SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z91_E_4LEE401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU O 221
LEU O 225
THR O 151
LEU O 154
LEU O 218
 None
 1.03A 4z91A-1dbvO:
0.0
4z91B-1dbvO:
0.0
4z91C-1dbvO:
0.0
4z91D-1dbvO:
0.0
4z91E-1dbvO:
0.0		 4z91A-1dbvO:
21.49
4z91B-1dbvO:
21.49
4z91C-1dbvO:
21.49
4z91D-1dbvO:
21.49
4z91E-1dbvO:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 LEU C 194
LEU C 171
LEU C 224
THR C 317
LEU C 237
 None
 1.04A 4z91A-1ea9C:
0.0
4z91B-1ea9C:
0.0
4z91C-1ea9C:
0.0
4z91D-1ea9C:
0.0
4z91E-1ea9C:
0.0		 4z91A-1ea9C:
21.04
4z91B-1ea9C:
21.04
4z91C-1ea9C:
21.04
4z91D-1ea9C:
21.04
4z91E-1ea9C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		6 THR C 220
LEU C 171
LEU C 224
THR C 317
LEU C 237
LEU C 194
 None
 1.33A 4z91A-1ea9C:
0.0
4z91B-1ea9C:
0.0
4z91C-1ea9C:
0.0
4z91D-1ea9C:
0.0
4z91E-1ea9C:
0.0		 4z91A-1ea9C:
21.04
4z91B-1ea9C:
21.04
4z91C-1ea9C:
21.04
4z91D-1ea9C:
21.04
4z91E-1ea9C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 247
LEU A 341
LEU A 402
THR A 252
LEU A 262
 None
 0.97A 4z91A-1fcpA:
0.2
4z91B-1fcpA:
0.0
4z91C-1fcpA:
0.2
4z91D-1fcpA:
0.1
4z91E-1fcpA:
0.1		 4z91A-1fcpA:
17.13
4z91B-1fcpA:
17.13
4z91C-1fcpA:
17.13
4z91D-1fcpA:
17.13
4z91E-1fcpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 341
LEU A 402
THR A 252
LEU A 262
LEU A 247
 None
 0.95A 4z91A-1fcpA:
0.2
4z91B-1fcpA:
0.0
4z91C-1fcpA:
0.2
4z91D-1fcpA:
0.1
4z91E-1fcpA:
0.1		 4z91A-1fcpA:
17.13
4z91B-1fcpA:
17.13
4z91C-1fcpA:
17.13
4z91D-1fcpA:
17.13
4z91E-1fcpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 341
LEU A 402
THR A 252
LEU A 262
LEU A 247
 None
 0.96A 4z91A-1fcpA:
0.2
4z91B-1fcpA:
0.0
4z91C-1fcpA:
0.2
4z91D-1fcpA:
0.1
4z91E-1fcpA:
0.1		 4z91A-1fcpA:
17.13
4z91B-1fcpA:
17.13
4z91C-1fcpA:
17.13
4z91D-1fcpA:
17.13
4z91E-1fcpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 402
THR A 252
LEU A 262
LEU A 247
LEU A 341
 None
 0.91A 4z91A-1fcpA:
0.2
4z91B-1fcpA:
0.0
4z91C-1fcpA:
0.2
4z91D-1fcpA:
0.1
4z91E-1fcpA:
0.1		 4z91A-1fcpA:
17.13
4z91B-1fcpA:
17.13
4z91C-1fcpA:
17.13
4z91D-1fcpA:
17.13
4z91E-1fcpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 252
LEU A 262
LEU A 247
LEU A 341
LEU A 402
 None
 0.97A 4z91A-1fcpA:
0.2
4z91B-1fcpA:
0.0
4z91C-1fcpA:
0.2
4z91D-1fcpA:
0.1
4z91E-1fcpA:
0.1		 4z91A-1fcpA:
17.13
4z91B-1fcpA:
17.13
4z91C-1fcpA:
17.13
4z91D-1fcpA:
17.13
4z91E-1fcpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 274
LEU A 305
LEU A 152
THR A 163
LEU A 135
 None
 0.97A 4z91A-1iuqA:
0.0
4z91B-1iuqA:
0.0
4z91C-1iuqA:
0.0
4z91D-1iuqA:
0.0
4z91E-1iuqA:
0.0		 4z91A-1iuqA:
21.93
4z91B-1iuqA:
21.93
4z91C-1iuqA:
21.93
4z91D-1iuqA:
21.93
4z91E-1iuqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		5 LEU A 259
THR A 165
LEU A 240
LEU A 275
LEU A 263
 None
 0.99A 4z91A-1jbkA:
0.0
4z91B-1jbkA:
0.0
4z91C-1jbkA:
0.0
4z91D-1jbkA:
0.0
4z91E-1jbkA:
0.0		 4z91A-1jbkA:
20.06
4z91B-1jbkA:
20.06
4z91C-1jbkA:
20.06
4z91D-1jbkA:
20.06
4z91E-1jbkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		5 LEU A 275
LEU A 263
LEU A 259
THR A 165
LEU A 240
 None
 1.00A 4z91A-1jbkA:
0.0
4z91B-1jbkA:
0.0
4z91C-1jbkA:
0.0
4z91D-1jbkA:
0.0
4z91E-1jbkA:
0.0		 4z91A-1jbkA:
20.06
4z91B-1jbkA:
20.06
4z91C-1jbkA:
20.06
4z91D-1jbkA:
20.06
4z91E-1jbkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 143
LEU D 144
LEU D 153
LEU D 155
LEU D 139
 None
 1.05A 4z91A-1u0nD:
0.0
4z91B-1u0nD:
0.0
4z91C-1u0nD:
0.0
4z91D-1u0nD:
0.0
4z91E-1u0nD:
0.0		 4z91A-1u0nD:
21.55
4z91B-1u0nD:
21.55
4z91C-1u0nD:
21.55
4z91D-1u0nD:
21.55
4z91E-1u0nD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 155
LEU D 139
LEU D 143
LEU D 144
LEU D 153
 None
 1.02A 4z91A-1u0nD:
0.0
4z91B-1u0nD:
0.0
4z91C-1u0nD:
0.0
4z91D-1u0nD:
0.0
4z91E-1u0nD:
0.0		 4z91A-1u0nD:
21.55
4z91B-1u0nD:
21.55
4z91C-1u0nD:
21.55
4z91D-1u0nD:
21.55
4z91E-1u0nD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Porphyromonas
gingivalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 157
THR A 228
LEU A 225
LEU A 210
THR A 200
 None
 0.86A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Porphyromonas
gingivalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 210
THR A 200
LEU A 157
THR A 228
LEU A 225
 None
 0.82A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Porphyromonas
gingivalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 210
THR A 200
LEU A 201
LEU A 157
THR A 228
 None
 1.00A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Porphyromonas
gingivalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 225
LEU A 210
THR A 200
LEU A 157
THR A 228
 None
 0.87A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Porphyromonas
gingivalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 THR A 200
LEU A 157
THR A 228
LEU A 225
LEU A 210
 None
 0.90A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Porphyromonas
gingivalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		6 THR A 228
LEU A 225
LEU A 210
THR A 200
LEU A 201
LEU A 157
 None
 1.13A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7l GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 1

(Homo sapiens) 		PF05793
(TFIIF_alpha) 		5 LEU A 463
THR A 470
LEU A 473
LEU A 497
LEU A 500
 None
 1.03A 4z91A-2k7lA:
0.0
4z91B-2k7lA:
undetectable
4z91C-2k7lA:
undetectable
4z91D-2k7lA:
undetectable
4z91E-2k7lA:
undetectable		 4z91A-2k7lA:
12.50
4z91B-2k7lA:
12.50
4z91C-2k7lA:
12.50
4z91D-2k7lA:
12.50
4z91E-2k7lA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		6 LEU B 216
THR B 242
LEU B 218
LEU B 227
LEU B 231
LEU B 237
 None
 1.49A 4z91A-2p1nB:
0.0
4z91B-2p1nB:
0.0
4z91C-2p1nB:
0.0
4z91D-2p1nB:
0.0
4z91E-2p1nB:
0.0		 4z91A-2p1nB:
20.64
4z91B-2p1nB:
20.64
4z91C-2p1nB:
20.64
4z91D-2p1nB:
20.64
4z91E-2p1nB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 LEU A 132
LEU A  43
LEU A 102
LEU A 104
LEU A 117
 None
 1.04A 4z91A-2q3zA:
3.2
4z91B-2q3zA:
3.2
4z91C-2q3zA:
3.3
4z91D-2q3zA:
3.1
4z91E-2q3zA:
3.1		 4z91A-2q3zA:
18.70
4z91B-2q3zA:
18.70
4z91C-2q3zA:
18.70
4z91D-2q3zA:
18.70
4z91E-2q3zA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 LEU A 394
LEU A 436
LEU A 466
THR A 427
LEU A 424
 None
 1.05A 4z91A-2qk2A:
undetectable
4z91B-2qk2A:
2.1
4z91C-2qk2A:
1.9
4z91D-2qk2A:
undetectable
4z91E-2qk2A:
3.2		 4z91A-2qk2A:
24.92
4z91B-2qk2A:
24.92
4z91C-2qk2A:
24.92
4z91D-2qk2A:
24.92
4z91E-2qk2A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 LEU A 466
THR A 427
LEU A 424
LEU A 394
LEU A 436
 None
 1.02A 4z91A-2qk2A:
undetectable
4z91B-2qk2A:
2.1
4z91C-2qk2A:
1.9
4z91D-2qk2A:
undetectable
4z91E-2qk2A:
3.2		 4z91A-2qk2A:
24.92
4z91B-2qk2A:
24.92
4z91C-2qk2A:
24.92
4z91D-2qk2A:
24.92
4z91E-2qk2A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 THR A 427
LEU A 424
LEU A 394
LEU A 436
LEU A 466
 None
 1.04A 4z91A-2qk2A:
undetectable
4z91B-2qk2A:
2.1
4z91C-2qk2A:
1.9
4z91D-2qk2A:
undetectable
4z91E-2qk2A:
3.2		 4z91A-2qk2A:
24.92
4z91B-2qk2A:
24.92
4z91C-2qk2A:
24.92
4z91D-2qk2A:
24.92
4z91E-2qk2A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 THR A 400
THR A 396
LEU A 397
LEU A 385
LEU A 464
 None
 0.99A 4z91A-2xqyA:
3.0
4z91B-2xqyA:
2.7
4z91C-2xqyA:
2.8
4z91D-2xqyA:
2.4
4z91E-2xqyA:
3.2		 4z91A-2xqyA:
19.65
4z91B-2xqyA:
19.65
4z91C-2xqyA:
19.65
4z91D-2xqyA:
19.65
4z91E-2xqyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 LEU A 312
THR A 288
LEU A 291
LEU A 330
LEU A 334
 None
 0.99A 4z91A-2ychA:
undetectable
4z91B-2ychA:
undetectable
4z91C-2ychA:
undetectable
4z91D-2ychA:
undetectable
4z91E-2ychA:
undetectable		 4z91A-2ychA:
21.77
4z91B-2ychA:
21.77
4z91C-2ychA:
21.77
4z91D-2ychA:
21.77
4z91E-2ychA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 LEU A 330
LEU A 334
LEU A 312
THR A 288
LEU A 291
 None
 1.04A 4z91A-2ychA:
undetectable
4z91B-2ychA:
undetectable
4z91C-2ychA:
undetectable
4z91D-2ychA:
undetectable
4z91E-2ychA:
undetectable		 4z91A-2ychA:
21.77
4z91B-2ychA:
21.77
4z91C-2ychA:
21.77
4z91D-2ychA:
21.77
4z91E-2ychA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 THR A 288
LEU A 291
LEU A 330
LEU A 334
LEU A 312
 None
 1.03A 4z91A-2ychA:
undetectable
4z91B-2ychA:
undetectable
4z91C-2ychA:
undetectable
4z91D-2ychA:
undetectable
4z91E-2ychA:
undetectable		 4z91A-2ychA:
21.77
4z91B-2ychA:
21.77
4z91C-2ychA:
21.77
4z91D-2ychA:
21.77
4z91E-2ychA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE

(Aquifex
aeolicus) 		PF13419
(HAD_2) 		5 LEU A  56
THR A  26
LEU A  27
LEU A  23
LEU A  51
 None
 1.04A 4z91A-2yy6A:
undetectable
4z91B-2yy6A:
undetectable
4z91C-2yy6A:
undetectable
4z91D-2yy6A:
undetectable
4z91E-2yy6A:
undetectable		 4z91A-2yy6A:
20.86
4z91B-2yy6A:
20.86
4z91C-2yy6A:
20.86
4z91D-2yy6A:
20.86
4z91E-2yy6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 127
THR A 100
LEU A 101
LEU A 137
LEU A 139
 None
 0.94A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 137
LEU A 139
LEU A 127
THR A 100
LEU A 101
 None
 0.99A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 139
LEU A 127
THR A 100
LEU A 101
LEU A 137
 None
 1.01A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 THR A 100
LEU A 101
LEU A 137
LEU A 139
LEU A 127
 None
 1.00A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 THR A 100
LEU A 101
LEU A 137
LEU A 139
LEU A 127
 None
 1.02A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		6 LEU A 452
THR A 459
LEU A 457
LEU A 464
LEU A 465
LEU A 474
 None
 1.47A 4z91A-3b2dA:
undetectable
4z91B-3b2dA:
undetectable
4z91C-3b2dA:
undetectable
4z91D-3b2dA:
undetectable
4z91E-3b2dA:
undetectable		 4z91A-3b2dA:
19.67
4z91B-3b2dA:
19.67
4z91C-3b2dA:
19.67
4z91D-3b2dA:
19.67
4z91E-3b2dA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		6 THR A 459
LEU A 457
LEU A 464
LEU A 465
LEU A 474
LEU A 452
 None
 1.50A 4z91A-3b2dA:
undetectable
4z91B-3b2dA:
undetectable
4z91C-3b2dA:
undetectable
4z91D-3b2dA:
undetectable
4z91E-3b2dA:
undetectable		 4z91A-3b2dA:
19.67
4z91B-3b2dA:
19.67
4z91C-3b2dA:
19.67
4z91D-3b2dA:
19.67
4z91E-3b2dA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		5 LEU A  36
THR C  55
LEU C  58
THR A  39
LEU A  40
 None
 1.00A 4z91A-3cueA:
undetectable
4z91B-3cueA:
undetectable
4z91C-3cueA:
undetectable
4z91D-3cueA:
1.4
4z91E-3cueA:
undetectable		 4z91A-3cueA:
22.68
4z91B-3cueA:
22.68
4z91C-3cueA:
22.68
4z91D-3cueA:
22.68
4z91E-3cueA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		5 LEU A   7
LEU A  51
THR A   3
LEU A  49
LEU A 247
 None
 1.04A 4z91A-3k4yA:
1.6
4z91B-3k4yA:
1.7
4z91C-3k4yA:
undetectable
4z91D-3k4yA:
undetectable
4z91E-3k4yA:
undetectable		 4z91A-3k4yA:
19.94
4z91B-3k4yA:
19.94
4z91C-3k4yA:
19.94
4z91D-3k4yA:
19.94
4z91E-3k4yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		5 THR A   3
LEU A  49
LEU A 247
LEU A   7
LEU A  51
 None
 1.05A 4z91A-3k4yA:
1.6
4z91B-3k4yA:
1.7
4z91C-3k4yA:
undetectable
4z91D-3k4yA:
undetectable
4z91E-3k4yA:
undetectable		 4z91A-3k4yA:
19.94
4z91B-3k4yA:
19.94
4z91C-3k4yA:
19.94
4z91D-3k4yA:
19.94
4z91E-3k4yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 221
LEU A 224
LEU A 228
THR A 155
LEU A 158
 None
 0.97A 4z91A-3l0dA:
undetectable
4z91B-3l0dA:
undetectable
4z91C-3l0dA:
undetectable
4z91D-3l0dA:
undetectable
4z91E-3l0dA:
undetectable		 4z91A-3l0dA:
21.07
4z91B-3l0dA:
21.07
4z91C-3l0dA:
21.07
4z91D-3l0dA:
21.07
4z91E-3l0dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 221
LEU A 224
LEU A 228
THR A 155
LEU A 158
 None
 1.03A 4z91A-3l0dA:
undetectable
4z91B-3l0dA:
undetectable
4z91C-3l0dA:
undetectable
4z91D-3l0dA:
undetectable
4z91E-3l0dA:
undetectable		 4z91A-3l0dA:
21.07
4z91B-3l0dA:
21.07
4z91C-3l0dA:
21.07
4z91D-3l0dA:
21.07
4z91E-3l0dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 224
LEU A 228
THR A 155
LEU A 158
LEU A 221
 None
 0.97A 4z91A-3l0dA:
undetectable
4z91B-3l0dA:
undetectable
4z91C-3l0dA:
undetectable
4z91D-3l0dA:
undetectable
4z91E-3l0dA:
undetectable		 4z91A-3l0dA:
21.07
4z91B-3l0dA:
21.07
4z91C-3l0dA:
21.07
4z91D-3l0dA:
21.07
4z91E-3l0dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 228
THR A 155
LEU A 158
LEU A 221
LEU A 224
 None
 0.99A 4z91A-3l0dA:
undetectable
4z91B-3l0dA:
undetectable
4z91C-3l0dA:
undetectable
4z91D-3l0dA:
undetectable
4z91E-3l0dA:
undetectable		 4z91A-3l0dA:
21.07
4z91B-3l0dA:
21.07
4z91C-3l0dA:
21.07
4z91D-3l0dA:
21.07
4z91E-3l0dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 THR A 155
LEU A 158
LEU A 221
LEU A 224
LEU A 228
 None
 1.03A 4z91A-3l0dA:
undetectable
4z91B-3l0dA:
undetectable
4z91C-3l0dA:
undetectable
4z91D-3l0dA:
undetectable
4z91E-3l0dA:
undetectable		 4z91A-3l0dA:
21.07
4z91B-3l0dA:
21.07
4z91C-3l0dA:
21.07
4z91D-3l0dA:
21.07
4z91E-3l0dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 LEU A 194
LEU A 167
THR A 201
THR A 197
LEU A 198
 None
 0.99A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 THR A 197
LEU A 198
LEU A 194
LEU A 167
THR A 201
 None
 0.98A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 THR A 201
THR A 197
LEU A 198
LEU A 194
LEU A 167
 None
 0.98A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 THR A 201
THR A 197
LEU A 198
LEU A 194
LEU A 167
 None
 1.02A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		5 LEU A 180
THR A 248
LEU A 249
LEU A 240
LEU A 186
 None
 1.05A 4z91A-3n2oA:
5.1
4z91B-3n2oA:
5.2
4z91C-3n2oA:
5.3
4z91D-3n2oA:
5.3
4z91E-3n2oA:
5.2		 4z91A-3n2oA:
19.08
4z91B-3n2oA:
19.08
4z91C-3n2oA:
19.08
4z91D-3n2oA:
19.08
4z91E-3n2oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		5 THR A 248
LEU A 249
LEU A 240
LEU A 186
LEU A 180
 None
 0.99A 4z91A-3n2oA:
5.1
4z91B-3n2oA:
5.2
4z91C-3n2oA:
5.3
4z91D-3n2oA:
5.3
4z91E-3n2oA:
5.2		 4z91A-3n2oA:
19.08
4z91B-3n2oA:
19.08
4z91C-3n2oA:
19.08
4z91D-3n2oA:
19.08
4z91E-3n2oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		5 THR A 248
LEU A 249
LEU A 240
LEU A 186
LEU A 180
 None
 1.03A 4z91A-3n2oA:
5.1
4z91B-3n2oA:
5.2
4z91C-3n2oA:
5.3
4z91D-3n2oA:
5.3
4z91E-3n2oA:
5.2		 4z91A-3n2oA:
19.08
4z91B-3n2oA:
19.08
4z91C-3n2oA:
19.08
4z91D-3n2oA:
19.08
4z91E-3n2oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 242
LEU A 252
THR A 260
LEU A 275
LEU A 272
 None
 0.91A 4z91A-3o0tA:
undetectable
4z91B-3o0tA:
undetectable
4z91C-3o0tA:
undetectable
4z91D-3o0tA:
undetectable
4z91E-3o0tA:
undetectable		 4z91A-3o0tA:
22.32
4z91B-3o0tA:
22.32
4z91C-3o0tA:
22.32
4z91D-3o0tA:
22.32
4z91E-3o0tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 272
LEU A 242
LEU A 252
THR A 260
LEU A 275
 None
 0.95A 4z91A-3o0tA:
undetectable
4z91B-3o0tA:
undetectable
4z91C-3o0tA:
undetectable
4z91D-3o0tA:
undetectable
4z91E-3o0tA:
undetectable		 4z91A-3o0tA:
22.32
4z91B-3o0tA:
22.32
4z91C-3o0tA:
22.32
4z91D-3o0tA:
22.32
4z91E-3o0tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfm GGDEF DOMAIN PROTEIN

(Pseudomonas
protegens) 		PF00563
(EAL) 		6 LEU A 500
LEU A 530
LEU A 550
LEU A 546
THR A 504
LEU A 505
 None
 1.47A 4z91A-3pfmA:
undetectable
4z91B-3pfmA:
undetectable
4z91C-3pfmA:
undetectable
4z91D-3pfmA:
undetectable
4z91E-3pfmA:
undetectable		 4z91A-3pfmA:
22.12
4z91B-3pfmA:
22.12
4z91C-3pfmA:
22.12
4z91D-3pfmA:
22.12
4z91E-3pfmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfm GGDEF DOMAIN PROTEIN

(Pseudomonas
protegens) 		PF00563
(EAL) 		6 LEU A 546
THR A 504
LEU A 505
LEU A 500
LEU A 530
LEU A 550
 None
 1.45A 4z91A-3pfmA:
undetectable
4z91B-3pfmA:
undetectable
4z91C-3pfmA:
undetectable
4z91D-3pfmA:
undetectable
4z91E-3pfmA:
undetectable		 4z91A-3pfmA:
22.12
4z91B-3pfmA:
22.12
4z91C-3pfmA:
22.12
4z91D-3pfmA:
22.12
4z91E-3pfmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		6 LEU A 546
THR A 504
LEU A 505
LEU A 500
LEU A 530
LEU A 550
 None
None
None
None
None
EDO  A   3 ( 4.8A)
 1.43A 4z91A-3pjxA:
undetectable
4z91B-3pjxA:
undetectable
4z91C-3pjxA:
1.9
4z91D-3pjxA:
undetectable
4z91E-3pjxA:
1.9		 4z91A-3pjxA:
21.50
4z91B-3pjxA:
21.50
4z91C-3pjxA:
21.50
4z91D-3pjxA:
21.50
4z91E-3pjxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		5 LEU A  93
LEU A 128
THR A 117
LEU A 118
LEU A 114
 KCX  A  92 ( 4.6A)
None
None
None
None
 0.95A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		5 LEU A  93
LEU A 128
THR A 117
LEU A 118
LEU A 114
 KCX  A  92 ( 4.6A)
None
None
None
None
 0.97A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		5 LEU A 114
LEU A  93
LEU A 128
THR A 117
LEU A 118
 None
KCX  A  92 ( 4.6A)
None
None
None
 0.94A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		5 LEU A 128
THR A 117
LEU A 118
LEU A 114
LEU A  93
 None
None
None
None
KCX  A  92 ( 4.6A)
 0.98A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		5 THR A 117
LEU A 118
LEU A 114
LEU A  93
LEU A 128
 None
None
None
KCX  A  92 ( 4.6A)
None
 0.96A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 164
LEU A 209
LEU A 196
THR A 167
LEU A 168
 None
 0.89A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 196
THR A 167
LEU A 168
LEU A 164
LEU A 209
 None
 0.92A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 198
THR A 167
LEU A 168
LEU A 164
LEU A 209
 None
 0.91A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 209
LEU A 196
THR A 167
LEU A 168
LEU A 164
 None
 0.92A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 THR A 167
LEU A 168
LEU A 164
LEU A 209
LEU A 196
 None
 0.88A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 THR A 167
LEU A 168
LEU A 164
LEU A 209
LEU A 196
 None
 0.92A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		5 LEU A  75
LEU A  40
LEU A  88
LEU A 115
LEU A 105
 None
 0.99A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		5 LEU A  88
LEU A 115
LEU A 105
LEU A  75
LEU A  40
 None
 1.01A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		5 LEU A 105
LEU A  75
LEU A  40
LEU A  88
LEU A 115
 None
 1.02A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		5 LEU A 115
LEU A 105
LEU A  75
LEU A  40
LEU A  88
 None
 1.04A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 LEU A 421
THR A 415
LEU A 435
LEU A 411
THR A 401
 None
 1.03A 4z91A-4kh3A:
undetectable
4z91B-4kh3A:
undetectable
4z91C-4kh3A:
undetectable
4z91D-4kh3A:
undetectable
4z91E-4kh3A:
undetectable		 4z91A-4kh3A:
21.07
4z91B-4kh3A:
21.07
4z91C-4kh3A:
21.07
4z91D-4kh3A:
21.07
4z91E-4kh3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A  84
LEU A 157
LEU A 227
THR A 153
LEU A 229
 None
 0.97A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A  84
LEU A 157
LEU A 227
THR A 153
LEU A 229
 None
 1.01A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A 157
LEU A 227
THR A 153
LEU A 229
LEU A  84
 None
 0.94A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 THR A 153
LEU A 229
LEU A  84
LEU A 157
LEU A 227
 None
 1.03A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 THR A 386
LEU A 389
THR A 408
LEU A 409
LEU A 456
 None
 1.03A 4z91A-4lglA:
undetectable
4z91B-4lglA:
undetectable
4z91C-4lglA:
undetectable
4z91D-4lglA:
1.2
4z91E-4lglA:
undetectable		 4z91A-4lglA:
17.65
4z91B-4lglA:
17.65
4z91C-4lglA:
17.65
4z91D-4lglA:
17.65
4z91E-4lglA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		5 LEU A  50
THR A  28
LEU A  31
LEU A  75
LEU A  63
 None
 1.05A 4z91A-4qbuA:
undetectable
4z91B-4qbuA:
undetectable
4z91C-4qbuA:
1.2
4z91D-4qbuA:
1.3
4z91E-4qbuA:
undetectable		 4z91A-4qbuA:
21.43
4z91B-4qbuA:
21.43
4z91C-4qbuA:
21.43
4z91D-4qbuA:
21.43
4z91E-4qbuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnr LEUCINE-RICH-REPEAT
PROTEIN

(Methanosarcina
barkeri) 		PF08477
(Roc)
PF16095
(COR) 		5 LEU A 401
LEU A 440
LEU A 445
LEU A 413
LEU A 399
 None
 1.04A 4z91A-4wnrA:
undetectable
4z91B-4wnrA:
undetectable
4z91C-4wnrA:
undetectable
4z91D-4wnrA:
undetectable
4z91E-4wnrA:
undetectable		 4z91A-4wnrA:
21.01
4z91B-4wnrA:
21.01
4z91C-4wnrA:
21.01
4z91D-4wnrA:
21.01
4z91E-4wnrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 LEU A  35
LEU A 250
LEU A 120
THR A  45
LEU A  48
 None
None
None
CL  A 403 (-4.0A)
None
 0.88A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable		 4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 LEU A  35
LEU A 250
LEU A 120
THR A  45
LEU A  48
 None
None
None
CL  A 403 (-4.0A)
None
 0.92A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable		 4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 LEU A 120
THR A  45
LEU A  48
LEU A  35
LEU A 250
 None
CL  A 403 (-4.0A)
None
None
None
 0.89A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable		 4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 LEU A 250
LEU A 120
THR A  45
LEU A  48
LEU A  35
 None
None
CL  A 403 (-4.0A)
None
None
 0.95A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable		 4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 THR A  45
LEU A  48
LEU A  35
LEU A 250
LEU A 120
 CL  A 403 (-4.0A)
None
None
None
None
 0.96A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable		 4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A  10
LEU A   5
LEU A 281
LEU A 228
LEU A 226
 None
 1.05A 4z91A-5dxiA:
undetectable
4z91B-5dxiA:
undetectable
4z91C-5dxiA:
undetectable
4z91D-5dxiA:
undetectable
4z91E-5dxiA:
undetectable		 4z91A-5dxiA:
19.94
4z91B-5dxiA:
19.94
4z91C-5dxiA:
19.94
4z91D-5dxiA:
19.94
4z91E-5dxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A 226
LEU A  10
LEU A   5
LEU A 281
LEU A 228
 None
 1.04A 4z91A-5dxiA:
undetectable
4z91B-5dxiA:
undetectable
4z91C-5dxiA:
undetectable
4z91D-5dxiA:
undetectable
4z91E-5dxiA:
undetectable		 4z91A-5dxiA:
19.94
4z91B-5dxiA:
19.94
4z91C-5dxiA:
19.94
4z91D-5dxiA:
19.94
4z91E-5dxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A 281
LEU A 228
LEU A 226
LEU A  10
LEU A   5
 None
 0.98A 4z91A-5dxiA:
undetectable
4z91B-5dxiA:
undetectable
4z91C-5dxiA:
undetectable
4z91D-5dxiA:
undetectable
4z91E-5dxiA:
undetectable		 4z91A-5dxiA:
19.94
4z91B-5dxiA:
19.94
4z91C-5dxiA:
19.94
4z91D-5dxiA:
19.94
4z91E-5dxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 THR M 129
LEU M 130
THR M 153
LEU M 154
LEU M 150
 None
 1.03A 4z91A-5lc5M:
undetectable
4z91B-5lc5M:
undetectable
4z91C-5lc5M:
undetectable
4z91D-5lc5M:
undetectable
4z91E-5lc5M:
undetectable		 4z91A-5lc5M:
21.55
4z91B-5lc5M:
21.55
4z91C-5lc5M:
21.55
4z91D-5lc5M:
21.55
4z91E-5lc5M:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 242
LEU A 252
THR A 260
LEU A 275
LEU A 272
 None
 0.92A 4z91A-5mufA:
undetectable
4z91B-5mufA:
undetectable
4z91C-5mufA:
undetectable
4z91D-5mufA:
undetectable
4z91E-5mufA:
undetectable		 4z91A-5mufA:
21.69
4z91B-5mufA:
21.69
4z91C-5mufA:
21.69
4z91D-5mufA:
21.69
4z91E-5mufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 252
THR A 260
LEU A 275
LEU A 272
LEU A 242
 None
 1.01A 4z91A-5mufA:
undetectable
4z91B-5mufA:
undetectable
4z91C-5mufA:
undetectable
4z91D-5mufA:
undetectable
4z91E-5mufA:
undetectable		 4z91A-5mufA:
21.69
4z91B-5mufA:
21.69
4z91C-5mufA:
21.69
4z91D-5mufA:
21.69
4z91E-5mufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 272
LEU A 242
LEU A 252
THR A 260
LEU A 275
 None
 0.97A 4z91A-5mufA:
undetectable
4z91B-5mufA:
undetectable
4z91C-5mufA:
undetectable
4z91D-5mufA:
undetectable
4z91E-5mufA:
undetectable		 4z91A-5mufA:
21.69
4z91B-5mufA:
21.69
4z91C-5mufA:
21.69
4z91D-5mufA:
21.69
4z91E-5mufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 138
LEU A 551
LEU A 524
THR A 145
LEU A 142
 None
GOL  A 802 ( 3.6A)
GOL  A 802 ( 4.4A)
None
None
 1.00A 4z91A-5oasA:
1.0
4z91B-5oasA:
1.0
4z91C-5oasA:
1.1
4z91D-5oasA:
1.1
4z91E-5oasA:
1.1		 4z91A-5oasA:
18.19
4z91B-5oasA:
18.19
4z91C-5oasA:
18.19
4z91D-5oasA:
18.19
4z91E-5oasA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 142
LEU A 138
LEU A 551
LEU A 524
THR A 145
 None
None
GOL  A 802 ( 3.6A)
GOL  A 802 ( 4.4A)
None
 1.01A 4z91A-5oasA:
1.0
4z91B-5oasA:
1.0
4z91C-5oasA:
1.1
4z91D-5oasA:
1.1
4z91E-5oasA:
1.1		 4z91A-5oasA:
18.19
4z91B-5oasA:
18.19
4z91C-5oasA:
18.19
4z91D-5oasA:
18.19
4z91E-5oasA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 THR A 145
LEU A 142
LEU A 138
LEU A 551
LEU A 524
 None
None
None
GOL  A 802 ( 3.6A)
GOL  A 802 ( 4.4A)
 1.04A 4z91A-5oasA:
1.0
4z91B-5oasA:
1.0
4z91C-5oasA:
1.1
4z91D-5oasA:
1.1
4z91E-5oasA:
1.1		 4z91A-5oasA:
18.19
4z91B-5oasA:
18.19
4z91C-5oasA:
18.19
4z91D-5oasA:
18.19
4z91E-5oasA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 5 LEU A 196
LEU A 203
LEU A 177
THR A 181
LEU A 192
 None
 1.04A 4z91A-5zxdA:
undetectable
4z91B-5zxdA:
undetectable
4z91C-5zxdA:
undetectable
4z91D-5zxdA:
undetectable
4z91E-5zxdA:
undetectable		 4z91A-5zxdA:
undetectable
4z91B-5zxdA:
undetectable
4z91C-5zxdA:
undetectable
4z91D-5zxdA:
undetectable
4z91E-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 5 LEU A 203
LEU A 177
THR A 181
LEU A 192
LEU A 196
 None
 1.04A 4z91A-5zxdA:
undetectable
4z91B-5zxdA:
undetectable
4z91C-5zxdA:
undetectable
4z91D-5zxdA:
undetectable
4z91E-5zxdA:
undetectable		 4z91A-5zxdA:
undetectable
4z91B-5zxdA:
undetectable
4z91C-5zxdA:
undetectable
4z91D-5zxdA:
undetectable
4z91E-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 5 THR A 181
LEU A 192
LEU A 196
LEU A 203
LEU A 177
 None
 1.02A 4z91A-5zxdA:
undetectable
4z91B-5zxdA:
undetectable
4z91C-5zxdA:
undetectable
4z91D-5zxdA:
undetectable
4z91E-5zxdA:
undetectable		 4z91A-5zxdA:
undetectable
4z91B-5zxdA:
undetectable
4z91C-5zxdA:
undetectable
4z91D-5zxdA:
undetectable
4z91E-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 5 LEU A  53
THR A 104
LEU A 107
LEU A 160
LEU A 283
 None
 1.02A 4z91A-6dawA:
undetectable
4z91B-6dawA:
undetectable
4z91C-6dawA:
undetectable
4z91D-6dawA:
undetectable
4z91E-6dawA:
undetectable		 4z91A-6dawA:
13.62
4z91B-6dawA:
13.62
4z91C-6dawA:
13.62
4z91D-6dawA:
13.62
4z91E-6dawA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 5 THR A 104
LEU A 107
LEU A 160
LEU A 283
LEU A  53
 None
 1.00A 4z91A-6dawA:
undetectable
4z91B-6dawA:
undetectable
4z91C-6dawA:
undetectable
4z91D-6dawA:
undetectable
4z91E-6dawA:
undetectable		 4z91A-6dawA:
13.62
4z91B-6dawA:
13.62
4z91C-6dawA:
13.62
4z91D-6dawA:
13.62
4z91E-6dawA:
13.62