SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4G_A_IPHA905

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.02A 4z4gA-1jftA:
7.5		 4z4gA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 ASP A 271
ALA A 275
THR A 242
THR A 245
 PLP  A 601 (-2.9A)
None
PLP  A 601 ( 4.6A)
None
 1.47A 4z4gA-1js6A:
undetectable		 4z4gA-1js6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 ASP A 342
ALA A 340
THR A 355
TYR A 353
 None
 1.44A 4z4gA-1lmlA:
0.0		 4z4gA-1lmlA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		4 ASP A 111
ALA A  21
THR A 240
THR A 252
 None
 1.43A 4z4gA-1o0xA:
0.0		 4z4gA-1o0xA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		4 ASP A 158
ALA A 133
THR A 156
THR A 155
 None
 1.40A 4z4gA-1pzsA:
undetectable		 4z4gA-1pzsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		4 ASP A  78
ALA A 120
THR A 113
TYR A 115
 None
 1.49A 4z4gA-1ve4A:
undetectable		 4z4gA-1ve4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		4 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.41A 4z4gA-1w2wA:
undetectable		 4z4gA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.31A 4z4gA-1yiqA:
0.0		 4z4gA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		4 ASP A 334
ALA A 339
THR A 221
THR A 303
 None
 1.46A 4z4gA-2b61A:
3.3		 4z4gA-2b61A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe0 SMALL MYRISTOYLATED
PROTEIN 1

(Leishmania
major) 		PF09149
(DUF1935) 		4 ALA A  49
THR A  98
THR A  20
TYR A  51
 None
 1.33A 4z4gA-2fe0A:
undetectable		 4z4gA-2fe0A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.41A 4z4gA-2i2xB:
5.2		 4z4gA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF10384
(Scm3)
PF15511
(CENP-T_C) 		4 ASP A 208
ALA A  31
THR A 205
THR A 203
 None
 1.44A 4z4gA-2l5aA:
undetectable		 4z4gA-2l5aA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		4 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.47A 4z4gA-2nvoA:
4.0		 4z4gA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 ALA A 229
THR A 246
THR A 222
TYR A 227
 None
 1.22A 4z4gA-2o5vA:
undetectable		 4z4gA-2o5vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oux MAGNESIUM
TRANSPORTER

(Enterococcus
faecalis) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.12A 4z4gA-2ouxA:
undetectable		 4z4gA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 ALA A 213
THR A 244
THR A 243
TYR A 172
 None
 1.50A 4z4gA-2quqA:
undetectable		 4z4gA-2quqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.43A 4z4gA-2uu7A:
undetectable		 4z4gA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.42A 4z4gA-2uu7A:
undetectable		 4z4gA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		4 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.44A 4z4gA-2w48A:
undetectable		 4z4gA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ALA B 146
THR B 221
THR B 178
TYR B 149
 None
 1.49A 4z4gA-2y7cB:
undetectable		 4z4gA-2y7cB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASP A 327
ALA A 331
THR A 351
THR A 350
 None
 1.34A 4z4gA-2yfhA:
3.9		 4z4gA-2yfhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9r KETOSTEROID
ISOMERASE-LIKE
PROTEIN

(Pectobacterium
atrosepticum) 		PF12680
(SnoaL_2) 		4 ALA A  15
THR A  34
THR A 124
TYR A  19
 None
None
None
UNL  A 136 (-4.8A)
 1.15A 4z4gA-3d9rA:
undetectable		 4z4gA-3d9rA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASP A 100
ALA A  78
THR A  99
THR A  86
 SKM  A 300 (-2.9A)
None
None
None
 1.46A 4z4gA-3dooA:
undetectable		 4z4gA-3dooA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.46A 4z4gA-3fbgA:
undetectable		 4z4gA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		4 ALA A 257
THR A 603
THR A 262
TYR A 261
 None
 1.14A 4z4gA-3gyxA:
undetectable		 4z4gA-3gyxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A  87
THR A 296
THR A 295
TYR A 328
 CA  A 601 (-2.1A)
None
None
None
 1.47A 4z4gA-3hjrA:
2.2		 4z4gA-3hjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 ASP A  74
ALA A  41
THR A  34
THR A 102
 None
None
None
AAE  A 501 (-4.0A)
 1.37A 4z4gA-3i09A:
4.8		 4z4gA-3i09A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.15A 4z4gA-3i3vA:
undetectable		 4z4gA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.10A 4z4gA-3kb6A:
3.0		 4z4gA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.19A 4z4gA-3kjrA:
undetectable		 4z4gA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.38A 4z4gA-3lpdA:
undetectable		 4z4gA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 229
ALA A 185
THR A 180
THR A 112
 None
None
FDA  A 518 (-3.9A)
None
 1.37A 4z4gA-3oibA:
undetectable		 4z4gA-3oibA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ASP A 262
ALA A 121
THR A 119
THR A  82
 None
None
NAD  A 500 (-3.7A)
NAD  A 500 (-3.1A)
 1.26A 4z4gA-3ojlA:
2.4		 4z4gA-3ojlA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 564
ALA A  31
THR A  59
TYR A  33
 None
 1.46A 4z4gA-3qlbA:
undetectable		 4z4gA-3qlbA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani) 		PF01083
(Cutinase) 		4 ALA A 127
THR A 144
THR A 167
TYR A 162
 None
 1.29A 4z4gA-3qpcA:
5.6		 4z4gA-3qpcA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.38A 4z4gA-3r7kA:
undetectable		 4z4gA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		4 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.41A 4z4gA-3sl1A:
4.5		 4z4gA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.34A 4z4gA-3ti7A:
undetectable		 4z4gA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 ASP A 314
ALA A 256
THR A 307
TYR A 313
 None
 1.25A 4z4gA-3vohA:
undetectable		 4z4gA-3vohA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		4 ALA B 167
THR B 135
THR B 203
TYR B 202
 None
 1.35A 4z4gA-4ci0B:
2.5		 4z4gA-4ci0B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djh KAPPA-TYPE OPIOID
RECEPTOR, LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A 155
ALA A 166
THR A  94
THR A  92
 None
 1.48A 4z4gA-4djhA:
undetectable		 4z4gA-4djhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.40A 4z4gA-4hpvA:
undetectable		 4z4gA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij5 PHOSPHOSERINE
PHOSPHATASE 1

(Hydrogenobacter
thermophilus) 		PF00300
(His_Phos_1) 		4 ASP A 175
ALA A 177
THR A 197
TYR A 204
 None
 1.23A 4z4gA-4ij5A:
2.1		 4z4gA-4ij5A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jng NUCLEOCAPSID PROTEIN

(Sathuperi
orthobunyavirus) 		PF00952
(Bunya_nucleocap) 		4 ASP A 156
ALA A 154
THR A 139
TYR A 158
 None
 1.39A 4z4gA-4jngA:
undetectable		 4z4gA-4jngA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		4 ASP A 289
ALA A 284
THR A 288
THR A 269
 None
None
None
NA  A 402 (-3.3A)
 1.37A 4z4gA-4jnqA:
undetectable		 4z4gA-4jnqA:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 ASP A 535
ALA A 541
THR A 850
THR A 853
TYR A 855
 None
 0.12A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.50A 4z4gA-4lbwA:
undetectable		 4z4gA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF06013
(WXG100)
PF06013
(WXG100) 		4 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.28A 4z4gA-4lwsB:
undetectable		 4z4gA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		4 ASP A 431
ALA A 429
THR A 389
TYR A 432
 MMA  A 502 (-3.1A)
None
None
MMA  A 502 (-3.8A)
 1.47A 4z4gA-4mq0A:
undetectable		 4z4gA-4mq0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASP O 195
ALA O 199
THR O 181
THR O 179
 None
None
None
NAD  O 401 ( 4.9A)
 1.49A 4z4gA-4o59O:
undetectable		 4z4gA-4o59O:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ASP A  16
ALA A  36
THR A  38
THR A 207
 None
 1.48A 4z4gA-4o6rA:
3.2		 4z4gA-4o6rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 ASP A 142
ALA A  53
THR A 271
THR A 283
 CO  A 301 ( 2.5A)
NA  A 305 ( 4.5A)
NA  A 305 ( 3.9A)
None
 1.49A 4z4gA-4ookA:
undetectable		 4z4gA-4ookA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.27A 4z4gA-4qtfA:
undetectable		 4z4gA-4qtfA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 ASP A  31
ALA A  46
THR A  48
THR A 252
 INS  A 402 ( 4.3A)
None
None
None
 0.99A 4z4gA-4rv3A:
undetectable		 4z4gA-4rv3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		4 ASP A 147
ALA A 140
THR A 116
THR A 152
 None
 1.27A 4z4gA-4u1aA:
2.7		 4z4gA-4u1aA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		4 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.36A 4z4gA-4uhhA:
undetectable		 4z4gA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlt RESPONSE REGULATOR
RECEIVER PROTEIN

(Dyadobacter
fermentans) 		PF00072
(Response_reg) 		4 ASP A   2
ALA A   0
THR A  26
THR A  27
 None
 1.33A 4z4gA-4xltA:
3.1		 4z4gA-4xltA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxt FUSION OF PREDICTED
ZN-DEPENDENT
AMIDASE/PEPTIDASE
(CELL WALL
HYDROLASE/DD-CARBOXY
PEPTIDASE FAMILY)
AND UNCHARACTERIZED
DOMAIN OF ERFK
FAMILY
PEPTODOGLYCAN-BINDIN
G DOMAIN

(Clostridium
acetobutylicum) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		4 ASP A 270
ALA A 265
THR A 225
TYR A 269
 None
 1.31A 4z4gA-4xxtA:
undetectable		 4z4gA-4xxtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7q NUDF PROTEIN

(Bdellovibrio
bacteriovorus) 		PF00293
(NUDIX) 		4 ASP A 122
ALA A  45
THR A  85
THR A  88
 None
GOL  A 207 (-3.5A)
None
None
 1.48A 4z4gA-5c7qA:
undetectable		 4z4gA-5c7qA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.35A 4z4gA-5czrA:
undetectable		 4z4gA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))

(Clostridioides
difficile) 		PF08501
(Shikimate_dh_N) 		4 ASP A 101
ALA A  79
THR A 100
THR A  87
 None
 1.46A 4z4gA-5dzsA:
4.9		 4z4gA-5dzsA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 ASP A  89
ALA A 161
THR A 134
THR A 135
 None
 1.48A 4z4gA-5ey8A:
2.3		 4z4gA-5ey8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ASP A 529
ALA A 485
THR A 483
THR A 496
 None
 1.49A 4z4gA-5f75A:
undetectable		 4z4gA-5f75A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 ASP A 174
ALA A 172
THR A 157
THR A 150
 A  C   2 ( 4.1A)
None
None
None
 1.33A 4z4gA-5habA:
undetectable		 4z4gA-5habA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.33A 4z4gA-5hlbA:
undetectable		 4z4gA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		4 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.16A 4z4gA-5im2A:
undetectable		 4z4gA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.27A 4z4gA-5jrjA:
undetectable		 4z4gA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 4 ALA A 269
THR A 323
THR A 326
TYR A 271
 CA  A 502 (-4.6A)
None
None
None
 1.28A 4z4gA-5minA:
undetectable		 4z4gA-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 ASP A 529
ALA A 485
THR A 483
THR A 496
 None
None
CU  A 604 ( 4.8A)
None
 1.45A 4z4gA-5oexA:
undetectable		 4z4gA-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		4 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.45A 4z4gA-5swvC:
undetectable		 4z4gA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		4 ASP A 250
ALA A 258
THR A 286
THR A 285
 None
 1.50A 4z4gA-5tj6A:
3.6		 4z4gA-5tj6A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 ASP A 538
ALA A 544
THR A 853
THR A 856
 None
 0.73A 4z4gA-5vm9A:
55.6		 4z4gA-5vm9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 ASP A 538
ALA A 544
THR A 856
TYR A 858
 None
 0.57A 4z4gA-5vm9A:
55.6		 4z4gA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 ASP A 537
ALA A 543
THR A 852
TYR A 857
 None
 0.68A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		4 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.33A 4z4gA-5wtfA:
undetectable		 4z4gA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 ASP A 261
ALA A 297
THR A 267
TYR A 266
 None
 1.46A 4z4gA-5xmdA:
undetectable		 4z4gA-5xmdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi GUANINE
NUCLEOTIDE-BINDING
PROTEIN BETA
SUBUNIT, PUTATIVE

(Trichomonas
vaginalis) 		no annotation 4 ASP g 324
ALA g  35
THR g 307
TYR g 322
 None
 1.36A 4z4gA-5xyig:
undetectable		 4z4gA-5xyig:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 ASP A 193
ALA A 263
THR A 405
TYR A 418
 CA  A 801 (-2.2A)
None
None
None
 1.43A 4z4gA-5yl7A:
2.2		 4z4gA-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A 136
ALA A 140
THR A 134
THR A 133
 None
 1.47A 4z4gA-5z9yA:
undetectable		 4z4gA-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 ASP A 430
ALA A 462
THR A 464
THR A 531
 None
 1.48A 4z4gA-6aunA:
4.5		 4z4gA-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.95A 4z4gA-6f91A:
undetectable		 4z4gA-6f91A:
undetectable