SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z7F_E_FOLE201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu2 MITOCHONDRIAL IMPORT
RECEPTOR SUBUNIT
TOM20-3

(Arabidopsis
thaliana) 		PF06552
(TOM20_plant) 		5 SER A  45
ALA A  20
TYR A  24
THR A  62
ASN A  83
 None
 1.36A 4z7fE-1zu2A:
0.4		 4z7fE-1zu2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0x POSSIBLE FLAVIN
REDUCTASE

(Histophilus
somni) 		PF01613
(Flavin_Reduct) 		5 ALA A  55
TYR A  58
PHE A  61
ASN A  70
THR A  22
 SO4  A 164 (-3.5A)
None
None
None
None
 1.47A 4z7fE-2r0xA:
undetectable		 4z7fE-2r0xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH

(Actinoplanes
sp. SE50/110) 		PF01547
(SBP_bac_1) 		5 ALA A  41
PHE A  21
THR A  20
ASN A  24
THR A  76
 None
 1.34A 4z7fE-3oo9A:
0.0		 4z7fE-3oo9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		5 ALA A 166
PHE A 148
THR A 150
ASN A 236
THR A 121
 None
None
None
GDP  A1395 (-3.5A)
None
 1.39A 4z7fE-3zf8A:
1.0		 4z7fE-3zf8A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		6 MET A  68
ALA A  74
PHE A  80
THR A  81
ASN A 117
THR A 121
 FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
 0.86A 4z7fE-4z7fA:
21.2		 4z7fE-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		6 SER A  38
MET A  68
ALA A  74
PHE A  80
ASN A 117
THR A 121
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
 1.08A 4z7fE-4z7fA:
21.2		 4z7fE-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		6 SER A  38
MET A  68
TYR A  76
PHE A  80
ASN A 117
THR A 121
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.8A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
 1.20A 4z7fE-4z7fA:
21.2		 4z7fE-4z7fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 SER A  86
ALA A 145
TYR A 148
PHE A 142
THR A 141
 None
 1.27A 4z7fE-5nofA:
0.0		 4z7fE-5nofA:
17.72