SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZBQ_A_ACTA605_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		4 TYR A 219
HIS A  46
ARG A 218
ASN A 217
 None
 1.18A 4zbqA-1dbiA:
undetectable		 4zbqA-1dbiA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TYR A 828
GLY A 417
GLU A 789
ARG A 868
 None
 1.34A 4zbqA-1hwwA:
undetectable		 4zbqA-1hwwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 TYR A1303
HIS A1312
GLY A1311
GLU A1390
 None
 1.27A 4zbqA-1ntyA:
undetectable		 4zbqA-1ntyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF09261
(Alpha-mann_mid)
PF07748
(Glyco_hydro_38C) 		4 TYR D 775
GLY B 390
GLU D 728
ARG D 815
 None
 1.39A 4zbqA-1o7dD:
undetectable		 4zbqA-1o7dD:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))

(Escherichia
coli) 		PF02253
(PLA1) 		4 TYR C 140
HIS C 142
ARG C 157
ASN C 156
 None
HDS  C 270 (-3.9A)
None
None
 1.08A 4zbqA-1qd6C:
undetectable		 4zbqA-1qd6C:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A 303
GLU A 135
ARG A 288
ASN A 290
 None
 1.28A 4zbqA-1qe0A:
undetectable		 4zbqA-1qe0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 HIS A  98
GLY A  65
GLU A  95
ARG A  67
 IPE  A 900 (-4.0A)
IPE  A 900 (-3.4A)
IPE  A 900 ( 4.8A)
None
 1.13A 4zbqA-1rqjA:
3.2		 4zbqA-1rqjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 HIS A  75
GLY A  42
GLU A  72
ARG A  44
 None
 1.22A 4zbqA-1rtrA:
2.1		 4zbqA-1rtrA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 HIS A  67
GLY A  71
GLU A  95
ARG A  98
ASN A  99
 None
 0.78A 4zbqA-1tf0A:
46.6		 4zbqA-1tf0A:
76.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 TYR A  30
GLY A  71
ARG A  98
ASN A  99
 None
 0.44A 4zbqA-1tf0A:
46.6		 4zbqA-1tf0A:
76.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2

(Bos taurus;
Bos taurus) 		PF00022
(Actin)
PF00022
(Actin) 		4 TYR A 184
HIS A 410
GLY B 201
ARG A 123
 None
 1.33A 4zbqA-1u2vA:
undetectable		 4zbqA-1u2vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		4 TYR A 326
GLY A 319
GLU A 315
ARG A 210
 None
None
SRP  A 900 (-3.5A)
None
 1.23A 4zbqA-1wleA:
2.3		 4zbqA-1wleA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A 155
GLY A 156
GLU A 223
ASN A 229
 NAP  A 801 (-4.4A)
NAP  A 801 ( 3.1A)
NAP  A 801 ( 4.9A)
NAP  A 801 (-3.3A)
 1.24A 4zbqA-1yb5A:
undetectable		 4zbqA-1yb5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF02567
(PhzC-PhzF) 		4 TYR A 141
HIS A 192
GLY A 194
ASN A 190
 None
 1.13A 4zbqA-1ym5A:
undetectable		 4zbqA-1ym5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 HIS A  74
GLY A  41
GLU A  71
ARG A  43
 None
 1.31A 4zbqA-2azkA:
3.8		 4zbqA-2azkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddu REELIN

(Mus musculus) 		no annotation 4 HIS A1420
GLY A1421
ARG A1371
ASN A1540
 None
 1.37A 4zbqA-2dduA:
undetectable		 4zbqA-2dduA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 HIS A  67
GLY A  34
GLU A  64
ARG A  36
 UNL  A 274 (-3.9A)
MLY  A  35 ( 2.4A)
UNL  A 274 ( 4.5A)
None
 1.02A 4zbqA-2ftzA:
undetectable		 4zbqA-2ftzA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		4 HIS A 118
GLY A  85
GLU A 115
ARG A  87
 None
 1.09A 4zbqA-2h8oA:
3.3		 4zbqA-2h8oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Elizabethkingia
meningoseptica) 		PF01408
(GFO_IDH_MocA) 		4 TYR A 217
HIS A 299
GLY A 222
GLU A 223
 None
 1.37A 4zbqA-2ixbA:
undetectable		 4zbqA-2ixbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		4 HIS A  85
GLY A  52
GLU A  82
ARG A  54
 None
 1.04A 4zbqA-2j1oA:
4.0		 4zbqA-2j1oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 TYR A 156
GLY A 175
GLU A 208
ARG A 173
 None
 1.16A 4zbqA-2j6hA:
undetectable		 4zbqA-2j6hA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oh3 COG1633:
UNCHARACTERIZED
CONSERVED PROTEIN

(Magnetospirillum
magnetotacticum) 		PF02915
(Rubrerythrin) 		4 TYR A 111
HIS A  52
GLU A  55
ARG A  59
 None
 1.37A 4zbqA-2oh3A:
undetectable		 4zbqA-2oh3A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 521
GLY A 519
GLU A 493
ARG A 530
 None
 1.25A 4zbqA-2wanA:
undetectable		 4zbqA-2wanA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 HIS B  77
GLY B  44
GLU B  74
ARG B  46
 None
 1.28A 4zbqA-3aqcB:
2.6		 4zbqA-3aqcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		4 TYR A 193
GLY A 291
GLU A 279
ARG A 283
 None
 1.36A 4zbqA-3ax6A:
undetectable		 4zbqA-3ax6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 TYR A 471
HIS A 405
GLY A 314
ARG A 437
 None
None
SO4  A1006 ( 3.8A)
SO4  A1006 (-3.7A)
 1.31A 4zbqA-3azqA:
undetectable		 4zbqA-3azqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		4 HIS A 357
GLY A   8
GLU A   7
ARG A  14
 None
 1.28A 4zbqA-3bryA:
undetectable		 4zbqA-3bryA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		4 TYR A  66
HIS A 152
GLY A 216
ARG A 219
 None
 1.22A 4zbqA-3cdxA:
undetectable		 4zbqA-3cdxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 248
HIS A 295
GLY A 246
GLU A 219
 None
GOL  A 372 (-4.7A)
None
NA  A 371 (-3.1A)
 1.34A 4zbqA-3cyjA:
undetectable		 4zbqA-3cyjA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czq PUTATIVE
POLYPHOSPHATE KINASE
2

(Sinorhizobium
meliloti) 		PF03976
(PPK2) 		4 TYR A 134
GLU A 158
ARG A 154
ASN A 153
 None
 0.97A 4zbqA-3czqA:
undetectable		 4zbqA-3czqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		4 TYR A  77
GLY A 117
GLU A 180
ASN A 181
 None
 1.21A 4zbqA-3d3aA:
undetectable		 4zbqA-3d3aA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 HIS A  65
GLY A  66
GLU A 164
ARG A  86
 FAD  A 609 (-4.0A)
None
None
None
 1.19A 4zbqA-3da1A:
undetectable		 4zbqA-3da1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		4 TYR A  88
HIS A 224
GLY A 114
GLU A 196
 OXE  A 243 (-4.2A)
OXE  A 243 (-4.1A)
None
None
 1.35A 4zbqA-3e0xA:
undetectable		 4zbqA-3e0xA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 173
GLU A 148
ARG A 144
ASN A 145
 None
 1.28A 4zbqA-3fbgA:
undetectable		 4zbqA-3fbgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf9 INTERSECTIN 2

(Homo sapiens) 		PF00621
(RhoGEF) 		4 TYR A1273
GLU A1193
ARG A1325
ASN A1236
 None
 1.30A 4zbqA-3gf9A:
undetectable		 4zbqA-3gf9A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycolicibacterium
smegmatis) 		PF01648
(ACPS) 		4 HIS A  80
GLY A  78
GLU A  29
ARG A  81
 HIS  A  80 (-1.0A)
GLY  A  78 (-0.0A)
GLU  A  29 (-0.5A)
ARG  A  81 (-0.6A)
 1.30A 4zbqA-3gwmA:
undetectable		 4zbqA-3gwmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 329
HIS A  23
GLY A  12
ASN A  21
 None
 1.38A 4zbqA-3hpfA:
undetectable		 4zbqA-3hpfA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv3 INTERSECTIN-1

(Mus musculus) 		PF00621
(RhoGEF)
PF14604
(SH3_9) 		4 TYR A1322
GLU A1242
ARG A1374
ASN A1285
 None
 1.28A 4zbqA-3jv3A:
undetectable		 4zbqA-3jv3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		4 HIS A  76
GLY A  43
GLU A  73
ARG A  45
 IPE  A 902 (-4.3A)
IPE  A 902 (-3.6A)
IPE  A 902 ( 4.6A)
None
 1.17A 4zbqA-3krcA:
3.8		 4zbqA-3krcA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 HIS A  74
GLY A  41
GLU A  71
ARG A  43
 None
 1.33A 4zbqA-3m0gA:
2.2		 4zbqA-3m0gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 HIS A  82
GLY A  47
GLU A  79
ARG A  49
 None
 0.95A 4zbqA-3m9uA:
undetectable		 4zbqA-3m9uA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 GLY A 428
GLU A 235
ARG A 237
ASN A 217
 None
 1.30A 4zbqA-3n71A:
undetectable		 4zbqA-3n71A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		4 HIS A 263
GLY A 250
ARG A 299
ASN A 296
 CSA  A 203 ( 4.1A)
None
None
None
 1.32A 4zbqA-3npfA:
undetectable		 4zbqA-3npfA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		4 HIS A  76
GLY A  43
GLU A  73
ARG A  45
 DMA  A 299 (-4.0A)
DMA  A 299 ( 3.7A)
DMA  A 299 ( 4.4A)
None
 1.11A 4zbqA-3p41A:
3.9		 4zbqA-3p41A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 HIS A  75
GLY A  41
GLU A  72
ARG A  43
 None
 1.16A 4zbqA-3p8lA:
2.1		 4zbqA-3p8lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 HIS A  75
GLY A  41
GLU A  72
ARG A  44
 None
 0.82A 4zbqA-3p8rA:
3.8		 4zbqA-3p8rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 HIS A  75
GLY A  42
GLU A  72
ARG A  44
 None
 1.13A 4zbqA-3p8rA:
3.8		 4zbqA-3p8rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 GLY A 497
GLU A 255
ARG A 492
ASN A 258
 None
 1.10A 4zbqA-3ps5A:
undetectable		 4zbqA-3ps5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 HIS A  85
GLY A  46
GLU A  82
ARG A  48
 DMA  A 500 (-3.7A)
DMA  A 500 (-3.4A)
DMA  A 500 ( 4.6A)
None
 0.94A 4zbqA-3q1oA:
2.1		 4zbqA-3q1oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbv INTERSECTIN-1

(Homo sapiens) 		PF00621
(RhoGEF)
PF16652
(PH_13) 		4 TYR B1329
GLU B1249
ARG B1381
ASN B1292
 None
 1.32A 4zbqA-3qbvB:
undetectable		 4zbqA-3qbvB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		4 HIS A  51
GLY A  24
ARG A  60
ASN A  48
 None
 1.15A 4zbqA-3qtgA:
undetectable		 4zbqA-3qtgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 TYR A  83
GLY A 123
GLU A 186
ASN A 187
 CL  A 801 (-4.2A)
None
None
GAL  A 900 (-3.2A)
 1.20A 4zbqA-3thcA:
undetectable		 4zbqA-3thcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		4 HIS A  81
GLY A  48
GLU A  78
ARG A  50
 PO4  A 324 ( 3.9A)
PO4  A 324 (-3.5A)
PO4  A 324 ( 4.9A)
None
 1.03A 4zbqA-3ts7A:
3.5		 4zbqA-3ts7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		4 HIS A  84
GLY A  51
GLU A  81
ARG A  53
 None
 1.09A 4zbqA-3ucaA:
4.1		 4zbqA-3ucaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 HIS A  89
GLY A  90
GLU A  87
ASN A 241
 MN  A   1 (-3.3A)
None
None
MN  A   1 (-4.2A)
 1.22A 4zbqA-3ujpA:
undetectable		 4zbqA-3ujpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		4 TYR A 249
GLY A 229
GLU A 228
ASN A 225
 None
 1.22A 4zbqA-3v8hA:
undetectable		 4zbqA-3v8hA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		4 HIS A  76
GLY A  43
GLU A  73
ARG A  45
 None
 1.10A 4zbqA-3zouA:
2.2		 4zbqA-3zouA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 GLY A 180
GLU A 181
ARG A 156
ASN A 157
 None
 1.24A 4zbqA-3zyjA:
undetectable		 4zbqA-3zyjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		4 HIS A 388
GLY A 389
ARG A 369
ASN A 368
 SO4  A 420 (-4.6A)
SO4  A 420 (-3.3A)
SO4  A 420 (-3.6A)
SO4  A 420 (-4.8A)
 1.33A 4zbqA-4bofA:
undetectable		 4zbqA-4bofA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		4 HIS A  76
GLY A  43
GLU A  73
ARG A  45
 GOL  A 402 (-4.4A)
GOL  A 402 (-3.6A)
GOL  A 402 ( 4.8A)
None
 1.04A 4zbqA-4f62A:
3.6		 4zbqA-4f62A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 HIS A  78
GLY A  45
GLU A  75
ARG A  47
 DMA  A 402 (-3.9A)
DMA  A 402 (-3.5A)
DMA  A 402 ( 4.9A)
None
 1.19A 4zbqA-4gp1A:
2.4		 4zbqA-4gp1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 TYR A 281
HIS A 277
GLY A 146
ASN A 150
 None
 1.24A 4zbqA-4hwvA:
undetectable		 4zbqA-4hwvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A  96
GLY A 136
GLU A 198
ASN A 199
 GAL  A1130 (-4.7A)
None
None
GAL  A1130 (-3.5A)
 1.12A 4zbqA-4iugA:
undetectable		 4zbqA-4iugA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 TYR A 508
HIS A 466
GLU A 528
ARG A 527
 None
 1.35A 4zbqA-4jzaA:
2.2		 4zbqA-4jzaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		4 HIS A  79
GLY A  46
GLU A  76
ARG A  48
 None
 0.98A 4zbqA-4kkmA:
3.9		 4zbqA-4kkmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		4 HIS A  71
GLY A  37
GLU A  68
ARG A  39
 None
 1.10A 4zbqA-4lfeA:
3.5		 4zbqA-4lfeA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 HIS A  73
GLY A  40
GLU A  70
ARG A  42
 IPE  A 301 (-3.9A)
IPE  A 301 (-3.6A)
None
None
 1.29A 4zbqA-4llsA:
undetectable		 4zbqA-4llsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 4 TYR B  53
HIS B  35
GLY B  37
GLU B  31
 None
None
None
FDA  B 402 (-2.7A)
 1.04A 4zbqA-4mo2B:
undetectable		 4zbqA-4mo2B:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 623
HIS A 405
ARG A 407
ASN A 672
 None
 1.37A 4zbqA-4nreA:
undetectable		 4zbqA-4nreA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		4 GLY A  51
GLU A 204
ARG A 197
ASN A 200
 None
 1.16A 4zbqA-4ns4A:
undetectable		 4zbqA-4ns4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		4 TYR A 340
HIS A 297
GLY A 300
ASN A 294
 GRG  A 503 (-4.5A)
GRG  A 502 ( 4.1A)
FDA  A 501 (-3.2A)
GRG  A 503 (-4.6A)
 1.10A 4zbqA-4opuA:
2.3		 4zbqA-4opuA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 TYR A  30
HIS A  67
GLY A  71
GLU A  95
ARG A  98
ASN A  99
 None
 0.70A 4zbqA-4po0A:
50.2		 4zbqA-4po0A:
71.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0k DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
thetaiotaomicron) 		PF00877
(NLPC_P60) 		4 HIS A 263
GLY A 250
ARG A 299
ASN A 296
 CSA  A 203 ( 4.0A)
CL  A 401 ( 4.8A)
CL  A 401 (-4.4A)
CL  A 401 (-3.9A)
 1.36A 4zbqA-4r0kA:
undetectable		 4zbqA-4r0kA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 4 TYR B  62
HIS B  42
GLY B  44
GLU B  38
 None
None
None
FAD  B 401 (-2.6A)
 1.25A 4zbqA-4rphB:
undetectable		 4zbqA-4rphB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		4 HIS A 228
GLY A 283
GLU A 278
ASN A 224
 None
 1.13A 4zbqA-4rqoA:
undetectable		 4zbqA-4rqoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1k POLYHEDRIN

(Uranotaenia
sapphirina
cypovirus) 		PF17515
(CPV_Polyhedrin) 		4 TYR A  23
GLY A 200
GLU A 199
ASN A 196
 None
 1.36A 4zbqA-4s1kA:
undetectable		 4zbqA-4s1kA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		4 HIS A  67
GLY A  34
GLU A  64
ARG A  36
 None
 1.07A 4zbqA-4wk5A:
3.6		 4zbqA-4wk5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  68
GLY A  18
GLU A 182
ASN A 181
 GLU  A 301 (-2.8A)
None
None
GLU  A 301 ( 3.5A)
 1.26A 4zbqA-4wxjA:
undetectable		 4zbqA-4wxjA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		4 HIS A  79
GLY A  46
GLU A  76
ARG A  48
 None
 1.12A 4zbqA-5aypA:
3.1		 4zbqA-5aypA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 TYR A 116
GLU A 144
ARG A 122
ASN A 143
 None
 1.39A 4zbqA-5cd6A:
undetectable		 4zbqA-5cd6A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 TYR A  30
HIS A  67
GLY A  71
GLU A  95
ARG A  98
ASN A  99
 None
 0.52A 4zbqA-5dqfA:
55.7		 4zbqA-5dqfA:
99.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 HIS A 108
GLY A 113
GLU A 112
ASN A 111
 None
 0.93A 4zbqA-5f56A:
undetectable		 4zbqA-5f56A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 GLY A 671
GLU A 638
ARG A 636
ASN A 669
 None
 1.24A 4zbqA-5g0hA:
undetectable		 4zbqA-5g0hA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 TYR A  30
HIS A  67
GLY A  71
ASN A  99
 None
 0.91A 4zbqA-5ghkA:
47.5		 4zbqA-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 HIS A  75
GLY A  40
GLU A  72
ARG A  42
 PO4  A 501 (-4.5A)
PO4  A 501 (-3.5A)
None
None
 1.12A 4zbqA-5h9dA:
2.9		 4zbqA-5h9dA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		4 TYR B1472
GLU B1249
ARG B1524
ASN B1292
 None
 1.26A 4zbqA-5hzkB:
undetectable		 4zbqA-5hzkB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 HIS B 984
GLY B 985
ARG B 766
ASN B 762
 None
 1.14A 4zbqA-5ip9B:
undetectable		 4zbqA-5ip9B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC3

(Saccharomyces
cerevisiae) 		PF03870
(RNA_pol_Rpb8) 		4 TYR H 141
GLY H  99
GLU H 138
ASN H 139
 None
 1.22A 4zbqA-5ip9H:
undetectable		 4zbqA-5ip9H:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Geoglobus
acetivorans) 		PF00348
(polyprenyl_synt) 		4 HIS A  74
GLY A  41
GLU A  71
ARG A  43
 None
 1.03A 4zbqA-5jfqA:
undetectable		 4zbqA-5jfqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llb POLYPHOSPHATE KINASE
2

(Francisella
tularensis) 		no annotation 4 TYR C 103
GLU C 127
ARG C 123
ASN C 122
 None
6YZ  C 303 ( 4.0A)
None
6YZ  C 303 (-3.4A)
 0.92A 4zbqA-5llbC:
undetectable		 4zbqA-5llbC:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 HIS A 215
GLY A 217
GLU A 360
ARG A 356
 ZN  A 512 ( 3.3A)
None
None
None
 1.04A 4zbqA-5m8tA:
undetectable		 4zbqA-5m8tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 TYR B 279
HIS B 438
GLU B 435
ARG B 283
 None
 1.31A 4zbqA-5ofbB:
2.1		 4zbqA-5ofbB:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 HIS A  67
GLY A  71
GLU A  95
ARG A  98
ASN A  99
 None
 0.93A 4zbqA-5oriA:
50.9		 4zbqA-5oriA:
75.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 TYR A  30
GLY A  71
GLU A  95
ARG A  98
ASN A  99
 None
 0.66A 4zbqA-5oriA:
50.9		 4zbqA-5oriA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 TYR A 398
HIS A 329
GLY A 394
GLU A 393
 None
 1.03A 4zbqA-5tprA:
undetectable		 4zbqA-5tprA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
OMEGA

(Mycolicibacterium
smegmatis) 		PF01192
(RNA_pol_Rpb6) 		4 TYR E  65
GLY E  77
GLU E  95
ARG E  57
 None
 1.09A 4zbqA-5tw1E:
undetectable		 4zbqA-5tw1E:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uem 354NC37 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TYR H  33
HIS H  53
GLY H  55
ARG H  71
 None
 1.08A 4zbqA-5uemH:
undetectable		 4zbqA-5uemH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 TYR A  30
HIS A  67
GLY A  71
ARG A  98
ASN A  99
 None
 0.47A 4zbqA-5yxeA:
45.7		 4zbqA-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT

(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		no annotation
no annotation 		4 TYR B  83
GLY C 239
GLU B 241
ASN C 235
 None
 1.32A 4zbqA-6cxhB:
undetectable		 4zbqA-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR A  77
GLY A 117
GLU A 180
ASN A 181
 GLA  A 801 (-4.5A)
None
None
GLA  A 801 (-2.9A)
 1.21A 4zbqA-6eonA:
undetectable		 4zbqA-6eonA:
22.03