SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZBR_A_NPSA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
5 ALA A  31
LEU A  17
LEU A  33
ALA A  62
SER A 128
None
1.21A 4zbrA-1b41A:
undetectable
4zbrA-1b41A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igq TRANSCRIPTIONAL
REPRESSOR PROTEIN
KORB


(Escherichia
coli)
PF06613
(KorB_C)
5 ARG A 316
ALA A 318
ASP A 338
LEU A 334
ALA A 345
None
1.07A 4zbrA-1igqA:
undetectable
4zbrA-1igqA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN


(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
5 ALA A 200
ASP A 158
ALA A 171
SER A 219
ALA A 215
None
1.13A 4zbrA-1k1bA:
undetectable
4zbrA-1k1bA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus)
PF01501
(Glyco_transf_8)
5 ALA A 153
LEU A 167
LEU A  84
SER A  69
ALA A  70
None
1.14A 4zbrA-1ll2A:
undetectable
4zbrA-1ll2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
5 ALA A 138
LEU A 108
ALA A 104
LEU A 135
ALA A 132
None
1.22A 4zbrA-1p88A:
undetectable
4zbrA-1p88A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO


(Pseudomonas
aeruginosa)
PF01126
(Heme_oxygenase)
5 ARG A  80
ALA A  84
LEU A 147
LEU A  54
ALA A  51
None
1.18A 4zbrA-1sk7A:
undetectable
4zbrA-1sk7A:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
8 ARG A 209
ALA A 213
ASP A 324
LEU A 327
LEU A 347
ALA A 350
SER A 480
LEU A 481
DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1001 (-4.7A)
DKA  A1001 (-4.1A)
DKA  A1002 ( 4.3A)
DKA  A1002 ( 3.8A)
DKA  A1002 (-3.4A)
None
0.48A 4zbrA-1tf0A:
46.9
4zbrA-1tf0A:
76.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
7 ARG A 209
ALA A 213
LEU A 327
LEU A 347
ALA A 350
LYS A 351
SER A 480
DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1001 (-4.1A)
DKA  A1002 ( 4.3A)
DKA  A1002 ( 3.8A)
DKA  A1002 (-2.6A)
DKA  A1002 (-3.4A)
0.78A 4zbrA-1tf0A:
46.9
4zbrA-1tf0A:
76.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE


(Escherichia
coli)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
5 ASP A 337
LEU A 336
LEU A 135
ALA A 131
LEU A 346
None
1.16A 4zbrA-1tj7A:
undetectable
4zbrA-1tj7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli)
PF02541
(Ppx-GppA)
5 ALA A  95
LEU A  51
SER A  20
LEU A  47
ALA A  48
None
None
SO4  A 701 (-3.0A)
None
None
1.21A 4zbrA-1u6zA:
undetectable
4zbrA-1u6zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A 259
LEU A  21
SER A  35
LEU A  34
ALA A  31
None
1.09A 4zbrA-1ulqA:
0.0
4zbrA-1ulqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Pyrococcus
furiosus)
PF00290
(Trp_syntA)
5 ARG A 185
ALA A 186
ASP A 146
LEU A 162
ALA A 140
None
0.95A 4zbrA-1wdwA:
undetectable
4zbrA-1wdwA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3


(Homo sapiens)
PF03127
(GAT)
5 LEU A 276
LEU A 262
ALA A 266
SER A 287
LEU A 286
None
1.01A 4zbrA-1wr6A:
2.4
4zbrA-1wr6A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E


(Homo sapiens)
PF01532
(Glyco_hydro_47)
5 LEU A 408
ALA A 355
SER A 346
LEU A 345
ALA A 342
None
1.16A 4zbrA-1x9dA:
2.6
4zbrA-1x9dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3


(Homo sapiens)
PF03127
(GAT)
5 LEU G 276
LEU G 262
ALA G 266
SER G 287
LEU G 286
None
1.16A 4zbrA-1yd8G:
undetectable
4zbrA-1yd8G:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C


(Mycobacterium
tuberculosis)
PF09407
(AbiEi_1)
PF13338
(AbiEi_4)
5 ALA A 106
LEU A 154
LEU A 183
ALA A 182
SER A 193
None
1.14A 4zbrA-1zelA:
undetectable
4zbrA-1zelA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli)
PF01144
(CoA_trans)
6 ALA A  91
LEU A 154
ALA A 106
SER A  80
LEU A  82
ALA A  83
None
1.25A 4zbrA-2ahwA:
undetectable
4zbrA-2ahwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE


(Thermotoga
maritima)
PF05161
(MOFRL)
PF13660
(DUF4147)
5 ALA A  27
LEU A  32
ALA A  55
SER A 122
ALA A  48
None
1.21A 4zbrA-2b8nA:
undetectable
4zbrA-2b8nA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE


(Thermus
thermophilus)
PF01134
(GIDA)
5 LEU A  81
LEU A  22
ALA A  23
LEU A 223
ALA A 224
None
1.20A 4zbrA-2culA:
undetectable
4zbrA-2culA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ALA A 288
LEU A 299
LEU A 247
LEU A 253
ALA A 252
None
1.20A 4zbrA-2dpnA:
undetectable
4zbrA-2dpnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR


(Mycobacterium
tuberculosis)
PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD)
5 ALA A 178
LEU A 211
ALA A 214
SER A 265
ALA A 262
None
1.18A 4zbrA-2fezA:
undetectable
4zbrA-2fezA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgg HYPOTHETICAL PROTEIN
RV2632C/MT2708


(Mycobacterium
tuberculosis)
PF08962
(DUF1876)
5 ALA A  26
ALA A  43
SER A  66
LEU A  65
ALA A  62
None
1.03A 4zbrA-2fggA:
undetectable
4zbrA-2fggA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A


(Solanum
lycopersicum)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
5 ARG A 597
ALA A 308
ASP A 326
LEU A   7
SER A 602
None
1.15A 4zbrA-2fonA:
undetectable
4zbrA-2fonA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE


(Homo sapiens)
PF00171
(Aldedh)
5 ALA A 492
LEU A 392
ALA A 393
LEU A 524
ALA A 523
None
1.07A 4zbrA-2h5gA:
undetectable
4zbrA-2h5gA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis)
PF00696
(AA_kinase)
6 ALA A 149
LEU A 158
LEU A 210
ALA A 156
LEU A 204
ALA A 205
None
1.45A 4zbrA-2jjxA:
undetectable
4zbrA-2jjxA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3o TUSP1

(Nephila
antipodiana)
PF12042
(RP1-2)
5 ALA A  78
LEU A  15
ALA A  16
LEU A 107
ALA A 108
None
1.19A 4zbrA-2k3oA:
1.9
4zbrA-2k3oA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6h FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN


(Gallus gallus;
unidentified)
PF03623
(Focal_AT)
5 ALA A 121
LEU A 125
LEU A  21
LEU A  51
ALA A  50
None
1.10A 4zbrA-2l6hA:
5.0
4zbrA-2l6hA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens)
PF01442
(Apolipoprotein)
5 ASP A 153
ALA A 100
SER A 263
LEU A 261
ALA A 259
None
1.10A 4zbrA-2l7bA:
3.0
4zbrA-2l7bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME


(Agrobacterium
fabrum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 381
ASP A 355
LEU A 354
LEU A  13
ALA A 320
None
1.19A 4zbrA-2nqlA:
undetectable
4zbrA-2nqlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201


(Pseudomonas
aeruginosa)
PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF)
5 ALA A 505
ASP A 456
LEU A 510
ALA A 508
LEU A 558
None
1.20A 4zbrA-2oceA:
undetectable
4zbrA-2oceA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi8 PUTATIVE REGULATORY
PROTEIN SCO4313


(Streptomyces
coelicolor)
PF00440
(TetR_N)
5 ALA A 138
LEU A 214
LEU A  92
SER A  85
ALA A  82
None
0.98A 4zbrA-2oi8A:
3.2
4zbrA-2oi8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE


(Azospirillum
brasilense)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A 141
LEU A   3
ALA A 170
LEU A   7
ALA A   4
None
1.15A 4zbrA-2q5oA:
undetectable
4zbrA-2q5oA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU


(Haemophilus
influenzae)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 ASP A 208
LEU A 184
ALA A 185
LEU A 198
ALA A  83
None
1.12A 4zbrA-2v0jA:
undetectable
4zbrA-2v0jA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00171
(Aldedh)
5 ALA A  75
LEU A 113
ALA A 110
LEU A 167
ALA A 164
None
1.19A 4zbrA-2xdrA:
undetectable
4zbrA-2xdrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE


(Thermus
thermophilus)
PF03747
(ADP_ribosyl_GH)
5 ALA A 135
LEU A  16
ALA A 290
LEU A  65
ALA A  66
None
1.14A 4zbrA-2yzwA:
undetectable
4zbrA-2yzwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
5 ALA A 625
LEU A 388
ALA A 392
LEU A 403
ALA A 400
None
1.02A 4zbrA-3aqpA:
undetectable
4zbrA-3aqpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695


(Pyrococcus
furiosus)
PF01814
(Hemerythrin)
PF13596
(PAS_10)
5 ALA A 240
LEU A 142
SER A 248
LEU A 247
ALA A 139
None
1.13A 4zbrA-3caxA:
3.2
4zbrA-3caxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 ALA A 167
LEU A 202
ALA A 178
LEU A 196
ALA A 197
None
1.15A 4zbrA-3cinA:
undetectable
4zbrA-3cinA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD


(Deinococcus
radiodurans)
PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4)
6 ALA A 309
LEU A 283
LEU A 708
ALA A 707
LEU A 479
ALA A 478
None
1.30A 4zbrA-3e1sA:
undetectable
4zbrA-3e1sA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris)
PF00696
(AA_kinase)
5 ALA A 150
LEU A 159
LEU A 210
LEU A 204
ALA A 205
None
1.17A 4zbrA-3ek5A:
undetectable
4zbrA-3ek5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A 228
LEU A 269
ALA A 266
LEU A 336
ALA A 335
None
1.18A 4zbrA-3eyaA:
undetectable
4zbrA-3eyaA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go9 INSULINASE FAMILY
PROTEASE


(Yersinia pestis)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 ASP A 300
LEU A 301
LEU A 383
LYS A 379
LEU A 386
PEG  A 607 (-3.3A)
None
None
None
None
1.13A 4zbrA-3go9A:
undetectable
4zbrA-3go9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF


(Escherichia
coli)
PF01545
(Cation_efflux)
PF16916
(ZT_dimer)
5 ALA A  82
ALA A 149
SER A 204
LEU A 205
ALA A 201
None
1.06A 4zbrA-3h90A:
2.5
4zbrA-3h90A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE


(Aeromonas
sobria)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
5 ALA A 352
LEU A 423
ALA A  62
LEU A 364
ALA A 422
None
1.10A 4zbrA-3hjrA:
undetectable
4zbrA-3hjrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE


(Cupriavidus
pinatubonensis)
no annotation 5 ALA A 240
LEU A 235
ALA A 234
LEU A 264
ALA A 263
None
1.12A 4zbrA-3iupA:
undetectable
4zbrA-3iupA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 5 ASP A 820
LEU A 817
ALA A 811
LEU A 878
ALA A 918
None
1.13A 4zbrA-3j3iA:
undetectable
4zbrA-3j3iA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
5 LEU A 241
ALA A 296
SER A 261
LEU A 257
ALA A 256
None
1.21A 4zbrA-3k5wA:
undetectable
4zbrA-3k5wA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT


(Streptococcus
thermophilus)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 ALA A 103
ASP A 110
LEU A  67
SER A  62
LEU A  63
None
1.12A 4zbrA-3lkdA:
undetectable
4zbrA-3lkdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1
LEUCINE-RICH IMMUNE
MOLECULE 1


(Anopheles
gambiae)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 ASP B 681
LEU B 680
LEU A 487
ALA A 483
LEU B 690
None
1.13A 4zbrA-3ojaB:
undetectable
4zbrA-3ojaB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rij SC_2CX5

(Thermus
thermophilus)
PF04073
(tRNA_edit)
5 ALA A  60
LEU A  85
LEU A  95
ALA A  87
ALA A  94
None
1.19A 4zbrA-3rijA:
undetectable
4zbrA-3rijA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 5 ALA M 394
LEU M 478
ALA M 347
LEU M 355
ALA M 352
None
1.14A 4zbrA-3rkoM:
undetectable
4zbrA-3rkoM:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
5 ALA A 427
LEU A 423
LEU A 415
LEU A 531
ALA A 530
None
0.98A 4zbrA-3rx8A:
undetectable
4zbrA-3rx8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
6 ARG A 146
ALA A 142
ASP A 199
LEU A 202
LEU A  49
ALA A  46
None
1.40A 4zbrA-3snxA:
undetectable
4zbrA-3snxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 ALA A 225
ASP A 251
LEU A 250
LEU A 240
ALA A 239
None
1.20A 4zbrA-3tsdA:
undetectable
4zbrA-3tsdA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE


(Campylobacter
jejuni)
PF00180
(Iso_dh)
5 ALA A  42
LEU A   9
ALA A  10
SER A  93
LEU A  56
None
1.17A 4zbrA-3uduA:
undetectable
4zbrA-3uduA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0t PERAKINE REDUCTASE

(Rauvolfia
serpentina)
PF00248
(Aldo_ket_red)
5 LEU A 181
LEU A 264
ALA A 263
LEU A 293
ALA A 292
None
1.11A 4zbrA-3v0tA:
undetectable
4zbrA-3v0tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 ALA A 237
ASP A 239
LEU A  22
ALA A  25
ALA A   5
None
1.18A 4zbrA-3v2hA:
undetectable
4zbrA-3v2hA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN


(Prochloron
didemni)
PF00082
(Peptidase_S8)
5 LEU A 146
ALA A 228
SER A 254
LEU A 282
ALA A 279
None
1.12A 4zbrA-3zxyA:
undetectable
4zbrA-3zxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abx DNA REPAIR PROTEIN
RECN


(Deinococcus
radiodurans)
no annotation 5 ASP A 314
LEU A 313
LEU A 226
SER A 324
LEU A 323
None
1.15A 4zbrA-4abxA:
3.6
4zbrA-4abxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 ALA A 274
LEU A 263
ALA A 258
SER A 297
ALA A 294
None
1.13A 4zbrA-4b52A:
2.1
4zbrA-4b52A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00169
(PH)
PF16746
(BAR_3)
5 LEU A 159
ALA A 155
SER A 133
LEU A 134
ALA A 162
None
0.90A 4zbrA-4ckgA:
2.0
4zbrA-4ckgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fso PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
5 ARG A 236
ALA A 293
SER A 232
LEU A 260
ALA A 261
None
None
None
C8E  A 504 ( 4.7A)
None
1.21A 4zbrA-4fsoA:
undetectable
4zbrA-4fsoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb1 DHP1

(synthetic
construct)
no annotation 5 LEU A   4
LEU A 114
ALA A 118
LEU A  14
ALA A 111
None
1.10A 4zbrA-4hb1A:
2.1
4zbrA-4hb1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l62 TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF16925
(TetR_C_13)
5 ASP A  71
LEU A  67
LEU A 136
LEU A 140
ALA A 158
None
1.19A 4zbrA-4l62A:
5.1
4zbrA-4l62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Neisseria
meningitidis)
PF13561
(adh_short_C2)
5 ALA A 227
ASP A 229
LEU A  28
ALA A  31
ALA A  11
None
1.12A 4zbrA-4m8sA:
undetectable
4zbrA-4m8sA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA


(Planctopirus
limnophila)
PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5)
5 ALA A 259
LEU A 252
LEU A 303
LEU A 299
ALA A 199
None
1.15A 4zbrA-4mtnA:
undetectable
4zbrA-4mtnA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
5 ALA A 213
LEU A 327
LEU A 347
SER A 480
LEU A 481
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.7A)
NPS  A 602 ( 4.2A)
None
None
0.55A 4zbrA-4po0A:
50.2
4zbrA-4po0A:
71.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 ARG A 209
ALA A 213
ASP A 324
LEU A 327
LEU A 347
LEU A 481
NPS  A 602 (-3.6A)
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.4A)
NPS  A 602 ( 4.7A)
NPS  A 602 ( 4.2A)
None
0.73A 4zbrA-4po0A:
50.2
4zbrA-4po0A:
71.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsx TYPE III EFFECTOR
HOPA1


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 ALA A 140
LEU A 349
SER A 363
LEU A 360
ALA A 348
None
1.21A 4zbrA-4rsxA:
2.0
4zbrA-4rsxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 ARG A 287
ALA A 288
LEU A  42
ALA A 303
ALA A 257
EDO  A 404 (-3.6A)
None
None
None
None
1.12A 4zbrA-4wjmA:
undetectable
4zbrA-4wjmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x82 ZINC TRANSPORTER
ZIP4


(Pteropus alecto)
no annotation 5 ALA B  92
LEU B  46
LEU B 180
LEU B 176
ALA B 177
None
1.08A 4zbrA-4x82B:
undetectable
4zbrA-4x82B:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
5 ALA A 127
LEU A 427
ALA A 431
LEU A 449
ALA A 424
None
1.06A 4zbrA-4xciA:
undetectable
4zbrA-4xciA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
5 ALA A 514
LEU A  78
LEU A 103
LEU A 449
ALA A 448
None
1.04A 4zbrA-4xciA:
undetectable
4zbrA-4xciA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN


(Thermus
thermophilus)
PF00877
(NLPC_P60)
PF01476
(LysM)
5 ALA A 215
LEU A 192
LEU A 209
SER A 129
LEU A 132
None
1.16A 4zbrA-4xcmA:
undetectable
4zbrA-4xcmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 ALA A 143
LEU A 104
LEU A 155
SER A 208
ALA A 204
None
1.06A 4zbrA-4xriA:
undetectable
4zbrA-4xriA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis)
PF00004
(AAA)
PF05362
(Lon_C)
5 ALA A 684
LEU A 769
ALA A 597
SER A 678
ALA A 679
None
None
None
4KZ  A 801 (-1.4A)
4KZ  A 801 (-3.5A)
1.12A 4zbrA-4yplA:
2.2
4zbrA-4yplA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Oceanimonas
doudoroffii)
PF00171
(Aldedh)
5 ALA A 286
ASP A 370
LEU A 368
LEU A 268
ALA A 264
None
1.12A 4zbrA-4zz7A:
undetectable
4zbrA-4zz7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5arm CSP3

(Methylosinus
trichosporium)
no annotation 5 ALA A  68
LEU A  87
ALA A  91
LEU A  21
ALA A 128
None
1.18A 4zbrA-5armA:
undetectable
4zbrA-5armA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE


(Burkholderia
cenocepacia)
PF03309
(Pan_kinase)
5 ALA A 135
LEU A 146
LEU A 212
ALA A 208
ALA A 215
None
0.95A 4zbrA-5b8hA:
undetectable
4zbrA-5b8hA:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
8 ALA A 212
ASP A 323
LEU A 326
LEU A 346
ALA A 349
SER A 479
LEU A 480
ALA A 481
CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.7A)
CZE  A 613 ( 4.7A)
CZE  A 613 ( 3.8A)
CZE  A 613 ( 4.7A)
None
None
CZE  A 613 ( 4.6A)
0.40A 4zbrA-5dqfA:
55.4
4zbrA-5dqfA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
6 ARG A 208
ALA A 212
LEU A 346
SER A 479
LEU A 480
ALA A 481
CZE  A 613 ( 3.5A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 3.8A)
None
None
CZE  A 613 ( 4.6A)
0.83A 4zbrA-5dqfA:
55.4
4zbrA-5dqfA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
7 ALA A 213
ASP A 324
LEU A 327
LEU A 347
ALA A 350
SER A 480
LEU A 481
None
0.38A 4zbrA-5ghkA:
47.5
4zbrA-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
6 ALA d 127
LEU d 425
ALA d 429
SER d 445
LEU d 447
ALA d 444
None
1.35A 4zbrA-5gw5d:
undetectable
4zbrA-5gw5d:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 ALA h 510
LEU h  83
LEU h 108
LEU h 446
ALA h 445
None
1.03A 4zbrA-5gw5h:
undetectable
4zbrA-5gw5h:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E


(Homo sapiens)
PF01532
(Glyco_hydro_47)
5 LEU A 408
ALA A 355
SER A 346
LEU A 345
ALA A 342
None
1.19A 4zbrA-5kijA:
undetectable
4zbrA-5kijA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus)
PF08715
(Viral_protease)
5 ALA A 136
ASP A 144
LEU A 151
ALA A 150
LYS A  87
ACT  A 405 ( 3.6A)
None
ACT  A 405 ( 4.5A)
None
ACT  A 402 (-2.6A)
1.21A 4zbrA-5ko3A:
undetectable
4zbrA-5ko3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 5 ALA A 120
LEU A 155
LEU A 112
ALA A 154
ALA A 108
None
1.17A 4zbrA-5n3uA:
undetectable
4zbrA-5n3uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 5 ALA A 233
LEU A 215
ALA A 214
LEU A 244
ALA A 243
None
1.11A 4zbrA-5n3uA:
undetectable
4zbrA-5n3uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 5 ALA A 524
LEU A 519
LEU A  65
SER A  61
LEU A  60
None
1.06A 4zbrA-5nd1A:
undetectable
4zbrA-5nd1A:
7.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 9 ARG A 208
ALA A 212
ASP A 323
LEU A 326
LEU A 346
ALA A 349
LYS A 350
SER A 479
LEU A 480
None
0.60A 4zbrA-5oriA:
50.7
4zbrA-5oriA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud6 DIHYDRODIPICOLINATE
SYNTHASE


(Cyanidioschyzon
merolae)
no annotation 5 ALA A 268
ASP A 286
LEU A 295
LEU A 257
ALA A 256
None
1.22A 4zbrA-5ud6A:
undetectable
4zbrA-5ud6A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN


(Legionella
pneumophila)
no annotation 5 ALA A 101
LEU A 169
ALA A 172
LEU A 160
ALA A 161
None
1.15A 4zbrA-5vrqA:
undetectable
4zbrA-5vrqA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuf PUTATIVE MEMBRANE
PROTEIN


(Colwellia
psychrerythraea)
PF03458
(UPF0126)
5 ALA A 190
LEU A  92
ALA A  96
LEU A 153
ALA A 154
None
1.07A 4zbrA-5wufA:
undetectable
4zbrA-5wufA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C


(Paenibacillus
sp. A11-2)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
5 ALA A 382
LEU A 258
ALA A  85
SER A 204
LEU A 205
None
0.85A 4zbrA-5xdeA:
3.6
4zbrA-5xdeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 8 ARG A 209
ALA A 213
ASP A 324
LEU A 327
LEU A 347
ALA A 350
SER A 480
LEU A 481
None
0.46A 4zbrA-5yxeA:
45.8
4zbrA-5yxeA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-)
no annotation 5 ALA A  64
LEU A  79
LEU A  96
LEU A  90
ALA A  91
None
LLP  A  34 ( 3.9A)
None
None
None
1.20A 4zbrA-6a2fA:
undetectable
4zbrA-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE


(Ideonella
sakaiensis)
no annotation 5 ALA A  53
LEU A 104
ALA A 108
SER A 148
LEU A 149
None
1.20A 4zbrA-6aneA:
undetectable
4zbrA-6aneA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei)
no annotation 5 ASP A 326
LEU A 325
LEU A 349
ALA A 353
LEU A 335
None
1.17A 4zbrA-6bfiA:
4.7
4zbrA-6bfiA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN


(Escherichia
coli)
no annotation 5 LEU L 185
ALA L 130
SER L 121
LEU L 123
ALA L 122
None
1.19A 4zbrA-6ehsL:
undetectable
4zbrA-6ehsL:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila)
no annotation 5 ALA A 287
LEU A 264
LEU A 278
ALA A 266
ALA A 277
None
1.07A 4zbrA-6f72A:
undetectable
4zbrA-6f72A:
9.76