SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z69_I_DIFI1006

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		5 ARG A 110
PHE A  19
LEU A 226
ILE A 313
ALA A 105
 None
 1.44A 4z69I-1dofA:
0.0		 4z69I-1dofA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwu RIBOSOMAL PROTEIN L1

(Methanothermococcus
thermolithotrophicus) 		PF00687
(Ribosomal_L1) 		5 ARG A 126
PHE A 105
LEU A  85
ILE A  80
ALA A  95
 None
 1.46A 4z69I-1dwuA:
undetectable		 4z69I-1dwuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 LYS A   1
PHE A  95
LEU A  53
ILE A  99
ALA A  15
 None
 1.31A 4z69I-1ef9A:
undetectable		 4z69I-1ef9A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 TRP A 161
PHE A  76
LEU A  37
SER A 218
ALA A  92
 None
 1.37A 4z69I-1ledA:
undetectable		 4z69I-1ledA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		5 ARG A 108
PHE A 135
LEU A  98
ILE A 130
ALA A 122
 None
 1.42A 4z69I-1ofmA:
undetectable		 4z69I-1ofmA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 PHE A 264
LEU A 256
ILE A 257
SER A 301
ALA A 299
 None
 1.36A 4z69I-1p9eA:
undetectable		 4z69I-1p9eA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 TRP A  88
ARG A 545
ARG A 150
ILE A 127
ALA A 103
 None
 1.40A 4z69I-1po0A:
undetectable		 4z69I-1po0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 ARG A 425
PHE A 351
LEU A 220
ILE A 223
ALA A 428
 None
 1.39A 4z69I-1q15A:
0.9		 4z69I-1q15A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR

(Escherichia
coli) 		PF04542
(Sigma70_r2)
PF04546
(Sigma70_ner) 		5 PHE A 165
ARG A 157
LEU A 161
ILE A 162
SER A 159
 None
 1.47A 4z69I-1sigA:
2.1		 4z69I-1sigA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ARG A 218
ARG A 222
PHE A 223
ILE A 264
SER A 287
ALA A 291
 CIT  A2001 (-4.0A)
CIT  A2001 ( 2.9A)
None
None
None
CIT  A2001 ( 3.9A)
 1.42A 4z69I-1tf0A:
37.7		 4z69I-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ARG A 218
PHE A 223
LEU A 260
ILE A 264
SER A 287
ALA A 291
 CIT  A2001 (-4.0A)
None
None
None
None
CIT  A2001 ( 3.9A)
 1.09A 4z69I-1tf0A:
37.7		 4z69I-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LYS A 199
ARG A 222
PHE A 223
ILE A 264
SER A 287
ALA A 291
 CIT  A2001 ( 2.7A)
CIT  A2001 ( 2.9A)
None
None
None
CIT  A2001 ( 3.9A)
 0.87A 4z69I-1tf0A:
37.7		 4z69I-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		8 LYS A 199
TRP A 214
PHE A 223
ARG A 257
LEU A 260
ILE A 264
SER A 287
ALA A 291
 CIT  A2001 ( 2.7A)
None
None
DKA  A1003 (-4.1A)
None
None
None
CIT  A2001 ( 3.9A)
 0.65A 4z69I-1tf0A:
37.7		 4z69I-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 ARG A 116
ARG A  59
LEU A  62
ILE A  46
ALA A  51
 None
 1.44A 4z69I-2zhyA:
3.6		 4z69I-2zhyA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zot SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		5 ARG A  64
LEU A  82
ILE A 163
SER A  62
ALA A  85
 None
 1.47A 4z69I-2zotA:
undetectable		 4z69I-2zotA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		no annotation 5 PHE A  26
LEU A  10
ILE A  70
SER A  65
ALA A  63
 None
 1.43A 4z69I-3anwA:
3.9		 4z69I-3anwA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 ARG A 102
PHE A  34
LEU A  14
ILE A  65
SER A  12
 None
 1.44A 4z69I-3bq9A:
1.5		 4z69I-3bq9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		5 ARG A 447
LEU A 508
ILE A 506
SER A 493
ALA A 470
 None
1PE  A   2 (-4.7A)
None
None
None
 1.42A 4z69I-3fo5A:
undetectable		 4z69I-3fo5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyi PROTEIN DUF199/WHIA

(Thermotoga
maritima) 		PF02650
(HTH_WhiA)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA) 		5 ARG A 249
ARG A 250
ARG A 283
LEU A 281
ILE A 277
 None
 1.24A 4z69I-3hyiA:
2.5		 4z69I-3hyiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keq REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Streptococcus
agalactiae) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		5 ARG A  14
PHE A  56
LEU A  79
ILE A  78
ALA A  12
 None
 1.11A 4z69I-3keqA:
undetectable		 4z69I-3keqA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 PHE A  11
ARG A  46
LEU A  47
ILE A  49
SER A 103
 None
 1.00A 4z69I-3mzhA:
undetectable		 4z69I-3mzhA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8x ZETA-TOXIN

(Streptococcus
pyogenes) 		PF06414
(Zeta_toxin) 		5 PHE B  69
LEU B 106
ILE B  64
SER B 104
ALA B 101
 None
 1.39A 4z69I-3q8xB:
2.9		 4z69I-3q8xB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ARG A  56
ARG A  99
LEU A 374
ILE A 372
ALA A 383
 FAD  A 773 (-4.2A)
None
None
None
None
 1.30A 4z69I-3redA:
undetectable		 4z69I-3redA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 5 ARG A 342
PHE A 343
LEU A  61
ILE A  58
SER A  56
 None
 1.35A 4z69I-3wnbA:
undetectable		 4z69I-3wnbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 ARG A 171
PHE A 200
LEU A 213
ILE A 215
ALA A 384
 None
 1.36A 4z69I-4krfA:
undetectable		 4z69I-4krfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		5 ARG A  85
PHE A 194
LEU A 251
ILE A 304
ALA A  76
 None
 1.47A 4z69I-4nz0A:
undetectable		 4z69I-4nz0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Chitinophaga
pinensis) 		PF00561
(Abhydrolase_1) 		5 ARG A 184
LEU A  63
ILE A  65
SER A  27
ALA A  11
 None
 1.05A 4z69I-4pw0A:
undetectable		 4z69I-4pw0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 ARG A1230
PHE A1126
LEU A1202
ILE A1256
SER A1206
 None
 1.33A 4z69I-4r04A:
3.7		 4z69I-4r04A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		5 PHE A 234
LEU A 248
ILE A 247
SER A 188
ALA A 192
 None
None
None
None
FRU  A 504 ( 4.6A)
 1.44A 4z69I-4rk9A:
undetectable		 4z69I-4rk9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxt FUSION OF PREDICTED
ZN-DEPENDENT
AMIDASE/PEPTIDASE
(CELL WALL
HYDROLASE/DD-CARBOXY
PEPTIDASE FAMILY)
AND UNCHARACTERIZED
DOMAIN OF ERFK
FAMILY
PEPTODOGLYCAN-BINDIN
G DOMAIN

(Clostridium
acetobutylicum) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		5 ARG A  95
PHE A  86
LEU A 117
ILE A  69
SER A 110
 None
 1.47A 4z69I-4xxtA:
undetectable		 4z69I-4xxtA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cze PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		5 ARG B  31
LEU B  14
ILE B  17
SER B  19
ALA B  29
 None
 1.47A 4z69I-5czeB:
undetectable		 4z69I-5czeB:
10.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		7 LYS A 198
PHE A 222
ARG A 256
LEU A 259
ILE A 263
SER A 286
ALA A 290
 PG4  A 602 ( 4.3A)
None
PG4  A 602 (-4.1A)
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.9A)
PG4  A 602 (-3.4A)
 0.88A 4z69I-5dqfA:
38.4		 4z69I-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 LYS A 198
TRP A 213
PHE A 222
LEU A 259
ILE A 263
ALA A 290
 PG4  A 602 ( 4.3A)
None
None
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.4A)
 1.09A 4z69I-5dqfA:
38.4		 4z69I-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 TRP A 213
ARG A 217
PHE A 222
LEU A 259
ILE A 263
 None
CL  A 617 ( 4.6A)
None
PG4  A 602 ( 4.5A)
None
 1.18A 4z69I-5dqfA:
38.4		 4z69I-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 LYS A 195
PHE A 223
ARG A 257
LEU A 260
SER A 287
 None
 1.07A 4z69I-5ghkA:
36.4		 4z69I-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 LYS A 199
ARG A 222
PHE A 223
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
 0.92A 4z69I-5ghkA:
36.4		 4z69I-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 LYS A 199
TRP A 214
ARG A 222
PHE A 223
LEU A 260
ALA A 291
 None
 0.89A 4z69I-5ghkA:
36.4		 4z69I-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 TRP A 214
ARG A 218
ARG A 222
PHE A 223
LEU A 260
ALA A 291
 None
 0.98A 4z69I-5ghkA:
36.4		 4z69I-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ARG A 150
ARG A 362
LEU A 447
SER A 359
ALA A 357
 None
 1.37A 4z69I-5gz4A:
undetectable		 4z69I-5gz4A:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 TRP A 213
ARG A 217
PHE A 222
ARG A 256
LEU A 259
SER A 286
ALA A 290
 None
 1.05A 4z69I-5oriA:
37.0		 4z69I-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 TRP A 213
PHE A 222
ARG A 256
LEU A 259
ILE A 263
SER A 286
ALA A 290
 None
 0.87A 4z69I-5oriA:
37.0		 4z69I-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae) 		PF01116
(F_bP_aldolase) 		5 ARG A 290
LEU A 282
ILE A 245
SER A 284
ALA A 287
 EDO  A 404 (-3.1A)
None
None
None
None
 1.47A 4z69I-5u4nA:
undetectable		 4z69I-5u4nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 ARG A 104
PHE A 173
ARG A 108
LEU A 154
ILE A 198
 None
 1.24A 4z69I-5uhkA:
undetectable		 4z69I-5uhkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ARG A 254
ARG A 219
LEU A 119
ILE A 118
ALA A 181
 GOL  A 403 (-3.8A)
GOL  A 403 (-3.7A)
None
None
GOL  A 403 (-3.4A)
 1.12A 4z69I-5x18A:
undetectable		 4z69I-5x18A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LYS A 195
PHE A 223
ARG A 257
LEU A 260
ILE A 264
SER A 287
 None
 1.28A 4z69I-5yxeA:
37.2		 4z69I-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LYS A 199
PHE A 223
ARG A 257
LEU A 260
ILE A 264
SER A 287
 None
 0.87A 4z69I-5yxeA:
37.2		 4z69I-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LYS A 199
TRP A 214
PHE A 223
ARG A 257
ILE A 264
 None
 1.13A 4z69I-5yxeA:
37.2		 4z69I-5yxeA:
11.11