SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z90_F_4LEF402_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b25 | PROTEIN(FORMALDEHYDEFERREDOXINOXIDOREDUCTASE) (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 4 | LEU A 373ALA A 352LEU A 384ALA A 388 | None | 0.54A | 4z90F-1b25A:0.04z90G-1b25A:0.04z90H-1b25A:0.04z90J-1b25A:0.0 | 4z90F-1b25A:20.504z90G-1b25A:20.504z90H-1b25A:20.504z90J-1b25A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ci9 | PROTEIN(CARBOXYLESTERASE) (Burkholderiagladioli) |
PF00144(Beta-lactamase) | 5 | LEU A 369ALA A 281LEU A 367ALA A 287LEU A 73 | None | 1.01A | 4z90F-1ci9A:0.04z90G-1ci9A:0.04z90H-1ci9A:0.04z90J-1ci9A:0.0 | 4z90F-1ci9A:21.384z90G-1ci9A:21.384z90H-1ci9A:21.384z90J-1ci9A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d2z | DEATH DOMAIN OFPELLE (Drosophilamelanogaster) |
PF00531(Death) | 4 | LEU A 49LEU A 58LEU A 45ALA A 113 | None | 0.67A | 4z90F-1d2zA:undetectable4z90G-1d2zA:undetectable4z90H-1d2zA:undetectable4z90J-1d2zA:undetectable | 4z90F-1d2zA:18.184z90G-1d2zA:18.184z90H-1d2zA:18.184z90J-1d2zA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fx4 | RECEPTOR-TYPEADENYLATE CYCLASEGRESAG 4.3 (Trypanosomabrucei) |
PF00211(Guanylate_cyc) | 4 | LEU A1069LEU A1091ALA A 953LEU A1061 | None | 0.65A | 4z90F-1fx4A:0.04z90G-1fx4A:0.04z90H-1fx4A:undetectable4z90J-1fx4A:undetectable | 4z90F-1fx4A:21.044z90G-1fx4A:21.044z90H-1fx4A:21.044z90J-1fx4A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzg | DELTA-AMINOLEVULINICACID DEHYDRATASE (Pseudomonasaeruginosa) |
PF00490(ALAD) | 5 | LEU A 83LEU A 85ALA A 111LEU A 122ALA A 72 | NoneNoneNoneSO4 A1340 (-4.8A)None | 1.24A | 4z90F-1gzgA:0.04z90G-1gzgA:0.04z90H-1gzgA:0.04z90J-1gzgA:0.0 | 4z90F-1gzgA:21.594z90G-1gzgA:21.594z90H-1gzgA:21.594z90J-1gzgA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 4 | LEU A 106ALA A 137LEU A 110ALA A 141 | None | 0.67A | 4z90F-1hcuA:1.04z90G-1hcuA:1.14z90H-1hcuA:1.04z90J-1hcuA:1.1 | 4z90F-1hcuA:22.314z90G-1hcuA:22.314z90H-1hcuA:22.314z90J-1hcuA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i4s | RIBONUCLEASE III (Aquifexaeolicus) |
PF14622(Ribonucleas_3_3) | 4 | LEU A 21ALA A 115ALA A 111LEU A 7 | None | 0.68A | 4z90F-1i4sA:undetectable4z90G-1i4sA:undetectable4z90H-1i4sA:undetectable4z90J-1i4sA:undetectable | 4z90F-1i4sA:19.144z90G-1i4sA:19.144z90H-1i4sA:19.144z90J-1i4sA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 5 | LEU A 287LEU A 211ALA A 222ALA A 250LEU A 284 | None | 1.24A | 4z90F-1ileA:3.54z90G-1ileA:3.64z90H-1ileA:3.64z90J-1ileA:2.1 | 4z90F-1ileA:17.364z90G-1ileA:17.364z90H-1ileA:17.364z90J-1ileA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2b | ARCHAEOSINETRNA-GUANINETRANSGLYCOSYLASE (Pyrococcushorikoshii) |
PF01472(PUA)PF01702(TGT)PF14809(TGT_C1)PF14810(TGT_C2) | 5 | LEU A 150ALA A 153LEU A 184ALA A 166LEU A 146 | None | 1.09A | 4z90F-1j2bA:0.04z90G-1j2bA:undetectable4z90H-1j2bA:0.04z90J-1j2bA:0.0 | 4z90F-1j2bA:21.124z90G-1j2bA:21.124z90H-1j2bA:21.124z90J-1j2bA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kej | TERMINALDEOXYNUCLEOTIDYLTRANSFERASE SHORTISOFORM (Mus musculus) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 4 | LEU A 406LEU A 408ALA A 318LEU A 435 | None | 0.61A | 4z90F-1kejA:0.04z90G-1kejA:0.04z90H-1kejA:0.04z90J-1kejA:0.0 | 4z90F-1kejA:19.794z90G-1kejA:19.794z90H-1kejA:19.794z90J-1kejA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lns | X-PROLYL DIPEPTIDYLAMINOPEPTIDASE (Lactococcuslactis) |
PF02129(Peptidase_S15)PF08530(PepX_C)PF09168(PepX_N) | 4 | LEU A 619ALA A 634LEU A 711LEU A 754 | None | 0.63A | 4z90F-1lnsA:0.04z90G-1lnsA:0.04z90H-1lnsA:0.04z90J-1lnsA:0.0 | 4z90F-1lnsA:17.574z90G-1lnsA:17.574z90H-1lnsA:17.574z90J-1lnsA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mdf | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 303LEU A 278ALA A 229ALA A 264LEU A 300 | None | 1.46A | 4z90F-1mdfA:undetectable4z90G-1mdfA:undetectable4z90H-1mdfA:undetectable4z90J-1mdfA:undetectable | 4z90F-1mdfA:19.644z90G-1mdfA:19.644z90H-1mdfA:19.644z90J-1mdfA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mn6 | POLYKETIDE SYNTHASEIV (Streptomycesvenezuelae) |
PF00975(Thioesterase) | 4 | LEU A 29ALA A 217LEU A 197ALA A 79 | None | 0.58A | 4z90F-1mn6A:undetectable4z90G-1mn6A:undetectable4z90H-1mn6A:undetectable4z90J-1mn6A:undetectable | 4z90F-1mn6A:19.354z90G-1mn6A:19.354z90H-1mn6A:19.354z90J-1mn6A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n11 | ANKYRIN (Homo sapiens) |
PF00023(Ank)PF12796(Ank_2)PF13637(Ank_4)PF13857(Ank_5) | 5 | LEU A 490LEU A 474ALA A 478ALA A 510ALA A 521 | None | 1.01A | 4z90F-1n11A:undetectable4z90G-1n11A:undetectable4z90H-1n11A:undetectable4z90J-1n11A:undetectable | 4z90F-1n11A:18.644z90G-1n11A:18.644z90H-1n11A:18.644z90J-1n11A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ngr | P75 LOW AFFINITYNEUROTROPHINRECEPTOR (Rattusnorvegicus) |
PF00531(Death) | 5 | LEU A 360ALA A 402LEU A 364ALA A 398LEU A 352 | None | 0.91A | 4z90F-1ngrA:undetectable4z90G-1ngrA:undetectable4z90H-1ngrA:undetectable4z90J-1ngrA:undetectable | 4z90F-1ngrA:15.564z90G-1ngrA:15.564z90H-1ngrA:15.564z90J-1ngrA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nps | DEVELOPMENT-SPECIFICPROTEIN S (Myxococcusxanthus) |
PF00030(Crystall) | 4 | LEU A 71LEU A 51ALA A 49ALA A 68 | None | 0.61A | 4z90F-1npsA:undetectable4z90G-1npsA:undetectable4z90H-1npsA:undetectable4z90J-1npsA:undetectable | 4z90F-1npsA:13.984z90G-1npsA:13.984z90H-1npsA:13.984z90J-1npsA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nxi | CONSERVEDHYPOTHETICAL PROTEINVC0424 (Vibrio cholerae) |
PF06877(RraB) | 5 | LEU A 104ALA A 60LEU A 107ALA A 56ALA A 86 | None | 1.02A | 4z90F-1nxiA:undetectable4z90G-1nxiA:undetectable4z90H-1nxiA:undetectable4z90J-1nxiA:undetectable | 4z90F-1nxiA:16.674z90G-1nxiA:16.674z90H-1nxiA:16.674z90J-1nxiA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o9g | RRNAMETHYLTRANSFERASE (Streptomycesviridochromogenes) |
PF11599(AviRa) | 5 | LEU A 69ALA A 43ALA A 211LEU A 65ALA A 36 | None | 1.08A | 4z90F-1o9gA:undetectable4z90G-1o9gA:undetectable4z90H-1o9gA:undetectable4z90J-1o9gA:undetectable | 4z90F-1o9gA:24.114z90G-1o9gA:24.114z90H-1o9gA:24.114z90J-1o9gA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o9g | RRNAMETHYLTRANSFERASE (Streptomycesviridochromogenes) |
PF11599(AviRa) | 5 | LEU A 69LEU A 55ALA A 211LEU A 65ALA A 36 | None | 1.15A | 4z90F-1o9gA:undetectable4z90G-1o9gA:undetectable4z90H-1o9gA:undetectable4z90J-1o9gA:undetectable | 4z90F-1o9gA:24.114z90G-1o9gA:24.114z90H-1o9gA:24.114z90J-1o9gA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ojl | TRANSCRIPTIONALREGULATORY PROTEINZRAR (Salmonellaenterica) |
PF00158(Sigma54_activat)PF02954(HTH_8) | 4 | LEU A 382LEU A 349ALA A 323ALA A 368 | None | 0.67A | 4z90F-1ojlA:undetectable4z90G-1ojlA:undetectable4z90H-1ojlA:undetectable4z90J-1ojlA:undetectable | 4z90F-1ojlA:21.814z90G-1ojlA:21.814z90H-1ojlA:21.814z90J-1ojlA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1on0 | YYCN PROTEIN (Bacillussubtilis) |
PF00583(Acetyltransf_1) | 5 | LEU A 113ALA A 117LEU A 125ALA A 89LEU A 76 | None | 1.08A | 4z90F-1on0A:undetectable4z90G-1on0A:undetectable4z90H-1on0A:undetectable4z90J-1on0A:undetectable | 4z90F-1on0A:18.074z90G-1on0A:18.074z90H-1on0A:18.074z90J-1on0A:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pg6 | HYPOTHETICAL PROTEINSPYM3_0169 (Streptococcuspyogenes) |
PF01987(AIM24) | 5 | LEU A 86LEU A 88ALA A 115LEU A 23ALA A 78 | None | 1.29A | 4z90F-1pg6A:undetectable4z90G-1pg6A:undetectable4z90H-1pg6A:undetectable4z90J-1pg6A:undetectable | 4z90F-1pg6A:20.494z90G-1pg6A:20.494z90H-1pg6A:20.494z90J-1pg6A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8r | CROSSOVER JUNCTIONENDODEOXYRIBONUCLEASE RUSA (Escherichiacoli) |
PF05866(RusA) | 4 | LEU A 112ALA A 85LEU A 8ALA A 78 | None | 0.60A | 4z90F-1q8rA:undetectable4z90G-1q8rA:undetectable4z90H-1q8rA:undetectable4z90J-1q8rA:undetectable | 4z90F-1q8rA:16.334z90G-1q8rA:16.334z90H-1q8rA:16.334z90J-1q8rA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 4 | LEU A 261ALA A 274LEU A 265LEU A 221 | None | 0.68A | 4z90F-1rk2A:undetectable4z90G-1rk2A:undetectable4z90H-1rk2A:undetectable4z90J-1rk2A:undetectable | 4z90F-1rk2A:22.874z90G-1rk2A:22.874z90H-1rk2A:22.874z90J-1rk2A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ul1 | FLAP ENDONUCLEASE-1 (Homo sapiens) |
PF00752(XPG_N)PF00867(XPG_I) | 4 | LEU X 226ALA X 246LEU X 230LEU X 216 | None | 0.65A | 4z90F-1ul1X:undetectable4z90G-1ul1X:undetectable4z90H-1ul1X:undetectable4z90J-1ul1X:undetectable | 4z90F-1ul1X:21.994z90G-1ul1X:21.994z90H-1ul1X:21.994z90J-1ul1X:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wwl | MONOCYTEDIFFERENTIATIONANTIGEN CD14 (Mus musculus) |
no annotation | 4 | LEU A 232ALA A 228ALA A 224LEU A 235 | None | 0.67A | 4z90F-1wwlA:undetectable4z90G-1wwlA:undetectable4z90H-1wwlA:undetectable4z90J-1wwlA:undetectable | 4z90F-1wwlA:22.824z90G-1wwlA:22.824z90H-1wwlA:22.824z90J-1wwlA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4c | MALTOSE BINDINGPROTEIN FUSED WITHDESIGNED HELICALPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 4 | ALA A 621LEU A 638ALA A 582ALA A 625 | None | 0.67A | 4z90F-1y4cA:7.14z90G-1y4cA:7.04z90H-1y4cA:6.34z90J-1y4cA:7.0 | 4z90F-1y4cA:18.914z90G-1y4cA:18.914z90H-1y4cA:18.914z90J-1y4cA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4c | MALTOSE BINDINGPROTEIN FUSED WITHDESIGNED HELICALPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 4 | LEU A 579ALA A 566LEU A 583ALA A 637 | None | 0.60A | 4z90F-1y4cA:7.14z90G-1y4cA:7.04z90H-1y4cA:6.34z90J-1y4cA:7.0 | 4z90F-1y4cA:18.914z90G-1y4cA:18.914z90H-1y4cA:18.914z90J-1y4cA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4c | MALTOSE BINDINGPROTEIN FUSED WITHDESIGNED HELICALPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 4 | LEU A 583ALA A 637LEU A 579ALA A 566 | None | 0.68A | 4z90F-1y4cA:7.14z90G-1y4cA:7.04z90H-1y4cA:6.34z90J-1y4cA:7.0 | 4z90F-1y4cA:18.914z90G-1y4cA:18.914z90H-1y4cA:18.914z90J-1y4cA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4c | MALTOSE BINDINGPROTEIN FUSED WITHDESIGNED HELICALPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 4 | LEU A 607ALA A 648LEU A 611ALA A 555 | None | 0.67A | 4z90F-1y4cA:7.14z90G-1y4cA:7.04z90H-1y4cA:6.34z90J-1y4cA:7.0 | 4z90F-1y4cA:18.914z90G-1y4cA:18.914z90H-1y4cA:18.914z90J-1y4cA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4c | MALTOSE BINDINGPROTEIN FUSED WITHDESIGNED HELICALPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 4 | LEU A 634ALA A 621LEU A 638ALA A 582 | None | 0.64A | 4z90F-1y4cA:7.14z90G-1y4cA:7.04z90H-1y4cA:6.34z90J-1y4cA:7.0 | 4z90F-1y4cA:18.914z90G-1y4cA:18.914z90H-1y4cA:18.914z90J-1y4cA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yaa | ASPARTATEAMINOTRANSFERASE (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 5 | LEU A 392LEU A 337ALA A 401ALA A 403LEU A 35 | None | 1.30A | 4z90F-1yaaA:undetectable4z90G-1yaaA:undetectable4z90H-1yaaA:undetectable4z90J-1yaaA:undetectable | 4z90F-1yaaA:23.084z90G-1yaaA:23.084z90H-1yaaA:23.084z90J-1yaaA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yxo | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE 1 (Pseudomonasaeruginosa) |
PF04166(PdxA) | 4 | LEU A1041ALA A1036ALA A1118ALA A1034 | None | 0.63A | 4z90F-1yxoA:undetectable4z90G-1yxoA:undetectable4z90H-1yxoA:undetectable4z90J-1yxoA:undetectable | 4z90F-1yxoA:22.744z90G-1yxoA:22.744z90H-1yxoA:22.744z90J-1yxoA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a1j | DNA EXCISION REPAIRPROTEIN ERCC-1 (Homo sapiens) |
PF14520(HHH_5) | 4 | LEU B 285LEU B 271ALA B 266LEU B 239 | None | 0.48A | 4z90F-2a1jB:undetectable4z90G-2a1jB:undetectable4z90H-2a1jB:undetectable4z90J-2a1jB:undetectable | 4z90F-2a1jB:12.104z90G-2a1jB:12.104z90H-2a1jB:12.104z90J-2a1jB:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ay9 | AROMATIC AMINO ACIDAMINOTRANSFERASE (Paracoccusdenitrificans) |
PF00155(Aminotran_1_2) | 5 | LEU A 392LEU A 337ALA A 401ALA A 403LEU A 35 | None | 1.21A | 4z90F-2ay9A:undetectable4z90G-2ay9A:undetectable4z90H-2ay9A:undetectable4z90J-2ay9A:undetectable | 4z90F-2ay9A:22.284z90G-2ay9A:22.284z90H-2ay9A:22.284z90J-2ay9A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dc0 | PROBABLE AMIDASE (Thermusthermophilus) |
PF01425(Amidase) | 5 | LEU A 164ALA A 109ALA A 107LEU A 223ALA A 100 | None | 1.34A | 4z90F-2dc0A:undetectable4z90G-2dc0A:undetectable4z90H-2dc0A:undetectable4z90J-2dc0A:undetectable | 4z90F-2dc0A:21.144z90G-2dc0A:21.144z90H-2dc0A:21.144z90J-2dc0A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dou | PROBABLEN-SUCCINYLDIAMINOPIMELATEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | LEU A 104ALA A 127LEU A 100ALA A 120LEU A 114 | None | 0.92A | 4z90F-2douA:undetectable4z90G-2douA:undetectable4z90H-2douA:undetectable4z90J-2douA:undetectable | 4z90F-2douA:23.154z90G-2douA:23.154z90H-2douA:23.154z90J-2douA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | LEU A 311ALA A 284ALA A 286LEU A 270ALA A 280 | None | 1.21A | 4z90F-2elcA:undetectable4z90G-2elcA:undetectable4z90H-2elcA:undetectable4z90J-2elcA:undetectable | 4z90F-2elcA:22.474z90G-2elcA:22.474z90H-2elcA:22.474z90J-2elcA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqt | UDP-N-ACETYLENOLPYRUVYLGLUCOSAMINEREDUCTASE (Thermuscaldophilus) |
PF01565(FAD_binding_4)PF02873(MurB_C) | 5 | LEU A 98LEU A 83ALA A 111LEU A 166ALA A 126 | NoneNoneFAD A 601 (-4.1A)NoneNone | 0.85A | 4z90F-2gqtA:undetectable4z90G-2gqtA:undetectable4z90H-2gqtA:undetectable4z90J-2gqtA:undetectable | 4z90F-2gqtA:20.934z90G-2gqtA:20.934z90H-2gqtA:20.934z90J-2gqtA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2id3 | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF16859(TetR_C_11) | 4 | LEU A 39ALA A 30ALA A 48LEU A 65 | None | 0.60A | 4z90F-2id3A:2.64z90G-2id3A:2.74z90H-2id3A:2.64z90J-2id3A:2.6 | 4z90F-2id3A:18.834z90G-2id3A:18.834z90H-2id3A:18.834z90J-2id3A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2id5 | LEUCINE RICH REPEATNEURONAL 6A (Homo sapiens) |
PF07679(I-set)PF13306(LRR_5)PF13855(LRR_8) | 4 | LEU A 164ALA A 171ALA A 147LEU A 140 | None | 0.61A | 4z90F-2id5A:undetectable4z90G-2id5A:undetectable4z90H-2id5A:undetectable4z90J-2id5A:undetectable | 4z90F-2id5A:22.004z90G-2id5A:22.004z90H-2id5A:22.004z90J-2id5A:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjf | L-LYSINE EPSILONAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00202(Aminotran_3) | 4 | LEU A 402ALA A 444LEU A 406ALA A 440 | None | 0.64A | 4z90F-2jjfA:undetectable4z90G-2jjfA:undetectable4z90H-2jjfA:undetectable4z90J-2jjfA:undetectable | 4z90F-2jjfA:21.414z90G-2jjfA:21.414z90H-2jjfA:21.414z90J-2jjfA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l6b | NR1C (Escherichiacoli) |
PF12796(Ank_2) | 5 | LEU A 62ALA A 66ALA A 70LEU A 94ALA A 50 | None | 1.42A | 4z90F-2l6bA:undetectable4z90G-2l6bA:undetectable4z90H-2l6bA:undetectable4z90J-2l6bA:undetectable | 4z90F-2l6bA:13.664z90G-2l6bA:13.664z90H-2l6bA:13.664z90J-2l6bA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2no5 | (S)-2-HALOACIDDEHALOGENASE IVA (Burkholderiacepacia) |
PF13419(HAD_2) | 5 | LEU A 130LEU A 139ALA A 116LEU A 126ALA A 12 | NoneNoneNoneNoneASL A 11 ( 3.3A) | 1.09A | 4z90F-2no5A:undetectable4z90G-2no5A:undetectable4z90H-2no5A:undetectable4z90J-2no5A:undetectable | 4z90F-2no5A:19.574z90G-2no5A:19.574z90H-2no5A:19.574z90J-2no5A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q80 | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 4 | LEU A 158LEU A 162ALA A 111LEU A 56 | None | 0.67A | 4z90F-2q80A:undetectable4z90G-2q80A:3.04z90H-2q80A:undetectable4z90J-2q80A:2.0 | 4z90F-2q80A:21.844z90G-2q80A:21.844z90H-2q80A:21.844z90J-2q80A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8q | IRON-REGULATEDSURFACE DETERMINANTE (Staphylococcusaureus) |
PF01497(Peripla_BP_2) | 4 | LEU A 145LEU A 149ALA A 276ALA A 272 | None | 0.63A | 4z90F-2q8qA:undetectable4z90G-2q8qA:undetectable4z90H-2q8qA:undetectable4z90J-2q8qA:undetectable | 4z90F-2q8qA:22.394z90G-2q8qA:22.394z90H-2q8qA:22.394z90J-2q8qA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2waa | XYLAN ESTERASE,PUTATIVE, AXE2C (Cellvibriojaponicus) |
PF13472(Lipase_GDSL_2) | 4 | LEU A 333LEU A 228LEU A 329ALA A 303 | None | 0.64A | 4z90F-2waaA:undetectable4z90G-2waaA:undetectable4z90H-2waaA:undetectable4z90J-2waaA:undetectable | 4z90F-2waaA:20.434z90G-2waaA:20.434z90H-2waaA:20.434z90J-2waaA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zau | SELENIDE, WATERDIKINASE (Aquifexaeolicus) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | LEU A 226ALA A 229LEU A 333ALA A 240LEU A 289 | None | 0.97A | 4z90F-2zauA:undetectable4z90G-2zauA:undetectable4z90H-2zauA:undetectable4z90J-2zauA:undetectable | 4z90F-2zauA:22.104z90G-2zauA:22.104z90H-2zauA:22.104z90J-2zauA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zop | PUTATIVEUNCHARACTERIZEDPROTEIN TTHB164 (Thermusthermophilus) |
PF09701(Cas_Cmr5) | 4 | LEU A 78ALA A 82LEU A 48LEU A 70 | None | 0.62A | 4z90F-2zopA:2.14z90G-2zopA:2.04z90H-2zopA:2.24z90J-2zopA:2.0 | 4z90F-2zopA:16.774z90G-2zopA:16.774z90H-2zopA:16.774z90J-2zopA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agf | GLUTAMINASE 1 (Bacillussubtilis) |
PF04960(Glutaminase) | 4 | LEU A 198ALA A 133ALA A 129ALA A 181 | None | 0.65A | 4z90F-3agfA:undetectable4z90G-3agfA:undetectable4z90H-3agfA:undetectable4z90J-3agfA:undetectable | 4z90F-3agfA:18.804z90G-3agfA:18.804z90H-3agfA:18.804z90J-3agfA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aoe | GLUTAMATEDEHYDROGENASE (Thermusthermophilus) |
no annotation | 5 | LEU E 295LEU E 293ALA E 312ALA E 336LEU E 323 | None | 1.48A | 4z90F-3aoeE:undetectable4z90G-3aoeE:undetectable4z90H-3aoeE:undetectable4z90J-3aoeE:undetectable | 4z90F-3aoeE:21.484z90G-3aoeE:21.484z90H-3aoeE:21.484z90J-3aoeE:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b95 | EUCHROMATICHISTONE-LYSINEN-METHYLTRANSFERASE1 (Homo sapiens) |
PF12796(Ank_2)PF13637(Ank_4) | 4 | LEU A 879ALA A 883LEU A 895ALA A 891 | None | 0.66A | 4z90F-3b95A:undetectable4z90G-3b95A:undetectable4z90H-3b95A:undetectable4z90J-3b95A:undetectable | 4z90F-3b95A:19.354z90G-3b95A:19.354z90H-3b95A:19.354z90J-3b95A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjd | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE (Pseudomonasaeruginosa) |
PF14515(HOASN)PF14518(Haem_oxygenas_2) | 5 | LEU A 63ALA A 19ALA A 23ALA A 25LEU A 42 | None | 1.22A | 4z90F-3bjdA:undetectable4z90G-3bjdA:undetectable4z90H-3bjdA:undetectable4z90J-3bjdA:undetectable | 4z90F-3bjdA:19.844z90G-3bjdA:19.844z90H-3bjdA:19.844z90J-3bjdA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c87 | ENTEROCHELINESTERASE (Shigellaflexneri) |
PF00756(Esterase)PF11806(DUF3327) | 4 | LEU A 384ALA A 278LEU A 388ALA A 197 | None | 0.63A | 4z90F-3c87A:3.64z90G-3c87A:2.94z90H-3c87A:2.94z90J-3c87A:3.4 | 4z90F-3c87A:21.694z90G-3c87A:21.694z90H-3c87A:21.694z90J-3c87A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cb0 | 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE (Brucellamelitensis) |
PF01613(Flavin_Reduct) | 5 | LEU A 122LEU A 84ALA A 92ALA A 94ALA A 110 | None | 1.46A | 4z90F-3cb0A:undetectable4z90G-3cb0A:undetectable4z90H-3cb0A:undetectable4z90J-3cb0A:undetectable | 4z90F-3cb0A:17.184z90G-3cb0A:17.184z90H-3cb0A:17.184z90J-3cb0A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ck6 | PUTATIVE MEMBRANETRANSPORT PROTEIN (Vibrioparahaemolyticus) |
PF01544(CorA) | 4 | LEU A 76ALA A 190LEU A 78ALA A 212 | None | 0.68A | 4z90F-3ck6A:5.14z90G-3ck6A:5.14z90H-3ck6A:5.14z90J-3ck6A:3.9 | 4z90F-3ck6A:20.454z90G-3ck6A:20.454z90H-3ck6A:20.454z90J-3ck6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ck6 | PUTATIVE MEMBRANETRANSPORT PROTEIN (Vibrioparahaemolyticus) |
PF01544(CorA) | 4 | LEU A 78ALA A 212LEU A 76ALA A 190 | None | 0.68A | 4z90F-3ck6A:5.14z90G-3ck6A:5.14z90H-3ck6A:5.14z90J-3ck6A:3.9 | 4z90F-3ck6A:20.454z90G-3ck6A:20.454z90H-3ck6A:20.454z90J-3ck6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cux | MALATE SYNTHASE (Bacillusanthracis) |
PF01274(Malate_synthase) | 4 | LEU A 133ALA A 136LEU A 160ALA A 103 | None | 0.59A | 4z90F-3cuxA:1.44z90G-3cuxA:1.44z90H-3cuxA:undetectable4z90J-3cuxA:undetectable | 4z90F-3cuxA:22.484z90G-3cuxA:22.484z90H-3cuxA:22.484z90J-3cuxA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cux | MALATE SYNTHASE (Bacillusanthracis) |
PF01274(Malate_synthase) | 4 | LEU A 160ALA A 103LEU A 133ALA A 136 | None | 0.56A | 4z90F-3cuxA:1.44z90G-3cuxA:1.44z90H-3cuxA:undetectable4z90J-3cuxA:undetectable | 4z90F-3cuxA:22.484z90G-3cuxA:22.484z90H-3cuxA:22.484z90J-3cuxA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv2 | MALATE SYNTHASE A (Escherichiacoli) |
PF01274(Malate_synthase) | 4 | LEU A 136ALA A 139LEU A 163ALA A 106 | NoneNoneNoneCOA A1002 (-3.6A) | 0.65A | 4z90F-3cv2A:2.74z90G-3cv2A:1.94z90H-3cv2A:1.84z90J-3cv2A:3.1 | 4z90F-3cv2A:22.724z90G-3cv2A:22.724z90H-3cv2A:22.724z90J-3cv2A:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv2 | MALATE SYNTHASE A (Escherichiacoli) |
PF01274(Malate_synthase) | 4 | LEU A 163ALA A 106LEU A 136ALA A 139 | NoneCOA A1002 (-3.6A)NoneNone | 0.61A | 4z90F-3cv2A:2.74z90G-3cv2A:1.94z90H-3cv2A:1.84z90J-3cv2A:3.1 | 4z90F-3cv2A:22.724z90G-3cv2A:22.724z90H-3cv2A:22.724z90J-3cv2A:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwv | DNA GYRASE, BSUBUNIT, TRUNCATED (Myxococcusxanthus) |
PF00204(DNA_gyraseB) | 4 | LEU A 343ALA A 278ALA A 274LEU A 242 | None | 0.65A | 4z90F-3cwvA:undetectable4z90G-3cwvA:undetectable4z90H-3cwvA:undetectable4z90J-3cwvA:undetectable | 4z90F-3cwvA:19.954z90G-3cwvA:19.954z90H-3cwvA:19.954z90J-3cwvA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8n | UROPORPHYRINOGEN-IIISYNTHASE (Thermusthermophilus) |
PF02602(HEM4) | 5 | LEU A 167ALA A 4ALA A 210LEU A 190ALA A 6 | None | 0.94A | 4z90F-3d8nA:undetectable4z90G-3d8nA:undetectable4z90H-3d8nA:undetectable4z90J-3d8nA:undetectable | 4z90F-3d8nA:21.054z90G-3d8nA:21.054z90H-3d8nA:21.054z90J-3d8nA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dm5 | SIGNAL RECOGNITION54 KDA PROTEIN (Pyrococcusfuriosus) |
PF00448(SRP54)PF02881(SRP54_N)PF02978(SRP_SPB) | 4 | LEU A 10LEU A 83LEU A 6ALA A 38 | None | 0.63A | 4z90F-3dm5A:3.54z90G-3dm5A:2.14z90H-3dm5A:3.44z90J-3dm5A:3.7 | 4z90F-3dm5A:21.434z90G-3dm5A:21.434z90H-3dm5A:21.434z90J-3dm5A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8t | PREDICTED ATPASEINVOLVED INREPLICATION CONTROL,CDC46/MCM FAMILY (Methanopyruskandleri) |
PF00493(MCM) | 4 | LEU A 279LEU A 271ALA A 312ALA A 319 | None | 0.61A | 4z90F-3f8tA:undetectable4z90G-3f8tA:undetectable4z90H-3f8tA:undetectable4z90J-3f8tA:undetectable | 4z90F-3f8tA:23.404z90G-3f8tA:23.404z90H-3f8tA:23.404z90J-3f8tA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8a | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE G (Thermusthermophilus) |
PF02527(GidB) | 5 | LEU A 195LEU A 163ALA A 182ALA A 180LEU A 199 | None | 1.17A | 4z90F-3g8aA:undetectable4z90G-3g8aA:undetectable4z90H-3g8aA:undetectable4z90J-3g8aA:undetectable | 4z90F-3g8aA:18.554z90G-3g8aA:18.554z90H-3g8aA:18.554z90J-3g8aA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkm | OS03G0854200 PROTEIN (Oryza sativa) |
PF01138(RNase_PH) | 4 | LEU A 84LEU A 88ALA A 126ALA A 119 | None | 0.66A | 4z90F-3hkmA:undetectable4z90G-3hkmA:undetectable4z90H-3hkmA:undetectable4z90J-3hkmA:undetectable | 4z90F-3hkmA:21.084z90G-3hkmA:21.084z90H-3hkmA:21.084z90J-3hkmA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hra | ANKYRIN REPEATFAMILY PROTEIN (Enterococcusfaecalis) |
PF12796(Ank_2)PF13857(Ank_5) | 4 | LEU A 9ALA A 13ALA A 46LEU A 25 | None | 0.65A | 4z90F-3hraA:undetectable4z90G-3hraA:undetectable4z90H-3hraA:undetectable4z90J-3hraA:undetectable | 4z90F-3hraA:21.054z90G-3hraA:21.054z90H-3hraA:21.054z90J-3hraA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hra | ANKYRIN REPEATFAMILY PROTEIN (Enterococcusfaecalis) |
PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU A 25LEU A 9ALA A 13ALA A 46ALA A 57 | None | 1.12A | 4z90F-3hraA:undetectable4z90G-3hraA:undetectable4z90H-3hraA:undetectable4z90J-3hraA:undetectable | 4z90F-3hraA:21.054z90G-3hraA:21.054z90H-3hraA:21.054z90J-3hraA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il7 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Staphylococcusaureus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | LEU A 135ALA A 62ALA A 161LEU A 94 | None | 0.67A | 4z90F-3il7A:undetectable4z90G-3il7A:undetectable4z90H-3il7A:undetectable4z90J-3il7A:undetectable | 4z90F-3il7A:23.294z90G-3il7A:23.294z90H-3il7A:23.294z90J-3il7A:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js8 | CHOLESTEROL OXIDASE (Chromobacteriumsp. DS-1) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 5 | LEU A 135ALA A 104LEU A 113LEU A 139ALA A 210 | None | 0.95A | 4z90F-3js8A:undetectable4z90G-3js8A:undetectable4z90H-3js8A:undetectable4z90J-3js8A:undetectable | 4z90F-3js8A:20.984z90G-3js8A:20.984z90H-3js8A:20.984z90J-3js8A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0s | ADENYLATE KINASE (Desulfovibriogigas) |
PF00406(ADK) | 4 | LEU A 72LEU A 69ALA A 98LEU A 82 | None | 0.67A | 4z90F-3l0sA:undetectable4z90G-3l0sA:undetectable4z90H-3l0sA:undetectable4z90J-3l0sA:undetectable | 4z90F-3l0sA:22.014z90G-3l0sA:22.014z90H-3l0sA:22.014z90J-3l0sA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lez | BETA-LACTAMASE (Oceanobacillusiheyensis) |
PF13354(Beta-lactamase2) | 5 | LEU A 60ALA A 274ALA A 64LEU A 49ALA A 294 | None | 0.90A | 4z90F-3lezA:undetectable4z90G-3lezA:undetectable4z90H-3lezA:undetectable4z90J-3lezA:undetectable | 4z90F-3lezA:20.864z90G-3lezA:20.864z90H-3lezA:20.864z90J-3lezA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lvu | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Ruegeriapomeroyi) |
PF00496(SBP_bac_5) | 5 | LEU A 440LEU A 462ALA A 339ALA A 335LEU A 438 | NoneNoneNoneNoneGOL A 604 (-4.5A) | 1.46A | 4z90F-3lvuA:undetectable4z90G-3lvuA:undetectable4z90H-3lvuA:undetectable4z90J-3lvuA:undetectable | 4z90F-3lvuA:21.884z90G-3lvuA:21.884z90H-3lvuA:21.884z90J-3lvuA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ml0 | PENICILLIN GACYLASE, BETASUBUNIT (Alcaligenesfaecalis) |
PF01804(Penicil_amidase) | 5 | LEU B 321LEU B 342ALA B 426ALA B 422LEU B 301 | None | 1.16A | 4z90F-3ml0B:undetectable4z90G-3ml0B:undetectable4z90H-3ml0B:undetectable4z90J-3ml0B:undetectable | 4z90F-3ml0B:20.434z90G-3ml0B:20.434z90H-3ml0B:20.434z90J-3ml0B:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mv3 | COATOMER SUBUNITEPSILON (Saccharomycescerevisiae) |
PF04733(Coatomer_E) | 4 | LEU B 204ALA B 216LEU B 208ALA B 251 | None | 0.66A | 4z90F-3mv3B:3.54z90G-3mv3B:3.54z90H-3mv3B:3.64z90J-3mv3B:3.4 | 4z90F-3mv3B:22.704z90G-3mv3B:22.704z90H-3mv3B:22.704z90J-3mv3B:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvk | PROTEIN FUCU (Bifidobacteriumlongum) |
PF05025(RbsD_FucU) | 4 | LEU A 56LEU A 137ALA A 106LEU A 60 | None | 0.57A | 4z90F-3mvkA:undetectable4z90G-3mvkA:undetectable4z90H-3mvkA:undetectable4z90J-3mvkA:undetectable | 4z90F-3mvkA:19.124z90G-3mvkA:19.124z90H-3mvkA:19.124z90J-3mvkA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwt | NUCLEOPROTEIN (Lassamammarenavirus) |
PF00843(Arena_nucleocap)PF17290(Arena_ncap_C) | 5 | LEU A 554LEU A 445ALA A 448ALA A 452ALA A 376 | None | 1.34A | 4z90F-3mwtA:undetectable4z90G-3mwtA:undetectable4z90H-3mwtA:undetectable4z90J-3mwtA:undetectable | 4z90F-3mwtA:20.444z90G-3mwtA:20.444z90H-3mwtA:20.444z90J-3mwtA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myu | HIGH AFFINITYTRANSPORT SYSTEMPROTEIN P37 (Mycoplasmagenitalium) |
PF06646(Mycoplasma_p37) | 4 | LEU A 59ALA A 323LEU A 63LEU A 34 | None | 0.65A | 4z90F-3myuA:undetectable4z90G-3myuA:undetectable4z90H-3myuA:undetectable4z90J-3myuA:undetectable | 4z90F-3myuA:21.434z90G-3myuA:21.434z90H-3myuA:21.434z90J-3myuA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0u | PROBABLEN-GLYCOSYLASE/DNALYASE (Thermotogamaritima) |
no annotation | 4 | LEU A 79ALA A 59LEU A 47LEU A 75 | None | 0.64A | 4z90F-3n0uA:undetectable4z90G-3n0uA:undetectable4z90H-3n0uA:undetectable4z90J-3n0uA:undetectable | 4z90F-3n0uA:20.244z90G-3n0uA:20.244z90H-3n0uA:20.244z90J-3n0uA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxs | LAO/AO TRANSPORTSYSTEM ATPASE (Mycolicibacteriumsmegmatis) |
PF03308(ArgK) | 4 | LEU A 43ALA A 25ALA A 21ALA A 144 | None | 0.66A | 4z90F-3nxsA:undetectable4z90G-3nxsA:undetectable4z90H-3nxsA:undetectable4z90J-3nxsA:undetectable | 4z90F-3nxsA:21.204z90G-3nxsA:21.204z90H-3nxsA:21.204z90J-3nxsA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9z | UROPORPHYRINOGEN IIICOSYNTHASE (HEMD) (Helicobacterpylori) |
PF02602(HEM4) | 4 | LEU A 113ALA A 136LEU A 28LEU A 38 | None | 0.68A | 4z90F-3p9zA:undetectable4z90G-3p9zA:undetectable4z90H-3p9zA:undetectable4z90J-3p9zA:undetectable | 4z90F-3p9zA:18.834z90G-3p9zA:18.834z90H-3p9zA:18.834z90J-3p9zA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnx | PUTATIVESULFURTRANSFERASEDSRE (Syntrophomonaswolfei) |
PF13686(DrsE_2) | 5 | LEU A 46ALA A 110ALA A 25LEU A 10ALA A 18 | None | 1.17A | 4z90F-3pnxA:undetectable4z90G-3pnxA:undetectable4z90H-3pnxA:undetectable4z90J-3pnxA:undetectable | 4z90F-3pnxA:19.504z90G-3pnxA:19.504z90H-3pnxA:19.504z90J-3pnxA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv2 | DEGQ (Legionellafallonii) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 4 | LEU A 412ALA A 416LEU A 355ALA A 401 | None | 0.64A | 4z90F-3pv2A:undetectable4z90G-3pv2A:undetectable4z90H-3pv2A:undetectable4z90J-3pv2A:undetectable | 4z90F-3pv2A:22.084z90G-3pv2A:22.084z90H-3pv2A:22.084z90J-3pv2A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsj | NUDIX HYDROLASE (Alicyclobacillusacidocaldarius) |
PF00293(NUDIX) | 4 | LEU A 117LEU A 121ALA A 89ALA A 81 | None | 0.62A | 4z90F-3qsjA:undetectable4z90G-3qsjA:undetectable4z90H-3qsjA:undetectable4z90J-3qsjA:undetectable | 4z90F-3qsjA:19.634z90G-3qsjA:19.634z90H-3qsjA:19.634z90J-3qsjA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rms | UNCHARACTERIZEDPROTEIN (Saccharomonosporaviridis) |
PF16827(zf-HC3) | 5 | LEU A 105LEU A 95ALA A 62ALA A 64ALA A 78 | None | 1.12A | 4z90F-3rmsA:undetectable4z90G-3rmsA:undetectable4z90H-3rmsA:undetectable4z90J-3rmsA:undetectable | 4z90F-3rmsA:16.294z90G-3rmsA:16.294z90H-3rmsA:16.294z90J-3rmsA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | LEU A 398ALA A 400LEU A 353ALA A 132LEU A 392 | None | 1.04A | 4z90F-3rv6A:undetectable4z90G-3rv6A:undetectable4z90H-3rv6A:undetectable4z90J-3rv6A:undetectable | 4z90F-3rv6A:22.544z90G-3rv6A:22.544z90H-3rv6A:22.544z90J-3rv6A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdf | DIHYDRODIPICOLINATESYNTHASE (Acinetobacterbaumannii) |
PF00701(DHDPS) | 5 | LEU A 102LEU A 130ALA A 123ALA A 125ALA A 85 | None | 1.35A | 4z90F-3tdfA:undetectable4z90G-3tdfA:undetectable4z90H-3tdfA:undetectable4z90J-3tdfA:undetectable | 4z90F-3tdfA:20.934z90G-3tdfA:20.934z90H-3tdfA:20.934z90J-3tdfA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | LEU A 75ALA A 78LEU A 146ALA A 62LEU A 66 | None | 1.26A | 4z90F-3tmaA:undetectable4z90G-3tmaA:undetectable4z90H-3tmaA:undetectable4z90J-3tmaA:undetectable | 4z90F-3tmaA:21.524z90G-3tmaA:21.524z90H-3tmaA:21.524z90J-3tmaA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tx1 | UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINEREDUCTASE (Listeriamonocytogenes) |
PF01565(FAD_binding_4)PF02873(MurB_C) | 4 | LEU A 188ALA A 95LEU A 116ALA A 108 | None | 0.64A | 4z90F-3tx1A:undetectable4z90G-3tx1A:undetectable4z90H-3tx1A:undetectable4z90J-3tx1A:undetectable | 4z90F-3tx1A:19.944z90G-3tx1A:19.944z90H-3tx1A:19.944z90J-3tx1A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va9 | SENSOR HISTIDINEKINASE (Rhodopseudomonaspalustris) |
PF05227(CHASE3) | 4 | LEU A 99ALA A 52LEU A 103ALA A 167 | None | 0.62A | 4z90F-3va9A:6.14z90G-3va9A:7.54z90H-3va9A:7.24z90J-3va9A:7.6 | 4z90F-3va9A:19.254z90G-3va9A:19.254z90H-3va9A:19.254z90J-3va9A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va9 | SENSOR HISTIDINEKINASE (Rhodopseudomonaspalustris) |
PF05227(CHASE3) | 4 | LEU A 103ALA A 167LEU A 99ALA A 52 | None | 0.62A | 4z90F-3va9A:6.14z90G-3va9A:7.54z90H-3va9A:7.24z90J-3va9A:7.6 | 4z90F-3va9A:19.254z90G-3va9A:19.254z90H-3va9A:19.254z90J-3va9A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | LEU A3855LEU A3834ALA A3837ALA A3841LEU A3567 | None | 1.32A | 4z90F-3vkgA:undetectable4z90G-3vkgA:undetectable4z90H-3vkgA:undetectable4z90J-3vkgA:undetectable | 4z90F-3vkgA:6.734z90G-3vkgA:6.734z90H-3vkgA:6.734z90J-3vkgA:6.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcx | SPHINGOMYELINASE C (Streptomycesgriseocarneus) |
PF03372(Exo_endo_phos) | 5 | ALA A 79ALA A 75ALA A 101LEU A 146ALA A 108 | None | 1.06A | 4z90F-3wcxA:undetectable4z90G-3wcxA:undetectable4z90H-3wcxA:undetectable4z90J-3wcxA:undetectable | 4z90F-3wcxA:22.594z90G-3wcxA:22.594z90H-3wcxA:22.594z90J-3wcxA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0v | L-LYSINE OXIDASE (Trichodermaviride) |
PF01593(Amino_oxidase) | 4 | LEU A 296LEU A 301ALA A 458LEU A 291 | None | 0.67A | 4z90F-3x0vA:undetectable4z90G-3x0vA:undetectable4z90H-3x0vA:undetectable4z90J-3x0vA:undetectable | 4z90F-3x0vA:21.604z90G-3x0vA:21.604z90H-3x0vA:21.604z90J-3x0vA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zpj | TON_1535 (Thermococcusonnurineus) |
no annotation | 4 | LEU A 248LEU A 290LEU A 244ALA A 269 | None | 0.60A | 4z90F-3zpjA:undetectable4z90G-3zpjA:2.64z90H-3zpjA:1.64z90J-3zpjA:1.5 | 4z90F-3zpjA:21.614z90G-3zpjA:21.614z90H-3zpjA:21.614z90J-3zpjA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ays | AMYLOSUCRASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase) | 4 | LEU A 452ALA A 494LEU A 468LEU A 456 | None | 0.67A | 4z90F-4aysA:undetectable4z90G-4aysA:undetectable4z90H-4aysA:undetectable4z90J-4aysA:undetectable | 4z90F-4aysA:18.884z90G-4aysA:18.884z90H-4aysA:18.884z90J-4aysA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b45 | CELL DIVISIONPROTEIN FTSZ (Haloferaxvolcanii) |
PF00091(Tubulin) | 5 | LEU A 315ALA A 223LEU A 217ALA A 159LEU A 193 | None | 1.19A | 4z90F-4b45A:undetectable4z90G-4b45A:undetectable4z90H-4b45A:undetectable4z90J-4b45A:undetectable | 4z90F-4b45A:22.524z90G-4b45A:22.524z90H-4b45A:22.524z90J-4b45A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bt1 | TRANSCRIPTIONALREGULATOR (Escherichiavirus Mu) |
no annotation | 4 | LEU A 380LEU A 347ALA A 321ALA A 366 | None | 0.66A | 4z90F-4bt1A:undetectable4z90G-4bt1A:undetectable4z90H-4bt1A:undetectable4z90J-4bt1A:undetectable | 4z90F-4bt1A:12.854z90G-4bt1A:12.854z90H-4bt1A:12.854z90J-4bt1A:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g25 | PENTATRICOPEPTIDEREPEAT-CONTAININGPROTEIN AT2G32230,MITOCHONDRIAL (Arabidopsisthaliana) |
PF16953(PRORP)PF17177(PPR_long) | 5 | LEU A 100LEU A 104ALA A 116LEU A 130ALA A 123 | None | 1.01A | 4z90F-4g25A:2.94z90G-4g25A:3.04z90H-4g25A:3.04z90J-4g25A:2.9 | 4z90F-4g25A:19.774z90G-4g25A:19.774z90H-4g25A:19.774z90J-4g25A:19.77 |