SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z7F_C_FOLC201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b33 ALLOPHYCOCYANIN,
ALPHA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 ARG A  61
ALA A 127
THR A 120
THR A  77
LEU A  81
 None
None
BLA  A 201 ( 3.8A)
None
None
 1.40A 4z7fC-1b33A:
1.3		 4z7fC-1b33A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 SER A 247
PHE A 324
THR A 319
THR A 124
LEU A 128
 None
 1.44A 4z7fC-1c4oA:
0.7		 4z7fC-1c4oA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ALA A 124
PHE A 501
THR A 499
THR A 529
LEU A 533
 None
 1.40A 4z7fC-1h0hA:
0.0		 4z7fC-1h0hA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		5 SER A 255
ALA A  70
ASN A 248
THR A 105
LEU A 130
 None
 1.36A 4z7fC-1hnoA:
undetectable		 4z7fC-1hnoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 SER A 273
ALA A 330
THR A 337
THR A 445
ARG A 257
 None
None
None
None
PO4  A 501 (-3.7A)
 1.31A 4z7fC-1k6mA:
0.1		 4z7fC-1k6mA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lba T7 LYSOZYME

(Escherichia
virus T7) 		PF01510
(Amidase_2) 		5 ALA A 121
PHE A 133
THR A 146
ASN A 142
ARG A 104
 None
 1.36A 4z7fC-1lbaA:
0.0		 4z7fC-1lbaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1njf DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF13177
(DNA_pol3_delta2) 		5 ALA A  95
THR A 157
THR A  52
LEU A 124
ARG A  56
 None
AGS  A 402 ( 4.8A)
AGS  A 402 (-3.7A)
None
None
 1.37A 4z7fC-1njfA:
0.1		 4z7fC-1njfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A  28
ASN A 194
THR A 212
LEU A 241
ARG A 248
 None
 1.27A 4z7fC-1sb3A:
0.0		 4z7fC-1sb3A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ARG A 339
ALA A 314
THR A 163
THR A 300
LEU A 304
 None
 1.03A 4z7fC-1uufA:
undetectable		 4z7fC-1uufA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		5 ARG A 209
SER A 177
PHE A  94
THR A 284
LEU A  92
 None
 1.41A 4z7fC-1v33A:
undetectable		 4z7fC-1v33A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x40 ARAP2

(Homo sapiens) 		PF00536
(SAM_1) 		5 ALA A  46
PHE A  34
PHE A  39
THR A  40
LEU A  52
 None
 1.45A 4z7fC-1x40A:
undetectable		 4z7fC-1x40A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		5 ALA B  95
THR B 157
THR B  52
LEU B 124
ARG B  56
 None
None
ADP  B 802 (-3.7A)
None
None
 1.42A 4z7fC-1xxiB:
undetectable		 4z7fC-1xxiB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1l PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
BETA ISOFORM

(Rattus
norvegicus) 		PF02121
(IP_trans) 		5 ALA A 192
PHE A   7
PHE A 221
THR A 222
LYS A  60
 None
None
PCW  A 501 (-4.9A)
None
PCW  A 501 ( 3.8A)
 1.29A 4z7fC-2a1lA:
undetectable		 4z7fC-2a1lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		5 SER A  20
ALA A 100
PHE A  98
LEU A  57
ARG A  43
 None
 1.27A 4z7fC-2dvuA:
undetectable		 4z7fC-2dvuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 SER A  63
ALA A  12
PHE A  19
THR A  20
LEU A 153
 None
 1.47A 4z7fC-2gerA:
undetectable		 4z7fC-2gerA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		5 SER A 487
ALA A 330
PHE A 290
PHE A 307
LEU A 288
 None
 1.33A 4z7fC-2gmhA:
undetectable		 4z7fC-2gmhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 SER A  63
ALA A  12
PHE A  19
THR A  20
LEU A 153
 None
 1.49A 4z7fC-2gr9A:
undetectable		 4z7fC-2gr9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		5 ALA A 349
PHE A 401
THR A 398
ASN A 408
THR A 377
 None
 1.45A 4z7fC-2iv0A:
undetectable		 4z7fC-2iv0A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 SER A 345
ALA A 276
PHE A 332
THR A 256
LEU A 257
 None
 1.45A 4z7fC-2jjpA:
undetectable		 4z7fC-2jjpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6

(Homo sapiens) 		PF01852
(START) 		5 ARG A 176
SER A 131
THR A 187
LEU A  78
ARG A  71
 None
 1.49A 4z7fC-2mouA:
undetectable		 4z7fC-2mouA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 289
PHE A 282
THR A 281
THR A 305
LEU A 309
 None
 1.18A 4z7fC-2ovlA:
undetectable		 4z7fC-2ovlA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		5 ALA A  16
PHE A  13
THR A  75
ASN A  84
LEU A 151
 None
 1.14A 4z7fC-2q7sA:
undetectable		 4z7fC-2q7sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w59 IGY FCU3-4

(Gallus gallus) 		PF07654
(C1-set) 		5 SER A 358
ALA A 497
PHE A 503
THR A 501
THR A 505
 None
 1.42A 4z7fC-2w59A:
undetectable		 4z7fC-2w59A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 ARG A 225
PHE A 281
THR A 270
ASN A 260
LEU A 237
 None
 1.36A 4z7fC-2z2bA:
undetectable		 4z7fC-2z2bA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 PHE A 516
THR A 573
ASN A 582
LEU A 633
ARG A 636
 None
 1.41A 4z7fC-2zj8A:
undetectable		 4z7fC-2zj8A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ARG A 455
SER A  58
PHE A 138
THR A 135
ASN A  92
 None
 1.15A 4z7fC-3ehmA:
2.0		 4z7fC-3ehmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ALA A 277
PHE A 301
THR A 342
THR A 348
LEU A 308
 None
 1.08A 4z7fC-3oeeA:
undetectable		 4z7fC-3oeeA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		5 ALA A 165
THR A 177
ASN A  72
THR A  96
LEU A 130
 None
 1.45A 4z7fC-3orwA:
undetectable		 4z7fC-3orwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666) 		PF04909
(Amidohydro_2) 		5 SER A  20
ALA A 100
PHE A  98
LEU A  57
ARG A  43
 None
 1.23A 4z7fC-3s4tA:
undetectable		 4z7fC-3s4tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4j HISTIDINE KINASE 4

(Arabidopsis
thaliana) 		PF03924
(CHASE) 		5 ALA A 204
PHE A 184
THR A 188
LEU A 163
ARG A 195
 ZIP  A 400 ( 4.1A)
None
None
None
None
 1.18A 4z7fC-3t4jA:
undetectable		 4z7fC-3t4jA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 SER A 342
ALA A  51
PHE A 336
THR A 329
LEU A 313
 None
 1.43A 4z7fC-3u95A:
undetectable		 4z7fC-3u95A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 SER A  73
THR A 152
ASN A 112
THR A 159
LEU A 102
 ET  A 301 (-2.7A)
None
ET  A 301 (-4.2A)
ET  A 301 (-3.8A)
None
 1.45A 4z7fC-3v78A:
undetectable		 4z7fC-3v78A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 ALA A 425
PHE A 404
ASN A 335
THR A 402
LEU A 433
 None
 1.43A 4z7fC-3vfdA:
undetectable		 4z7fC-3vfdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 LYS A 342
ALA A 382
THR A 386
THR A 364
LEU A 362
 None
 1.29A 4z7fC-4aezA:
undetectable		 4z7fC-4aezA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 5 ARG A 160
PHE A 201
THR A 197
THR A 254
LEU A 271
 None
 1.46A 4z7fC-4czxA:
undetectable		 4z7fC-4czxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2l PROTEIN F1L

(Vaccinia virus) 		PF11099
(M11L) 		5 ARG A  74
PHE A 166
THR A 167
THR A 150
ARG A 154
 None
 1.04A 4z7fC-4d2lA:
undetectable		 4z7fC-4d2lA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 SER A 343
PHE A 315
PHE A 316
THR A 317
LEU A 277
 None
 1.43A 4z7fC-4fgvA:
undetectable		 4z7fC-4fgvA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 PHE A 198
PHE A 194
ASN A 132
LEU A 224
ARG A 228
 None
 1.44A 4z7fC-4fxqA:
undetectable		 4z7fC-4fxqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		5 SER A 175
PHE A 215
THR A 148
THR A 217
LEU A 308
 None
 1.46A 4z7fC-4h0oA:
undetectable		 4z7fC-4h0oA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4huq UNCHARACTERIZED
PROTEIN

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		5 SER S  40
PHE S  78
PHE S  81
THR S  82
LYS S 144
 None
 1.35A 4z7fC-4huqS:
19.9		 4z7fC-4huqS:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 ALA A 198
PHE A 163
THR A 161
ASN A 185
LEU A  34
 None
 1.49A 4z7fC-4iq4A:
undetectable		 4z7fC-4iq4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ALA A 308
PHE A 323
THR A 321
LEU A 108
ARG A 142
 None
 1.49A 4z7fC-4mniA:
undetectable		 4z7fC-4mniA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qid BACTERIORHODOPSIN-I

(Haloquadratum
walsbyi) 		PF01036
(Bac_rhodopsin) 		5 ALA A 167
PHE A 179
THR A 175
ASN A 184
LEU A 160
 None
None
None
ACT  A 303 ( 4.8A)
None
 1.48A 4z7fC-4qidA:
2.2		 4z7fC-4qidA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		5 ALA A 233
PHE A 294
THR A 311
THR A 296
LEU A 251
 None
 1.43A 4z7fC-4rzzA:
undetectable		 4z7fC-4rzzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		5 ARG A 234
ALA A 233
PHE A 294
THR A 311
LEU A 251
 None
 1.35A 4z7fC-4rzzA:
undetectable		 4z7fC-4rzzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		5 ARG A  73
SER A 114
PHE A  81
THR A 134
LEU A 146
 None
 1.13A 4z7fC-4wfiA:
undetectable		 4z7fC-4wfiA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		8 SER A  38
ALA A  74
PHE A  77
PHE A  80
THR A  81
ASN A 117
THR A 121
LYS A 145
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.6A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
FOL  A 201 (-3.7A)
 0.86A 4z7fC-4z7fA:
27.7		 4z7fC-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		9 SER A  38
ALA A  74
PHE A  77
PHE A  80
THR A  81
THR A 121
LEU A 125
ARG A 142
LYS A 145
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.6A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-2.6A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
 0.59A 4z7fC-4z7fA:
27.7		 4z7fC-4z7fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ALA A 276
PHE A 300
THR A 341
THR A 347
LEU A 307
 None
 1.15A 4z7fC-5dn6A:
undetectable		 4z7fC-5dn6A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 SER A 272
ALA A 329
THR A 336
THR A 444
ARG A 256
 None
F6P  A 604 ( 4.9A)
None
F6P  A 604 ( 3.3A)
NEP  A 257 ( 3.7A)
 1.26A 4z7fC-5htkA:
undetectable		 4z7fC-5htkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		5 ALA A  27
PHE A  22
PHE A 242
THR A 239
LEU A  86
 None
 1.36A 4z7fC-5ig2A:
undetectable		 4z7fC-5ig2A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ALA A 267
PHE A 291
THR A 332
THR A 338
LEU A 298
 None
 1.11A 4z7fC-5ik2A:
undetectable		 4z7fC-5ik2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 ALA A 288
PHE A 312
THR A 353
THR A 359
LEU A 319
 None
 1.16A 4z7fC-6f5dA:
undetectable		 4z7fC-6f5dA:
undetectable