SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z69_A_DIFA1007

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwu RIBOSOMAL PROTEIN L1

(Methanothermococcus
thermolithotrophicus)
PF00687
(Ribosomal_L1)
5 ARG A 126
LEU A 123
LEU A  85
ILE A  80
ALA A  95
None
1.46A 4z69A-1dwuA:
0.3
4z69A-1dwuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli)
PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2)
5 ARG A 494
LEU A 491
LEU A 379
ILE A 387
ALA A 370
None
1.35A 4z69A-1fuiA:
1.7
4z69A-1fuiA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE


(Pseudomonas
putida)
PF00221
(Lyase_aromatic)
5 ARG A 247
LEU A 293
LEU A 501
ILE A 219
ALA A 254
None
0.80A 4z69A-1gk2A:
2.4
4z69A-1gk2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbx ETS-DOMAIN PROTEIN
ELK-4


(Homo sapiens)
PF00178
(Ets)
5 ARG G  43
LEU G  44
LEU G  11
ILE G  24
ALA G  38
None
1.36A 4z69A-1hbxG:
undetectable
4z69A-1hbxG:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
6 ARG A 218
LEU A 219
LEU A 260
ILE A 264
SER A 287
ALA A 291
CIT  A2001 (-4.0A)
None
None
None
None
CIT  A2001 ( 3.9A)
1.13A 4z69A-1tf0A:
37.7
4z69A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
7 LYS A 199
TRP A 214
LEU A 219
LEU A 260
ILE A 264
SER A 287
ALA A 291
CIT  A2001 ( 2.7A)
None
None
None
None
None
CIT  A2001 ( 3.9A)
0.64A 4z69A-1tf0A:
37.7
4z69A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida)
PF01212
(Beta_elim_lyase)
5 ARG A 127
LEU A 126
LEU A 176
ILE A 147
ALA A 164
None
1.19A 4z69A-1v72A:
0.0
4z69A-1v72A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Helicobacter
pylori)
PF02540
(NAD_synthase)
5 ARG A 170
LEU A   8
LEU A  44
ILE A 156
ALA A 168
None
1.48A 4z69A-1xngA:
2.4
4z69A-1xngA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjl 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
GAMMA 1


(Rattus
norvegicus)
PF00169
(PH)
5 ARG A 144
LEU A  24
ILE A  29
SER A  27
ALA A 147
None
1.46A 4z69A-2fjlA:
undetectable
4z69A-2fjlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN


(Bacillus
anthracis)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
5 LEU A  90
LEU A  74
ILE A  37
SER A  76
ALA A  79
None
1.36A 4z69A-2jjmA:
0.0
4z69A-2jjmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvc PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF11829
(DUF3349)
5 ARG A  37
LEU A  93
LEU A  15
SER A  28
ALA A  30
None
1.46A 4z69A-2kvcA:
undetectable
4z69A-2kvcA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 ARG E 489
LEU E 485
LEU E 511
SER E 509
ALA E 505
None
1.30A 4z69A-2nxxE:
0.0
4z69A-2nxxE:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa)
PF13088
(BNR_2)
5 ARG A 260
ARG A 198
LEU A 255
SER A 240
ALA A 238
None
1.37A 4z69A-2w38A:
undetectable
4z69A-2w38A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 19
PEROXISOMAL
BIOGENESIS FACTOR 3


(Homo sapiens)
PF04882
(Peroxin-3)
no annotation
5 LEU B  26
LEU A 107
ILE A 103
SER A  88
ALA A  91
None
1.38A 4z69A-3ajbB:
undetectable
4z69A-3ajbB:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli)
PF10672
(Methyltrans_SAM)
5 LEU A 128
LEU A 144
ILE A 153
SER A 142
ALA A 138
None
1.48A 4z69A-3c0kA:
undetectable
4z69A-3c0kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2


(Homo sapiens)
PF01852
(START)
5 ARG A 447
LEU A 508
ILE A 506
SER A 493
ALA A 470
None
1PE  A   2 (-4.7A)
None
None
None
1.45A 4z69A-3fo5A:
undetectable
4z69A-3fo5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA


(Mycobacterium
tuberculosis)
no annotation 5 ARG A 182
LEU A 181
ILE A 225
SER A 228
ALA A 232
None
1.36A 4z69A-3hf9A:
undetectable
4z69A-3hf9A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ARG A 515
LEU A 566
LEU A 797
ILE A 800
ALA A 814
None
1.30A 4z69A-3hhdA:
undetectable
4z69A-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE


(Legionella
pneumophila)
PF01636
(APH)
5 ARG A 306
LEU A 297
ILE A 161
SER A 176
ALA A 172
None
1.50A 4z69A-3i1aA:
2.6
4z69A-3i1aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
5 ARG A 103
LEU A 100
LEU A  56
SER A  58
ALA A  62
None
1.34A 4z69A-3swdA:
undetectable
4z69A-3swdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Bradyrhizobium
sp. ORS 278)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TRP A 349
LEU A 345
LEU A 272
ILE A 278
SER A 105
None
1.37A 4z69A-3toyA:
undetectable
4z69A-3toyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE


(Zymomonas
mobilis)
PF00724
(Oxidored_FMN)
5 LEU A 205
LEU A 253
ILE A 255
SER A 251
ALA A 247
None
1.22A 4z69A-4a3uA:
undetectable
4z69A-4a3uA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE


(Clostridioides
difficile)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ARG A  98
LEU A  97
LEU A 261
ILE A  11
ALA A 103
None
1.42A 4z69A-4dd5A:
undetectable
4z69A-4dd5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE


(Clostridioides
difficile)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ARG A  98
LEU A 392
LEU A 261
ILE A  11
ALA A 103
None
1.21A 4z69A-4dd5A:
undetectable
4z69A-4dd5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwv TTC1975 PEPTIDASE

(Meiothermus
taiwanensis)
PF13654
(AAA_32)
5 ARG A  36
LEU A  39
LEU A  67
ILE A 311
ALA A  62
None
1.36A 4z69A-4fwvA:
3.1
4z69A-4fwvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbq MUCOSAL ADDRESSIN
CELL ADHESION
MOLECULE 1


(Homo sapiens)
PF09085
(Adhes-Ig_like)
5 LEU A 129
LEU A 103
ILE A 199
SER A  99
ALA A 111
None
1.20A 4z69A-4hbqA:
undetectable
4z69A-4hbqA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF


(Pseudomonas
fluorescens)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
5 LEU A 184
LEU A 100
ILE A 104
SER A 160
ALA A 162
None
1.06A 4z69A-4id0A:
2.1
4z69A-4id0A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE


(Cupriavidus
metallidurans)
PF05292
(MCD)
PF17408
(MCD_N)
5 TRP A 425
LEU A 375
LEU A 349
ILE A 345
ALA A 392
None
1.36A 4z69A-4ks9A:
undetectable
4z69A-4ks9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu1 MAF-LIKE PROTEIN
YCEF


(Escherichia
coli)
PF02545
(Maf)
5 ARG A 185
LEU A 184
LEU A  17
ILE A  66
ALA A 179
None
1.31A 4z69A-4lu1A:
undetectable
4z69A-4lu1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o06 PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P27


(Saccharomyces
cerevisiae)
PF00595
(PDZ)
5 LEU A 213
LEU A 186
ILE A 160
SER A 200
ALA A 149
None
None
None
PG4  A 301 (-2.9A)
None
1.30A 4z69A-4o06A:
undetectable
4z69A-4o06A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens)
no annotation 5 LEU A 381
LEU A 360
ILE A 363
SER A 160
ALA A 157
None
None
None
A  D  17 ( 4.1A)
None
1.47A 4z69A-4qikA:
2.7
4z69A-4qikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE


(Plasmodium
vivax)
PF00082
(Peptidase_S8)
5 LEU A 170
LEU A 186
ILE A 193
SER A 184
ALA A 180
None
1.23A 4z69A-4tr2A:
undetectable
4z69A-4tr2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus)
PF00604
(Flu_PB2)
5 ARG C 299
LEU C 298
LEU C 280
ILE C 266
SER C 282
None
1.36A 4z69A-4wsbC:
undetectable
4z69A-4wsbC:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsi MAGUK P55 SUBFAMILY
MEMBER 5


(Homo sapiens)
PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2)
5 ARG A 498
LEU A 499
LEU A 484
ILE A 595
ALA A 651
None
1.47A 4z69A-4wsiA:
undetectable
4z69A-4wsiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Moraxella
catarrhalis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 LYS A 143
LEU A 244
LEU A 163
ILE A 181
ALA A 173
None
1.46A 4z69A-4zqgA:
2.3
4z69A-4zqgA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LEU A 218
LEU A 259
ILE A 263
SER A 286
ALA A 290
None
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.9A)
PG4  A 602 (-3.4A)
0.56A 4z69A-5dqfA:
38.4
4z69A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LYS A 198
LEU A 259
ILE A 263
SER A 286
ALA A 290
PG4  A 602 ( 4.3A)
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.9A)
PG4  A 602 (-3.4A)
0.94A 4z69A-5dqfA:
38.4
4z69A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LYS A 198
TRP A 213
LEU A 259
ILE A 263
ALA A 290
PG4  A 602 ( 4.3A)
None
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.4A)
1.17A 4z69A-5dqfA:
38.4
4z69A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 TRP A 213
ARG A 217
LEU A 218
LEU A 259
ILE A 263
None
CL  A 617 ( 4.6A)
None
PG4  A 602 ( 4.5A)
None
1.14A 4z69A-5dqfA:
38.4
4z69A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 TRP A 213
LEU A 218
LEU A 259
ILE A 263
ALA A 290
None
None
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.4A)
0.79A 4z69A-5dqfA:
38.4
4z69A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
6 LYS A 199
TRP A 214
LEU A 219
LEU A 260
SER A 287
ALA A 291
None
0.93A 4z69A-5ghkA:
36.3
4z69A-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
5 TRP A 214
ARG A 218
LEU A 219
LEU A 260
ALA A 291
None
0.95A 4z69A-5ghkA:
36.3
4z69A-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
5 LEU B1156
LEU B1174
ILE B1172
SER B1134
ALA B1078
None
1.17A 4z69A-5gztB:
undetectable
4z69A-5gztB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
5 LEU A1156
LEU A1174
ILE A1172
SER A1134
ALA A1078
None
1.18A 4z69A-5gzuA:
undetectable
4z69A-5gzuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC


(Homo sapiens)
PF00063
(Myosin_head)
5 ARG A 398
LEU A 401
LEU A 364
ILE A 577
SER A 366
DMS  A 805 (-3.4A)
None
None
None
None
1.24A 4z69A-5hmpA:
2.6
4z69A-5hmpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B


(Homo sapiens)
PF00646
(F-box)
5 ARG A1219
LEU A1218
LEU A1186
ILE A1225
ALA A1221
None
1.09A 4z69A-5jh5A:
undetectable
4z69A-5jh5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Acidaminococcus
sp. BV3L6)
no annotation 5 ARG A 341
LEU A 340
LEU A 477
SER A 473
ALA A 449
None
1.44A 4z69A-5kk5A:
undetectable
4z69A-5kk5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-9

(Caenorhabditis
elegans)
no annotation 5 LEU D 319
LEU D 102
ILE D 312
SER D 104
ALA D 107
None
1.10A 4z69A-5nkmD:
undetectable
4z69A-5nkmD:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata)
no annotation 5 LEU A 176
ARG A 180
LEU A 120
ILE A 106
ALA A 126
None
1.23A 4z69A-5nnbA:
undetectable
4z69A-5nnbA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE


(Zobellia
galactanivorans)
no annotation 5 TRP A 226
LEU A 275
LEU A 541
ILE A 252
ALA A 174
None
1.16A 4z69A-5opqA:
undetectable
4z69A-5opqA:
10.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 5 ARG A 198
LEU A 259
ILE A 263
SER A 286
ALA A 290
None
1.23A 4z69A-5oriA:
36.9
4z69A-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 6 LEU A 218
ARG A 217
LEU A 259
ILE A 263
SER A 286
ALA A 290
None
1.46A 4z69A-5oriA:
36.9
4z69A-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 6 TRP A 213
ARG A 217
LEU A 218
LEU A 259
SER A 286
ALA A 290
None
1.07A 4z69A-5oriA:
36.9
4z69A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae)
PF01116
(F_bP_aldolase)
5 ARG A 290
LEU A 282
ILE A 245
SER A 284
ALA A 287
EDO  A 404 (-3.1A)
None
None
None
None
1.40A 4z69A-5u4nA:
undetectable
4z69A-5u4nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvd NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN


(Paracoccidioides
brasiliensis)
no annotation 5 LEU A 196
ARG A 200
LEU A 144
ILE A 171
SER A 169
None
1.34A 4z69A-5uvdA:
undetectable
4z69A-5uvdA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3


(Oryzias latipes)
PF01094
(ANF_receptor)
5 TRP B 456
LEU B 461
ILE B 324
SER B 301
ALA B 298
None
1.38A 4z69A-5x2oB:
undetectable
4z69A-5x2oB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 LEU M 401
LEU M 452
ILE M 455
SER M 495
ALA M 497
None
1.28A 4z69A-5xtbM:
undetectable
4z69A-5xtbM:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 5 LYS A 195
LEU A 219
LEU A 260
ILE A 264
SER A 287
None
1.20A 4z69A-5yxeA:
37.2
4z69A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 5 LYS A 199
LEU A 219
LEU A 260
ILE A 264
SER A 287
None
0.84A 4z69A-5yxeA:
37.2
4z69A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9x HEPATITIS B VIRUS X
INTERACTING PROTEIN
RAGULATOR COMPLEX
PROTEIN LAMTOR4


(Homo sapiens)
no annotation 5 LEU D  55
LEU E 130
ILE E 158
SER E 128
ALA E 124
None
1.15A 4z69A-6b9xD:
undetectable
4z69A-6b9xD:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Paraburkholderia
phymatum)
no annotation 5 ARG A  30
LEU A  29
LEU A  37
ILE A  13
ALA A  23
None
1.41A 4z69A-6d9yA:
undetectable
4z69A-6d9yA:
9.79