SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZBR_A_ACTA608_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0x PROTEIN (EPHA4
RECEPTOR TYROSINE
KINASE)

(Mus musculus) 		PF07647
(SAM_2) 		3 LYS A 924
ARG A 927
HIS A 961
 None
 1.18A 4zbrA-1b0xA:
0.0		 4zbrA-1b0xA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 LYS A  21
ARG A  22
HIS A  19
 None
 1.23A 4zbrA-1e43A:
0.0		 4zbrA-1e43A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e44 COLICIN E3

(Escherichia
coli) 		PF09000
(Cytotoxic) 		3 LYS B  89
ARG B  90
HIS B  71
 None
 1.26A 4zbrA-1e44B:
undetectable		 4zbrA-1e44B:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN

(Caenorhabditis
elegans) 		PF00795
(CN_hydrolase)
PF01230
(HIT) 		3 LYS A 231
ARG A 232
HIS A 228
 None
 1.18A 4zbrA-1emsA:
undetectable		 4zbrA-1emsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		3 LYS A 314
ARG A 307
HIS A 312
 None
 1.21A 4zbrA-1h4pA:
0.0		 4zbrA-1h4pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjh PROTEIN (ATP-BINDING
DOMAIN OF PROTEIN
MJ0577)

(Methanocaldococcus
jannaschii) 		PF00582
(Usp) 		3 LYS A 160
ARG A 159
HIS A 129
 None
 1.27A 4zbrA-1mjhA:
0.0		 4zbrA-1mjhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G) 		3 LYS G 157
ARG G 156
HIS D 439
 None
 1.14A 4zbrA-1mtyG:
0.3		 4zbrA-1mtyG:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LYS A 338
ARG A 337
HIS A 290
 None
 1.13A 4zbrA-1n21A:
2.1		 4zbrA-1n21A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		3 LYS A   2
ARG A   5
HIS A   6
 None
 0.99A 4zbrA-1o9gA:
0.0		 4zbrA-1o9gA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qg1 PROTEIN (GROWTH
FACTOR RECEPTOR
BINDING PROTEIN)

(Homo sapiens) 		PF00017
(SH2) 		3 LYS E  21
ARG E  23
HIS E  24
 None
 0.85A 4zbrA-1qg1E:
undetectable		 4zbrA-1qg1E:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		3 LYS 3 218
ARG 3 220
HIS 3 106
 None
 0.89A 4zbrA-1rhi3:
undetectable		 4zbrA-1rhi3:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		3 LYS A 162
ARG A 166
HIS A 167
 None
 1.25A 4zbrA-1sg9A:
2.8		 4zbrA-1sg9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr2 PUTATIVE SENSOR-LIKE
HISTIDINE KINASE
YOJN

(Escherichia
coli) 		PF01627
(Hpt) 		3 LYS A 870
ARG A 868
HIS A 865
 None
 1.26A 4zbrA-1sr2A:
2.6		 4zbrA-1sr2A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuv PROTEIN YGIN

(Escherichia
coli) 		PF03992
(ABM) 		3 LYS A  89
ARG A  11
HIS A  16
 None
 1.24A 4zbrA-1tuvA:
2.7		 4zbrA-1tuvA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf7 WILMS' TUMOR PROTEIN

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 LYS A   1
ARG A  14
HIS A  17
 None
 1.15A 4zbrA-1xf7A:
undetectable		 4zbrA-1xf7A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LYS A 272
ARG A 308
HIS A 275
 None
 1.06A 4zbrA-1xkhA:
undetectable		 4zbrA-1xkhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF12840
(HTH_20) 		3 LYS A  63
ARG A  31
HIS A  61
 None
 1.11A 4zbrA-1y0uA:
undetectable		 4zbrA-1y0uA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Streptococcus
pneumoniae) 		PF02390
(Methyltransf_4) 		3 LYS A 127
ARG A 128
HIS A 125
 None
 1.15A 4zbrA-1yzhA:
undetectable		 4zbrA-1yzhA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		3 LYS A 184
ARG A 188
HIS A 182
 None
 1.09A 4zbrA-2atfA:
undetectable		 4zbrA-2atfA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayd WRKY TRANSCRIPTION
FACTOR 1

(Arabidopsis
thaliana) 		PF03106
(WRKY) 		3 LYS A 318
ARG A 327
HIS A 342
 None
 1.23A 4zbrA-2aydA:
undetectable		 4zbrA-2aydA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azw MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 LYS A 132
ARG A 133
HIS A 136
 None
 1.24A 4zbrA-2azwA:
undetectable		 4zbrA-2azwA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diy THIOREDOXIN-LIKE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 LYS A 117
ARG A 121
HIS A 122
 None
 1.17A 4zbrA-2diyA:
undetectable		 4zbrA-2diyA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 LYS A  64
ARG A  69
HIS A  66
 None
 1.22A 4zbrA-2fmlA:
undetectable		 4zbrA-2fmlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		3 LYS A 123
ARG A  76
HIS A  73
 None
 0.96A 4zbrA-2gfiA:
undetectable		 4zbrA-2gfiA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		3 LYS A 123
ARG A 170
HIS A  73
 None
 1.24A 4zbrA-2gfiA:
undetectable		 4zbrA-2gfiA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5j CASPASE-3, P17
SUBUNIT

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 LYS A 110
ARG A 111
HIS A 108
 None
 1.01A 4zbrA-2h5jA:
undetectable		 4zbrA-2h5jA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 LYS A 555
ARG A 551
HIS A 549
 None
 1.15A 4zbrA-2h88A:
undetectable		 4zbrA-2h88A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixq PROTEIN AFAD

(Escherichia
coli) 		PF05775
(AfaD) 		3 LYS A  57
ARG A  60
HIS A  61
 LYS  A  57 ( 0.0A)
ARG  A  60 ( 0.6A)
HIS  A  61 ( 1.0A)
 1.06A 4zbrA-2ixqA:
undetectable		 4zbrA-2ixqA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		3 LYS A 318
ARG A 319
HIS A 316
 None
 1.06A 4zbrA-2jg2A:
undetectable		 4zbrA-2jg2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0k STAGE III
SPORULATION PROTEIN
D

(Bacillus
subtilis) 		PF12116
(SpoIIID) 		3 LYS A  64
ARG A  67
HIS A  68
 None
 1.15A 4zbrA-2l0kA:
undetectable		 4zbrA-2l0kA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 LYS A 497
ARG A 498
HIS A 495
 None
 1.20A 4zbrA-2nrxA:
2.5		 4zbrA-2nrxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqr SENSORY TRANSDUCTION
PROTEIN REGX3

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LYS A 199
ARG A 200
HIS A 197
 None
 0.86A 4zbrA-2oqrA:
undetectable		 4zbrA-2oqrA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		3 LYS A 258
ARG A 256
HIS A 212
 None
 0.86A 4zbrA-2p4gA:
undetectable		 4zbrA-2p4gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		3 LYS A 182
ARG A 212
HIS A 237
 None
 1.14A 4zbrA-2pgeA:
1.5		 4zbrA-2pgeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 LYS A 725
ARG A 737
HIS A 727
 None
 1.20A 4zbrA-2q1fA:
1.7		 4zbrA-2q1fA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		3 LYS A 359
ARG A  10
HIS A   9
 HCY  A1375 (-4.8A)
None
None
 1.14A 4zbrA-2v95A:
undetectable		 4zbrA-2v95A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		3 LYS A  80
ARG A  78
HIS A 103
 None
 1.12A 4zbrA-2vunA:
undetectable		 4zbrA-2vunA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 LYS A  75
ARG A  76
HIS A  40
 None
 1.19A 4zbrA-2xijA:
0.7		 4zbrA-2xijA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xws SIROHYDROCHLORIN
COBALTOCHELATASE

(Archaeoglobus
fulgidus) 		PF01903
(CbiX) 		3 LYS A  26
ARG A  27
HIS A  24
 None
 1.25A 4zbrA-2xwsA:
undetectable		 4zbrA-2xwsA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0m MALE-SPECIFIC LETHAL
1 HOMOLOG

(Mus musculus) 		PF15275
(PEHE) 		3 LYS B 507
ARG B 508
HIS B 509
 None
 1.24A 4zbrA-2y0mB:
undetectable		 4zbrA-2y0mB:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		3 LYS A  54
ARG A  57
HIS A 182
 None
 1.20A 4zbrA-2z9vA:
undetectable		 4zbrA-2z9vA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A 235
ARG A 236
HIS A 233
 None
 0.97A 4zbrA-3a74A:
undetectable		 4zbrA-3a74A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdd REGULATORY PROTEIN
MARR

(Streptococcus
suis) 		PF01047
(MarR) 		3 LYS A  66
ARG A  32
HIS A  64
 None
GOL  A 144 ( 3.2A)
GOL  A 144 (-4.5A)
 0.94A 4zbrA-3bddA:
undetectable		 4zbrA-3bddA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs5 PROTEIN AVEUGLE

(Drosophila
melanogaster) 		PF07647
(SAM_2) 		3 LYS A  33
ARG A  37
HIS A  38
 None
 1.10A 4zbrA-3bs5A:
2.3		 4zbrA-3bs5A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN

(Mus musculus) 		PF13806
(Rieske_2) 		3 LYS A  14
ARG A  39
HIS A 120
 None
 1.26A 4zbrA-3d89A:
undetectable		 4zbrA-3d89A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A  72
ARG A  73
HIS A  11
 None
 1.05A 4zbrA-3fk4A:
undetectable		 4zbrA-3fk4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		3 LYS A 127
ARG A 128
HIS A 125
 None
SO4  A 406 (-2.8A)
SO4  A 406 (-3.6A)
 1.18A 4zbrA-3fsgA:
undetectable		 4zbrA-3fsgA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it8 2L PROTEIN

(Tanapox virus) 		no annotation 3 LYS D 129
ARG D 119
HIS D 121
 None
 1.24A 4zbrA-3it8D:
undetectable		 4zbrA-3it8D:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		3 LYS A 169
ARG A 137
HIS A 167
 None
 0.80A 4zbrA-3j4jA:
undetectable		 4zbrA-3j4jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		3 LYS A 178
ARG A 175
HIS A 174
 None
 0.80A 4zbrA-3kwpA:
undetectable		 4zbrA-3kwpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LYS A  65
ARG A 201
HIS A  67
 None
 1.26A 4zbrA-3ladA:
2.8		 4zbrA-3ladA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		3 LYS A  61
ARG A  62
HIS A 138
 None
 1.24A 4zbrA-3memA:
undetectable		 4zbrA-3memA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3p MOBILE INTRON
PROTEIN

(Bacillus phage
0305phi8-36) 		PF04480
(DUF559) 		3 LYS A 202
ARG A 235
HIS A 261
 None
 0.90A 4zbrA-3r3pA:
undetectable		 4zbrA-3r3pA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 LYS A 337
ARG A 335
HIS A 370
 UNX  A 502 ( 3.9A)
None
None
 1.17A 4zbrA-3smtA:
undetectable		 4zbrA-3smtA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 LYS A 279
ARG A 280
HIS A 270
 None
 1.11A 4zbrA-3u44A:
undetectable		 4zbrA-3u44A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		3 LYS A1151
ARG A1150
HIS A1149
 None
 0.89A 4zbrA-3zgxA:
undetectable		 4zbrA-3zgxA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh0 PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		3 LYS A 125
ARG A 122
HIS A 121
 HEM  A 200 (-4.1A)
None
None
 1.19A 4zbrA-3zh0A:
2.1		 4zbrA-3zh0A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 LYS A 114
ARG A 117
HIS A 121
 None
 1.25A 4zbrA-4adeA:
undetectable		 4zbrA-4adeA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT ALPHA

(Homo sapiens) 		PF02045
(CBFB_NFYA) 		3 LYS A 282
ARG A 281
HIS A 277
 None
 1.08A 4zbrA-4awlA:
undetectable		 4zbrA-4awlA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bop OTU
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02338
(OTU) 		3 LYS A 327
ARG A 323
HIS A 336
 PO4  A1438 (-3.0A)
None
None
 1.10A 4zbrA-4bopA:
undetectable		 4zbrA-4bopA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyv HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS B 124
ARG B 127
HIS B 159
 None
 1.00A 4zbrA-4cyvB:
undetectable		 4zbrA-4cyvB:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		3 LYS A 334
ARG A 338
HIS A 314
 None
 1.10A 4zbrA-4fixA:
2.3		 4zbrA-4fixA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl0 GALECTIN

(Toxascaris
leonina) 		PF00337
(Gal-bind_lectin) 		3 LYS A  14
ARG A  12
HIS A  43
 None
 1.23A 4zbrA-4hl0A:
undetectable		 4zbrA-4hl0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij5 PHOSPHOSERINE
PHOSPHATASE 1

(Hydrogenobacter
thermophilus) 		PF00300
(His_Phos_1) 		3 LYS A 138
ARG A 139
HIS A 140
 None
 1.25A 4zbrA-4ij5A:
undetectable		 4zbrA-4ij5A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		3 LYS A 176
ARG A 175
HIS A 118
 None
 1.24A 4zbrA-4k68A:
undetectable		 4zbrA-4k68A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 LYS A 165
ARG A 133
HIS A 136
 ATP  A 602 (-2.6A)
None
None
 1.18A 4zbrA-4m9xA:
undetectable		 4zbrA-4m9xA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		3 LYS A  83
ARG A  84
HIS A  54
 None
None
SO4  A 503 (-3.4A)
 1.03A 4zbrA-4mz1A:
undetectable		 4zbrA-4mz1A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n05 PUTATIVE RYANODINE
RECEPTOR

(Bacteroides
thetaiotaomicron) 		no annotation 3 LYS B  59
ARG B  54
HIS B  61
 None
 1.18A 4zbrA-4n05B:
undetectable		 4zbrA-4n05B:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		3 LYS A 385
ARG A 392
HIS A 425
 None
 1.25A 4zbrA-4nz0A:
undetectable		 4zbrA-4nz0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojh ACYLPHOSPHATASE

(Sulfolobus
solfataricus) 		PF00708
(Acylphosphatase) 		3 LYS A  67
ARG A  71
HIS A  36
 None
 0.76A 4zbrA-4ojhA:
undetectable		 4zbrA-4ojhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps0 CASPASE-3

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 LYS A 110
ARG A 111
HIS A 108
 None
 0.84A 4zbrA-4ps0A:
undetectable		 4zbrA-4ps0A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 LYS B 956
ARG B 958
HIS B 968
 None
 1.20A 4zbrA-4qiwB:
undetectable		 4zbrA-4qiwB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 LYS A 976
ARG A 972
HIS A 961
 None
 0.95A 4zbrA-4wd9A:
undetectable		 4zbrA-4wd9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		3 LYS A 546
ARG A 598
HIS A 555
 None
 0.84A 4zbrA-4wzwA:
3.8		 4zbrA-4wzwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		3 LYS A 194
ARG A  30
HIS A  31
 None
 1.16A 4zbrA-4zf4A:
undetectable		 4zbrA-4zf4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 412
ARG A 413
HIS A 402
 None
 1.18A 4zbrA-5amsA:
undetectable		 4zbrA-5amsA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LYS A   2
ARG A 154
HIS A 172
 None
 1.26A 4zbrA-5co8A:
2.2		 4zbrA-5co8A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 LYS A 431
ARG A 435
HIS A 451
 PG4  A 604 (-2.9A)
None
None
 0.75A 4zbrA-5dqfA:
55.4		 4zbrA-5dqfA:
99.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 LYS B 272
ARG B 273
HIS B 265
 None
 1.10A 4zbrA-5e6sB:
undetectable		 4zbrA-5e6sB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 LYS C 185
ARG C 186
HIS C 164
 None
 1.19A 4zbrA-5eg6C:
undetectable		 4zbrA-5eg6C:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		3 LYS A 653
ARG A 654
HIS A 560
 None
 1.21A 4zbrA-5gkqA:
undetectable		 4zbrA-5gkqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 LYS A  29
ARG A  33
HIS A  34
 None
 1.23A 4zbrA-5ikpA:
undetectable		 4zbrA-5ikpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LYS A 223
ARG A 225
HIS A  83
 None
None
NAG  A1002 (-3.9A)
 1.22A 4zbrA-5j6sA:
3.6		 4zbrA-5j6sA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lal DIRIGENT PROTEIN 6

(Arabidopsis
thaliana) 		PF03018
(Dirigent) 		3 LYS A 178
ARG A 176
HIS A  48
 EDO  A 210 ( 4.7A)
None
None
 1.04A 4zbrA-5lalA:
undetectable		 4zbrA-5lalA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		3 LYS A  86
ARG A 121
HIS A 120
 None
 1.22A 4zbrA-5llqA:
undetectable		 4zbrA-5llqA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		3 LYS A 698
ARG A 699
HIS A 701
 PLP  A1002 (-2.8A)
GLC  A1001 ( 4.9A)
None
 1.07A 4zbrA-5lrbA:
undetectable		 4zbrA-5lrbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 3 LYS A  28
ARG A 408
HIS A  30
 None
 1.09A 4zbrA-5minA:
undetectable		 4zbrA-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4g HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 101
ARG H  98
HIS H  32
 None
EDO  H 302 (-3.5A)
EDO  H 302 (-3.9A)
 1.27A 4zbrA-5n4gH:
undetectable		 4zbrA-5n4gH:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 LYS T2589
ARG T2594
HIS T2592
 None
 1.22A 4zbrA-5ojsT:
undetectable		 4zbrA-5ojsT:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0v FRATAXIN HOMOLOG,
MITOCHONDRIAL
IRON SULFUR CLUSTER
ASSEMBLY PROTEIN 1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01491
(Frataxin_Cyay)
PF01491
(Frataxin_Cyay) 		3 LYS a  32
ARG a  33
HIS A  95
 None
 1.12A 4zbrA-5t0va:
undetectable		 4zbrA-5t0va:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		3 LYS A 117
ARG A 121
HIS A 122
 None
 1.08A 4zbrA-5t81A:
undetectable		 4zbrA-5t81A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcv 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 1

(Petunia x
hybrida) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 LYS A 191
ARG A 210
HIS A 211
 None
 1.09A 4zbrA-5tcvA:
undetectable		 4zbrA-5tcvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		3 LYS A 163
ARG A 162
HIS A 161
 None
 1.05A 4zbrA-5tprA:
1.2		 4zbrA-5tprA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l VIRAL PROTEIN 3

(Rhinovirus B) 		PF00073
(Rhv) 		3 LYS B 218
ARG B 220
HIS B 106
 None
 0.88A 4zbrA-5w3lB:
undetectable		 4zbrA-5w3lB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk2 DIACYLGLYCEROL
LIPASE

(Aspergillus
oryzae) 		no annotation 3 LYS A 186
ARG A 182
HIS A 220
 None
 1.12A 4zbrA-5xk2A:
undetectable		 4zbrA-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 LYS C2227
ARG C2228
HIS C2225
 None
 1.16A 4zbrA-5y3rC:
undetectable		 4zbrA-5y3rC:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 3 LYS A 397
ARG A 398
HIS A 361
 None
 1.26A 4zbrA-5yh1A:
undetectable		 4zbrA-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yma PUTATIVE RRNA
PROCESSING PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 LYS A  54
ARG A  55
HIS A  85
 None
 1.14A 4zbrA-5ymaA:
undetectable		 4zbrA-5ymaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT

(Homo sapiens) 		no annotation 3 LYS A 151
ARG A 127
HIS A 149
 None
 0.85A 4zbrA-6au6A:
undetectable		 4zbrA-6au6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bha CASPASE-3

(Homo sapiens) 		no annotation 3 LYS A 110
ARG A 111
HIS A 108
 None
 1.09A 4zbrA-6bhaA:
undetectable		 4zbrA-6bhaA:
undetectable