SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4H_A_IPHA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		4 TYR A  13
LEU A  71
GLU A  70
TYR A  66
 None
 1.36A 4z4hA-1c1kA:
undetectable		 4z4hA-1c1kA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR B 545
LYS B 544
LEU B 667
GLU B 671
 None
 1.45A 4z4hA-1gl9B:
4.2		 4z4hA-1gl9B:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.34A 4z4hA-1h4pA:
1.0		 4z4hA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oah CYTOCHROME C NITRITE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF02335
(Cytochrom_C552) 		4 TYR A 112
LYS A  81
GLU A 114
TYR A  79
 HEM  A1520 (-4.9A)
None
CA  A1526 ( 3.4A)
None
 1.36A 4z4hA-1oahA:
undetectable		 4z4hA-1oahA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		4 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.13A 4z4hA-1ybeA:
0.0		 4z4hA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 LYS A 399
LEU A 324
GLU A 325
TYR A 321
 None
 1.50A 4z4hA-2f6dA:
0.0		 4z4hA-2f6dA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 TYR A 105
LEU A 192
GLU A 190
TYR A 191
 None
 1.40A 4z4hA-2quqA:
0.0		 4z4hA-2quqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 250
LYS A 246
LEU A 342
GLU A 347
 None
 1.23A 4z4hA-2r66A:
2.8		 4z4hA-2r66A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		4 TYR A  24
LYS A  59
LEU A 103
GLU A 104
 None
 0.93A 4z4hA-2za8A:
undetectable		 4z4hA-2za8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 TYR A  21
LYS A  25
LEU A  29
GLU A  30
 None
 1.20A 4z4hA-3gnqA:
0.0		 4z4hA-3gnqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.02A 4z4hA-3i23A:
5.0		 4z4hA-3i23A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 LYS A 579
LEU A 597
GLU A 612
TYR A 253
 None
 1.48A 4z4hA-3o98A:
2.5		 4z4hA-3o98A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 LYS A 611
LEU A 742
GLU A 717
TYR A 716
 None
 1.31A 4z4hA-3tbkA:
undetectable		 4z4hA-3tbkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 LYS A  26
LEU A  10
GLU A   9
TYR A   5
 None
 1.47A 4z4hA-3vbjA:
undetectable		 4z4hA-3vbjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 TYR A 198
LYS A 197
LEU A 133
GLU A 194
 None
 1.30A 4z4hA-3vohA:
undetectable		 4z4hA-3vohA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 TYR A 487
LEU A 492
GLU A 491
TYR A 502
 None
 1.47A 4z4hA-3vr1A:
5.1		 4z4hA-3vr1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zys DYNAMIN-1

(Homo sapiens) 		PF00169
(PH) 		4 TYR C  92
LYS C  90
LEU C  57
TYR C  55
 None
 1.21A 4z4hA-3zysC:
undetectable		 4z4hA-3zysC:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 TYR A 473
LYS A 470
LEU A 597
GLU A 596
 None
 1.25A 4z4hA-4ay2A:
undetectable		 4z4hA-4ay2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.23A 4z4hA-4e2iA:
undetectable		 4z4hA-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5b DR_1245 PROTEIN

(Deinococcus
radiodurans) 		PF10722
(YbjN) 		4 LYS A  68
LEU A 137
GLU A 138
TYR A 134
 None
 1.32A 4z4hA-4h5bA:
undetectable		 4z4hA-4h5bA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 LYS A 389
LEU A 363
GLU A 362
TYR A 366
 None
 1.38A 4z4hA-4n78A:
undetectable		 4z4hA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 TYR A 229
LYS A 294
LEU A 287
GLU A 290
 None
 1.43A 4z4hA-4oanA:
undetectable		 4z4hA-4oanA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.20A 4z4hA-4on9A:
undetectable		 4z4hA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 TYR H 232
LYS H 234
LEU H  78
GLU H  77
 None
 1.40A 4z4hA-4qfkH:
undetectable		 4z4hA-4qfkH:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygs HYDROLASE

(Thermococcus
onnurineus) 		PF13419
(HAD_2) 		4 TYR A 114
LYS A 118
LEU A  18
GLU A  15
 None
 1.29A 4z4hA-4ygsA:
2.8		 4z4hA-4ygsA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.29A 4z4hA-5gu6A:
1.9		 4z4hA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		4 TYR A 299
LYS A 300
GLU A 379
TYR A 376
 None
 1.42A 4z4hA-5ipyA:
undetectable		 4z4hA-5ipyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg8 FERRITIN LIGHT CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 TYR A  27
LYS A  62
LEU A 106
GLU A 107
 None
 0.94A 4z4hA-5lg8A:
undetectable		 4z4hA-5lg8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.20A 4z4hA-5m5pA:
undetectable		 4z4hA-5m5pA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 TYR A 140
LYS A 163
LEU A 111
GLU A 110
 None
 1.45A 4z4hA-5uamA:
undetectable		 4z4hA-5uamA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 TYR A 655
LYS A 661
LEU A 695
GLU A 696
TYR A 699
 None
 0.82A 4z4hA-5vm9A:
55.9		 4z4hA-5vm9A:
79.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 TYR A 863
LYS A 862
LEU A 753
GLU A 754
 None
 1.39A 4z4hA-5w21A:
undetectable		 4z4hA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.91A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.55A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 4 TYR A  36
LEU A  50
GLU A  54
TYR A  40
 None
 1.46A 4z4hA-5x89A:
undetectable		 4z4hA-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 TYR A  79
LEU A  10
GLU A   9
TYR A  92
 None
 1.47A 4z4hA-6eyyA:
undetectable		 4z4hA-6eyyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-) 		no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
 None
 0.98A 4z4hA-6fdtA:
undetectable		 4z4hA-6fdtA:
undetectable