SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZDY_A_1YNA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		6 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
MET A 517
 None
 1.34A 4zdyA-1d0nA:
0.0		 4zdyA-1d0nA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		5 GLY A 475
PHE B 376
ILE B 375
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.20A 4zdyA-1e6vA:
0.0		 4zdyA-1e6vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 ILE A 108
GLY A 130
THR A 152
LEU A 175
PHE A 169
 None
 1.14A 4zdyA-1imjA:
undetectable		 4zdyA-1imjA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j83 ENDO-1,4-BETA
GLUCANASE ENGF

(Clostridium
cellulovorans) 		PF03424
(CBM_17_28) 		5 GLY A1136
PHE A1041
GLY A1048
PHE A1189
MET A1186
 None
 1.24A 4zdyA-1j83A:
undetectable		 4zdyA-1j83A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 GLY A  54
ILE A 956
GLY A 950
LEU A 938
PHE A 225
 None
 1.13A 4zdyA-1jqoA:
0.0		 4zdyA-1jqoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		5 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.14A 4zdyA-1k1dA:
0.0		 4zdyA-1k1dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		5 GLY A 231
ILE A  71
GLY A 164
THR A 225
LEU A 167
 None
 1.22A 4zdyA-1mo2A:
0.0		 4zdyA-1mo2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		5 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.08A 4zdyA-1nphA:
0.0		 4zdyA-1nphA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 GLY K  60
ILE K 204
PHE K  34
GLY K 223
LEU K 219
 None
None
None
None
IOD  K1920 ( 4.1A)
 1.20A 4zdyA-1oxxK:
undetectable		 4zdyA-1oxxK:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 GLY A 237
PHE A 320
GLY A 307
THR A  98
THR A 239
 K  A 502 ( 4.7A)
None
None
None
None
 1.07A 4zdyA-1p9eA:
undetectable		 4zdyA-1p9eA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		5 GLY A  46
ILE A  35
GLY A  92
LEU A  98
PHE A  79
 None
 1.11A 4zdyA-1phzA:
undetectable		 4zdyA-1phzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 GLY A  93
PHE A  71
ILE A  73
PHE A  31
THR A  95
 None
 1.13A 4zdyA-1smrA:
undetectable		 4zdyA-1smrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		5 GLY A 141
ILE A  25
GLY A 234
LEU A 237
THR A 111
 None
 1.17A 4zdyA-1t70A:
undetectable		 4zdyA-1t70A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 GLY A 145
ILE A 240
GLY A 192
LEU A 132
HIS A 134
 None
 1.13A 4zdyA-1vcjA:
undetectable		 4zdyA-1vcjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 GLY A 638
TYR A 649
PHE A 674
GLY A 695
THR A 717
 None
 1.20A 4zdyA-1vrqA:
undetectable		 4zdyA-1vrqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		5 GLY A 119
TYR A  86
ILE A 216
GLY A  26
HIS A 156
 GLN  A 227 (-3.9A)
None
None
None
GLN  A 227 (-4.0A)
 1.18A 4zdyA-1wdnA:
undetectable		 4zdyA-1wdnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 GLY A  55
TYR A 362
ILE A 334
GLY A 368
THR A 405
 None
 1.19A 4zdyA-1wzaA:
undetectable		 4zdyA-1wzaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 GLY A  55
PHE A 145
ILE A 128
GLY A 207
THR A  58
 None
 1.13A 4zdyA-1ytmA:
undetectable		 4zdyA-1ytmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		5 GLY A 140
TYR A 233
ILE A 220
GLY A 251
THR A  12
 None
BTN  A1275 (-4.6A)
None
None
None
 1.12A 4zdyA-2c4iA:
undetectable		 4zdyA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		5 GLY A 310
ILE A 251
GLY A 234
THR A 299
LEU A 214
 None
 1.20A 4zdyA-2dwcA:
undetectable		 4zdyA-2dwcA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 190
ILE A 319
GLY A 280
THR A 264
PHE A 409
 None
 1.17A 4zdyA-2gqdA:
undetectable		 4zdyA-2gqdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		5 GLY A  44
PHE A 353
ILE A 366
PHE A 302
GLY A 203
 None
 1.21A 4zdyA-2ibpA:
undetectable		 4zdyA-2ibpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		5 GLY A 171
PHE A 333
ILE A 307
THR A  53
PHE A 244
 None
None
None
None
NHE  A   1 (-3.6A)
 1.23A 4zdyA-2ichA:
undetectable		 4zdyA-2ichA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mks RNA-BINDING MOTIF
PROTEIN, X
CHROMOSOME

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  36
THR A  21
LEU A  17
PHE A  13
MET A  42
 None
 1.24A 4zdyA-2mksA:
undetectable		 4zdyA-2mksA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		5 PHE A 189
GLY A 187
LEU A  76
PHE A 204
THR A 292
 None
 1.07A 4zdyA-2nq2A:
1.4		 4zdyA-2nq2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		5 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.96A 4zdyA-2ow4A:
undetectable		 4zdyA-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 PHE A 216
ILE A   7
LEU A 235
THR A 146
MET A 172
 None
 1.12A 4zdyA-2p17A:
undetectable		 4zdyA-2p17A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		5 GLY A 806
ILE A 696
GLY A 591
THR A 664
MET A 657
 SO4  A   1 ( 4.6A)
None
None
None
RIE  A 876 (-4.1A)
 1.14A 4zdyA-2r4fA:
undetectable		 4zdyA-2r4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		5 TYR A 541
PHE A 534
ILE A 537
GLY A 509
PHE A 212
 None
 1.21A 4zdyA-2rfoA:
undetectable		 4zdyA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 GLY A 401
TYR A 459
GLY A 287
THR A 283
THR A 374
 NI  A1614 (-3.7A)
None
None
None
None
 1.18A 4zdyA-2uvfA:
undetectable		 4zdyA-2uvfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 TYR A 141
PHE A  88
ILE A 117
LEU A  36
THR A  45
 None
 1.19A 4zdyA-2va8A:
2.8		 4zdyA-2va8A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 GLY A 516
PHE A 529
GLY A 417
THR A 303
HIS A 427
 GOL  A1771 (-4.3A)
None
None
None
GOL  A1771 ( 4.3A)
 1.18A 4zdyA-2wdaA:
undetectable		 4zdyA-2wdaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 GLY A 270
TYR A 335
GLY A 659
PHE A 311
THR A 268
 None
GOL  A 901 ( 4.7A)
FAD  A 801 (-3.8A)
None
None
 1.24A 4zdyA-2yr5A:
undetectable		 4zdyA-2yr5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.05A 4zdyA-3bs8A:
undetectable		 4zdyA-3bs8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		5 GLY A 118
PHE A 283
ILE A 248
GLY A 140
LEU A 233
 None
 1.15A 4zdyA-3c5iA:
undetectable		 4zdyA-3c5iA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 GLY A 173
TYR A 260
ILE A 279
THR A 244
PHE A 259
 None
 1.09A 4zdyA-3cg3A:
undetectable		 4zdyA-3cg3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		5 GLY A  88
PHE A 202
ILE A 177
GLY A 194
THR A  50
 None
 1.13A 4zdyA-3f4sA:
undetectable		 4zdyA-3f4sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum) 		PF01633
(Choline_kinase) 		6 GLY A 188
PHE A 353
ILE A 318
GLY A 210
LEU A 303
THR A 297
 None
 1.31A 4zdyA-3fi8A:
undetectable		 4zdyA-3fi8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLY A 244
ILE A 269
GLY A 237
THR A 225
LEU A 240
 None
 1.21A 4zdyA-3g8mA:
undetectable		 4zdyA-3g8mA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.10A 4zdyA-3ihgA:
undetectable		 4zdyA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iox AGI/II

(Streptococcus
mutans) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		5 GLY A 662
GLY A 575
THR A 585
LEU A 553
THR A 541
 None
 1.22A 4zdyA-3ioxA:
undetectable		 4zdyA-3ioxA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 GLY A 216
ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.99A 4zdyA-3jr3A:
undetectable		 4zdyA-3jr3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 334
PHE A  57
PHE A 199
HIS A 296
THR A 330
 None
 1.20A 4zdyA-3ledA:
undetectable		 4zdyA-3ledA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		5 ILE A 221
GLY A  18
LEU A 276
HIS A 275
THR A 268
 None
 1.20A 4zdyA-3mmtA:
undetectable		 4zdyA-3mmtA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
 None
 1.12A 4zdyA-3n23B:
undetectable		 4zdyA-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nio GUANIDINOBUTYRASE

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 ILE A 135
GLY A  44
LEU A 306
PHE A 242
THR A 298
 None
 1.20A 4zdyA-3nioA:
undetectable		 4zdyA-3nioA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 PHE A 486
ILE A 485
PHE A 220
GLY A 246
MET A 226
 None
 1.08A 4zdyA-3ombA:
undetectable		 4zdyA-3ombA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 GLY A 498
ILE B 332
GLY B 465
THR A 489
LEU A 383
 None
 1.06A 4zdyA-3opyA:
undetectable		 4zdyA-3opyA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 101
THR A 260
HIS A  36
PHE A 143
THR A 291
 ADP  A 307 (-4.3A)
None
None
None
None
 1.17A 4zdyA-3pygA:
undetectable		 4zdyA-3pygA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  41
TYR A   9
PHE A 102
GLY A  66
THR A  38
 None
 1.20A 4zdyA-3q4dA:
undetectable		 4zdyA-3q4dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.11A 4zdyA-3r44A:
undetectable		 4zdyA-3r44A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.23A 4zdyA-3sfwA:
undetectable		 4zdyA-3sfwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 GLY A  63
ILE A 185
GLY A 149
LEU A 124
PHE A 118
 None
 1.21A 4zdyA-3t8jA:
undetectable		 4zdyA-3t8jA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 398
ILE A  62
GLY A  82
HIS A  87
THR A 399
 None
 1.05A 4zdyA-3u4aA:
undetectable		 4zdyA-3u4aA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		5 GLY A 125
PHE A 225
ILE A 214
GLY A 237
THR A 203
 None
 1.21A 4zdyA-3vbeA:
undetectable		 4zdyA-3vbeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 GLY A 760
TYR A 749
ILE A 665
GLY A 639
LEU A 754
 None
 1.22A 4zdyA-3wajA:
undetectable		 4zdyA-3wajA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 ILE A 268
PHE A 317
LEU A 357
PHE A 364
THR A 450
 None
 1.20A 4zdyA-3wbhA:
0.2		 4zdyA-3wbhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		5 TYR A 385
ILE A 377
GLY A 372
THR A 312
THR A 318
 None
 1.17A 4zdyA-3wrfA:
undetectable		 4zdyA-3wrfA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.16A 4zdyA-4b6gA:
undetectable		 4zdyA-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT
IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS)
PF14574
(DUF4445) 		5 GLY A 428
ILE I 251
GLY A 379
THR A 382
LEU A 413
 B12  I1631 ( 4.0A)
None
None
None
None
 1.18A 4zdyA-4c1nA:
undetectable		 4zdyA-4c1nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 GLY A 144
ILE A 239
GLY A 191
LEU A 131
HIS A 133
 None
 1.13A 4zdyA-4cpnA:
undetectable		 4zdyA-4cpnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.13A 4zdyA-4egtA:
undetectable		 4zdyA-4egtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 GLY A 412
ILE A 446
LEU A 384
THR A 407
MET A 405
 None
 1.05A 4zdyA-4fnvA:
undetectable		 4zdyA-4fnvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		5 GLY A 240
PHE A  77
ILE A  80
LEU A 234
THR A 242
 None
 1.11A 4zdyA-4fs3A:
undetectable		 4zdyA-4fs3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 GLY A 660
ILE A 523
PHE A 675
GLY A 536
THR A 661
 None
 1.19A 4zdyA-4gfhA:
1.0		 4zdyA-4gfhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		5 ILE A  83
PHE A   3
GLY A  32
LEU A 160
HIS A 159
 None
None
None
None
CL  A 302 (-4.7A)
 1.23A 4zdyA-4h3zA:
undetectable		 4zdyA-4h3zA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 188
ILE A 317
GLY A 278
THR A 262
PHE A 407
 None
 1.14A 4zdyA-4ls5A:
undetectable		 4zdyA-4ls5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqb THYMIDYLATE KINASE

(Staphylococcus
aureus) 		PF02223
(Thymidylate_kin) 		5 GLY A  39
ILE A 142
GLY A  14
THR A  17
THR A  35
 None
None
PG4  A 302 (-3.5A)
PG4  A 302 (-3.8A)
None
 1.24A 4zdyA-4mqbA:
undetectable		 4zdyA-4mqbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 5 GLY A 368
ILE A 381
LEU A 391
HIS A 397
THR A 367
 None
 1.24A 4zdyA-4rmxA:
undetectable		 4zdyA-4rmxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.08A 4zdyA-4x1zA:
undetectable		 4zdyA-4x1zA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp HEAVY CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  85
ILE H  34
GLY H 104
PHE H  63
THR H  87
 None
 1.10A 4zdyA-4xmpH:
undetectable		 4zdyA-4xmpH:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A2748
TYR A2526
PHE A2365
ILE A2355
GLY A2381
 None
 1.14A 4zdyA-4z37A:
undetectable		 4zdyA-4z37A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		5 GLY C  35
ILE C 182
PHE C 232
THR C  91
MET C 100
 None
 1.17A 4zdyA-5a53C:
undetectable		 4zdyA-5a53C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00632
(HECT) 		5 TYR A 661
ILE A 765
PHE A 752
GLY A 643
LEU A 652
 None
 1.24A 4zdyA-5c91A:
undetectable		 4zdyA-5c91A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgy HEAVY CHAIN OF FAB

(Homo sapiens) 		no annotation 5 GLY H  89
ILE H  34
GLY H 118
PHE H  64
THR H  91
 None
 1.06A 4zdyA-5cgyH:
undetectable		 4zdyA-5cgyH:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 GLY A  65
TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.57A 4zdyA-5fsaA:
56.9		 4zdyA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.00A 4zdyA-5fsaA:
56.9		 4zdyA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 GLY A 265
PHE A  95
ILE A  66
GLY A  90
PHE A 279
 None
 1.15A 4zdyA-5g37A:
undetectable		 4zdyA-5g37A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 PHE A  93
ILE A  76
GLY A 112
LEU A 151
THR A 169
 None
 1.22A 4zdyA-5gvaA:
undetectable		 4zdyA-5gvaA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		6 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.77A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 GLY A  73
TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
None
 0.50A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		6 TYR A 126
ILE A 139
THR A 318
LEU A 380
THR A 507
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
VOR  A 602 ( 4.2A)
 1.38A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
ES19

(Kluyveromyces
lactis) 		PF01090
(Ribosomal_S19e) 		5 GLY T  98
PHE T  14
ILE T 135
LEU T 108
PHE T  54
 G  21500 ( 3.7A)
None
None
None
None
 1.23A 4zdyA-5it9T:
undetectable		 4zdyA-5it9T:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 GLY A  74
TYR A 127
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.52A 4zdyA-5jlcA:
59.6		 4zdyA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		6 GLY A 316
THR A 319
LEU A 381
HIS A 382
THR A 510
MET A 512
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.95A 4zdyA-5jlcA:
59.6		 4zdyA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kai CYTOCHROME C-550

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
 1.03A 4zdyA-5kaiV:
undetectable		 4zdyA-5kaiV:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.10A 4zdyA-5m7rA:
2.2		 4zdyA-5m7rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqf APICAL MEMBRANE
ANTIGEN 1

(Plasmodium
falciparum) 		PF02430
(AMA-1) 		5 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.19A 4zdyA-5nqfA:
undetectable		 4zdyA-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofu FBP PROTEIN

(Leishmania
major) 		PF00316
(FBPase) 		5 GLY A 162
ILE A 249
GLY A 122
LEU A 279
PHE A 322
 None
CL  A 403 (-4.0A)
F6P  A 402 (-3.6A)
None
None
 1.10A 4zdyA-5ofuA:
undetectable		 4zdyA-5ofuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 435
ILE A  90
GLY A 110
HIS A 115
THR A 436
 None
 1.10A 4zdyA-5tf0A:
undetectable		 4zdyA-5tf0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.08A 4zdyA-5uhkA:
undetectable		 4zdyA-5uhkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 509
PHE A 150
LEU A 486
PHE A 479
THR A 510
 None
 1.00A 4zdyA-5v9xA:
undetectable		 4zdyA-5v9xA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.22A 4zdyA-5vvoA:
undetectable		 4zdyA-5vvoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 GLY A 319
ILE A 106
GLY A 302
LEU A  81
PHE A  89
 None
 1.15A 4zdyA-5w19A:
undetectable		 4zdyA-5w19A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xey PHLORETIN HYDROLASE

(Mycobacteroides
abscessus) 		no annotation 5 GLY A 225
PHE A 177
ILE A 175
LEU A 277
THR A 107
 None
 1.08A 4zdyA-5xeyA:
undetectable		 4zdyA-5xeyA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 5 GLY A 418
PHE A 328
ILE A 172
GLY A 326
HIS A 378
 None
 1.23A 4zdyA-5yowA:
undetectable		 4zdyA-5yowA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzn -

(-) 		no annotation 5 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.10A 4zdyA-5zznV:
undetectable		 4zdyA-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 GLY A  44
GLY A   9
THR A  32
LEU A  54
THR A  46
 None
 1.24A 4zdyA-6cj7A:
undetectable		 4zdyA-6cj7A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 548
ILE A 522
GLY A 517
THR A 515
LEU A 947
 None
 1.23A 4zdyA-6eojA:
undetectable		 4zdyA-6eojA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 5 GLY C 237
ILE F 354
GLY F 348
LEU F 332
PHE F 329
 None
 1.24A 4zdyA-6f0kC:
undetectable		 4zdyA-6f0kC:
10.18