0.94A 4zdzA-3n0rA:
undetectable		 4zdzA-3n0rA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 PHE A 408
ILE A 402
GLY A 254
MET A 343
 PHE  A 408 ( 1.3A)
ILE  A 402 ( 0.4A)
GLY  A 254 ( 0.0A)
MET  A 343 ( 0.0A)
 0.93A 4zdzA-3o96A:
undetectable		 4zdzA-3o96A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 PHE A 486
ILE A 485
PHE A 220
GLY A 246
MET A 226
 None
 1.12A 4zdzA-3ombA:
3.1		 4zdzA-3ombA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 ILE A  71
GLY A  57
THR A 140
LEU A 137
 None
 0.90A 4zdzA-3onqA:
undetectable		 4zdzA-3onqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Burkholderia
pseudomallei) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 ILE A 216
GLY A 192
THR A 177
LEU A 197
 None
 0.92A 4zdzA-3tk8A:
undetectable		 4zdzA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ILE A 471
GLY A 407
LEU A 446
MET A 418
 None
 0.88A 4zdzA-3vueA:
undetectable		 4zdzA-3vueA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.93A 4zdzA-4ayjA:
undetectable		 4zdzA-4ayjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 990
GLY A 948
THR A 904
LEU A 847
 None
 0.94A 4zdzA-4c3hA:
undetectable		 4zdzA-4c3hA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 PHE A 312
ILE A 356
GLY A 425
LEU A 399
 None
 0.80A 4zdzA-4db1A:
1.6		 4zdzA-4db1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		4 PHE A  70
ILE A 275
PHE A  74
GLY A 252
 None
 0.94A 4zdzA-4e3eA:
undetectable		 4zdzA-4e3eA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		4 PHE A 342
ILE A 343
GLY A 354
LEU A 398
 None
 0.75A 4zdzA-4effA:
undetectable		 4zdzA-4effA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		4 ILE A 250
PHE A 273
LEU A 269
MET A 358
 None
 0.64A 4zdzA-4f6oA:
undetectable		 4zdzA-4f6oA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.91A 4zdzA-4g59C:
undetectable		 4zdzA-4g59C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 432
GLY A 247
THR A 243
LEU A 443
 None
 0.90A 4zdzA-4hjlA:
undetectable		 4zdzA-4hjlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		5 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.20A 4zdzA-4i3fA:
undetectable		 4zdzA-4i3fA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Rhodospirillum
rubrum) 		no annotation 4 PHE A  23
PHE A  19
LEU A 112
MET A 108
 None
None
HEM  A 300 (-4.5A)
None
 0.92A 4zdzA-4k8fA:
undetectable		 4zdzA-4k8fA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		4 ILE A  74
PHE A  67
GLY A 101
LEU A 296
 None
 0.92A 4zdzA-4magA:
undetectable		 4zdzA-4magA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli) 		PF00905
(Transpeptidase) 		4 PHE A 243
ILE A 233
PHE A 229
GLY A 211
 None
 0.85A 4zdzA-4mllA:
undetectable		 4zdzA-4mllA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  79
GLY A  52
THR A  56
LEU A  74
 GDS  A 301 ( 3.8A)
None
None
None
 0.81A 4zdzA-4mzwA:
undetectable		 4zdzA-4mzwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN

(Pseudomonas
aeruginosa) 		PF03480
(DctP) 		4 PHE A 182
ILE A 172
GLY A 208
LEU A 216
 None
 0.93A 4zdzA-4nf0A:
undetectable		 4zdzA-4nf0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 PHE A 312
ILE A 356
GLY A 425
LEU A 399
 None
 0.78A 4zdzA-4p7hA:
undetectable		 4zdzA-4p7hA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.77A 4zdzA-4puaA:
undetectable		 4zdzA-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		4 ILE A 232
GLY A 298
THR A 300
LEU A 324
 None
 0.94A 4zdzA-4pvcA:
undetectable		 4zdzA-4pvcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5w MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		4 ILE A2086
GLY A2062
THR A2064
LEU A2046
 None
 0.94A 4zdzA-4q5wA:
undetectable		 4zdzA-4q5wA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 ILE B  40
GLY B  59
THR B  62
LEU B  22
 None
 0.86A 4zdzA-4rltB:
undetectable		 4zdzA-4rltB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 4 ILE A 156
PHE A 149
GLY A 119
MET A 135
 None
 0.85A 4zdzA-4roeA:
1.6		 4zdzA-4roeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 PHE B 104
ILE B  20
GLY B  67
THR A  58
 None
 0.92A 4zdzA-4rv2B:
undetectable		 4zdzA-4rv2B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		4 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.93A 4zdzA-4rz2A:
undetectable		 4zdzA-4rz2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 PHE A 325
ILE A 116
PHE A 319
THR A 535
 41U  A 605 ( 4.7A)
None
None
None
 0.89A 4zdzA-4xnuA:
undetectable		 4zdzA-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 PHE A 303
ILE A 167
PHE A 241
GLY A 161
 None
 0.94A 4zdzA-4yzzA:
undetectable		 4zdzA-4yzzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ILE D 617
GLY D 341
THR D 343
LEU D 494
 None
 0.85A 4zdzA-5a6bD:
2.8		 4zdzA-5a6bD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus) 		PF12146
(Hydrolase_4) 		4 PHE A  34
ILE A 106
PHE A  38
LEU A 224
 None
 0.81A 4zdzA-5cmlA:
undetectable		 4zdzA-5cmlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		4 PHE A 289
GLY A 480
THR A  35
LEU A  37
 None
 0.89A 4zdzA-5d2eA:
undetectable		 4zdzA-5d2eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 PHE A 349
THR A 274
LEU A 205
MET A 268
 None
 0.81A 4zdzA-5dbxA:
undetectable		 4zdzA-5dbxA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		7 PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
MET A 508
 X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.71A 4zdzA-5fsaA:
56.6		 4zdzA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.90A 4zdzA-5gyzA:
undetectable		 4zdzA-5gyzA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		6 PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.39A 4zdzA-5hs1A:
63.5		 4zdzA-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 PHE A 275
ILE A 274
GLY A 312
THR A 383
 None
 0.84A 4zdzA-5jboA:
undetectable		 4zdzA-5jboA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		6 PHE A 135
ILE A 140
PHE A 237
GLY A 315
LEU A 381
MET A 512
 1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.77A 4zdzA-5jlcA:
59.0		 4zdzA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		6 PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
 1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.60A 4zdzA-5jlcA:
59.0		 4zdzA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		4 ILE A 343
GLY A 405
THR A 493
LEU A 505
 None
 0.95A 4zdzA-5jmdA:
undetectable		 4zdzA-5jmdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 PHE B1144
ILE B1147
PHE B1081
MET B1015
 None
 0.80A 4zdzA-5jpnB:
undetectable		 4zdzA-5jpnB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		4 PHE A 184
ILE A 220
PHE A 189
GLY A 254
 None
None
COA  A 401 (-4.8A)
COA  A 401 (-3.3A)
 0.94A 4zdzA-5kf2A:
undetectable		 4zdzA-5kf2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 434
GLY A 341
THR A 345
LEU A 418
 SLU  A 601 ( 4.3A)
SLU  A 601 (-4.0A)
None
None
 0.91A 4zdzA-5kyvA:
undetectable		 4zdzA-5kyvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 ILE A  90
PHE A  96
THR A1852
MET A1846
 None
 0.93A 4zdzA-5lkiA:
undetectable		 4zdzA-5lkiA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)

(Helicobacter
pylori) 		PF04085
(MreC) 		4 PHE C 204
ILE C 203
GLY C 136
LEU C 114
 None
 0.89A 4zdzA-5lp5C:
undetectable		 4zdzA-5lp5C:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ua2 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 161
ILE A 181
GLY A 119
MET A 125
 None
 0.90A 4zdzA-5ua2A:
1.9		 4zdzA-5ua2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 0.87A 4zdzA-5uhkA:
undetectable		 4zdzA-5uhkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Neisseria
gonorrhoeae) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 196
PHE A 264
GLY A 266
LEU A  74
 None
 0.93A 4zdzA-5vevA:
undetectable		 4zdzA-5vevA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 4 ILE A 284
GLY A 288
THR A 368
LEU A 112
 None
 0.78A 4zdzA-5wkaA:
0.1		 4zdzA-5wkaA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 PHE A 207
ILE A 185
GLY A 214
THR A  70
 None
 0.91A 4zdzA-5wt4A:
undetectable		 4zdzA-5wt4A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 430
GLY A 245
THR A 241
LEU A 441
 None
 0.89A 4zdzA-5xbpA:
undetectable		 4zdzA-5xbpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 ILE A 411
GLY A 387
THR A 485
LEU A 491
 None
 0.88A 4zdzA-5xqoA:
undetectable		 4zdzA-5xqoA:
10.30