SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZBR_A_DIFA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 305
ASN A  94
ALA A  95
VAL A  98
ARG A  99
 None
NAD  A1306 (-4.1A)
None
None
None
 1.02A 4zbrA-1gv0A:
undetectable		 4zbrA-1gv0A:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LEU A 394
ASN A 405
ALA A 406
VAL A 409
ARG A 410
LYS A 545
 None
 1.20A 4zbrA-1tf0A:
46.9		 4zbrA-1tf0A:
76.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ASP A 269
ALA A 268
VAL A 265
ARG A 278
LYS A  30
 None
None
None
SO4  A 464 ( 4.1A)
None
 1.44A 4zbrA-1xp4A:
0.5		 4zbrA-1xp4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erh COLICIN E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		5 ASP A  31
ALA A  28
VAL A  27
LYS A  24
GLU A  21
 None
 1.47A 4zbrA-2erhA:
2.9		 4zbrA-2erhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		5 LEU A 524
ASP A 365
ASN A 369
ALA A 364
VAL A 371
 None
 1.45A 4zbrA-2nlzA:
0.0		 4zbrA-2nlzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ASP A 239
ASN A 426
ALA A 427
VAL A 374
GLU A 419
 None
 1.18A 4zbrA-3boeA:
undetectable		 4zbrA-3boeA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 222
ASP A 185
ASN A 188
ALA A 189
VAL A 192
 None
 0.83A 4zbrA-3ddmA:
1.3		 4zbrA-3ddmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		5 ASP A  28
ASN A  31
ALA A  32
VAL A  35
ARG A  36
 None
 1.33A 4zbrA-3i0pA:
0.0		 4zbrA-3i0pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		5 LEU A  23
ASP A  28
ASN A  31
ALA A  32
VAL A  35
 None
 1.47A 4zbrA-3i0pA:
0.0		 4zbrA-3i0pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU B 250
ASP A  67
ALA A  70
VAL A  72
ARG A  74
 F3S  B1002 (-4.0A)
None
None
None
None
 1.32A 4zbrA-4c3oB:
undetectable		 4zbrA-4c3oB:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LEU A 394
ASN A 405
ALA A 406
VAL A 409
ARG A 410
 None
NPS  A 603 (-4.5A)
NPS  A 603 ( 4.0A)
None
NPS  A 601 (-4.5A)
 0.37A 4zbrA-4po0A:
50.2		 4zbrA-4po0A:
71.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 LEU B 206
ASP B 294
ASN B 231
ALA B 230
VAL B 233
 None
 1.09A 4zbrA-5dlqB:
4.6		 4zbrA-5dlqB:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 LEU A 393
ASP A 401
ASN A 404
ALA A 405
VAL A 408
ARG A 409
LYS A 540
GLU A 541
 None
CL  A 615 ( 3.8A)
None
None
None
None
SO4  A 609 (-4.0A)
SO4  A 609 (-3.9A)
 0.52A 4zbrA-5dqfA:
55.4		 4zbrA-5dqfA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 LEU A 394
ASN A 405
ALA A 406
VAL A 409
ARG A 410
 None
 0.33A 4zbrA-5ghkA:
47.5		 4zbrA-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5x PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 LEU A 242
ASP A  98
ALA A  22
VAL A  47
GLU A 139
 None
 0.97A 4zbrA-5h5xA:
undetectable		 4zbrA-5h5xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASP A 373
ALA A 377
VAL A 379
ARG A 381
LYS A  51
 None
 1.49A 4zbrA-5jp0A:
undetectable		 4zbrA-5jp0A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 LEU A 393
ASN A 404
ALA A 405
VAL A 408
ARG A 409
 None
 0.52A 4zbrA-5oriA:
50.7		 4zbrA-5oriA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 LEU A1086
ASP A1074
ALA A1077
VAL A1079
GLU A1070
 7L6  A1506 (-4.2A)
None
7L6  A1506 (-3.6A)
None
None
 1.45A 4zbrA-5tuyA:
undetectable		 4zbrA-5tuyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 ASP A 197
ALA A 189
VAL A 187
LYS A 200
GLU A  29
 None
 1.30A 4zbrA-5uagA:
undetectable		 4zbrA-5uagA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 ASN A 818
ALA A 819
VAL A 865
ARG A 766
GLU A 862
 None
 1.43A 4zbrA-5yimA:
1.5		 4zbrA-5yimA:
9.82