SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZBR_A_NPSA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		5 PHE A 134
LEU A 138
TYR A 140
GLY A 132
SER A 127
 None
 1.36A 4zbrA-1d0nA:
undetectable		 4zbrA-1d0nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 LEU A 122
PHE A 181
LEU A 129
GLY A 117
LEU A  93
 None
 1.33A 4zbrA-1do5A:
undetectable		 4zbrA-1do5A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		5 LEU A 222
GLY A 171
CYH A 149
LEU A 215
SER A   4
 None
 1.17A 4zbrA-1dqpA:
undetectable		 4zbrA-1dqpA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 322
LYS A 328
SER A 293
LEU A 292
SER A 302
 None
 1.36A 4zbrA-1ee0A:
undetectable		 4zbrA-1ee0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 5 LEU A 219
PHE A  57
LEU A  53
TYR A  50
GLY A 304
 None
 1.31A 4zbrA-1hm7A:
undetectable		 4zbrA-1hm7A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 ASN A 504
PHE A 630
LEU A 557
SER A 544
SER A 509
 None
 1.49A 4zbrA-1hn0A:
2.4		 4zbrA-1hn0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		5 LEU A  24
PHE A 108
LEU A 130
GLY A  42
SER A  67
 None
 1.30A 4zbrA-1hnoA:
undetectable		 4zbrA-1hnoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 PHE A 219
LEU A 215
GLY A 115
SER A 117
LEU A 120
 None
 1.44A 4zbrA-1mc3A:
undetectable		 4zbrA-1mc3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A  15
LEU A  16
GLY A 206
SER A 204
LEU A  32
 None
 1.39A 4zbrA-1odfA:
undetectable		 4zbrA-1odfA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 ASN A 476
PHE A 102
LEU A 119
TYR A 485
GLY A 111
 None
None
None
HEM  A 900 (-4.2A)
ZN  A 950 ( 4.4A)
 1.16A 4zbrA-1qw5A:
2.4		 4zbrA-1qw5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		5 PHE G 134
LEU G 138
TYR G 140
GLY G 132
SER G 127
 None
 1.32A 4zbrA-1rgiG:
undetectable		 4zbrA-1rgiG:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 LEU A 387
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LYS A 414
GLY A 434
LEU A 453
SER A 489
 None
 0.56A 4zbrA-1tf0A:
46.9		 4zbrA-1tf0A:
76.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis) 		PF01391
(Collagen) 		5 LEU A  97
LEU A 151
GLY A 149
SER A 146
SER A 205
 None
 1.45A 4zbrA-1wckA:
undetectable		 4zbrA-1wckA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 LEU A 248
ASN A 249
PHE A 220
GLY A 240
SER A 255
 None
 1.34A 4zbrA-1xa6A:
undetectable		 4zbrA-1xa6A:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 387
ASN A 391
CYH A 392
LEU A 407
TYR A 411
 None
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 (-4.5A)
4EB  A1000 (-3.3A)
 1.14A 4zbrA-1ysxA:
3.8		 4zbrA-1ysxA:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LEU A 387
ASN A 391
CYH A 392
PHE A 403
LEU A 407
LYS A 414
 None
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-4.5A)
4EB  A1000 (-3.9A)
 1.00A 4zbrA-1ysxA:
3.8		 4zbrA-1ysxA:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		5 LEU A 116
PHE A 202
LEU A 238
TYR A 235
GLY A 173
 None
 1.40A 4zbrA-2bejA:
undetectable		 4zbrA-2bejA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		5 PHE A 202
LEU A 238
TYR A 235
GLY A 173
LEU A  11
 None
 1.44A 4zbrA-2bejA:
undetectable		 4zbrA-2bejA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		5 LEU A  54
GLY A  57
SER A  33
LEU A  28
SER A 129
 None
None
None
CL  A1001 (-4.0A)
None
 1.36A 4zbrA-2f28A:
undetectable		 4zbrA-2f28A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 232
CYH A 182
PHE A 391
GLY A 392
LEU A 285
 None
 1.29A 4zbrA-2p0uA:
undetectable		 4zbrA-2p0uA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8t HYPOTHETICAL PROTEIN
PH0730

(Pyrococcus
horikoshii) 		PF14544
(DUF4443) 		5 LEU A  50
LEU A  27
GLY A  32
SER A  37
LEU A  40
 None
 1.14A 4zbrA-2p8tA:
undetectable		 4zbrA-2p8tA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q03 UNCHARACTERIZED
PROTEIN

(Shewanella
denitrificans) 		PF11528
(DUF3224) 		5 LEU A  46
PHE A 100
LEU A  85
GLY A 118
LEU A 134
 None
None
None
GOL  A 138 (-3.5A)
None
 0.96A 4zbrA-2q03A:
undetectable		 4zbrA-2q03A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 PHE A 142
LEU A 240
GLY A 118
CYH A 126
LEU A  39
 None
 1.28A 4zbrA-2uz0A:
undetectable		 4zbrA-2uz0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  89
LEU A  35
GLY A  66
SER A  71
LEU A  94
 None
 1.41A 4zbrA-2veaA:
undetectable		 4zbrA-2veaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		5 LEU A 151
PHE A 233
LEU A 191
TYR A 194
GLY A 230
 None
 1.41A 4zbrA-2x9pA:
5.2		 4zbrA-2x9pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 ASN A 161
PHE A  87
LEU A 190
GLY A  86
LEU A 256
 None
 1.21A 4zbrA-2yh2A:
undetectable		 4zbrA-2yh2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 288
ASN A 292
LEU A 248
GLY A 296
SER A 271
 None
 1.47A 4zbrA-2zviA:
undetectable		 4zbrA-2zviA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		5 LEU A  98
TYR A 101
GLY A 250
SER A 248
LEU A 246
 None
 1.49A 4zbrA-3a2bA:
undetectable		 4zbrA-3a2bA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 ASN A 342
PHE A 346
GLY A 298
SER A 302
SER A 413
 None
 1.36A 4zbrA-3aqpA:
undetectable		 4zbrA-3aqpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6a TERMINASE LARGE
SUBUNIT

(Escherichia
virus RB49) 		PF17289
(Terminase_6C) 		5 LEU A 410
CYH A 399
LEU A 467
TYR A 473
GLY A 460
 None
 1.44A 4zbrA-3c6aA:
undetectable		 4zbrA-3c6aA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A  52
LEU A  10
GLY A 256
SER A 260
LEU A  87
 None
 1.19A 4zbrA-3dm5A:
3.7		 4zbrA-3dm5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		5 LEU A 276
PHE A 206
LEU A 389
GLY A 272
LEU A 325
 None
 1.38A 4zbrA-3eq2A:
undetectable		 4zbrA-3eq2A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id6 PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		5 PHE A  48
LEU A  39
TYR A 124
LYS A 128
GLY A  12
 None
 1.47A 4zbrA-3id6A:
undetectable		 4zbrA-3id6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		5 LEU A  11
CYH A 101
PHE A  38
LEU A  36
LEU A  16
 None
 1.48A 4zbrA-3ixrA:
undetectable		 4zbrA-3ixrA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 222
PHE B 480
LEU B 469
GLY B 229
LEU B 197
 None
 1.10A 4zbrA-3kx2B:
undetectable		 4zbrA-3kx2B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		5 LEU A 295
PHE A 316
GLY A 354
LEU A 357
SER A 376
 None
 1.40A 4zbrA-3n0lA:
2.1		 4zbrA-3n0lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		5 PHE A 316
LEU A 383
GLY A 354
LEU A 357
SER A 376
 None
 1.25A 4zbrA-3n0lA:
2.1		 4zbrA-3n0lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuf PRD-CONTAINING
TRANSCRIPTION
REGULATOR

(Lactobacillus
paracasei) 		no annotation 5 LEU A 107
PHE A  45
TYR A  33
SER A  85
LEU A  88
 None
None
EDO  A 308 (-4.4A)
None
None
 1.34A 4zbrA-3nufA:
3.4		 4zbrA-3nufA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 258
PHE A 370
LEU A 358
GLY A 211
LEU A 311
 None
 1.13A 4zbrA-3pfeA:
undetectable		 4zbrA-3pfeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlx ADENYLATE KINASE 2

(Plasmodium
falciparum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 LEU A  48
PHE A 141
LEU A 223
GLY A  40
SER A 237
 None
None
None
ADP  A 246 (-3.0A)
None
 0.95A 4zbrA-3tlxA:
undetectable		 4zbrA-3tlxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyj BCLA PROTEIN

(Bacillus
anthracis) 		no annotation 5 LEU A  97
LEU A 151
GLY A 149
SER A 146
SER A 205
 None
 1.48A 4zbrA-3tyjA:
undetectable		 4zbrA-3tyjA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 LEU A 172
LEU A  11
TYR A  89
GLY A   8
SER A 134
 None
 1.39A 4zbrA-4gm6A:
undetectable		 4zbrA-4gm6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 LEU A  80
GLY A  11
CYH A  53
LEU A  46
SER A  85
 None
 1.31A 4zbrA-4j9uA:
2.9		 4zbrA-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		5 LEU A 405
ASN A 370
CYH A 308
TYR A 366
SER A 408
 None
 1.48A 4zbrA-4kyiA:
3.6		 4zbrA-4kyiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 PHE A 465
TYR A 455
GLY A 466
SER A 471
SER A 305
 MES  A 501 ( 4.9A)
None
None
None
None
 1.42A 4zbrA-4lihA:
undetectable		 4zbrA-4lihA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU B 453
PHE B 385
GLY B 386
CYH B 435
LEU B 428
 None
 1.35A 4zbrA-4m69B:
undetectable		 4zbrA-4m69B:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7r ANAMORSIN

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 LEU A 117
LEU A 139
SER A 146
LEU A 104
SER A  89
 None
 1.49A 4zbrA-4m7rA:
undetectable		 4zbrA-4m7rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mso SERINE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
cenocepacia) 		PF00464
(SHMT) 		5 LEU A 187
TYR A 156
GLY A 119
SER A 121
LEU A 148
 None
 1.38A 4zbrA-4msoA:
2.4		 4zbrA-4msoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 PHE A 371
LEU A 330
GLY A 359
SER A 357
SER A 327
 NAG  A1105 (-4.7A)
None
None
NAG  A1105 (-3.2A)
MAN  A1110 (-3.5A)
 1.50A 4zbrA-4nenA:
undetectable		 4zbrA-4nenA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 PHE A 448
TYR A 439
GLY A 449
SER A 454
SER A 285
 None
 1.34A 4zbrA-4o6rA:
undetectable		 4zbrA-4o6rA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 ASN A 499
PHE A 567
LEU A 574
TYR A 578
LEU A 521
 None
 1.17A 4zbrA-4pjuA:
2.6		 4zbrA-4pjuA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		8 LEU A 387
ASN A 391
LEU A 407
TYR A 411
LYS A 414
GLY A 434
LEU A 453
SER A 489
 NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.60A 4zbrA-4po0A:
50.2		 4zbrA-4po0A:
71.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		8 LEU A 387
ASN A 391
PHE A 403
LEU A 407
TYR A 411
GLY A 434
LEU A 453
SER A 489
 NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
None
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.42A 4zbrA-4po0A:
50.2		 4zbrA-4po0A:
71.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 LEU A 387
CYH A 381
GLY A 399
CYH A 404
SER A 206
 None
ZN  A 801 (-2.3A)
ZN  A 801 (-4.6A)
ZN  A 801 (-2.3A)
None
 1.42A 4zbrA-4q48A:
undetectable		 4zbrA-4q48A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 505
PHE A 455
LEU A 483
GLY A 448
LEU A 527
 None
 1.25A 4zbrA-4qmeA:
undetectable		 4zbrA-4qmeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qok MEL5 TCR CHAIN BETA

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU E  21
TYR E  89
SER E  17
LEU E  81
SER E  86
 None
None
EDO  E 301 ( 4.0A)
None
None
 1.25A 4zbrA-4qokE:
undetectable		 4zbrA-4qokE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 735
PHE A 829
LEU A 752
GLY A 754
LEU A 685
 None
 1.46A 4zbrA-4w8jA:
2.6		 4zbrA-4w8jA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN

(Clostridioides
difficile) 		PF02661
(Fic) 		5 LEU A 178
PHE A   5
LEU A   9
TYR A  20
LEU A  79
 None
 1.38A 4zbrA-4x2dA:
undetectable		 4zbrA-4x2dA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		5 LEU A 205
ASN A 209
CYH A 210
GLY A 218
SER A  81
 None
 0.93A 4zbrA-4xhcA:
2.9		 4zbrA-4xhcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 105
CYH A 115
PHE A 117
LEU A  79
GLY A  72
 None
 1.41A 4zbrA-4zoxA:
undetectable		 4zbrA-4zoxA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		5 PHE A  48
LEU A 152
GLY A 454
LEU A 388
SER A  44
 None
 1.26A 4zbrA-5c2iA:
undetectable		 4zbrA-5c2iA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cu1 DMSP LYASE

(Ruegeria
pomeroyi) 		PF16867
(DMSP_lyase) 		5 LEU A  31
LEU A 100
GLY A 102
SER A 109
LEU A  35
 None
 1.35A 4zbrA-5cu1A:
undetectable		 4zbrA-5cu1A:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		10 LEU A 386
ASN A 390
PHE A 402
LEU A 406
TYR A 410
LYS A 413
GLY A 433
SER A 448
LEU A 452
SER A 488
 None
 0.48A 4zbrA-5dqfA:
55.4		 4zbrA-5dqfA:
99.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Arabidopsis
thaliana) 		PF00520
(Ion_trans) 		5 LEU A 206
CYH A 574
LEU A 663
GLY A 570
SER A 210
 None
 1.45A 4zbrA-5dqqA:
undetectable		 4zbrA-5dqqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 LEU A 151
ASN A 187
CYH A 186
TYR A 257
GLY A 229
 EDO  A 614 ( 4.7A)
CA  A 643 ( 4.8A)
None
EDO  A 614 (-4.1A)
None
 1.22A 4zbrA-5ecuA:
undetectable		 4zbrA-5ecuA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		9 LEU A 387
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LYS A 414
GLY A 434
LEU A 453
SER A 489
 None
 0.61A 4zbrA-5ghkA:
47.5		 4zbrA-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		5 PHE A 463
TYR A 454
GLY A 464
SER A 469
SER A 304
 None
 1.41A 4zbrA-5gtkA:
undetectable		 4zbrA-5gtkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PHE A 467
TYR A 458
GLY A 468
SER A 473
SER A 306
 IAC  A 701 (-4.5A)
None
None
None
None
 1.45A 4zbrA-5iuwA:
undetectable		 4zbrA-5iuwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 LEU A  49
PHE A 145
LEU A 147
GLY A 121
LEU A  37
 None
 1.33A 4zbrA-5kreA:
undetectable		 4zbrA-5kreA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0q MAB 8C7 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU C  20
TYR C  94
SER C  16
LEU C  86
SER C  91
 None
None
SO4  C 303 (-4.3A)
None
None
 1.21A 4zbrA-5l0qC:
undetectable		 4zbrA-5l0qC:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 PHE A  23
LEU A 384
GLY A 394
SER A 252
LEU A 398
 None
 1.43A 4zbrA-5l94A:
undetectable		 4zbrA-5l94A:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 LEU A 386
ASN A 390
PHE A 402
LEU A 406
TYR A 410
LYS A 413
GLY A 433
LEU A 452
SER A 488
 None
 0.66A 4zbrA-5oriA:
50.7		 4zbrA-5oriA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 5 LEU A 158
ASN A 195
CYH A 194
TYR A 258
GLY A 230
 EDO  A 411 (-3.7A)
None
None
EDO  A 411 (-4.0A)
None
 1.25A 4zbrA-5wh8A:
undetectable		 4zbrA-5wh8A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmb DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A 545
LEU A 519
SER A 538
LEU A 537
SER A 511
 None
 1.48A 4zbrA-5wmbA:
undetectable		 4zbrA-5wmbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 323
TYR A 306
LYS A 329
SER A 294
SER A 303
 None
 1.29A 4zbrA-5wx4A:
undetectable		 4zbrA-5wx4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 267
PHE A 525
LEU A 514
GLY A 274
LEU A 242
 None
 0.90A 4zbrA-5xdrA:
undetectable		 4zbrA-5xdrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum) 		no annotation 5 LEU A 150
PHE A  25
LEU A 207
GLY A  29
SER A 232
 None
 1.15A 4zbrA-5ybpA:
undetectable		 4zbrA-5ybpA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 9 LEU A 387
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LYS A 414
GLY A 434
LEU A 453
SER A 489
 None
 0.63A 4zbrA-5yxeA:
45.8		 4zbrA-5yxeA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 5 LEU B 622
PHE B 641
LEU B 645
GLY B 630
CYH B 629
 None
 1.27A 4zbrA-6b4jB:
undetectable		 4zbrA-6b4jB:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1w POLYCYSTIN-2

(Homo sapiens) 		no annotation 5 LEU A 256
LEU A 441
CYH A 437
LEU A 291
SER A 286
 None
 1.21A 4zbrA-6d1wA:
3.3		 4zbrA-6d1wA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 5 LEU A 119
PHE A 149
LEU A 102
GLY A 142
SER A 109
 None
 1.36A 4zbrA-6f9gA:
undetectable		 4zbrA-6f9gA:
7.20