SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z7F_A_FOLA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		5 TYR A 379
PHE A 380
THR A 381
ASN A  24
ARG A  28
 None
None
MPD  A 501 ( 4.7A)
None
None
 1.37A 4z7fA-1hx6A:
0.0		 4z7fA-1hx6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jli YOP PROTEINS
TRANSLOCATION
PROTEIN

(Yersinia pestis) 		PF01312
(Bac_export_2) 		5 SER A 257
ALA A 320
TYR A 317
THR A 288
ASN A 249
 None
 1.31A 4z7fA-2jliA:
undetectable		 4z7fA-2jliA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		5 LEU A 151
ALA A 236
TYR A 163
THR A 320
ASN A 206
 None
HEM  A 401 (-3.4A)
HEM  A 401 ( 4.8A)
None
None
 1.35A 4z7fA-2nwbA:
0.7		 4z7fA-2nwbA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 985
MET A 618
ALA A 643
PHE A 589
THR A 588
 None
 1.18A 4z7fA-2qf7A:
0.0		 4z7fA-2qf7A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 ASP A 285
ALA A 291
PHE A  89
THR A  88
ARG A   8
 None
 1.28A 4z7fA-3hxwA:
0.0		 4z7fA-3hxwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz8 MOUSE ANTI V3
ANTIBODY 7C8 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A  69
SER A  56
PHE A  29
THR A  28
ASN A  35
 None
 1.25A 4z7fA-3nz8A:
undetectable		 4z7fA-3nz8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		5 LEU A  92
SER A  64
ALA A 129
TYR A 148
THR A 125
 None
NAG  A1001 (-3.1A)
None
None
None
 1.48A 4z7fA-3ojaA:
0.0		 4z7fA-3ojaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		5 MET A 220
ALA A 226
PHE A 424
THR A 425
ASN A 448
 None
None
PEG  A 614 ( 3.6A)
None
None
 1.38A 4z7fA-4fasA:
0.0		 4z7fA-4fasA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		5 LEU A 386
LYS A 385
ALA A 325
TYR A 139
ARG A 128
 None
GOL  A 707 (-2.7A)
None
None
None
 1.28A 4z7fA-4fo0A:
0.0		 4z7fA-4fo0A:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4huq UNCHARACTERIZED
PROTEIN

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		5 SER S  40
ASP S  66
PHE S  81
THR S  82
ARG S 141
 None
 1.02A 4z7fA-4huqS:
19.5		 4z7fA-4huqS:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 LEU A 985
MET A 618
ALA A 643
PHE A 589
THR A 588
 None
 1.21A 4z7fA-4jx6A:
undetectable		 4z7fA-4jx6A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		5 MET A 419
ALA A 415
PHE A 436
THR A 432
ASN A 443
 None
 1.47A 4z7fA-4owtA:
undetectable		 4z7fA-4owtA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z7f FOLATE ECF
TRANSPORTER

(Enterococcus
faecalis) 		PF12822
(ECF_trnsprt) 		12 LEU A  35
LYS A  36
SER A  38
ASP A  64
MET A  68
ALA A  74
TYR A  76
PHE A  80
THR A  81
ASN A 117
ARG A 142
LYS A 145
 FOL  A 201 (-4.4A)
FOL  A 201 (-2.9A)
FOL  A 201 (-3.5A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.8A)
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
 0.03A 4z7fA-4z7fA:
33.7		 4z7fA-4z7fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 LEU A 317
ASP A 330
ALA A 349
PHE A 353
THR A 354
 None
 1.36A 4z7fA-5fqdA:
undetectable		 4z7fA-5fqdA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 LEU A 808
ALA A 804
PHE A 851
ARG A 847
LYS A 769
 None
 1.27A 4z7fA-5fqdA:
undetectable		 4z7fA-5fqdA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9k LIPOCALIN AI-4

(Rhodnius
prolixus) 		PF03973
(Triabin) 		5 ALA A  96
TYR A  94
PHE A  81
THR A  92
ASN A  57
 None
 1.48A 4z7fA-5h9kA:
undetectable		 4z7fA-5h9kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 LEU A 341
SER A 338
ASP A 330
PHE A 262
THR A 261
 None
 1.01A 4z7fA-5n2gA:
undetectable		 4z7fA-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oh5 RIDL

(Legionella
pneumophila) 		no annotation 5 SER A 145
ASP A 124
THR A 125
ASN A 134
LYS A 173
 None
 1.45A 4z7fA-5oh5A:
undetectable		 4z7fA-5oh5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 5 LEU A  62
LYS A  63
SER A  65
ASN A 135
ARG A 131
 None
 1.46A 4z7fA-6bk5A:
undetectable		 4z7fA-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-) 		no annotation 5 LEU A 274
LYS A 271
SER A 267
ALA A 235
PHE A 318
 None
 1.28A 4z7fA-6grwA:
undetectable		 4z7fA-6grwA:
undetectable