SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z7F_B_FOLB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		5 TYR A 379
PHE A 380
THR A 381
ASN A  24
ARG A  28
 None
None
MPD  A 501 ( 4.7A)
None
None
 1.34A 4z7fB-1hx6A:
0.0		 4z7fB-1hx6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1l PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
BETA ISOFORM

(Rattus
norvegicus) 		PF02121
(IP_trans) 		5 ALA A 192
PHE A   7
PHE A 221
THR A 222
LYS A  60
 None
None
PCW  A 501 (-4.9A)
None
PCW  A 501 ( 3.8A)
 1.34A 4z7fB-2a1lA:
0.0		 4z7fB-2a1lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 ASP A 602
ALA A 969
TYR A 596
THR A 598
ASN A 617
 None
NA  A   6 (-4.7A)
None
None
NA  A   4 (-2.9A)
 1.29A 4z7fB-3bgaA:
0.0		 4z7fB-3bgaA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 ASP A 285
ALA A 291
PHE A  89
THR A  88
ARG A   8
 None
 1.11A 4z7fB-3hxwA:
undetectable		 4z7fB-3hxwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ASP A 155
ALA A 199
PHE A 223
THR A 195
THR A 257
 None
 1.40A 4z7fB-3l7zA:
0.0		 4z7fB-3l7zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		5 ALA A 166
PHE A 148
THR A 150
ASN A 236
THR A 121
 None
None
None
GDP  A1395 (-3.5A)
None
 1.31A 4z7fB-3zf8A:
0.9		 4z7fB-3zf8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans;
Homo sapiens) 		PF10275
(Peptidase_C65) 		5 ALA A  92
TYR A  90
PHE A 173
THR A 177
ARG A 107
 None
 1.46A 4z7fB-4dhzA:
0.1		 4z7fB-4dhzA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LYS A 285
ASP A 266
ALA A 317
PHE A 398
THR A 406
 None
 1.35A 4z7fB-4jb6A:
0.0		 4z7fB-4jb6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 MET A  85
ALA A  35
PHE A  67
THR A  31
THR A 283
 None
 1.45A 4z7fB-4joqA:
0.0		 4z7fB-4joqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 TYR A 264
PHE A 263
PHE A 213
THR A 212
THR A 254
 None
 1.42A 4z7fB-4wv3A:
0.0		 4z7fB-4wv3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz FUSION PROTEIN OF
SEC13 AND NUP145C

(Thermothelomyces
thermophila) 		PF00400
(WD40)
PF12110
(Nup96) 		5 LYS A1271
ASP A  39
ALA A1292
THR A  41
ARG A 270
 None
 1.45A 4z7fB-4yczA:
undetectable		 4z7fB-4yczA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN

(Schizosaccharomyces
pombe) 		PF07855
(ATG101) 		5 LYS A  21
ASP A  69
PHE A  67
THR A  70
THR A 110
 None
 1.48A 4z7fB-4yk8A:
undetectable		 4z7fB-4yk8A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		11 ASP A  64
MET A  68
ALA A  74
TYR A  76
PHE A  77
PHE A  80
THR A  81
ASN A 117
THR A 121
ARG A 142
LYS A 145
 FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.8A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
 0.60A 4z7fB-4z7fA:
26.7		 4z7fB-4z7fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 TYR A 258
PHE A 348
THR A 342
ARG A  12
LYS A 240
 None
 1.47A 4z7fB-5u24A:
undetectable		 4z7fB-5u24A:
22.40