SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z90_A_4LEA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		5 ALA A  39
LEU A  24
ALA A  12
LEU A  26
LEU A   4
 None
 1.04A 4z90A-1a9nA:
0.0
4z90B-1a9nA:
0.0
4z90C-1a9nA:
0.0
4z90D-1a9nA:
0.0
4z90E-1a9nA:
0.0		 4z90A-1a9nA:
20.06
4z90B-1a9nA:
20.06
4z90C-1a9nA:
20.06
4z90D-1a9nA:
20.06
4z90E-1a9nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 LEU A 130
ALA A 116
LEU A 132
LEU A 277
ALA A 120
 None
 0.82A 4z90A-1azwA:
0.0
4z90B-1azwA:
0.0
4z90C-1azwA:
0.0
4z90D-1azwA:
0.0
4z90E-1azwA:
0.0		 4z90A-1azwA:
21.94
4z90B-1azwA:
21.94
4z90C-1azwA:
21.94
4z90D-1azwA:
21.94
4z90E-1azwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		5 LEU A 470
LEU A 456
LEU A 459
LEU A 485
LEU A 468
 None
 1.09A 4z90A-1dceA:
3.6
4z90B-1dceA:
3.4
4z90C-1dceA:
4.2
4z90D-1dceA:
3.4
4z90E-1dceA:
3.9		 4z90A-1dceA:
20.36
4z90B-1dceA:
20.36
4z90C-1dceA:
20.36
4z90D-1dceA:
20.36
4z90E-1dceA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		5 LEU A 485
LEU A 468
LEU A 470
LEU A 456
LEU A 459
 None
 1.12A 4z90A-1dceA:
3.6
4z90B-1dceA:
3.4
4z90C-1dceA:
4.2
4z90D-1dceA:
3.4
4z90E-1dceA:
3.9		 4z90A-1dceA:
20.36
4z90B-1dceA:
20.36
4z90C-1dceA:
20.36
4z90D-1dceA:
20.36
4z90E-1dceA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		5 LEU A   4
LEU A  53
LEU A  49
ALA A 142
LEU A  38
 None
 1.06A 4z90A-1iu8A:
1.1
4z90B-1iu8A:
0.0
4z90C-1iu8A:
0.0
4z90D-1iu8A:
1.1
4z90E-1iu8A:
1.2		 4z90A-1iu8A:
21.26
4z90B-1iu8A:
21.26
4z90C-1iu8A:
21.26
4z90D-1iu8A:
21.26
4z90E-1iu8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		5 LEU A  49
ALA A 142
LEU A  38
LEU A   4
LEU A  53
 None
 1.07A 4z90A-1iu8A:
1.1
4z90B-1iu8A:
0.0
4z90C-1iu8A:
0.0
4z90D-1iu8A:
1.1
4z90E-1iu8A:
1.2		 4z90A-1iu8A:
21.26
4z90B-1iu8A:
21.26
4z90C-1iu8A:
21.26
4z90D-1iu8A:
21.26
4z90E-1iu8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Thermus
thermophilus) 		PF02542
(YgbB) 		5 LEU A  44
ALA A  94
LEU A 116
LEU A  98
ALA A 146
 None
 1.07A 4z90A-1iv3A:
0.0
4z90B-1iv3A:
0.0
4z90C-1iv3A:
0.0
4z90D-1iv3A:
0.0
4z90E-1iv3A:
0.0		 4z90A-1iv3A:
18.61
4z90B-1iv3A:
18.61
4z90C-1iv3A:
18.61
4z90D-1iv3A:
18.61
4z90E-1iv3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 LEU A  22
ALA A 150
LEU A 215
LEU A 219
LEU A   9
 None
 1.05A 4z90A-1jnyA:
undetectable
4z90B-1jnyA:
undetectable
4z90C-1jnyA:
undetectable
4z90D-1jnyA:
undetectable
4z90E-1jnyA:
undetectable		 4z90A-1jnyA:
21.35
4z90B-1jnyA:
21.35
4z90C-1jnyA:
21.35
4z90D-1jnyA:
21.35
4z90E-1jnyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ALA A 510
ALA A 521
LEU A 490
LEU A 474
ALA A 478
 None
 0.98A 4z90A-1n11A:
0.0
4z90B-1n11A:
0.0
4z90C-1n11A:
0.0
4z90D-1n11A:
0.0
4z90E-1n11A:
0.0		 4z90A-1n11A:
18.64
4z90B-1n11A:
18.64
4z90C-1n11A:
18.64
4z90D-1n11A:
18.64
4z90E-1n11A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 ALA A 211
LEU A  65
ALA A  36
LEU A  69
ALA A  43
 None
 1.06A 4z90A-1o9gA:
0.0
4z90B-1o9gA:
0.0
4z90C-1o9gA:
0.0
4z90D-1o9gA:
0.0
4z90E-1o9gA:
0.0		 4z90A-1o9gA:
24.11
4z90B-1o9gA:
24.11
4z90C-1o9gA:
24.11
4z90D-1o9gA:
24.11
4z90E-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 ALA A 211
LEU A  65
ALA A  36
LEU A  69
LEU A  55
 None
 1.13A 4z90A-1o9gA:
0.0
4z90B-1o9gA:
0.0
4z90C-1o9gA:
0.0
4z90D-1o9gA:
0.0
4z90E-1o9gA:
0.0		 4z90A-1o9gA:
24.11
4z90B-1o9gA:
24.11
4z90C-1o9gA:
24.11
4z90D-1o9gA:
24.11
4z90E-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 LEU A  69
LEU A  55
ALA A 211
LEU A  65
ALA A  36
 None
 1.14A 4z90A-1o9gA:
0.0
4z90B-1o9gA:
0.0
4z90C-1o9gA:
0.0
4z90D-1o9gA:
0.0
4z90E-1o9gA:
0.0		 4z90A-1o9gA:
24.11
4z90B-1o9gA:
24.11
4z90C-1o9gA:
24.11
4z90D-1o9gA:
24.11
4z90E-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on0 YYCN PROTEIN

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 LEU A 125
ALA A  89
LEU A  76
LEU A 113
ALA A 117
 None
 1.15A 4z90A-1on0A:
undetectable
4z90B-1on0A:
0.0
4z90C-1on0A:
0.0
4z90D-1on0A:
0.0
4z90E-1on0A:
0.0		 4z90A-1on0A:
18.07
4z90B-1on0A:
18.07
4z90C-1on0A:
18.07
4z90D-1on0A:
18.07
4z90E-1on0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		5 LEU A  46
ALA A 118
LEU A 120
ALA A 209
LEU A 100
 None
 1.12A 4z90A-1pq5A:
undetectable
4z90B-1pq5A:
undetectable
4z90C-1pq5A:
undetectable
4z90D-1pq5A:
undetectable
4z90E-1pq5A:
undetectable		 4z90A-1pq5A:
22.12
4z90B-1pq5A:
22.12
4z90C-1pq5A:
22.12
4z90D-1pq5A:
22.12
4z90E-1pq5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		5 LEU A 100
LEU A  46
ALA A 118
LEU A 120
ALA A 209
 None
 1.08A 4z90A-1pq5A:
undetectable
4z90B-1pq5A:
undetectable
4z90C-1pq5A:
undetectable
4z90D-1pq5A:
undetectable
4z90E-1pq5A:
undetectable		 4z90A-1pq5A:
22.12
4z90B-1pq5A:
22.12
4z90C-1pq5A:
22.12
4z90D-1pq5A:
22.12
4z90E-1pq5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 LEU A 846
LEU A  60
LEU A  63
LEU A  68
ALA A  72
 None
 1.14A 4z90A-1qb4A:
3.6
4z90B-1qb4A:
3.7
4z90C-1qb4A:
3.9
4z90D-1qb4A:
3.9
4z90E-1qb4A:
3.8		 4z90A-1qb4A:
16.69
4z90B-1qb4A:
16.69
4z90C-1qb4A:
16.69
4z90D-1qb4A:
16.69
4z90E-1qb4A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		5 LEU A  54
ALA A 170
LEU A  64
LEU A  66
LEU A  23
 None
 0.95A 4z90A-1qcjA:
undetectable
4z90B-1qcjA:
undetectable
4z90C-1qcjA:
undetectable
4z90D-1qcjA:
undetectable
4z90E-1qcjA:
undetectable		 4z90A-1qcjA:
23.78
4z90B-1qcjA:
23.78
4z90C-1qcjA:
23.78
4z90D-1qcjA:
23.78
4z90E-1qcjA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		5 ALA A 111
LEU A  89
LEU A   7
LEU A  21
ALA A 115
 None
 0.91A 4z90A-1rc7A:
undetectable
4z90B-1rc7A:
undetectable
4z90C-1rc7A:
undetectable
4z90D-1rc7A:
undetectable
4z90E-1rc7A:
undetectable		 4z90A-1rc7A:
21.13
4z90B-1rc7A:
21.13
4z90C-1rc7A:
21.13
4z90D-1rc7A:
21.13
4z90E-1rc7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 254
LEU B 236
LEU B 234
LEU B 400
ALA B 398
 None
 1.16A 4z90A-1tqyB:
undetectable
4z90B-1tqyB:
undetectable
4z90C-1tqyB:
undetectable
4z90D-1tqyB:
undetectable
4z90E-1tqyB:
undetectable		 4z90A-1tqyB:
23.49
4z90B-1tqyB:
23.49
4z90C-1tqyB:
23.49
4z90D-1tqyB:
23.49
4z90E-1tqyB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 131
LEU D 136
LEU D 139
LEU D 143
ALA D 119
 None
 1.17A 4z90A-1u0nD:
undetectable
4z90B-1u0nD:
undetectable
4z90C-1u0nD:
undetectable
4z90D-1u0nD:
undetectable
4z90E-1u0nD:
undetectable		 4z90A-1u0nD:
21.55
4z90B-1u0nD:
21.55
4z90C-1u0nD:
21.55
4z90D-1u0nD:
21.55
4z90E-1u0nD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 359
LEU A 341
ALA A 412
LEU A 376
LEU A 379
 None
 1.02A 4z90A-1uagA:
undetectable
4z90B-1uagA:
undetectable
4z90C-1uagA:
undetectable
4z90D-1uagA:
undetectable
4z90E-1uagA:
undetectable		 4z90A-1uagA:
21.38
4z90B-1uagA:
21.38
4z90C-1uagA:
21.38
4z90D-1uagA:
21.38
4z90E-1uagA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		5 ALA A  37
LEU A 185
LEU A 183
LEU A 217
ALA A  35
 None
 1.14A 4z90A-1uf3A:
undetectable
4z90B-1uf3A:
undetectable
4z90C-1uf3A:
undetectable
4z90D-1uf3A:
undetectable
4z90E-1uf3A:
undetectable		 4z90A-1uf3A:
20.25
4z90B-1uf3A:
20.25
4z90C-1uf3A:
20.25
4z90D-1uf3A:
20.25
4z90E-1uf3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		5 LEU A  90
LEU A 210
LEU A 206
LEU A 134
LEU A  86
 None
 1.15A 4z90A-1v4aA:
3.0
4z90B-1v4aA:
3.1
4z90C-1v4aA:
3.1
4z90D-1v4aA:
3.1
4z90E-1v4aA:
3.1		 4z90A-1v4aA:
21.62
4z90B-1v4aA:
21.62
4z90C-1v4aA:
21.62
4z90D-1v4aA:
21.62
4z90E-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		5 LEU A 134
LEU A  86
LEU A  90
LEU A 210
LEU A 206
 None
 1.14A 4z90A-1v4aA:
3.0
4z90B-1v4aA:
3.1
4z90C-1v4aA:
3.1
4z90D-1v4aA:
3.1
4z90E-1v4aA:
3.1		 4z90A-1v4aA:
21.62
4z90B-1v4aA:
21.62
4z90C-1v4aA:
21.62
4z90D-1v4aA:
21.62
4z90E-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 536
ALA A 539
LEU A 562
ALA A 555
LEU A 526
 None
 0.87A 4z90A-1v9pA:
2.9
4z90B-1v9pA:
3.0
4z90C-1v9pA:
2.5
4z90D-1v9pA:
2.7
4z90E-1v9pA:
2.9		 4z90A-1v9pA:
20.18
4z90B-1v9pA:
20.18
4z90C-1v9pA:
20.18
4z90D-1v9pA:
20.18
4z90E-1v9pA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 175
ALA A  12
LEU A 179
LEU A 212
ALA A  14
 None
 1.02A 4z90A-1wcxA:
undetectable
4z90B-1wcxA:
undetectable
4z90C-1wcxA:
undetectable
4z90D-1wcxA:
undetectable
4z90E-1wcxA:
undetectable		 4z90A-1wcxA:
19.17
4z90B-1wcxA:
19.17
4z90C-1wcxA:
19.17
4z90D-1wcxA:
19.17
4z90E-1wcxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 175
ALA A  14
LEU A 187
LEU A 212
LEU A 208
 None
 1.09A 4z90A-1wcxA:
undetectable
4z90B-1wcxA:
undetectable
4z90C-1wcxA:
undetectable
4z90D-1wcxA:
undetectable
4z90E-1wcxA:
undetectable		 4z90A-1wcxA:
19.17
4z90B-1wcxA:
19.17
4z90C-1wcxA:
19.17
4z90D-1wcxA:
19.17
4z90E-1wcxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 175
LEU A 179
LEU A 212
ALA A 218
ALA A  14
 None
 1.07A 4z90A-1wcxA:
undetectable
4z90B-1wcxA:
undetectable
4z90C-1wcxA:
undetectable
4z90D-1wcxA:
undetectable
4z90E-1wcxA:
undetectable		 4z90A-1wcxA:
19.17
4z90B-1wcxA:
19.17
4z90C-1wcxA:
19.17
4z90D-1wcxA:
19.17
4z90E-1wcxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 187
LEU A 212
LEU A 208
LEU A 175
ALA A  14
 None
 1.10A 4z90A-1wcxA:
undetectable
4z90B-1wcxA:
undetectable
4z90C-1wcxA:
undetectable
4z90D-1wcxA:
undetectable
4z90E-1wcxA:
undetectable		 4z90A-1wcxA:
19.17
4z90B-1wcxA:
19.17
4z90C-1wcxA:
19.17
4z90D-1wcxA:
19.17
4z90E-1wcxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 208
LEU A 175
ALA A  14
LEU A 187
LEU A 212
 None
 1.08A 4z90A-1wcxA:
undetectable
4z90B-1wcxA:
undetectable
4z90C-1wcxA:
undetectable
4z90D-1wcxA:
undetectable
4z90E-1wcxA:
undetectable		 4z90A-1wcxA:
19.17
4z90B-1wcxA:
19.17
4z90C-1wcxA:
19.17
4z90D-1wcxA:
19.17
4z90E-1wcxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 212
ALA A 218
ALA A  14
LEU A 175
LEU A 179
 None
 1.05A 4z90A-1wcxA:
undetectable
4z90B-1wcxA:
undetectable
4z90C-1wcxA:
undetectable
4z90D-1wcxA:
undetectable
4z90E-1wcxA:
undetectable		 4z90A-1wcxA:
19.17
4z90B-1wcxA:
19.17
4z90C-1wcxA:
19.17
4z90D-1wcxA:
19.17
4z90E-1wcxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 LEU A 316
ALA A 286
LEU A 356
ALA A 301
LEU A 325
 None
 1.13A 4z90A-1wdtA:
undetectable
4z90B-1wdtA:
undetectable
4z90C-1wdtA:
undetectable
4z90D-1wdtA:
undetectable
4z90E-1wdtA:
undetectable		 4z90A-1wdtA:
19.25
4z90B-1wdtA:
19.25
4z90C-1wdtA:
19.25
4z90D-1wdtA:
19.25
4z90E-1wdtA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		5 LEU C 392
ALA C 316
LEU C 312
LEU C 309
ALA C 332
 None
 1.06A 4z90A-2advC:
undetectable
4z90B-2advC:
undetectable
4z90C-2advC:
undetectable
4z90D-2advC:
undetectable
4z90E-2advC:
undetectable		 4z90A-2advC:
21.65
4z90B-2advC:
21.65
4z90C-2advC:
21.65
4z90D-2advC:
21.65
4z90E-2advC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 LEU A 537
LEU A 572
LEU A 554
LEU A 412
ALA A 410
 None
 1.11A 4z90A-2d0oA:
undetectable
4z90B-2d0oA:
undetectable
4z90C-2d0oA:
undetectable
4z90D-2d0oA:
undetectable
4z90E-2d0oA:
1.7		 4z90A-2d0oA:
20.41
4z90B-2d0oA:
20.41
4z90C-2d0oA:
20.41
4z90D-2d0oA:
20.41
4z90E-2d0oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 LEU A 554
LEU A 412
ALA A 410
LEU A 537
LEU A 572
 None
 1.13A 4z90A-2d0oA:
undetectable
4z90B-2d0oA:
undetectable
4z90C-2d0oA:
undetectable
4z90D-2d0oA:
undetectable
4z90E-2d0oA:
1.7		 4z90A-2d0oA:
20.41
4z90B-2d0oA:
20.41
4z90C-2d0oA:
20.41
4z90D-2d0oA:
20.41
4z90E-2d0oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
ALA A 127
LEU A 100
ALA A 120
LEU A 114
 None
 0.95A 4z90A-2douA:
undetectable
4z90B-2douA:
undetectable
4z90C-2douA:
undetectable
4z90D-2douA:
undetectable
4z90E-2douA:
undetectable		 4z90A-2douA:
23.15
4z90B-2douA:
23.15
4z90C-2douA:
23.15
4z90D-2douA:
23.15
4z90E-2douA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 114
LEU A 104
ALA A 127
LEU A 100
ALA A 120
 None
 0.95A 4z90A-2douA:
undetectable
4z90B-2douA:
undetectable
4z90C-2douA:
undetectable
4z90D-2douA:
undetectable
4z90E-2douA:
undetectable		 4z90A-2douA:
23.15
4z90B-2douA:
23.15
4z90C-2douA:
23.15
4z90D-2douA:
23.15
4z90E-2douA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		5 ALA A 188
LEU A  62
LEU A  64
LEU A  21
LEU A  25
 None
 1.13A 4z90A-2ebjA:
undetectable
4z90B-2ebjA:
undetectable
4z90C-2ebjA:
undetectable
4z90D-2ebjA:
undetectable
4z90E-2ebjA:
undetectable		 4z90A-2ebjA:
21.90
4z90B-2ebjA:
21.90
4z90C-2ebjA:
21.90
4z90D-2ebjA:
21.90
4z90E-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		5 LEU A  21
LEU A  25
ALA A 188
LEU A  62
LEU A  64
 None
 1.10A 4z90A-2ebjA:
undetectable
4z90B-2ebjA:
undetectable
4z90C-2ebjA:
undetectable
4z90D-2ebjA:
undetectable
4z90E-2ebjA:
undetectable		 4z90A-2ebjA:
21.90
4z90B-2ebjA:
21.90
4z90C-2ebjA:
21.90
4z90D-2ebjA:
21.90
4z90E-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		5 LEU A  62
LEU A  64
LEU A  21
LEU A  25
ALA A 188
 None
 1.06A 4z90A-2ebjA:
undetectable
4z90B-2ebjA:
undetectable
4z90C-2ebjA:
undetectable
4z90D-2ebjA:
undetectable
4z90E-2ebjA:
undetectable		 4z90A-2ebjA:
21.90
4z90B-2ebjA:
21.90
4z90C-2ebjA:
21.90
4z90D-2ebjA:
21.90
4z90E-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A 244
ALA A 220
LEU A 287
LEU A  86
ALA A 255
 None
 1.15A 4z90A-2ffhA:
2.2
4z90B-2ffhA:
1.8
4z90C-2ffhA:
1.8
4z90D-2ffhA:
1.9
4z90E-2ffhA:
1.9		 4z90A-2ffhA:
21.31
4z90B-2ffhA:
21.31
4z90C-2ffhA:
21.31
4z90D-2ffhA:
21.31
4z90E-2ffhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 LEU A 166
ALA A 126
LEU A  98
LEU A  83
ALA A 111
 None
None
None
None
FAD  A 601 (-4.1A)
 0.88A 4z90A-2gqtA:
undetectable
4z90B-2gqtA:
undetectable
4z90C-2gqtA:
undetectable
4z90D-2gqtA:
undetectable
4z90E-2gqtA:
undetectable		 4z90A-2gqtA:
20.93
4z90B-2gqtA:
20.93
4z90C-2gqtA:
20.93
4z90D-2gqtA:
20.93
4z90E-2gqtA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwj HYPOTHETICAL PROTEIN
ATU1540

(Agrobacterium
fabrum) 		PF08857
(ParBc_2) 		5 LEU A 182
ALA A 142
LEU A 139
LEU A 165
ALA A 146
 None
 1.03A 4z90A-2hwjA:
undetectable
4z90B-2hwjA:
undetectable
4z90C-2hwjA:
undetectable
4z90D-2hwjA:
undetectable
4z90E-2hwjA:
undetectable		 4z90A-2hwjA:
20.12
4z90B-2hwjA:
20.12
4z90C-2hwjA:
20.12
4z90D-2hwjA:
20.12
4z90E-2hwjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8i NP275

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  57
LEU A  67
ALA A  90
LEU A  77
ALA A  75
 None
 1.04A 4z90A-2j8iA:
undetectable
4z90B-2j8iA:
undetectable
4z90C-2j8iA:
undetectable
4z90D-2j8iA:
undetectable
4z90E-2j8iA:
undetectable		 4z90A-2j8iA:
14.33
4z90B-2j8iA:
14.33
4z90C-2j8iA:
14.33
4z90D-2j8iA:
14.33
4z90E-2j8iA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  37
LEU A  47
ALA A  70
LEU A  57
ALA A  55
 None
 1.08A 4z90A-2j8kA:
undetectable
4z90B-2j8kA:
undetectable
4z90C-2j8kA:
undetectable
4z90D-2j8kA:
undetectable
4z90E-2j8kA:
undetectable		 4z90A-2j8kA:
18.60
4z90B-2j8kA:
18.60
4z90C-2j8kA:
18.60
4z90D-2j8kA:
18.60
4z90E-2j8kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  57
LEU A  67
ALA A  90
LEU A  77
ALA A  75
 None
 1.05A 4z90A-2j8kA:
undetectable
4z90B-2j8kA:
undetectable
4z90C-2j8kA:
undetectable
4z90D-2j8kA:
undetectable
4z90E-2j8kA:
undetectable		 4z90A-2j8kA:
18.60
4z90B-2j8kA:
18.60
4z90C-2j8kA:
18.60
4z90D-2j8kA:
18.60
4z90E-2j8kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A  92
LEU A 102
ALA A 125
LEU A 112
ALA A 110
 None
 1.10A 4z90A-2j8kA:
undetectable
4z90B-2j8kA:
undetectable
4z90C-2j8kA:
undetectable
4z90D-2j8kA:
undetectable
4z90E-2j8kA:
undetectable		 4z90A-2j8kA:
18.60
4z90B-2j8kA:
18.60
4z90C-2j8kA:
18.60
4z90D-2j8kA:
18.60
4z90E-2j8kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A 102
LEU A 112
ALA A 135
LEU A 122
ALA A 120
 None
 1.10A 4z90A-2j8kA:
undetectable
4z90B-2j8kA:
undetectable
4z90C-2j8kA:
undetectable
4z90D-2j8kA:
undetectable
4z90E-2j8kA:
undetectable		 4z90A-2j8kA:
18.60
4z90B-2j8kA:
18.60
4z90C-2j8kA:
18.60
4z90D-2j8kA:
18.60
4z90E-2j8kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A 122
LEU A 132
ALA A 155
LEU A 142
ALA A 140
 None
 1.10A 4z90A-2j8kA:
undetectable
4z90B-2j8kA:
undetectable
4z90C-2j8kA:
undetectable
4z90D-2j8kA:
undetectable
4z90E-2j8kA:
undetectable		 4z90A-2j8kA:
18.60
4z90B-2j8kA:
18.60
4z90C-2j8kA:
18.60
4z90D-2j8kA:
18.60
4z90E-2j8kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A 127
LEU A 137
ALA A 160
LEU A 147
ALA A 145
 None
 1.03A 4z90A-2j8kA:
undetectable
4z90B-2j8kA:
undetectable
4z90C-2j8kA:
undetectable
4z90D-2j8kA:
undetectable
4z90E-2j8kA:
undetectable		 4z90A-2j8kA:
18.60
4z90B-2j8kA:
18.60
4z90C-2j8kA:
18.60
4z90D-2j8kA:
18.60
4z90E-2j8kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxt HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN Q

(Homo sapiens) 		no annotation 5 LEU A  21
LEU A  55
ALA A  51
LEU A  73
ALA A  39
 None
 1.02A 4z90A-2mxtA:
undetectable
4z90B-2mxtA:
undetectable
4z90C-2mxtA:
undetectable
4z90D-2mxtA:
undetectable
4z90E-2mxtA:
undetectable		 4z90A-2mxtA:
14.20
4z90B-2mxtA:
14.20
4z90C-2mxtA:
14.20
4z90D-2mxtA:
14.20
4z90E-2mxtA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		5 LEU A 126
ALA A  12
LEU A 130
LEU A 139
ALA A 116
 None
ASL  A  11 ( 3.3A)
None
None
None
 1.12A 4z90A-2no5A:
1.3
4z90B-2no5A:
undetectable
4z90C-2no5A:
undetectable
4z90D-2no5A:
undetectable
4z90E-2no5A:
undetectable		 4z90A-2no5A:
19.57
4z90B-2no5A:
19.57
4z90C-2no5A:
19.57
4z90D-2no5A:
19.57
4z90E-2no5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 LEU A 137
LEU A 142
LEU A 147
ALA A 150
ALA A 135
 None
 1.07A 4z90A-2o6wA:
undetectable
4z90B-2o6wA:
undetectable
4z90C-2o6wA:
undetectable
4z90D-2o6wA:
undetectable
4z90E-2o6wA:
undetectable		 4z90A-2o6wA:
20.82
4z90B-2o6wA:
20.82
4z90C-2o6wA:
20.82
4z90D-2o6wA:
20.82
4z90E-2o6wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 LEU A  60
LEU A 281
LEU A 214
ALA A  46
LEU A  72
 None
 1.11A 4z90A-2rd5A:
undetectable
4z90B-2rd5A:
undetectable
4z90C-2rd5A:
undetectable
4z90D-2rd5A:
undetectable
4z90E-2rd5A:
undetectable		 4z90A-2rd5A:
23.46
4z90B-2rd5A:
23.46
4z90C-2rd5A:
23.46
4z90D-2rd5A:
23.46
4z90E-2rd5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 LEU A  72
LEU A  60
LEU A 281
LEU A 214
ALA A  46
 None
 1.12A 4z90A-2rd5A:
undetectable
4z90B-2rd5A:
undetectable
4z90C-2rd5A:
undetectable
4z90D-2rd5A:
undetectable
4z90E-2rd5A:
undetectable		 4z90A-2rd5A:
23.46
4z90B-2rd5A:
23.46
4z90C-2rd5A:
23.46
4z90D-2rd5A:
23.46
4z90E-2rd5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 LEU A 214
ALA A  46
LEU A  72
LEU A  60
LEU A 281
 None
 1.17A 4z90A-2rd5A:
undetectable
4z90B-2rd5A:
undetectable
4z90C-2rd5A:
undetectable
4z90D-2rd5A:
undetectable
4z90E-2rd5A:
undetectable		 4z90A-2rd5A:
23.46
4z90B-2rd5A:
23.46
4z90C-2rd5A:
23.46
4z90D-2rd5A:
23.46
4z90E-2rd5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 LEU A 222
LEU A 132
ALA A 118
LEU A 134
LEU A 248
 None
 1.12A 4z90A-2ri6A:
undetectable
4z90B-2ri6A:
undetectable
4z90C-2ri6A:
undetectable
4z90D-2ri6A:
undetectable
4z90E-2ri6A:
undetectable		 4z90A-2ri6A:
21.66
4z90B-2ri6A:
21.66
4z90C-2ri6A:
21.66
4z90D-2ri6A:
21.66
4z90E-2ri6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw9 SINGLE-STRANDED DNA
BINDING PROTEIN

(Helicobacter
pylori) 		PF00436
(SSB) 		5 LEU A1055
ALA A1099
LEU A1102
LEU A1011
ALA A1053
 None
 1.08A 4z90A-2vw9A:
undetectable
4z90B-2vw9A:
undetectable
4z90C-2vw9A:
undetectable
4z90D-2vw9A:
undetectable
4z90E-2vw9A:
undetectable		 4z90A-2vw9A:
16.84
4z90B-2vw9A:
16.84
4z90C-2vw9A:
16.84
4z90D-2vw9A:
16.84
4z90E-2vw9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 LEU A 259
LEU A  26
LEU A  30
ALA A 291
LEU A 252
 None
 1.17A 4z90A-2ypqA:
0.2
4z90B-2ypqA:
0.4
4z90C-2ypqA:
0.2
4z90D-2ypqA:
undetectable
4z90E-2ypqA:
undetectable		 4z90A-2ypqA:
21.75
4z90B-2ypqA:
21.75
4z90C-2ypqA:
21.75
4z90D-2ypqA:
21.75
4z90E-2ypqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 832
LEU A 841
LEU A 845
LEU A 884
LEU A 867
 None
 1.06A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 845
LEU A 884
LEU A 867
LEU A 832
LEU A 841
 None
 1.05A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 867
LEU A 832
LEU A 841
LEU A 845
LEU A 884
 None
 1.03A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 884
LEU A 867
LEU A 832
LEU A 841
LEU A 845
 None
 1.04A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 167
ALA A   4
ALA A 210
LEU A 190
ALA A   6
 None
 0.94A 4z90A-3d8nA:
undetectable
4z90B-3d8nA:
undetectable
4z90C-3d8nA:
undetectable
4z90D-3d8nA:
undetectable
4z90E-3d8nA:
undetectable		 4z90A-3d8nA:
21.05
4z90B-3d8nA:
21.05
4z90C-3d8nA:
21.05
4z90D-3d8nA:
21.05
4z90E-3d8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 167
ALA A   4
LEU A 204
ALA A 210
ALA A   6
 None
 1.08A 4z90A-3d8nA:
undetectable
4z90B-3d8nA:
undetectable
4z90C-3d8nA:
undetectable
4z90D-3d8nA:
undetectable
4z90E-3d8nA:
undetectable		 4z90A-3d8nA:
21.05
4z90B-3d8nA:
21.05
4z90C-3d8nA:
21.05
4z90D-3d8nA:
21.05
4z90E-3d8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 167
ALA A   6
LEU A 179
LEU A 204
LEU A 200
 None
 1.13A 4z90A-3d8nA:
undetectable
4z90B-3d8nA:
undetectable
4z90C-3d8nA:
undetectable
4z90D-3d8nA:
undetectable
4z90E-3d8nA:
undetectable		 4z90A-3d8nA:
21.05
4z90B-3d8nA:
21.05
4z90C-3d8nA:
21.05
4z90D-3d8nA:
21.05
4z90E-3d8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 179
LEU A 204
LEU A 200
LEU A 167
ALA A   6
 None
 1.13A 4z90A-3d8nA:
undetectable
4z90B-3d8nA:
undetectable
4z90C-3d8nA:
undetectable
4z90D-3d8nA:
undetectable
4z90E-3d8nA:
undetectable		 4z90A-3d8nA:
21.05
4z90B-3d8nA:
21.05
4z90C-3d8nA:
21.05
4z90D-3d8nA:
21.05
4z90E-3d8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 LEU A 200
LEU A 167
ALA A   6
LEU A 179
LEU A 204
 None
 1.11A 4z90A-3d8nA:
undetectable
4z90B-3d8nA:
undetectable
4z90C-3d8nA:
undetectable
4z90D-3d8nA:
undetectable
4z90E-3d8nA:
undetectable		 4z90A-3d8nA:
21.05
4z90B-3d8nA:
21.05
4z90C-3d8nA:
21.05
4z90D-3d8nA:
21.05
4z90E-3d8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  57
LEU X  72
LEU X  67
ALA X  85
ALA X  80
 None
 1.16A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  82
LEU X  92
ALA X 115
LEU X 102
ALA X 100
 None
 0.98A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X  92
ALA X 115
LEU X 102
ALA X 100
LEU X  82
 None
 1.00A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 167
LEU X 185
ALA X 208
LEU X 195
ALA X 193
 None
 1.04A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 185
LEU X 162
LEU X 167
ALA X 170
ALA X 183
 None
 1.02A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 185
LEU X 190
LEU X 195
ALA X 198
ALA X 183
 None
 1.18A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 215
LEU X 220
LEU X 225
ALA X 228
ALA X 213
 None
 1.12A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 225
ALA X 228
ALA X 213
LEU X 215
LEU X 220
 None
 1.16A 4z90A-3du1X:
undetectable
4z90B-3du1X:
undetectable
4z90C-3du1X:
undetectable
4z90D-3du1X:
undetectable
4z90E-3du1X:
undetectable		 4z90A-3du1X:
20.92
4z90B-3du1X:
20.92
4z90C-3du1X:
20.92
4z90D-3du1X:
20.92
4z90E-3du1X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		5 LEU A  65
ALA A 104
ALA A 124
LEU A 120
LEU A  67
 None
 1.17A 4z90A-3fijA:
undetectable
4z90B-3fijA:
undetectable
4z90C-3fijA:
undetectable
4z90D-3fijA:
undetectable
4z90E-3fijA:
undetectable		 4z90A-3fijA:
21.92
4z90B-3fijA:
21.92
4z90C-3fijA:
21.92
4z90D-3fijA:
21.92
4z90E-3fijA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		5 LEU A 120
LEU A  67
LEU A  65
ALA A 104
ALA A 124
 None
 1.15A 4z90A-3fijA:
undetectable
4z90B-3fijA:
undetectable
4z90C-3fijA:
undetectable
4z90D-3fijA:
undetectable
4z90E-3fijA:
undetectable		 4z90A-3fijA:
21.92
4z90B-3fijA:
21.92
4z90C-3fijA:
21.92
4z90D-3fijA:
21.92
4z90E-3fijA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		5 ALA A 180
LEU A 171
LEU A 199
LEU A 195
ALA A 182
 None
 1.09A 4z90A-3g8aA:
undetectable
4z90B-3g8aA:
undetectable
4z90C-3g8aA:
undetectable
4z90D-3g8aA:
undetectable
4z90E-3g8aA:
undetectable		 4z90A-3g8aA:
18.55
4z90B-3g8aA:
18.55
4z90C-3g8aA:
18.55
4z90D-3g8aA:
18.55
4z90E-3g8aA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		5 LEU A 169
LEU A 181
LEU A 226
ALA A 249
ALA A 165
 None
 1.09A 4z90A-3h2bA:
undetectable
4z90B-3h2bA:
undetectable
4z90C-3h2bA:
undetectable
4z90D-3h2bA:
undetectable
4z90E-3h2bA:
undetectable		 4z90A-3h2bA:
21.43
4z90B-3h2bA:
21.43
4z90C-3h2bA:
21.43
4z90D-3h2bA:
21.43
4z90E-3h2bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hra ANKYRIN REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A  46
ALA A  57
LEU A  25
LEU A   9
ALA A  13
 None
 1.09A 4z90A-3hraA:
undetectable
4z90B-3hraA:
undetectable
4z90C-3hraA:
undetectable
4z90D-3hraA:
undetectable
4z90E-3hraA:
undetectable		 4z90A-3hraA:
21.05
4z90B-3hraA:
21.05
4z90C-3hraA:
21.05
4z90D-3hraA:
21.05
4z90E-3hraA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 ALA 3 493
LEU 3 480
LEU 3 524
LEU 3 505
ALA 3 449
 None
 0.95A 4z90A-3i9v3:
undetectable
4z90B-3i9v3:
undetectable
4z90C-3i9v3:
undetectable
4z90D-3i9v3:
undetectable
4z90E-3i9v3:
undetectable		 4z90A-3i9v3:
15.34
4z90B-3i9v3:
15.34
4z90C-3i9v3:
15.34
4z90D-3i9v3:
15.34
4z90E-3i9v3:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A 135
ALA A 104
LEU A 113
LEU A 139
ALA A 210
 None
 1.06A 4z90A-3js8A:
undetectable
4z90B-3js8A:
undetectable
4z90C-3js8A:
0.7
4z90D-3js8A:
undetectable
4z90E-3js8A:
undetectable		 4z90A-3js8A:
20.98
4z90B-3js8A:
20.98
4z90C-3js8A:
20.98
4z90D-3js8A:
20.98
4z90E-3js8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		5 ALA A  64
LEU A  49
ALA A 294
LEU A  60
ALA A 274
 None
 0.86A 4z90A-3lezA:
undetectable
4z90B-3lezA:
undetectable
4z90C-3lezA:
undetectable
4z90D-3lezA:
undetectable
4z90E-3lezA:
undetectable		 4z90A-3lezA:
20.86
4z90B-3lezA:
20.86
4z90C-3lezA:
20.86
4z90D-3lezA:
20.86
4z90E-3lezA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 ALA A 106
LEU A  65
LEU A  60
LEU A  56
LEU A 137
 None
 0.73A 4z90A-3mvkA:
undetectable
4z90B-3mvkA:
undetectable
4z90C-3mvkA:
undetectable
4z90D-3mvkA:
undetectable
4z90E-3mvkA:
undetectable		 4z90A-3mvkA:
19.12
4z90B-3mvkA:
19.12
4z90C-3mvkA:
19.12
4z90D-3mvkA:
19.12
4z90E-3mvkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 LEU A  56
LEU A 137
ALA A 106
LEU A  65
LEU A  60
 None
 0.72A 4z90A-3mvkA:
undetectable
4z90B-3mvkA:
undetectable
4z90C-3mvkA:
undetectable
4z90D-3mvkA:
undetectable
4z90E-3mvkA:
undetectable		 4z90A-3mvkA:
19.12
4z90B-3mvkA:
19.12
4z90C-3mvkA:
19.12
4z90D-3mvkA:
19.12
4z90E-3mvkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 LEU A  65
LEU A  60
LEU A  56
LEU A 137
ALA A 106
 None
 0.69A 4z90A-3mvkA:
undetectable
4z90B-3mvkA:
undetectable
4z90C-3mvkA:
undetectable
4z90D-3mvkA:
undetectable
4z90E-3mvkA:
undetectable		 4z90A-3mvkA:
19.12
4z90B-3mvkA:
19.12
4z90C-3mvkA:
19.12
4z90D-3mvkA:
19.12
4z90E-3mvkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 208
LEU A 185
LEU A 218
LEU A 228
ALA A 226
 None
 1.05A 4z90A-3nawA:
0.0
4z90B-3nawA:
1.8
4z90C-3nawA:
1.8
4z90D-3nawA:
1.8
4z90E-3nawA:
1.8		 4z90A-3nawA:
20.13
4z90B-3nawA:
20.13
4z90C-3nawA:
20.13
4z90D-3nawA:
20.13
4z90E-3nawA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 218
LEU A 228
ALA A 226
LEU A 208
LEU A 185
 None
 1.08A 4z90A-3nawA:
0.0
4z90B-3nawA:
1.8
4z90C-3nawA:
1.8
4z90D-3nawA:
1.8
4z90E-3nawA:
1.8		 4z90A-3nawA:
20.13
4z90B-3nawA:
20.13
4z90C-3nawA:
20.13
4z90D-3nawA:
20.13
4z90E-3nawA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 ALA A 257
LEU A 318
ALA A 232
LEU A 314
LEU A 260
 None
 1.08A 4z90A-3pshA:
undetectable
4z90B-3pshA:
undetectable
4z90C-3pshA:
undetectable
4z90D-3pshA:
undetectable
4z90E-3pshA:
undetectable		 4z90A-3pshA:
19.72
4z90B-3pshA:
19.72
4z90C-3pshA:
19.72
4z90D-3pshA:
19.72
4z90E-3pshA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 LEU A 314
LEU A 260
ALA A 257
LEU A 318
ALA A 232
 None
 1.08A 4z90A-3pshA:
undetectable
4z90B-3pshA:
undetectable
4z90C-3pshA:
undetectable
4z90D-3pshA:
undetectable
4z90E-3pshA:
undetectable		 4z90A-3pshA:
19.72
4z90B-3pshA:
19.72
4z90C-3pshA:
19.72
4z90D-3pshA:
19.72
4z90E-3pshA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8d DNA REPAIR PROTEIN
RECO

(Escherichia
coli) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		5 ALA A  36
LEU A  22
ALA A  49
LEU A  56
LEU A  58
 None
 0.92A 4z90A-3q8dA:
undetectable
4z90B-3q8dA:
undetectable
4z90C-3q8dA:
undetectable
4z90D-3q8dA:
1.2
4z90E-3q8dA:
undetectable		 4z90A-3q8dA:
17.55
4z90B-3q8dA:
17.55
4z90C-3q8dA:
17.55
4z90D-3q8dA:
17.55
4z90E-3q8dA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd9 QSOX FROM
TRYPANOSOMA BRUCEI
(TBQSOX)

(Trypanosoma
brucei) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 LEU A  86
ALA A 100
LEU A 158
LEU A  95
ALA A  98
 None
 1.06A 4z90A-3qd9A:
2.4
4z90B-3qd9A:
2.1
4z90C-3qd9A:
undetectable
4z90D-3qd9A:
undetectable
4z90E-3qd9A:
undetectable		 4z90A-3qd9A:
21.16
4z90B-3qd9A:
21.16
4z90C-3qd9A:
21.16
4z90D-3qd9A:
21.16
4z90E-3qd9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rms UNCHARACTERIZED
PROTEIN

(Saccharomonospora
viridis) 		PF16827
(zf-HC3) 		5 ALA A  64
ALA A  78
LEU A 105
LEU A  95
ALA A  62
 None
 1.16A 4z90A-3rmsA:
undetectable
4z90B-3rmsA:
undetectable
4z90C-3rmsA:
undetectable
4z90D-3rmsA:
undetectable
4z90E-3rmsA:
undetectable		 4z90A-3rmsA:
16.29
4z90B-3rmsA:
16.29
4z90C-3rmsA:
16.29
4z90D-3rmsA:
16.29
4z90E-3rmsA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 LEU A 392
LEU A 398
ALA A 400
LEU A 353
ALA A 132
 None
 1.16A 4z90A-3rv6A:
undetectable
4z90B-3rv6A:
undetectable
4z90C-3rv6A:
undetectable
4z90D-3rv6A:
undetectable
4z90E-3rv6A:
undetectable		 4z90A-3rv6A:
22.54
4z90B-3rv6A:
22.54
4z90C-3rv6A:
22.54
4z90D-3rv6A:
22.54
4z90E-3rv6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 590
LEU A 598
ALA A 511
LEU A 620
LEU A 618
 None
 0.97A 4z90A-3u9sA:
undetectable
4z90B-3u9sA:
undetectable
4z90C-3u9sA:
undetectable
4z90D-3u9sA:
undetectable
4z90E-3u9sA:
undetectable		 4z90A-3u9sA:
19.12
4z90B-3u9sA:
19.12
4z90C-3u9sA:
19.12
4z90D-3u9sA:
19.12
4z90E-3u9sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 598
ALA A 511
LEU A 620
LEU A 618
LEU A 590
 None
 1.02A 4z90A-3u9sA:
undetectable
4z90B-3u9sA:
undetectable
4z90C-3u9sA:
undetectable
4z90D-3u9sA:
undetectable
4z90E-3u9sA:
undetectable		 4z90A-3u9sA:
19.12
4z90B-3u9sA:
19.12
4z90C-3u9sA:
19.12
4z90D-3u9sA:
19.12
4z90E-3u9sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 620
LEU A 618
LEU A 590
LEU A 598
ALA A 511
 None
 1.03A 4z90A-3u9sA:
undetectable
4z90B-3u9sA:
undetectable
4z90C-3u9sA:
undetectable
4z90D-3u9sA:
undetectable
4z90E-3u9sA:
undetectable		 4z90A-3u9sA:
19.12
4z90B-3u9sA:
19.12
4z90C-3u9sA:
19.12
4z90D-3u9sA:
19.12
4z90E-3u9sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 392
ALA A 452
LEU A 432
LEU A 388
ALA A 456
 None
 0.95A 4z90A-3uw2A:
undetectable
4z90B-3uw2A:
undetectable
4z90C-3uw2A:
undetectable
4z90D-3uw2A:
undetectable
4z90E-3uw2A:
undetectable		 4z90A-3uw2A:
21.63
4z90B-3uw2A:
21.63
4z90C-3uw2A:
21.63
4z90D-3uw2A:
21.63
4z90E-3uw2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		5 LEU A 398
LEU A 279
LEU A 343
LEU A 347
ALA A 350
 None
None
None
None
EDO  A 503 (-3.9A)
 0.99A 4z90A-3wi3A:
2.8
4z90B-3wi3A:
2.6
4z90C-3wi3A:
2.8
4z90D-3wi3A:
2.5
4z90E-3wi3A:
2.7		 4z90A-3wi3A:
20.58
4z90B-3wi3A:
20.58
4z90C-3wi3A:
20.58
4z90D-3wi3A:
20.58
4z90E-3wi3A:
20.58