SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4H_A_IPHA904_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b64 ELONGATION FACTOR
1-BETA

(Homo sapiens) 		PF00736
(EF1_GNE) 		4 GLN A  81
PRO A  14
ILE A  50
ASP A  16
 None
 1.16A 4z4hA-1b64A:
3.1		 4z4hA-1b64A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		4 GLN A  19
PRO A  15
ILE A  17
ASP A  40
 None
 1.50A 4z4hA-1cteA:
undetectable		 4z4hA-1cteA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 ARG D 362
PRO D 361
ILE D 338
ASP D 336
 None
 1.40A 4z4hA-1dkgD:
5.6		 4z4hA-1dkgD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR

(Hirudo
medicinalis) 		no annotation 4 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 1.08A 4z4hA-1dtdB:
0.2		 4z4hA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		4 ARG A 361
PRO A 448
ILE A 360
ASP A 274
 None
 1.38A 4z4hA-1gcbA:
0.8		 4z4hA-1gcbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ARG A 770
GLN A 567
ILE A 619
ASP A 570
 None
 1.19A 4z4hA-1hwwA:
0.0		 4z4hA-1hwwA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		4 ARG A  66
GLN A  67
PRO A  51
ILE A  64
 None
 1.24A 4z4hA-1mg7A:
1.2		 4z4hA-1mg7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLN A 303
PRO A 199
ILE A 201
ASP A 207
 None
 0.99A 4z4hA-1mpxA:
3.8		 4z4hA-1mpxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 ARG A  64
GLN A  67
PRO A  66
ASP A 175
 None
 1.40A 4z4hA-1ukcA:
0.0		 4z4hA-1ukcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLN A 249
PRO A 254
ILE A 255
ASP A 258
 None
 1.34A 4z4hA-1v9kA:
undetectable		 4z4hA-1v9kA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 ARG A 282
GLN A   5
PRO A   4
ASP A 373
 None
 1.11A 4z4hA-2gahA:
undetectable		 4z4hA-2gahA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 ARG A 249
GLN A 252
PRO A 253
ILE A 248
 None
 1.47A 4z4hA-2obnA:
undetectable		 4z4hA-2obnA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oh1 ACETYLTRANSFERASE,
GNAT FAMILY

(Listeria
monocytogenes) 		no annotation 4 ARG A  83
GLN A  59
ILE A  81
ASP A  53
 None
 1.30A 4z4hA-2oh1A:
undetectable		 4z4hA-2oh1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ARG A 224
PRO A 259
ILE A 261
ASP A 262
 None
 1.34A 4z4hA-2v5dA:
2.9		 4z4hA-2v5dA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		4 GLN A 554
PRO A 553
ILE A 551
ASP A 524
 None
 1.17A 4z4hA-2v5iA:
undetectable		 4z4hA-2v5iA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7w SUPEROXIDE DISMUTASE
[FE]

(Aliivibrio
salmonicida) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLN A  88
PRO A  89
ILE A  97
ASP A  98
 None
 1.23A 4z4hA-2w7wA:
undetectable		 4z4hA-2w7wA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 GLN A 181
PRO A 179
ILE A 169
ASP A  58
 None
 1.10A 4z4hA-2x4lA:
3.6		 4z4hA-2x4lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		4 GLN A 177
PRO A 176
ILE A 357
ASP A 262
 None
 1.28A 4z4hA-2ybxA:
undetectable		 4z4hA-2ybxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ARG A 387
GLN A 394
PRO A 392
ASP A 125
 None
 1.46A 4z4hA-2zpaA:
undetectable		 4z4hA-2zpaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Porphyromonas
gingivalis) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		4 ARG A 272
GLN A 273
PRO A 284
ILE A 286
 None
 1.48A 4z4hA-3bioA:
3.5		 4z4hA-3bioA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.06A 4z4hA-3d1jA:
3.7		 4z4hA-3d1jA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		4 GLN A 227
PRO A 199
ILE A 159
ASP A 158
 EDO  A 369 ( 3.3A)
None
None
None
 1.40A 4z4hA-3ianA:
undetectable		 4z4hA-3ianA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		4 GLN A  77
PRO A  75
ILE A 142
ASP A  93
 None
None
NFM  A 401 ( 3.9A)
None
 1.15A 4z4hA-3ix1A:
undetectable		 4z4hA-3ix1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		4 GLN p 259
PRO p 355
ILE p 351
ASP p 353
 None
 1.41A 4z4hA-3japp:
undetectable		 4z4hA-3japp:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 GLN X 529
PRO X 488
ILE X 476
ASP X 475
 None
 1.19A 4z4hA-3kvnX:
2.2		 4z4hA-3kvnX:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lte RESPONSE REGULATOR

(Bermanella
marisrubri) 		PF00072
(Response_reg) 		4 GLN A 141
PRO A 142
ILE A 144
ASP A 164
 None
 1.02A 4z4hA-3lteA:
5.1		 4z4hA-3lteA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 ARG A  96
GLN B 550
PRO B 549
ASP A 100
 None
 1.38A 4z4hA-3ml0A:
undetectable		 4z4hA-3ml0A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.96A 4z4hA-3nwrA:
undetectable		 4z4hA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		4 GLN A 285
PRO A 282
ILE A  49
ASP A  48
 None
 1.44A 4z4hA-3o8jA:
2.3		 4z4hA-3o8jA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A 355
GLN A 197
ILE A  14
ASP A 215
 None
 1.14A 4z4hA-3ss6A:
undetectable		 4z4hA-3ss6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.08A 4z4hA-3u7vA:
2.7		 4z4hA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		4 ARG A 227
PRO A   5
ILE A 156
ASP A 155
 None
 1.27A 4z4hA-3w0fA:
undetectable		 4z4hA-3w0fA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		4 ARG A 270
GLN A 271
PRO A 282
ILE A 284
 None
 1.48A 4z4hA-3wbbA:
2.2		 4z4hA-3wbbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA

(Homo sapiens) 		PF01504
(PIP5K) 		4 GLN A 182
PRO A 181
ILE A 367
ASP A 267
 None
 1.25A 4z4hA-3x05A:
undetectable		 4z4hA-3x05A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 ARG A 465
GLN A 264
ILE A 228
ASP A 227
 None
 1.30A 4z4hA-4ag6A:
2.5		 4z4hA-4ag6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 GLN A 206
PRO A 178
ILE A 138
ASP A 137
 ACT  A1331 (-3.7A)
None
None
None
 1.41A 4z4hA-4axnA:
undetectable		 4z4hA-4axnA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 ARG A 135
GLN A 133
ILE A 128
ASP A 251
 None
 1.32A 4z4hA-4c0hA:
2.1		 4z4hA-4c0hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		4 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.08A 4z4hA-4da5A:
undetectable		 4z4hA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 ARG A 238
GLN A 200
PRO A 167
ILE A 196
 None
 1.34A 4z4hA-4fixA:
2.3		 4z4hA-4fixA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		4 GLN A 519
PRO A 521
ILE A 522
ASP A 507
 None
 1.37A 4z4hA-4fwwA:
undetectable		 4z4hA-4fwwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 184
PRO A 214
ILE A 213
ASP A 212
 None
 1.47A 4z4hA-4h2hA:
2.2		 4z4hA-4h2hA:
17.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 ARG A 686
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.30A 4z4hA-4krfA:
60.0		 4z4hA-4krfA:
82.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		4 ARG A 102
GLN A 197
ILE A 191
ASP A 190
 None
 1.39A 4z4hA-4l0cA:
3.8		 4z4hA-4l0cA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		4 GLN A 218
PRO A 190
ILE A 150
ASP A 149
 NAG  A 608 (-3.4A)
None
None
None
 1.41A 4z4hA-4mb5A:
3.5		 4z4hA-4mb5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 137
PRO A 136
ILE A 149
ASP A 151
 None
 1.38A 4z4hA-4o7pA:
undetectable		 4z4hA-4o7pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 ARG A 216
GLN A 237
PRO A 215
ILE A 186
 MRD  A 501 ( 4.7A)
MRD  A 501 (-3.8A)
None
CL  A 503 ( 4.7A)
 1.29A 4z4hA-4qfuA:
2.2		 4z4hA-4qfuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		4 ARG A 240
GLN A  52
PRO A  51
ASP A  54
 None
 1.39A 4z4hA-4r72A:
undetectable		 4z4hA-4r72A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 ARG B  11
GLN B  81
PRO B  16
ILE B 183
 None
 1.45A 4z4hA-4tx2B:
undetectable		 4z4hA-4tx2B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		4 GLN A 218
PRO A 190
ILE A 150
ASP A 149
 ACT  A 404 (-3.5A)
None
None
None
 1.38A 4z4hA-4w5zA:
undetectable		 4z4hA-4w5zA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzf 1,3-BETA-GLUCANASE

(Mycobacterium
tuberculosis) 		PF00722
(Glyco_hydro_16) 		4 ARG A  81
PRO A  93
ILE A  84
ASP A  91
 None
 1.37A 4z4hA-4wzfA:
undetectable		 4z4hA-4wzfA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		4 ARG A  48
PRO A  60
ILE A  51
ASP A  58
 None
 1.49A 4z4hA-4xdqA:
undetectable		 4z4hA-4xdqA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apm VP0

(Parechovirus A) 		PF00073
(Rhv) 		4 ARG C 150
PRO C 152
ILE C 119
ASP C 148
 None
 1.43A 4z4hA-5apmC:
undetectable		 4z4hA-5apmC:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 GLN A 254
PRO A 255
ILE A 292
ASP A 256
 None
 1.36A 4z4hA-5ck7A:
undetectable		 4z4hA-5ck7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ARG C 323
GLN C 341
ILE C 263
ASP C 264
 None
 1.30A 4z4hA-5dwzC:
undetectable		 4z4hA-5dwzC:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxd PUTATIVE
BETA-GLUCANASE

(Mycobacteroides
abscessus) 		PF00722
(Glyco_hydro_16) 		4 ARG A  51
PRO A  63
ILE A  54
ASP A  61
 None
 1.17A 4z4hA-5dxdA:
undetectable		 4z4hA-5dxdA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula) 		PF01328
(Peroxidase_2) 		4 ARG A 140
PRO A 142
ILE A  97
ASP A  94
 None
 1.30A 4z4hA-5fukA:
undetectable		 4z4hA-5fukA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.85A 4z4hA-5ijgA:
3.0		 4z4hA-5ijgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ARG A1153
GLN A1146
ILE A1157
ASP A1351
 None
 1.29A 4z4hA-5iy9A:
2.8		 4z4hA-5iy9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 GLN A1181
PRO A1179
ILE A1218
ASP A1199
 None
 1.36A 4z4hA-5jbeA:
undetectable		 4z4hA-5jbeA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ARG A 233
PRO A 130
ILE A 131
ASP A 132
 None
 1.46A 4z4hA-5jd4A:
4.0		 4z4hA-5jd4A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		4 ARG A 374
PRO A 280
ILE A 283
ASP A 284
 None
 1.49A 4z4hA-5kyoA:
undetectable		 4z4hA-5kyoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 ARG A 218
GLN A 239
PRO A 217
ILE A 188
 PO4  A 501 ( 4.7A)
None
None
None
 1.34A 4z4hA-5msyA:
undetectable		 4z4hA-5msyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ARG A  91
GLN A  93
ILE A 211
ASP A 212
 None
 1.50A 4z4hA-5uagA:
undetectable		 4z4hA-5uagA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani) 		PF00579
(tRNA-synt_1b) 		4 ARG A 546
PRO A 548
ILE A 547
ASP A 389
 None
 1.45A 4z4hA-5usfA:
2.7		 4z4hA-5usfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w10 CGMP-SPECIFIC
PHOSPHODIESTERASE

(Leptospira
interrogans) 		PF01590
(GAF) 		4 GLN A 155
PRO A 124
ILE A 126
ASP A 159
 None
 1.49A 4z4hA-5w10A:
undetectable		 4z4hA-5w10A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 ARG A 688
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.66A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.11A 4z4hA-5xctA:
undetectable		 4z4hA-5xctA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.08A 4z4hA-5xcuA:
undetectable		 4z4hA-5xcuA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 ARG A 883
GLN A 882
PRO A 881
ASP A 877
 None
 1.24A 4z4hA-6a91A:
undetectable		 4z4hA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 GLN A2222
PRO A2223
ILE A2224
ASP A2326
 None
 1.00A 4z4hA-6b3rA:
undetectable		 4z4hA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 4 ARG A 245
GLN A 119
ILE A 121
ASP A 160
 None
 1.33A 4z4hA-6bb9A:
undetectable		 4z4hA-6bb9A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D
V-TYPE PROTON ATPASE
SUBUNIT C'

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 GLN B 302
PRO B 203
ILE D  43
ASP D 121
 None
 1.45A 4z4hA-6c6lB:
undetectable		 4z4hA-6c6lB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A2162
PRO A2180
ILE A2288
ASP A2286
 None
 1.50A 4z4hA-6emkA:
undetectable		 4z4hA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 4 ARG A 269
GLN A 207
ILE A 265
ASP A 187
 None
 1.30A 4z4hA-6eubA:
undetectable		 4z4hA-6eubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 4 ARG A 269
GLN A 207
PRO A 206
ILE A 265
 None
 1.43A 4z4hA-6eubA:
undetectable		 4z4hA-6eubA:
undetectable