SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZDY_A_1YNA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		3 ALA A 728
TYR A 731
PRO A 689
 None
 0.68A 4zdyA-1bmtA:
0.0		 4zdyA-1bmtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ALA A 123
TYR A 125
PRO A 174
 None
 0.69A 4zdyA-1d2fA:
undetectable		 4zdyA-1d2fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		3 ALA A 119
TYR A 122
PRO A  66
 None
 0.72A 4zdyA-1dbiA:
0.0		 4zdyA-1dbiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		3 ALA 2 246
TYR 2  64
PRO 2  56
 None
 0.69A 4zdyA-1ev12:
undetectable		 4zdyA-1ev12:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 ALA A 306
TYR A 309
PRO A 266
 None
 0.49A 4zdyA-1fw8A:
0.0		 4zdyA-1fw8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 ALA A 728
TYR A 731
PRO A 689
 None
 0.68A 4zdyA-1k7yA:
0.0		 4zdyA-1k7yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oij PUTATIVE
ALKYLSULFATASE ATSK

(Pseudomonas
putida) 		PF02668
(TauD) 		3 ALA C 116
TYR C 117
PRO C 203
 None
 0.72A 4zdyA-1oijC:
0.0		 4zdyA-1oijC:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ALA A 161
TYR A 160
PRO A 184
 None
 0.68A 4zdyA-1pg5A:
0.0		 4zdyA-1pg5A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ALA A 504
TYR A 515
PRO A 491
 None
 0.60A 4zdyA-1pguA:
undetectable		 4zdyA-1pguA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 ALA A 377
TYR A 380
PRO A 337
 None
 0.60A 4zdyA-1qpgA:
undetectable		 4zdyA-1qpgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		3 ALA A  80
TYR A  79
PRO A 118
 None
 0.68A 4zdyA-1s0uA:
undetectable		 4zdyA-1s0uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ALA A 573
TYR A 574
PRO A 512
 None
None
MAN  A3008 (-4.3A)
 0.66A 4zdyA-1xc6A:
undetectable		 4zdyA-1xc6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		3 ALA 2 254
TYR 2  64
PRO 2  56
 None
 0.63A 4zdyA-1z7s2:
undetectable		 4zdyA-1z7s2:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ALA A 226
TYR A 229
PRO A 186
 None
 0.63A 4zdyA-2c3dA:
undetectable		 4zdyA-2c3dA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 ALA A 256
TYR A 259
PRO A 220
 None
 0.72A 4zdyA-2epjA:
undetectable		 4zdyA-2epjA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 ALA A  93
TYR A 104
PRO A  80
 None
 0.72A 4zdyA-2oajA:
undetectable		 4zdyA-2oajA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		3 ALA A 172
TYR A 175
PRO A 159
 None
 0.56A 4zdyA-2pg3A:
undetectable		 4zdyA-2pg3A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 ALA A 299
TYR A 296
PRO A 644
 None
 0.70A 4zdyA-2wjvA:
undetectable		 4zdyA-2wjvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		3 ALA A 156
TYR A 159
PRO A 177
 None
 0.66A 4zdyA-2wsxA:
undetectable		 4zdyA-2wsxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 ALA A 172
TYR A 177
PRO A 162
 None
 0.72A 4zdyA-2xd3A:
undetectable		 4zdyA-2xd3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 ALA A 299
TYR A 296
PRO A 644
 None
 0.68A 4zdyA-2xzoA:
undetectable		 4zdyA-2xzoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ALA A 159
TYR A 158
PRO A 200
 None
 0.68A 4zdyA-3aatA:
undetectable		 4zdyA-3aatA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		3 ALA A 437
TYR A 440
PRO A 116
 None
 0.69A 4zdyA-3cj1A:
undetectable		 4zdyA-3cj1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A 255
TYR A 258
PRO A 191
 None
 0.51A 4zdyA-3coiA:
undetectable		 4zdyA-3coiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		3 ALA A  72
TYR A  73
PRO A 146
 None
 0.67A 4zdyA-3e5mA:
undetectable		 4zdyA-3e5mA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		3 ALA A 419
TYR A 421
PRO A 413
 None
 0.72A 4zdyA-3eafA:
0.7		 4zdyA-3eafA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efa PUTATIVE
ACETYLTRANSFERASE

(Lactobacillus
plantarum) 		PF13673
(Acetyltransf_10) 		3 ALA A  46
TYR A  45
PRO A  63
 None
 0.69A 4zdyA-3efaA:
undetectable		 4zdyA-3efaA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 ALA 2 254
TYR 2  64
PRO 2  56
 None
 0.63A 4zdyA-3epc2:
undetectable		 4zdyA-3epc2:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 ALA 2 253
TYR 2  64
PRO 2  56
 None
 0.70A 4zdyA-3epd2:
undetectable		 4zdyA-3epd2:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 ALA 2 253
TYR 2  64
PRO 2  56
 None
 0.68A 4zdyA-3epf2:
undetectable		 4zdyA-3epf2:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Mus musculus) 		PF08005
(PHR) 		3 ALA A1306
TYR A1307
PRO A1340
 None
 0.71A 4zdyA-3gbwA:
undetectable		 4zdyA-3gbwA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		3 ALA A 138
TYR A 141
PRO A  98
 None
 0.53A 4zdyA-3kipA:
undetectable		 4zdyA-3kipA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ALA A 291
TYR A 294
PRO A 346
 None
 0.54A 4zdyA-3l22A:
undetectable		 4zdyA-3l22A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdd GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		no annotation 3 ALA A 115
TYR A 144
PRO A  92
 None
 0.70A 4zdyA-3pddA:
undetectable		 4zdyA-3pddA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 ALA A 204
TYR A 207
PRO A 111
 None
 0.67A 4zdyA-3qreA:
undetectable		 4zdyA-3qreA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 ALA A  26
TYR A  25
PRO A  55
 None
 0.69A 4zdyA-3zq4A:
undetectable		 4zdyA-3zq4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 3 ALA A 263
TYR A 266
PRO A 501
 None
 0.50A 4zdyA-4aw7A:
1.6		 4zdyA-4aw7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens) 		PF01344
(Kelch_1) 		3 ALA A 500
TYR A 499
PRO A 518
 None
 0.70A 4zdyA-4chbA:
undetectable		 4zdyA-4chbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		3 ALA A 446
TYR A 447
PRO A  70
 None
 0.57A 4zdyA-4ci7A:
undetectable		 4zdyA-4ci7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		3 ALA A  27
TYR A  29
PRO A 179
 None
 0.70A 4zdyA-4cp8A:
undetectable		 4zdyA-4cp8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 366
TYR A 142
PRO A 370
 None
 0.67A 4zdyA-4dhgA:
undetectable		 4zdyA-4dhgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyy ICMQ

(Legionella
pneumophila) 		PF09475
(Dot_icm_IcmQ) 		3 ALA Q 110
TYR Q 109
PRO Q 149
 None
 0.69A 4zdyA-4eyyQ:
undetectable		 4zdyA-4eyyQ:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B) 		PF00073
(Rhv) 		3 ALA 2 248
TYR 2  64
PRO 2  56
 None
 0.73A 4zdyA-4gb32:
undetectable		 4zdyA-4gb32:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		3 ALA A  34
TYR A  44
PRO A  17
 None
 0.67A 4zdyA-4gq1A:
undetectable		 4zdyA-4gq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		3 ALA A 141
TYR A 144
PRO A 123
 None
None
PEG  A 302 (-4.7A)
 0.73A 4zdyA-4inzA:
undetectable		 4zdyA-4inzA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8p FLAVODOXIN

(Bacteroides
uniformis) 		PF12682
(Flavodoxin_4) 		3 ALA A  30
TYR A  31
PRO A  58
 None
 0.63A 4zdyA-4j8pA:
undetectable		 4zdyA-4j8pA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		3 ALA 2 253
TYR 2  64
PRO 2  56
 None
 0.58A 4zdyA-4q4y2:
undetectable		 4zdyA-4q4y2:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		3 ALA A  27
TYR A  30
PRO A 149
 None
BFS  A 173 (-4.5A)
BFS  A 173 (-4.5A)
 0.71A 4zdyA-4stdA:
undetectable		 4zdyA-4stdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 ALA A 645
TYR A 644
PRO A 602
 None
 0.69A 4zdyA-4u48A:
undetectable		 4zdyA-4u48A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 ALA A 779
TYR A 778
PRO A 787
 None
 0.58A 4zdyA-4u48A:
undetectable		 4zdyA-4u48A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		3 ALA C  88
TYR C  91
PRO C 139
 None
 0.72A 4zdyA-4u9sC:
undetectable		 4zdyA-4u9sC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc3 TRANSLOCATOR PROTEIN
TSPO

(Rhodobacter
sphaeroides) 		PF03073
(TspO_MBR) 		3 ALA A  78
TYR A  77
PRO A  18
 None
 0.67A 4zdyA-4uc3A:
0.9		 4zdyA-4uc3A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN

(Chlamydomonas
reinhardtii) 		PF14779
(BBS1) 		3 ALA B 117
TYR B 127
PRO B  98
 None
 0.63A 4zdyA-4v0nB:
undetectable		 4zdyA-4v0nB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		3 ALA A 158
TYR A 157
PRO A 199
 None
 0.64A 4zdyA-4wb0A:
undetectable		 4zdyA-4wb0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrt STFQ
AROMATASE/CYCLASE

(Streptomyces
steffisburgensis) 		PF03364
(Polyketide_cyc) 		3 ALA A 280
TYR A 283
PRO A 234
 None
 0.47A 4zdyA-4xrtA:
undetectable		 4zdyA-4xrtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9d C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		3 ALA A  71
TYR A  70
PRO A  85
 None
 0.72A 4zdyA-4y9dA:
undetectable		 4zdyA-4y9dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 ALA A 290
TYR A 293
PRO A 596
 None
 0.55A 4zdyA-4ydqA:
undetectable		 4zdyA-4ydqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvs CAPSID PROTEIN VP0

(Enterovirus A) 		PF00073
(Rhv) 		3 ALA C 239
TYR C  64
PRO C  56
 None
 0.65A 4zdyA-4yvsC:
undetectable		 4zdyA-4yvsC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any E1

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		3 ALA A 121
TYR A 122
PRO A 208
 None
 0.66A 4zdyA-5anyA:
undetectable		 4zdyA-5anyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4e INTERLEUKIN-4
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09238
(IL4Ra_N) 		3 ALA B 135
TYR B 134
PRO B  98
 None
 0.72A 4zdyA-5e4eB:
undetectable		 4zdyA-5e4eB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 3 ALA A 458
TYR A 461
PRO A 513
 None
 0.52A 4zdyA-5f0oA:
1.3		 4zdyA-5f0oA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1b GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		3 ALA A 166
TYR A 162
PRO A  94
 None
 0.68A 4zdyA-5f1bA:
undetectable		 4zdyA-5f1bA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		3 ALA A 268
TYR A 271
PRO A 151
 None
 0.52A 4zdyA-5fifA:
undetectable		 4zdyA-5fifA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ALA A 113
TYR A 114
PRO A 639
 None
 0.62A 4zdyA-5fkcA:
undetectable		 4zdyA-5fkcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		3 ALA A 376
TYR A 375
PRO A 398
 None
 0.62A 4zdyA-5fnuA:
undetectable		 4zdyA-5fnuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		3 ALA A 427
TYR A 426
PRO A 445
 None
 0.66A 4zdyA-5fnuA:
undetectable		 4zdyA-5fnuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		3 ALA A 474
TYR A 473
PRO A 492
 None
 0.60A 4zdyA-5fnuA:
undetectable		 4zdyA-5fnuA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		3 ALA A  61
TYR A  64
PRO A 230
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
 0.27A 4zdyA-5fsaA:
56.9		 4zdyA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		3 ALA A  69
TYR A  72
PRO A 238
 None
 0.37A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		3 ALA A  17
TYR A  20
PRO A  49
 FAD  A 500 (-3.3A)
None
FAD  A 500 ( 3.6A)
 0.64A 4zdyA-5jcnA:
undetectable		 4zdyA-5jcnA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 ALA A  70
TYR A  73
PRO A 239
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
 0.07A 4zdyA-5jlcA:
59.6		 4zdyA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzg CAPSID PROTEIN VP0

(Rhinovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		3 ALA C 316
TYR C 130
PRO C 122
 None
 0.61A 4zdyA-5jzgC:
undetectable		 4zdyA-5jzgC:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		3 ALA C 250
TYR C  64
PRO C  56
 None
 0.62A 4zdyA-5k0uC:
undetectable		 4zdyA-5k0uC:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		3 ALA A 166
TYR A 162
PRO A  94
 None
 0.65A 4zdyA-5kenA:
undetectable		 4zdyA-5kenA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		3 ALA A  40
TYR A  43
PRO A 186
 None
None
OLC  A 606 (-4.4A)
 0.58A 4zdyA-5n6mA:
undetectable		 4zdyA-5n6mA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		3 ALA A 157
TYR A 160
PRO A 208
 8UN  A2201 (-3.2A)
None
None
 0.64A 4zdyA-5ndzA:
undetectable		 4zdyA-5ndzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		3 ALA A 157
TYR A 160
PRO A 208
 None
 0.66A 4zdyA-5nj6A:
undetectable		 4zdyA-5nj6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		3 ALA A 445
TYR A 444
PRO A 465
 None
 0.67A 4zdyA-5nkpA:
undetectable		 4zdyA-5nkpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		3 ALA A 494
TYR A 493
PRO A 512
 None
 0.63A 4zdyA-5nkpA:
undetectable		 4zdyA-5nkpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 3 ALA A4512
TYR A4513
PRO A4428
 None
 0.72A 4zdyA-5o6cA:
undetectable		 4zdyA-5o6cA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		3 ALA B 229
TYR B  62
PRO B  54
 None
 0.70A 4zdyA-5osnB:
undetectable		 4zdyA-5osnB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tov ADENOSYLHOMOCYSTEINA
SE

(Thermotoga
maritima) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 ALA A 351
TYR A 354
PRO A 159
 None
 0.61A 4zdyA-5tovA:
0.3		 4zdyA-5tovA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 3 ALA B 380
TYR B 383
PRO B 466
 None
FMT  B 604 (-4.7A)
FMT  B 603 ( 4.8A)
 0.62A 4zdyA-5txrB:
undetectable		 4zdyA-5txrB:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 ALA G 224
TYR G 223
PRO G 493
 None
 0.72A 4zdyA-5um8G:
undetectable		 4zdyA-5um8G:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvx TRYPSIN/CHYMOTRYPSIN
INHIBITOR

(Alocasia
macrorrhizos) 		no annotation 3 ALA A  20
TYR A  19
PRO A  79
 None
 0.50A 4zdyA-5wvxA:
undetectable		 4zdyA-5wvxA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		3 ALA A 137
TYR A 140
PRO A  97
 None
 0.45A 4zdyA-5x47A:
undetectable		 4zdyA-5x47A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L2

(Mycolicibacterium
smegmatis) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		3 ALA C 173
TYR C 172
PRO C 149
 None
 0.68A 4zdyA-5xymC:
undetectable		 4zdyA-5xymC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAD

(Cyanidioschyzon
merolae) 		no annotation 3 ALA D  29
TYR D  28
PRO D  88
 None
 0.65A 4zdyA-5zgbD:
undetectable		 4zdyA-5zgbD:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 ENVELOPE
GLYCOPROTEIN

(Marburg
marburgvirus) 		no annotation 3 ALA A 150
TYR A 146
PRO A  78
 None
 0.70A 4zdyA-6bp2A:
undetectable		 4zdyA-6bp2A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 3 ALA G 224
TYR G 223
PRO G 493
 None
 0.58A 4zdyA-6ck9G:
undetectable		 4zdyA-6ck9G:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 3 ALA A 166
TYR A 162
PRO A  94
 None
 0.70A 4zdyA-6f5uA:
undetectable		 4zdyA-6f5uA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 3 ALA A 166
TYR A 162
PRO A  94
 None
 0.66A 4zdyA-6f6sA:
undetectable		 4zdyA-6f6sA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 3 ALA B 108
TYR B 107
PRO B 155
 None
 0.70A 4zdyA-6fd2B:
undetectable		 4zdyA-6fd2B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 ALA a 147
TYR a 150
PRO a  93
 None
 0.39A 4zdyA-6fkha:
0.7		 4zdyA-6fkha:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 3 ALA A 376
TYR A 375
PRO A 398
 None
 0.60A 4zdyA-6fmqA:
undetectable		 4zdyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 3 ALA A 427
TYR A 426
PRO A 445
 None
 0.65A 4zdyA-6fmqA:
undetectable		 4zdyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 3 ALA A 474
TYR A 473
PRO A 492
 None
None
ACT  A 704 (-3.6A)
 0.60A 4zdyA-6fmqA:
undetectable		 4zdyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-) 		no annotation 3 ALA A 369
TYR A 368
PRO A 387
 None
 0.64A 4zdyA-6gy5A:
undetectable		 4zdyA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-) 		no annotation 3 ALA A 417
TYR A 416
PRO A 435
 None
None
EDO  A 704 ( 4.0A)
 0.68A 4zdyA-6gy5A:
undetectable		 4zdyA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-) 		no annotation 3 ALA A 464
TYR A 463
PRO A 482
 None
None
EDO  A 703 ( 4.9A)
 0.59A 4zdyA-6gy5A:
undetectable		 4zdyA-6gy5A:
undetectable