SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z69_A_DIFA1008_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 PHE A 289
VAL A 329
SER A 336
LEU A 337
VAL A 333
 None
 1.42A 4z69A-1a87A:
3.0		 4z69A-1a87A:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 PHE A 206
ALA A 210
PHE A 211
TRP A 214
VAL A 344
VAL A 482
 None
DKA  A1002 (-3.3A)
None
None
None
DKA  A1002 (-4.2A)
 0.61A 4z69A-1tf0A:
37.7		 4z69A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PHE A 206
ALA A 210
VAL A 344
SER A 480
VAL A 482
 None
DKA  A1002 (-3.3A)
None
DKA  A1002 (-3.4A)
DKA  A1002 (-4.2A)
 0.82A 4z69A-1tf0A:
37.7		 4z69A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 SER A 202
ALA A 213
PHE A 211
TRP A 214
VAL A 344
LEU A 481
VAL A 482
 None
DKA  A1001 ( 4.0A)
None
None
None
None
DKA  A1002 (-4.2A)
 1.40A 4z69A-1tf0A:
37.7		 4z69A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 SER A 202
PHE A 206
PHE A 211
TRP A 214
VAL A 344
LEU A 481
VAL A 482
 None
None
None
None
None
None
DKA  A1002 (-4.2A)
 1.32A 4z69A-1tf0A:
37.7		 4z69A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 SER A 202
PHE A 206
VAL A 344
SER A 480
LEU A 481
VAL A 482
 None
None
None
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
 1.46A 4z69A-1tf0A:
37.7		 4z69A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A  79
VAL A 117
SER A  82
LEU A  81
VAL A  83
 None
 1.34A 4z69A-2akzA:
1.5		 4z69A-2akzA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 SER A 208
ALA A  42
PHE A   7
SER A 217
LEU A 219
 None
 1.41A 4z69A-2rb5A:
undetectable		 4z69A-2rb5A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE C 264
ALA C 218
PHE C 255
TRP C 239
VAL C 236
 None
 1.40A 4z69A-2wtkC:
undetectable		 4z69A-2wtkC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 PHE A 442
ALA A 446
VAL A 380
SER A 374
VAL A 377
 None
 1.48A 4z69A-3a1iA:
2.3		 4z69A-3a1iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		5 PHE A  80
ALA A  60
SER A  20
LEU A  17
VAL A  16
 None
 1.24A 4z69A-3hjlA:
undetectable		 4z69A-3hjlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		5 PHE A 326
ALA A 168
PHE A 167
VAL A 134
SER A 158
 None
 1.48A 4z69A-3le2A:
undetectable		 4z69A-3le2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 SER A 229
PHE A 224
VAL A 185
LEU A 222
VAL A 221
 None
 1.39A 4z69A-3lk7A:
undetectable		 4z69A-3lk7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		5 PHE A 140
ALA A 143
PHE A 175
LEU A 205
VAL A 206
 None
 1.32A 4z69A-3m6mA:
1.3		 4z69A-3m6mA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		5 SER A 397
ALA A 243
SER A 125
LEU A 399
VAL A 400
 None
 1.32A 4z69A-3nc3A:
4.2		 4z69A-3nc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noj 4-CARBOXY-4-HYDROXY-
2-OXOADIPATE
ALDOLASE/OXALOACETAT
E DECARBOXYLASE

(Pseudomonas
putida) 		PF03737
(RraA-like) 		5 PHE A  74
ALA A  77
VAL A  86
LEU A 116
VAL A  88
 None
 1.42A 4z69A-3nojA:
undetectable		 4z69A-3nojA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obf PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Paenarthrobacter
aurescens) 		PF01614
(IclR) 		5 SER A 149
ALA A 284
VAL A 292
LEU A 138
VAL A 137
 None
 1.49A 4z69A-3obfA:
undetectable		 4z69A-3obfA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ALA A 179
PHE A 183
VAL A 256
SER A 171
VAL A 226
 None
 1.32A 4z69A-4eygA:
undetectable		 4z69A-4eygA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 SER A 256
ALA A 269
VAL A   8
SER A 252
VAL A 281
 None
 1.29A 4z69A-4g6cA:
undetectable		 4z69A-4g6cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivn TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF01380
(SIS)
PF01418
(HTH_6) 		5 ALA A 127
PHE A 129
TRP A 178
VAL A 204
VAL A 205
 None
 1.38A 4z69A-4ivnA:
undetectable		 4z69A-4ivnA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		5 SER A 233
ALA A 178
PHE A 458
VAL A 182
LEU A 170
 SER  A 233 ( 0.0A)
ALA  A 178 ( 0.0A)
PHE  A 458 ( 1.3A)
VAL  A 182 ( 0.6A)
LEU  A 170 ( 0.5A)
 1.27A 4z69A-4kqnA:
undetectable		 4z69A-4kqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF00989
(PAS) 		5 SER C 119
ALA C 147
PHE C 145
SER C 124
LEU C 120
 None
 1.33A 4z69A-4lryC:
undetectable		 4z69A-4lryC:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn0 BEROVIN

(Beroe
abyssicola) 		PF10591
(SPARC_Ca_bdg) 		5 PHE A 168
ALA A 164
PHE A 167
LEU A 179
VAL A 145
 None
 1.41A 4z69A-4mn0A:
2.8		 4z69A-4mn0A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		5 SER A  94
PHE A 235
PHE A 102
SER A 147
VAL A 232
 EDO  A 404 (-4.0A)
None
None
None
None
 1.47A 4z69A-4n6dA:
1.5		 4z69A-4n6dA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 PHE A 206
ALA A 210
TRP A 214
VAL A 344
SER A 480
VAL A 482
 None
 0.95A 4z69A-4po0A:
36.9		 4z69A-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 SER A 202
ALA A 213
TRP A 214
VAL A 344
LEU A 481
VAL A 482
 None
NPS  A 602 (-3.3A)
None
None
None
None
 1.10A 4z69A-4po0A:
36.9		 4z69A-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 SER A 202
PHE A 206
TRP A 214
VAL A 344
SER A 480
LEU A 481
VAL A 482
 None
 1.49A 4z69A-4po0A:
36.9		 4z69A-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 PHE A 114
ALA A  90
SER A  45
LEU A  49
VAL A  46
 None
 1.23A 4z69A-4y9tA:
undetectable		 4z69A-4y9tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		5 PHE A 531
ALA A 573
VAL A 580
SER A 787
LEU A 788
 None
None
None
SO4  A1002 (-3.1A)
None
 1.48A 4z69A-4yooA:
undetectable		 4z69A-4yooA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 SER A 363
ALA A 367
SER A 429
LEU A 359
VAL A 377
 None
 1.46A 4z69A-4ywoA:
undetectable		 4z69A-4ywoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 119
PHE A 122
TRP A 273
SER A 360
VAL A 356
 None
 1.48A 4z69A-5b7iA:
undetectable		 4z69A-5b7iA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 PHE A 206
ALA A 210
PHE A 211
TRP A 214
SER A 480
VAL A 482
 None
 0.92A 4z69A-5ghkA:
36.3		 4z69A-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 SER A 202
PHE A 206
PHE A 211
TRP A 214
SER A 480
VAL A 482
 None
 1.14A 4z69A-5ghkA:
36.3		 4z69A-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 SER A 202
PHE A 211
TRP A 214
SER A 480
LEU A 481
VAL A 482
 None
 1.39A 4z69A-5ghkA:
36.3		 4z69A-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqm PROTEIN UPS1,
MITOCHONDRIAL,MITOCH
ONDRIAL DISTRIBUTION
AND MORPHOLOGY
PROTEIN 35

(Saccharomyces
cerevisiae) 		PF04707
(PRELI)
PF05254
(UPF0203) 		5 SER A 145
PHE A 149
SER A 130
LEU A   3
VAL A   2
 None
 1.45A 4z69A-5jqmA:
undetectable		 4z69A-5jqmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		5 PHE A 480
PHE A 482
VAL A 488
SER A 518
VAL A 515
 None
 1.43A 4z69A-5k47A:
4.2		 4z69A-5k47A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ALA A 583
PHE A 584
VAL A 538
SER A 576
LEU A 577
 None
 1.00A 4z69A-5l1bA:
4.2		 4z69A-5l1bA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 PHE A 460
ALA A 459
PHE A 462
LEU A 412
VAL A 411
 None
 1.49A 4z69A-5l7dA:
undetectable		 4z69A-5l7dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S23,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 5 SER M 103
ALA M  83
PHE M 120
LEU M 101
VAL M 100
 A  E 653 ( 4.5A)
None
None
None
None
 1.17A 4z69A-5optM:
undetectable		 4z69A-5optM:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 SER A 201
ALA A 212
TRP A 213
LEU A 480
VAL A 481
 None
 1.41A 4z69A-5oriA:
36.9		 4z69A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 197
ALA A 212
VAL A 205
SER A 199
LEU A 266
 None
None
CIT  A 401 (-3.7A)
None
None
 1.29A 4z69A-5tnxA:
undetectable		 4z69A-5tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 5 PHE A 166
ALA A 162
PHE A 165
LEU A 177
VAL A 143
 None
None
None
None
CD  A 202 ( 4.9A)
 1.49A 4z69A-5vp3A:
undetectable		 4z69A-5vp3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1u UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ALA A 231
VAL A 277
SER A 271
LEU A 273
VAL A 274
 None
 1.41A 4z69A-5x1uA:
undetectable		 4z69A-5x1uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 PHE A 206
ALA A 210
PHE A 211
TRP A 214
SER A 480
VAL A 482
 None
 0.85A 4z69A-5yxeA:
37.2		 4z69A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 SER A 202
ALA A 213
PHE A 211
TRP A 214
LEU A 481
VAL A 482
 None
 1.44A 4z69A-5yxeA:
37.2		 4z69A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 SER A 202
PHE A 206
PHE A 211
TRP A 214
SER A 480
VAL A 482
 None
 1.10A 4z69A-5yxeA:
37.2		 4z69A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 SER A 202
PHE A 211
TRP A 214
SER A 480
LEU A 481
VAL A 482
 None
 1.26A 4z69A-5yxeA:
37.2		 4z69A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e2q -

(-) 		no annotation 5 ALA A  86
PHE A  85
VAL A  41
LEU A 113
VAL A 112
 None
 1.33A 4z69A-6e2qA:
undetectable		 4z69A-6e2qA:
undetectable