SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z69_A_DIFA1006_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bd7 CIRCULARLY PERMUTED
BB2-CRYSTALLIN

(Rattus
norvegicus) 		PF00030
(Crystall) 		4 ILE A   5
HIS A  16
LEU A  18
LYS A  26
 None
 1.05A 4z69A-1bd7A:
undetectable		 4z69A-1bd7A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 ILE A 326
HIS A 315
LEU A  36
GLY A 317
 None
 1.04A 4z69A-1eb3A:
0.2		 4z69A-1eb3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 ILE A  75
LEU A 237
GLY A 307
LYS A  40
 None
 1.02A 4z69A-1g7rA:
0.0		 4z69A-1g7rA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		4 ILE A 136
LEU A 157
GLY A 145
LYS A 146
 None
 0.97A 4z69A-1hjqA:
0.0		 4z69A-1hjqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqq S3-RNASE

(Pyrus pyrifolia) 		PF00445
(Ribonuclease_T2) 		4 ILE A  96
LEU A  35
TYR A   1
GLY A 175
 None
 0.99A 4z69A-1iqqA:
undetectable		 4z69A-1iqqA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		4 ILE A 229
HIS A 191
LEU A 230
GLY A 223
 None
 1.00A 4z69A-1k4yA:
2.6		 4z69A-1k4yA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 ILE A 256
LEU A 286
GLY A 166
LYS A 169
 None
 0.97A 4z69A-1l8wA:
0.0		 4z69A-1l8wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN GAMMA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C) 		4 ILE C 366
LEU C 377
TYR C 352
GLY C 344
 None
 1.04A 4z69A-1lwuC:
undetectable		 4z69A-1lwuC:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 ILE A 200
HIS A 204
LEU A 292
GLY A 395
 None
 1.00A 4z69A-1pvjA:
undetectable		 4z69A-1pvjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  40
HIS A 311
LEU A 325
GLY A  62
 None
 1.00A 4z69A-1qorA:
0.0		 4z69A-1qorA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE B 552
LEU B 503
TYR B 545
GLY B 541
 None
 0.85A 4z69A-1t3qB:
0.0		 4z69A-1t3qB:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ILE A 142
HIS A 146
LEU A 154
GLY A 189
 None
 0.98A 4z69A-1tf0A:
37.7		 4z69A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 349
LEU A 164
GLY A 195
LYS A 194
 None
 0.79A 4z69A-1tuoA:
undetectable		 4z69A-1tuoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		4 ILE A 280
LEU A 258
GLY A 226
LYS A 228
 None
 1.04A 4z69A-1wyeA:
undetectable		 4z69A-1wyeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 ILE A  84
HIS A  76
GLY A  81
LYS A  79
 None
POP  A3000 (-3.8A)
None
None
 0.86A 4z69A-1yqeA:
undetectable		 4z69A-1yqeA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 ILE A  29
LEU A 148
TYR A   6
LYS A  23
 None
 0.98A 4z69A-1z72A:
undetectable		 4z69A-1z72A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 ILE A  47
LEU A  74
GLY A  40
LYS A  41
 None
None
ACT  A 321 (-3.9A)
None
 0.81A 4z69A-2ajrA:
undetectable		 4z69A-2ajrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 ILE A  88
HIS A 215
LEU A  92
GLY A 160
 None
 1.00A 4z69A-2b2nA:
undetectable		 4z69A-2b2nA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		4 ILE A 176
HIS A 156
LEU A 164
GLY A 134
 None
None
None
SO4  A1301 (-3.5A)
 0.96A 4z69A-2e55A:
undetectable		 4z69A-2e55A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ILE A  88
HIS A 215
LEU A  92
GLY A 160
 None
 0.95A 4z69A-2eyqA:
undetectable		 4z69A-2eyqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		4 ILE A 230
HIS A 234
LEU A 391
GLY A 375
 None
 1.04A 4z69A-2h12A:
undetectable		 4z69A-2h12A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE B  63
LEU B  72
TYR B 111
GLY B  58
 None
 0.89A 4z69A-2i2xB:
3.8		 4z69A-2i2xB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifu GAMMA-SNAP

(Danio rerio) 		PF14938
(SNAP) 		4 LEU A 176
TYR A 183
GLY A 157
LYS A 158
 None
 1.00A 4z69A-2ifuA:
undetectable		 4z69A-2ifuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1u FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		4 ILE A 129
LEU A  67
GLY A 125
LYS A 124
 None
 0.96A 4z69A-2j1uA:
undetectable		 4z69A-2j1uA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0m LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		4 ILE A  53
LEU A  51
GLY A 124
LYS A 125
 None
 1.05A 4z69A-2n0mA:
undetectable		 4z69A-2n0mA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE

(Bacteroides
thetaiotaomicron) 		PF00596
(Aldolase_II) 		4 ILE A   2
HIS A   6
LEU A  39
GLY A  35
 None
 0.98A 4z69A-2opiA:
undetectable		 4z69A-2opiA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 117
LEU A 121
TYR A 273
LYS A 244
 None
 0.89A 4z69A-2xikA:
undetectable		 4z69A-2xikA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys1 DYNAMIN-2

(Homo sapiens) 		PF00169
(PH) 		4 ILE A  19
TYR A  29
GLY A  24
LYS A  23
 None
 1.01A 4z69A-2ys1A:
undetectable		 4z69A-2ys1A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 ILE A 198
LEU A  37
TYR A 229
GLY A  40
 None
 1.04A 4z69A-2yz2A:
undetectable		 4z69A-2yz2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 ILE A 511
LEU A 515
TYR A 424
GLY A 496
 None
 0.97A 4z69A-2zy2A:
undetectable		 4z69A-2zy2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		4 ILE A 108
LEU A  65
GLY A  51
LYS A  52
 None
 0.93A 4z69A-3b9gA:
undetectable		 4z69A-3b9gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq7 DIACYLGLYCEROL
KINASE DELTA

(Homo sapiens) 		PF07647
(SAM_2) 		4 ILE A  58
LEU A  59
GLY A  53
LYS A  51
 None
 0.96A 4z69A-3bq7A:
undetectable		 4z69A-3bq7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 ILE A 353
LEU A 335
GLY A 390
LYS A 389
 None
 1.04A 4z69A-3c0kA:
undetectable		 4z69A-3c0kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ILE A 247
LEU A 211
GLY A 215
LYS A 216
 None
 0.99A 4z69A-3cihA:
2.2		 4z69A-3cihA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP) 		4 ILE B  94
LEU B  98
GLY B 239
LYS B 238
 None
 1.05A 4z69A-3cueB:
undetectable		 4z69A-3cueB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 ILE A  69
LEU A  71
GLY A 349
LYS A 350
 None
 1.02A 4z69A-3danA:
2.4		 4z69A-3danA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 ILE B 200
LEU B 159
GLY B 137
LYS B 135
 None
 0.98A 4z69A-3draB:
undetectable		 4z69A-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 298
LEU A 198
GLY A 226
LYS A 225
 NAD  A 439 (-4.6A)
None
None
None
 1.00A 4z69A-3g1uA:
undetectable		 4z69A-3g1uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 342
LEU A 242
GLY A 270
LYS A 269
 NAD  A 601 (-4.3A)
None
None
None
 1.00A 4z69A-3glqA:
undetectable		 4z69A-3glqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 298
LEU A 198
GLY A 226
LYS A 225
 NAD  A 438 (-4.4A)
None
None
None
 1.03A 4z69A-3h9uA:
undetectable		 4z69A-3h9uA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 ILE A  88
HIS A 215
LEU A  92
GLY A 160
 None
 1.02A 4z69A-3hjhA:
undetectable		 4z69A-3hjhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 ILE A1173
LEU A1161
GLY A  21
LYS A  22
 None
 0.88A 4z69A-3jroA:
undetectable		 4z69A-3jroA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermoplasma
volcanium) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		4 ILE A 212
HIS A 240
LEU A 242
GLY A  88
 None
 0.81A 4z69A-3lpnA:
undetectable		 4z69A-3lpnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 305
LEU A 364
GLY A 351
LYS A 352
 None
 1.05A 4z69A-3n2bA:
undetectable		 4z69A-3n2bA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ILE A 205
LEU A 197
GLY A 202
LYS A 201
 None
 1.01A 4z69A-3pv4A:
undetectable		 4z69A-3pv4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 ILE A 111
LEU A  83
GLY A  10
LYS A  11
 None
 0.92A 4z69A-3r9wA:
undetectable		 4z69A-3r9wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 ILE A 278
LEU A 369
GLY A 258
LYS A 257
 None
 0.95A 4z69A-3tbkA:
3.3		 4z69A-3tbkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpu 42F3 BETA

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE B  46
HIS B  47
LEU B  76
GLY B  63
 None
 1.05A 4z69A-3tpuB:
undetectable		 4z69A-3tpuB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		4 ILE A 293
LEU A 228
GLY A 241
LYS A 243
 None
 1.01A 4z69A-3tqgA:
undetectable		 4z69A-3tqgA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpc PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Sulfurisphaera
tokodaii) 		PF08443
(RimK) 		4 ILE A  75
LEU A 272
TYR A 280
GLY A 183
 None
 1.04A 4z69A-3vpcA:
2.1		 4z69A-3vpcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		4 ILE A  36
LEU A  33
GLY A   5
LYS A   2
 None
 0.95A 4z69A-3vvjA:
undetectable		 4z69A-3vvjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		4 ILE A  31
LEU A  42
GLY A  67
LYS A  65
 None
 0.90A 4z69A-3wviA:
undetectable		 4z69A-3wviA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A1034
LEU A1029
GLY A1015
LYS A1014
 None
None
None
DTT  A1205 ( 4.3A)
 1.03A 4z69A-3wzdA:
undetectable		 4z69A-3wzdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A1034
LEU A1029
GLY A1015
LYS A1014
 None
 1.04A 4z69A-4agdA:
undetectable		 4z69A-4agdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		4 ILE A 149
HIS A 144
LEU A 121
GLY A 158
 None
 1.04A 4z69A-4atyA:
undetectable		 4z69A-4atyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 ILE A 277
LEU A 368
GLY A 257
LYS A 256
 None
 0.94A 4z69A-4ay2A:
3.0		 4z69A-4ay2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ILE A 444
HIS A 487
LEU A 509
GLY A 514
 None
 1.02A 4z69A-4byfA:
2.7		 4z69A-4byfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 ILE B 226
LEU B 117
TYR B 318
GLY B 221
 None
 1.01A 4z69A-4cakB:
undetectable		 4z69A-4cakB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		4 ILE A 383
LEU A 319
TYR A 338
GLY A 335
 None
 1.03A 4z69A-4cswA:
2.5		 4z69A-4cswA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		4 ILE i 545
LEU i 543
GLY i 618
LYS i 619
 None
 0.90A 4z69A-4d61i:
undetectable		 4z69A-4d61i:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ILE A  87
LEU A  84
TYR A  31
GLY A 139
 None
 1.02A 4z69A-4di1A:
undetectable		 4z69A-4di1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doh INTERLEUKIN-20
INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF00726
(IL10)
no annotation 		4 ILE A  64
LEU A  65
TYR R  76
GLY A 163
 None
 1.00A 4z69A-4dohA:
2.1		 4z69A-4dohA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5

(Mus musculus) 		no annotation 4 HIS A 476
TYR A 410
GLY A 402
LYS A 403
 None
 0.96A 4z69A-4gjhA:
undetectable		 4z69A-4gjhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		4 ILE A 169
LEU A 146
GLY A 207
LYS A 208
 None
None
None
PG4  A 409 (-2.9A)
 1.02A 4z69A-4h41A:
undetectable		 4z69A-4h41A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwm UNCHARACTERIZED
PROTEIN YEDD

(Klebsiella
pneumoniae) 		PF13987
(YedD) 		4 ILE A  88
LEU A  35
GLY A  63
LYS A  80
 None
 0.96A 4z69A-4hwmA:
undetectable		 4z69A-4hwmA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 319
LEU A 248
GLY A 281
LYS A 283
 None
 0.93A 4z69A-4hymA:
undetectable		 4z69A-4hymA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 HIS A 608
LEU A 561
TYR A 547
GLY A 553
 None
 1.01A 4z69A-4jzaA:
undetectable		 4z69A-4jzaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC

(Mycobacterium
marinum) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A 168
LEU A 175
TYR A 329
GLY A 348
 None
 1.04A 4z69A-4kamA:
undetectable		 4z69A-4kamA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5o PUTATIVE GLUTATHIONE
TRANSFERASE

(Clonorchis
sinensis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  75
HIS A  79
LEU A  20
GLY A  25
 None
ZN  A 303 (-3.0A)
None
None
 1.04A 4z69A-4l5oA:
undetectable		 4z69A-4l5oA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 340
LEU A 240
GLY A 268
LYS A 267
 NAD  A 503 (-4.3A)
None
None
None
 0.99A 4z69A-4lvcA:
undetectable		 4z69A-4lvcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 ILE B  48
LEU B  70
GLY B  66
LYS B  65
 None
 0.93A 4z69A-4nkoB:
undetectable		 4z69A-4nkoB:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 277
LEU A 368
GLY A 257
LYS A 256
 None
 0.78A 4z69A-4on9A:
3.0		 4z69A-4on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 406
LEU A 368
GLY A 257
LYS A 256
 None
 0.77A 4z69A-4on9A:
3.0		 4z69A-4on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 ILE A 186
LEU A 245
TYR A  47
GLY A 238
 None
 1.03A 4z69A-4p1cA:
1.5		 4z69A-4p1cA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 ILE A 369
HIS A 317
LEU A 387
GLY A 391
 None
 1.05A 4z69A-4re2A:
undetectable		 4z69A-4re2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		4 ILE A 151
LEU A 153
TYR A 218
GLY A 163
 None
 0.98A 4z69A-4xukA:
undetectable		 4z69A-4xukA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 594
LEU A 589
GLY A 573
LYS A 572
 None
 1.05A 4z69A-4yffA:
undetectable		 4z69A-4yffA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 ILE A  25
LEU A 142
GLY A 129
LYS A 126
 None
 1.01A 4z69A-4yisA:
2.6		 4z69A-4yisA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 ILE A 574
LEU A 596
GLY A 402
LYS A 374
 None
None
None
ZN  A 702 (-2.1A)
 1.02A 4z69A-5cbmA:
undetectable		 4z69A-5cbmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9d A6-TCR VBETA

(Homo sapiens) 		PF07686
(V-set) 		4 ILE E  46
HIS E  47
LEU E  76
GLY E  63
 None
 1.02A 4z69A-5e9dE:
undetectable		 4z69A-5e9dE:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqw PUTATIVE MAJOR COAT
PROTEIN

(Acidianus
tailed spindle
virus) 		no annotation 4 ILE A  18
LEU A  19
GLY A  13
LYS A  10
 None
 1.02A 4z69A-5eqwA:
undetectable		 4z69A-5eqwA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5y NON-LEE ENCODED
EFFECTOR PROTEIN
NLEB

(Escherichia
coli) 		no annotation 4 ILE A 314
HIS A 311
GLY A 225
LYS A 226
 None
 1.01A 4z69A-5h5yA:
2.4		 4z69A-5h5yA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC

(Escherichia
coli) 		PF09344
(Cas_CT1975) 		4 ILE D 160
LEU D 154
GLY D 176
LYS D 177
 None
None
None
C  L  35 ( 4.5A)
 0.99A 4z69A-5h9fD:
undetectable		 4z69A-5h9fD:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ia8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME
5,UBIQUITIN-FOLD
MODIFIER 1

(Homo sapiens) 		PF03671
(Ufm1) 		4 ILE A  57
HIS A  70
LEU A  74
GLY A  54
 None
 0.98A 4z69A-5ia8A:
undetectable		 4z69A-5ia8A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-FOLD
MODIFIER 1

(Homo sapiens) 		PF03671
(Ufm1) 		4 ILE C  57
HIS C  70
LEU C  74
GLY C  54
 None
 1.04A 4z69A-5iaaC:
undetectable		 4z69A-5iaaC:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 ILE A 406
LEU A 372
GLY A 629
LYS A 628
 None
 0.97A 4z69A-5na7A:
1.8		 4z69A-5na7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		4 ILE A 528
HIS A 522
LEU A 530
GLY A 524
 None
 1.04A 4z69A-5sy1A:
2.1		 4z69A-5sy1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tug FLAGELLAR
BIOSYNTHESIS PROTEIN
FLAG

(Sulfolobus
acidocaldarius) 		no annotation 4 HIS A  70
LEU A 113
TYR A 145
GLY A  73
 None
 1.03A 4z69A-5tugA:
undetectable		 4z69A-5tugA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 ILE A 155
LEU A 181
GLY A 152
LYS A 151
 None
 0.97A 4z69A-5ujsA:
undetectable		 4z69A-5ujsA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 354
LEU A 254
GLY A 282
LYS A 281
 NAD  A 501 (-4.3A)
None
None
None
 1.00A 4z69A-5utuA:
undetectable		 4z69A-5utuA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 340
LEU A 240
GLY A 268
LYS A 267
 NAD  A 501 (-4.4A)
None
None
None
 0.97A 4z69A-5v96A:
undetectable		 4z69A-5v96A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 362
LEU A 372
TYR A 401
GLY A 428
 None
 0.90A 4z69A-5vrbA:
undetectable		 4z69A-5vrbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 299
LEU A 199
GLY A 227
LYS A 226
 NAD  A 501 (-4.3A)
None
None
None
 1.03A 4z69A-5w4bA:
undetectable		 4z69A-5w4bA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 HIS A 318
LEU A 289
GLY A 282
LYS A 281
 None
 0.90A 4z69A-5wy4A:
undetectable		 4z69A-5wy4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		4 ILE A 223
LEU A 225
GLY A 316
LYS A 315
 None
 0.89A 4z69A-5xzbA:
undetectable		 4z69A-5xzbA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii) 		no annotation 4 ILE M 588
HIS M 542
LEU M 538
GLY L 230
 MQE  M 701 (-4.4A)
FE  L1005 ( 3.0A)
MQE  M 701 ( 4.9A)
None
 0.90A 4z69A-5yq7M:
2.9		 4z69A-5yq7M:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 ILE A 292
HIS A 226
LEU A 224
GLY A 255
 None
 1.03A 4z69A-5z5dA:
undetectable		 4z69A-5z5dA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 4 ILE A 322
HIS A 319
GLY A 233
LYS A 234
 None
 1.01A 4z69A-6dusA:
2.5		 4z69A-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 ILE B 321
LEU B 207
GLY B 235
LYS B 234
 NAD  B 501 (-4.4A)
None
None
None
 0.98A 4z69A-6f3mB:
undetectable		 4z69A-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 ILE A 302
LEU A 202
GLY A 230
LYS A 229
 NAD  A 502 (-4.3A)
None
None
None
 1.00A 4z69A-6gbnA:
undetectable		 4z69A-6gbnA:
undetectable