SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z7F_D_FOLD201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		5 ALA A 365
PHE A 391
ASN A 387
ASN A 384
THR A 390
 None
 1.25A 4z7fD-3lxqA:
0.0		 4z7fD-3lxqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqi SH3
DOMAIN-CONTAINING
PROTEIN

(Dictyostelium
discoideum) 		PF08397
(IMD) 		5 ARG A 181
ASP A 174
PHE A 116
ASN A 119
THR A 115
 None
 1.49A 4z7fD-4nqiA:
2.5		 4z7fD-4nqiA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		6 LYS A  36
SER A  38
ASP A  64
MET A  68
ALA A  74
LYS A 145
 FOL  A 201 (-2.9A)
FOL  A 201 (-3.5A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.7A)
 1.32A 4z7fD-4z7fA:
27.2		 4z7fD-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		8 SER A  38
ASP A  64
MET A  68
ALA A  74
ASN A  83
ASN A 117
THR A 121
LYS A 145
 FOL  A 201 (-3.5A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
None
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
FOL  A 201 (-3.7A)
 0.97A 4z7fD-4z7fA:
27.2		 4z7fD-4z7fA:
100.00